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All Journal The Indonesian Biomedical Journal Nusantara Medical Science Journal Jurnal Biologi Tropis Jurnal Ilmiah Ecosystem Oto Rhino Laryngologica Indonesiana YARSI Medical Journal International Journal of Nasopharyngeal Carcinoma Jurnal Riset Multidisiplin : Agrisosco
Abdul Qadar Punagi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Journal : Nusantara Medical Science Journal

 1 
IL-1β Expression of Patients with Chronic Rhinosinusitis is negatively correlated with Lund-Mackay score Lidya Turupadang; Muhammad Fadjar Perkasa; Abdul Qadar Punagi; Azmi Mi'rah Zakiah; Burhanuddin Bahar
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18765

Abstract

Introduction: IL-1β is one of the proinflammatory cytokines which is commonly found in various diseases, including Chronic Rhinosinusitis (CRS). It has been widely targeted as a therapeutic approach for inflammatory diseases. However, study of IL-1β expression and its correlation with CT-Scan grading scores in CRS is still scarce. Objective: To investigate IL-1β expression based on immunohistochemical examination and analyse its correlation with Lund-Mackay score in CRS with and without polyps. Method: This analytic observational study was done on 50 patients: 25 subjects in the CRS with Nasal Polyps (CRSwNP) group and 25 subjects in the CRS without Nasal Polyps (CRSsNP) group. The uncinate process was taken for immunohistochemical examination of IL-1β. Lund-Mackay score was calculated based on CT-Scan of the paranasal sinus. Result: IL-1β expression in CRSsNP (mean=36.38) was significantly higher than that in the CRSwNP (mean=14.62) with p<0.001. Lund-Mackay score in CRSwNP was higher (mean=35.22) compared to CRSnNP group (mean=15.78) with p<0.001. There was a moderate negative correlation (-0.403) between IL-1β expression and Lund-Mackay score (p<0.05). Conclusion: There was a moderate negative correlation between IL-1β expression and Lund-Mackay score. The IL-1β and the Lund-Mackay score in CRSwNP were lower and higher, respectively, than in CRSsNP
Correlation of Rhinomanometry Measurement and True Lateral Radiography towards the Degree of Upper Airway Obstruction in Patients with Adenoid Hypertrophy Nanda Mayasari; Sutji Pratiwi Rahardjo; Abdul Kadir; Muhammad Fajar Perkasa; Abdul Qadar Punagi
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18869

Abstract

Background: Adenoid hypertrophy is one of the most common disorders in children which may lead to upper airway obstruction. Various modalities to measure airway obstruction in patients with adenoid hypertrophy, including true lateral radiographs, nasoendoscopy, and rhinomanometry are available; however, the results from different studies are still controversial. This study aimed to determine the relationship between the results of rhinomanometry and the true lateral radiographs to the degree of upper airway obstruction in patients with adenoid hypertrophy. Methods: This cross-sectional study included a total of 33 patients with adenoid hypertrophy aged 5-18 years using a purposive sampling technique. Patients diagnosed with adenoid hypertrophy were subjected to a true lateral examination using lateral neck radiographs to measure the degree of airway obstruction. Subsequently, an active anterior rhinomanometry was performed by measuring resistance and nasal airflow and then measuring the degree of airway obstruction. Data analysis was done using Chi-Square test. Results: The rhinomanometric nasal resistance in the inspiratory phase was 0.4159 ± 0.15201 Pa/cm3/s and 0.3694 ± 0.13717 Pa/cm3/s in the expiration phase. The results showed a significant relationship between the true lateral radiographs and both nasal inspiratory (p=0.005) and expiratory resistance (p=0.004). Similarly, the relationship between the true lateral radiographs and nasal airflow on both inspiratory and expiratory rhinomanometry was significant (p<0.05). Conclusion: Rhinomanometric measurements can be used as an additional objective examination in assessing the degree of upper airway obstruction in patients with adenoid hypertrophy prior to surgery.
The Relationship between Neutrophil on Lymphocyte Ratio with Clinical Stage of Nasopharyngeal Carcinoma Patients Nur Fadhila Kurnia; Abdul Qadar Punagi
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.19121

Abstract

Introduction: The general objective of this study was to determine the relationship between the ratio of neutrophils to lymphocytes and the clinical stage in patients with nasopharyngeal carcinoma. While the specific goal is to know the characteristics of patients with nasopharyngeal carcinoma. Knowing the description of peripheral neutrophil levels in patients with nasopharyngeal carcinoma. Knowing the description of peripheral lymphocyte levels in patients with nasopharyngeal carcinoma. Knowing the picture of NLR at the clinical stage of patients with nasopharyngeal carcinoma. Methods:The target population in this study were all patients with nasopharyngeal carcinoma. The affordable population is all patients with nasopharyngeal carcinoma who are undergoing treatment at. RSUP. Dr Wahidin Sudirohusodo for the period July 2018 to July 2019.. Results: Based on statistical analysis of the data, this study did not find a significant relationship between the neutrophil-lymphocyte ratio and the clinical stage of nasopharyngeal carcinoma (P = 0.252), even after correcting for sex. Statistical tests were used to see whether or not there was a relationship. between these two variables is the Kruskal-Wallis test, which was chosen because it is a non-parametric comparative test for variables with more than two categories. Conclusions: Based on statistical analysis of the data, this study did not find a significant relationship between the neutrophil-lymphocyte ratio and the clinical stage of nasopharyngeal carcinoma (P = 0.252), even after correcting for sex.
Co-Authors Abdul Kadir Abdul Kadir Agri, Hardianti Agusalim Bukhari Alimah, Yarni Aminuddin Aminuddin Anak Agung Ayu Niti Wedayani Andi Alfian Zainuddin Andi Baso Sulaiman Andriani, Yunida Azmi Mi'rah Zakiah Budu Budu Burhanuddin Bahar Cangara, Husni Dewi Kurniawati Eka Savitri Eka Sunarwidhi Prasedya Emanuel Quadarusman Ervina Mariani Evans, Gunterus Fadjar Perkasa Fatmawati Arsyad Said Freddy George Kuhuwael Frederik George Kuhuwael Gaffar, Masyita Hamid, Firdaus Hamsu Kadriyan Hasbullah, Ayu Ameliyah Ima Arum Lestarini Irawan Yusuf Khaeruddin K Lidya Turupadang Mahmuddin, Ihsan Makbul, Hidayat Mochammad Hatta Muhammad Amsyar Akil Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Fajar Perkasa Nanda Mayasari Nani Iriani Djufri Nani Iriani Djufri Nova Audrey Luetta Pieter Nur Fadhila Kurnia Pandiangan, Marojahan Pieter, Nova Audrey Luetta Pratiwi Rahardjo, Sutji Rachmawati Djalal Rahardjo, Sutji P Rahmy Sujuthi, Ade Ramadhita, Nova Izza Salsa Restuningdyah, Novia Andansari Putri Rina Masadah Riskiana Djamin Rita Talango Romdhoni, Achmad Chusnu Sutji P. Rahardjo Syahrijuita, Syahrijuita Tanty Tanagi Toluhula Tobo, Gadis Sabrina UPIK ANDERIANI MISKAD, UPIK ANDERIANI