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Winda Rahmalia
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Jl. Ahmad Yani Pontianak, Kalimantan Barat 79124
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Energy Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Other

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UJI AKTIVITAS ANTIOKSIDAN FRAKSI ETIL ASETAT BIJI KESUMBA, FRAKSI ETIL ASETAT KUNYIT, DAN KOMBINASINYA Asniati, Asniati; Rahmalia, Winda; Sayekti, Endah
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art2

Abstract

Background: Antioxidants are compounds that can neutralize free radicals, so they can prevent degenerative diseases such as cardiovascular disease, carcinogenesis, and other diseases. Natural ingredients such as kesumba (Bixa orellana L.) seeds and turmeric (Curcuma longa L.) contain natural pigments that have antioxidant activity. Kesumba seeds contain bixin, and turmeric contains curcumin, each of which is an antioxidant compound that can protect cells in the body and prevent oxidative stress due to free radicals.Objective: To determine the effect of the combination ratio of the ethyl acetate fraction of kesumba seeds and the ethyl acetate fraction of turmeric on antioxidant activity.Method: Extraction was carried out by the maceration method, followed by fractionation. A qualitative test of the content of compounds in each extract and fraction of kesumba seeds and turmeric was carried out using the TLC method. The antioxidant activity test of each ethyl acetate fraction of kesumba seeds (FB) and ethyl acetate fraction of turmeric (FK) and their combination was carried out using the DPPH method.Result: The research showed that the antioxidant activity of the ethyl acetate fraction of kesumba seeds (FB) to the ethyl acetate fraction of turmeric (FK) was 242.95, 65.78, 42.48, 108.81, and 51.46 mg/L for each of the mass ratios (1:0), (3:7), (1:1), (7:3), and (0:1). The combination ratio of FB:FK, which is 1:1, has an effect on increasing antioxidant activity. This combination provides a synergistic effect that can increase antioxidant activity, with an IC50 value of 42.48 mg/L.Conclusion: Based on the results of the study, it can be concluded that the combination of the ethyl acetate fraction of kesumba seeds (FB) and the ethyl acetate fraction of turmeric (FK) has an effect on increasing antioxidant activity in the ratio of FB:FK (1:1) with an IC50 value of 42.48 mg/L, which is included in the very strong antioxidant category.Keywords: Kesumba seeds, turmeric, bixin, curcumin, antioxidant Intisari Latar belakang: Antioksidan adalah senyawa yang dapat menetralisir radikal bebas sehingga mampu mencegah penyakit-penyakit degeneratif seperti kardiovaskuler, karsinogenesis dan penyakit lainnya. Bahan alam seperti biji kesumba (Bixa orellana L.) dan kunyit (Curcuma longa L.) mengandung pigmen alami yang memiliki aktivitas antioksidan. Biji kesumba mengandung bixin dan kunyit mengandung kurkumin yang masing-masing merupakan senyawa antioksidan sehingga mampu melindungi sel-sel dalam tubuh dan mencegah stress oksidatif yang diakibatkan oleh radikal bebas. Tujuan: Untuk mengetahui pengaruh rasio kombinasi fraksi etil asetat biji kesumba dan fraksi etil asetat kunyit terhadap aktivitas antioksidan.Metode: Ekstraksi menggunakan metode maserasi dan dilanjutkan dengan fraksinasi. Uji kualitatif kandungan senyawa dalam masing-masing ekstrak dan fraksi bixin dan kurkumin dilakukan menggunakan metode kromatografi lapis tipis (KLT). Uji aktivitas antioksidan masing-masing fraksi etil asetat biji kesumba dan fraksi etil asetat kunyit serta kombinasinya dilakukan menggunakan metode DPPH.Hasil: Hasil penelitian menunjukkan bahwa tiap kombinasi rasio massa fraksi etil asetat biji kesumba (FB); fraksi etil asetat kunyit (1:0), (3:7), (1:1), (7:3) dan (0:1) memiliki aktivitas antioksidan berturut-turut sebesar 242,95; 65,78; 42,48; 108,81; dan 51,46 mg/L. Kombinasi tersebut memberikan efek sinergis yang dapat meningkatkan aktivitas antioksidan dengan nilai IC50 sebesar 42,48 mg/L. Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa pada kombinasi fraksi etil asetat biji kesumba (FB) dan fraksi etil asetat kunyit (FK) dengan rasio FB:FK (1:1) memberikan pengaruh pada peningkatan aktivitas antioksidan dengan nilai IC50 sebesar 42,48 mg/L yang termasuk dalam kategori antioksidan sangat kuat.Kata kunci: Biji kesumba, kunyit, bixin, kurkumin, antioksidan
PENGARUH KOMBINASI PIGMEN KURKUMIN-β-KAROTEN TERHADAP SPEKTRA ABSORPSI DAN NILAI SPF PADA SEDIAAN LOTION Yanti, Ninda Meili; Alimuddin, Andi Hairil; Rahmalia, Winda
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 3 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i3.77543

