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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Bioteknologi & Biosains Indonesia (JBBI) Pharmasipha JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Mandala Pharmacon Indonesia Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Indonesian Journal of Pharmaceutical Education International Journal of Science and Society (IJSOC) Jurnal Multidisiplin Madani (MUDIMA) East Asian Journal of Multidisciplinary Research (EAJMR) Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Tropis Indonesia Calakan: Jurnal Sastra, Bahasa, dan Budaya Fundamental : Jurnal Ilmiah Hukum
Ismi Rahmawati
Faculty of Pharmacy, Setia Budi University  
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Green Synthesis Of Silver Nanoparticles Of Leaf Extract Of Senduduk Bulu (Clidemia Hirta (L) D.Don) And Exploration Of The Antibacterial Activity Arvian, Dias Wahyu; Rahmawati, Ismi; Ikasari, Endang Diyah
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.574

Abstract

Senduduk bulu wild plant contains secondary metabolite compounds which used natural reducing agent on synthesis of silver nanoparticles (AgNPs). This research determine the optimum extract concentration and temperature in the process synthesis of silver nanoparticle, characteristics of silver nanoparticles and antibacterial activity of silver nanoparticles against S.aureus and E.coli. Synthesis of silver nanoparticles senduduk bulu leaf using variations extract concentration and temperature variations. The characteristics of silver nanoparticles senduduk bulu leaf were carried out using a UV-Vis Spectrophotometry, Particle Size Analyzer (PSA) and Scanning Electron Microscopy – Energy Dispersive X-Ray Spectroscopy (SEM-EDS). Antibacterial activity testing used the disc diffusion method. The results of research showed the silver nanoparticles of senduduk bulu leaf were successfully synthesized under optimal conditions an extract concentration of 1% and temperature of 60ºC indicated the colloid color changing to brown and maximum wavelength value of 413 nm with absorbance value of 2.9987. The size of colloidal AgNPs of senduduk bulu leaf was 59.2 ± 1.03 nm; zeta potential value -39.3±0.509 mV. The morphology of the AgNPs of senduduk bulu non uniform shape, the crystal size distribution is 50 – 230 nm with an average of 136 nm. The chemical composition of AgNPs crystals shows that silver (Ag) dominates with a weight concentration of 37.688% and atomic concentration of 7.605% at the peak of the 3 KeV spectrum. Feathered AgNPs had antibacterial activity against S.aureus of 14.1 ± 0.3 mm and E. coli of 13.5 ± 0.2 mm. Keywords: Green Synthesis, Silver Nanoparticle, Senduduk Bulu Leaf, Staphylococcus aureus and Escherichia coli.
PERBANDINGAN KRIM ANTIBAKTERI EKSTRAK PEGAGAN (Centella asiatica (L.) Urban) DENGAN VARIASI BASIS COLD CREAM DAN VANISHING CREAM TERHADAP Staphylococcus aureus Sutrisno, Sahya Rania; Rahmawati, Ismi
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p162-171

