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All Journal Jurnal Entropi Sainstek Alchemy : Journal of Chemistry Jurnal Pengabdian Pada Masyarakat Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Fullerene Journal of Chemistry JURNAL FARMASIMED (JFM) Dedikasi: Jurnal Pengabdian Masyarakat Damhil: Jurnal Pengabdian kepada Masyarakat
Suleman Duengo
Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Total Synthesis and Potential Bioactivity of Linear Peptide LSAVTPG Aloanis, Anderson Arnold; Paat, Vlagia Indira; Duengo, Suleman
Jurnal Kimia Fullerene Vol 11 No 2: Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v11i2.790

Abstract

The total synthesis of the linear peptide LSAVTPG was successfully carried out using the solid-phase peptide synthesis (SPPS) method. The synthesis employed the Fmoc/tBu protection strategy on a 2-chlorotrityl chloride resin as the solid support. Following chain assembly, the final peptide was cleaved from the resin using 95% trifluoroacetic acid (TFA), affording the target peptide with a yield of 81.6%. Structural confirmation was performed by high-resolution mass spectrometry (HRMS), which showed an observed ion at m/z 644.3621, consistent with the calculated value of m/z 644.3619 for C₂₈H₅₀N₇O₁₀. Purity and retention characteristics were further analyzed using analytical HPLC, where the peptide exhibited a retention time of 13.536 minutes. These results demonstrate that the SPPS method with Fmoc/tBu chemistry is an efficient strategy for the synthesis of the LSAVTPG peptide with high yield and analytical confirmation. The potential bioactivity screened computationally and showed some potential such as spanning oncology, cardiometabolic regulation, neurodegeneration, immunology, and inflammation.
Co-Authors A. Ghanaim Fasya Ahmad Kadir Kilo Akram La Kilo Anderson Arnold Aloanis Arviani Arviani Arviani Bait, Dewimuliawati J. Boima Situmeang Chairil Anwar Deasy Natalia Botutihe Duengo, Humairah Amatullah Erni Mohamad Harun, Nurul Fadilla Hendri Iyabu Julhim S Tangio Jumina Jumina La Ode Aman Lakasan, Ahmad Chandra M. Rahman Mardjan Paputungan Musa, Wenny JA Musa, Weny J.A. Naiyo, Marlina H. Najmi Abdjul Netty Ino Ischak Nita Suleman Nurhayati Bialangi Opir Rumape Paat, Vlagia Indira Pakuna, Nurpepi Podungge, Muhamad Ramdhan Rurini Retnowati Rurini Retnowati Ruslan, Rusnawati Syaifudin, Nuur Arif Van Gobel, Sri Indriyani Warsito Warsito Warsito Warsito Weny J.A Musa Wiwin Rewini Kunusa Yusuf, Andriyana Yuszda K Salimi Zelita Fitri Ente