Abstract

This research aimed to examine the effect of the combined use of curcumin and β-carotene pigments on their absorption spectra. Subsequently, these pigment combinations were incorporated into a lotion formulation to determine their respective Sun Protection Factor (SPF) values. Mixtures of curcumin and β-carotene were prepared at mass ratios (w/w) of 0:5, 1:4, 2:3, 3:2, 4:1, and 5:0. Their absorption spectra were analyzed with a UV-Vis spectrophotometer over the 200"“600 nm wavelength range using ethyl acetate as the solvent. Then, 6% of each pigment mixture was incorporated into a lotion base. The results of the UV-Vis analysis revealed no significant spectral shifts across the various mixtures. However, a notable increase in absorption intensity (a hyperchromic effect) was explicitly observed for the 1:4 mass ratio of curcumin to β-carotene. The SPF values for the lotion samples containing 6% of the pigment mixtures were as follows: 5.02 (0:5), 8.32 (1:4), 8.63 (2:3), 8.10 (3:2), 8.14 (4:1), and 8.09 (5:0). Although the observed increase was not statistically significant, these findings suggest that the combination of curcumin and β-carotene pigments can enhance the SPF value relative to that of the individual components.
Determination of Optimum Conditions for Biodiesel Synthesis from Bulk Palm Oil Using Red Mud-CaO Catalyst Nurdianty, Sri; Usman, Thamrin; Rahmalia, Winda
agriTECH Vol 45, No 1 (2025)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/agritech.79978

Abstract

The synthesis of biodiesel from bulk palm oil using methanol and a heterogeneous catalyst, red mud-CaO, has been carried out. This research aimed to investigate the effect of the ratio of red mud-CaO, percent catalyst, and reaction time on the conversion of methyl ester. Red mud and CaO catalysts were obtained from calcining red mud and clay bath CaCO3 (calcium carbonate) waste at 200°C and 900 o C for 5 and 4 hours, respectively. Biodiesel synthesis was carried out by adding bulk palm oil:methanol (1:10 v/v) and red mud-CaO heated for 1, 2, and 3 hours at 65 o C. In addition, the reaction was followed using thin-layer chromatography (TLC) and Gas Chromatography-Mass Spectrophotometry (GC-MS). Optimum reaction conditions were obtained at the ratio of red mud-CaO (1:1 w/w), catalyst 5%, and time of 2 hours indicated by the total formation of methyl ester on TLC plate. Meanwhile, red mudCaO (1:1 w/w) catalyst was characterized by x-ray diffraction (XRD) and x-ray fluorescence (XRF) to determine the crystal structure and element composition. The analysis was carried out using Fourier transform infra-red (FTIR) to determine the functional groups of catalyst. XRD characterization results showed that there were 4 highest peaks, namely 29.29° (CaCO3 ), 33.99° and 17.93° (Ca(OH)2 ), and 11.59° (aluminum silicate mineral). The 4 highest elemental contents were Ca, Fe, Al, and Si. FTIR characterization showed the peak wavenumbers 3641.60 cm -1 (Ca(OH)2 ),1423.47 cm -1 (O-C-O bond of carbonate), 981.77 cm -1 and 986.69 cm -1 (Si-O), 875.68 cm -1 and 713.66 cm -1 (Ca-O), 366.48 cm -1 (Al-O), and 426.27 cm -1 (Fe-O). According to GC-MS analysis, the most formed methyl ester compositions were methyl oleate (47.35%) and methyl palmitate (40.13%).
Pelatihan Pembuatan Tas Berbahan Dasar Sampah Plastik Sebagai Upaya Penerapan 3R pada Kelompok Sadar Wisata Teluk Majantu, Kelurahan Sedau, Singkawang Zahara, Titin Anita; Shofiyani, Anis; Sayekti, Endah; Gusrizal, Gusrizal; Alimuddin, Andi Hairil; Sapar, Ajuk; Rudiyansyah, Rudiyansyah; Wibowo, Muhamad Agus; Usman, Thamrin; Wahyuni, Nelly; Nofiani, Risa; Widiyantoro, Ari; Rahmalia, Winda; Rahayu, Warsi Kurnia
Abdimas Galuh Vol 6, No 1 (2024): Maret 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i1.12701

