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All Journal Journal of Pharmaceutical and Health Research LOSARI: Jurnal Pengabdian Kepada Masyarakat Journal of Fundamental and Applied Pharmaceutical Science JUKESHUM: Jurnal Pengabdian Masyarakat Mejuajua Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Kedokteran Hewan Jurnal Indah Sains dan Klinis
Vriezka Mierza
Universitas Tjut Nyak Dhien
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Journal : Jurnal Kedokteran Hewan

 1 
EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy Nerdy; Linta Meliala; Bunga Rimta Barus; Puji Lestari; Selamat Ginting; Peny Ariani; Vriezka Mierza; Tedy Kurniawan Bakri
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.069 KB) | DOI: 10.21157/j.ked.hewan.v15i1.18406

Abstract

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.
Co-Authors alma Handayani Lubis Anna Juniar Ari Usman Ariani, Peny Asmara Sari Nasution Bunga Rimta Barus Dwi Suryanto Eva Sartika Dasopang Ika Julianti Tambunan Juwairiah - Kanne Dachi Linta Meliala Linta Meliala M. Pandapotan Nasution Mariani Razali Mariany Razali Meutia Indriana Munir Alinu Mulki Nerdy, Nerdy Nilsya Febrika Zebua, Nilsya Febrika Nirwana Putri Nurmala Sari Nurmala Sari Pravil Mistriyanto Tambunan Pravil Mistryanto Tambunan Puji Lestari Ratih Paramitha Raudya Setya Wismoko Putri Rosniwaty Br. Bangun Salman Salman Saputri, Muharni Selamat Ginting Septiani, Dia Siti Elisa Sudewi Sudewi - Sudewi Sudewi Sumardi Sumardi Supran Hidayat Sihotang Supran Hidayat Sihotang Syarifah Nadia Tedy Kurniawan Bakri Werti Yessi Febriani Yessi Febriani