Abstract

Kegiatan pelatihan pembuatan tas goodie bags pada Kelompok Sadar Wisata (POKDARWIS) di Desa Teluk Makjantu bertujuan untuk memberikan pemahaman kepada POKDARWIS untuk menjaga lingkungan dengan melakukan pengelolaan sampah 3R. Sampah pelastik dipilih karena pemakaian kantong pelastik yang sudah menjadi barang yang tidak terpisahkan dari kehidupan manusia serta memiliki sifat yang sulit terdegradasi (nonbiodegradable) di lingkungan. Goodie bags berbahan dasar limbah pelastik diharapkan dapat menjadi wadah penyimpanan souvenir bagi POKDARWIS Desa Makjantu dalam melayani wisatawan. Pelatihan ini dilakukan dengan menyajikan teori dan praktek pembuatan goodie bags secara langsung, diharapkan masyarakat POKDARWIS dapat melakukan pengelolaan sampah dengan konsep 3R dan dapat membuat goodie bags dari limbah pelastik sebagai upaya pelestarian dan pengelolaan lingkungan. Pelatihan ini juga memberikan dampak terhadap keterampilan peserta dalam mengelola limbah pelastik menjadi barang yang dapat dimanfaatkan. Dengan demikian, program mengelolaan sampah dengan metode 3R dapat diterapkan. Melihat kondisi dan antusias peserta dapat dikatakan bahwa kegiatan ini sangat memberikan dampak positif bagi masyarakat Desa Teluk Majantu untuk  mendukung kegiatan pariwisata dalam hal pengelolaan sampah pelastik dengan tingkat kebermanfaatan dan keberlangsungannya sebesar 90%
Formulasi Krim Bibir dengan Ekstrak Antosianin dari Bunga Telang (Clitoria ternatea) sebagai Pewarna Alami Aprilia, Jelita; Rahmalia, Winda; Budi, Firman Shantya
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art4

Abstract

Background: Butterfly pea (Clitoria ternatea) is a tropical plant rich in anthocyanins, particularly from the flavonoid group, which has potential as a natural dye and antioxidant in cosmetic formulations.Objective: This study aims to investigate the phytochemical characteristics of anthocyanin extract from butterfly pea flowers and the physical and chemical stability of lip cream formulated with the extract.Method: Anthocyanin extract from butterfly pea flowers was formulated into a lip cream base at concentrations of 0, 2, 4, and 6%, followed by a physical stability test conducted over a period of one month on days 0, 7, 14, 21, and 28. The results were then compared with established standards.Results: The anthocyanin extract of butterfly pea flower contains flavonoids, saponins, tannins, and terpenoids. Four lip cream formulations prepared with varying concentrations of the extract exhibited a thick texture, a grape-like aroma, and colors ranging from ivory to purple. The formulations had viscosities between 5,500 and 13,000 cP, adhesion times ranging from 7.10 to 26.8 seconds, and spreadability values between 5 and 7.5 cm.Conclusion: All stability tests of the butterfly pea flower extract lip cream formulations met the required criteria, except for the homogeneity test. Formulation 1 (2%) was identified as the most optimal. All stability tests for the butterfly pea flower extract lip cream formulations met the required criteria, except for the homogeneity test. Formulation 1 was identified as the most optimal, containing 2% extract concentration.
Co-Authors Adhitiyawarman, Adhitiyawarman Agustiawan, Deri Ajuk Sapar Alimunddin, Andi Hairil Andi Hairil Alimuddin Anis Shofiyani Aprilia, Jelita Ari Widiyantoro Asniati, Asniati Chitra, Fara Endah Sayekti Fadly, Dzul Fani Indriani, Fani Firman Shantya Budi, Firman Shantya Gusrizal Gusrizal Heni Pujiastuti Imelda Hotmarisi Silalahi Lestari, Titiek Lubis, Yosef Novem Batistuta Naselia, Uray Amira Nelly Wahyuni Nurdianty, Sri Prayitno, Dwi Imam Putri, Alintianni Yolla Putri, Dea Malyana Rahayu, Warsi Kurnia Risa Nofiani Rudiyansyah Rudiyansyah Rudiyansyah, R. Sugandi, Didiek Suriyanti, Lieli Syamsi, Wisi Wilanda Th. Candra Wasis Agung Sutignya Thamrin Usman Titin Anita Zahara, Titin Anita Wibowo, Muhamad Agus Widiyananta, Surya Yanti, Ninda Meili Yohana Sutiknyawati Kusuma Dewi