Abstract

Cosmetic care products are designed to enhance human appearance. Centella asiatica (L). Urban, commonly known as gotu grain, is a natural ingredient that can be effectively used in anti-acne creams. The objective of this study is to investigate and compare the antimicrobial efficacy of cold cream and vanishing cream bases against Staphylococcus aureus, with a focus on determining their potential inhibitory effects. The preparation of cold cream involved a melt-emulsification process utilizing surfactants. In contrast, the vanishing cream was prepared using a melting method. Physical quality assessment was conducted through visual observation, evaluating organoleptic properties and homogeneity. The physical and antibacterial properties of the creams were evaluated using various standardized methods. Viscosity was measured using a Brookfield Viscometer, pH levels were assessed with a pH meter, spreadability and adhesion were evaluated using respective testers, and antibacterial activity was determined via the disc diffusion method. Statistical analysis of the physical quality test results was performed using the Independent Samples T-test, while antibacterial activity data were analyzed using One-Way ANOVA. The results of the physical quality evaluation revealed significant differences in the organoleptic properties among the gotu-gotu extract cream, cold cream base variation, and vanishing cream. However, no significant differences were observed in terms of homogeneity among the three formulations. The vanishing cream exhibited a significantly higher spreadability, with a mean value of 5.98 cm (n=3), compared to the cold cream base variation. Conversely, the vanishing cream displayed lower viscosity (mean: 3,560 cP, n=3) and adhesion (mean: 1.61 seconds, n=3) values compared to the cold cream base variation. The gotu-gotu extract cream formulated with a vanishing cream base exhibited potent antibacterial activity against Staphylococcus aureus, as evidenced by a significant inhibition zone diameter of 17.6 mm. This result meets the criteria for strong inhibition strength and is comparable to the positive control, demonstrating superior antibacterial efficacy relative to the cold cream base variation.
Akibat Hukum Putusan Pra Peradilan Terhadap Penetapan Tersangka Dugaan Melakukan Tindak Pidana Korupsi Di Sekretariat DPRD Tulang Bawang: (Studi Putusan Nomor: 6/Pid.Pra/2020/PN.Tjk) Rahmawati, Ismi; Hartono, Bambang; Hasan, Zainudin
Fundamental: Jurnal Ilmiah Hukum Vol. 10 No. 1 (2021): Fundamental: Jurnal Ilmiah Hukum
Publisher : Universitas Muhammadiyah Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34304/jf.v10i1.33

Abstract

Salah satu perkara pengajuan pra peradilan terhadap penetapan tersangka dugaan melakukan tindak pidana korupsi adalah Putusan Nomor: 6/Pid.Pra/2020/PN.Tjk, dimana pada putusan tersebut menyatakan bahwa berdasarkan pertimbangan-pertimbangan tersebut diatas, Hakim berkesimpulan bahwa tindakan tindakan Termohon yang menetapkan Pemohon sebagai Tersangka karena adanya penyimpangan pengeluaran anggaran Sekretariat DPRD Kabupaten Tulang Bawang Tahun Anggaran 2018-2019 telah sesuai peraturan perundang undangan, sehingga Surat Penetapan Tersangka Nomor S.Tap/03/VI/2020/ Ditreskrimsus tertanggal 23 Juni 2020 terhadap Pemohon adalah sah dan mempunyai kekuatan hukum mengikat. Memperhatikan Pasal 77 Undang-undang Nomor 8 Tahun 1981 tentang Hukum Acara Pidana, Putusan Mahkamah Konstitusi Nomor 21/PUU-XII/2014 tertanggal 28 April 2015 dan Peraturan Mahkamah Agung RI Nomor 4 Tahun 2016 serta peraturan perundang-undangan lain yang bersangkutan serta Menolak permohonan praperadilan Pemohon untuk seluruhnya. Permasalahan penelitian ini adalah: Bagaimana proses penyidikan tindak pidana korupsi Sekretariat DPRD Tulang Bawang oleh Polda Lampung, Apakah dasar pertimbangan hakim Pengadilan Negeri Tanjung Karang dalam putusan Nomor: 6/Pid.Pra/2020/PN.Tjk yang menolak permohonan pra peradilan tersangka? dan Apa akibat hukum dari Putusan Pra peradilan Nomor: 6/Pid.Pra/2020/PN.Tjk. Metode penelitian menggunakan pendekatan yuridis normatif dan empiris. Jenis data yang digunakan adalah data sekunder dan data primer. Pengumpulan data melalui penelitian kepustakaan (library research) dan penelitian lapangan (field research). Analisis data yang digunakan adalah yuridis kualitatif
Optimization of Antibacterial Gel Preparation Formula of Aloe Vera Leaf Flesh Fraction (Aloe Vera L.) Against Staphylococcus Epidermidis Using Simplex Lattice Design Method Setyaningrum, Dewi Anggraheni; Kuncahyo, Ilham; Rahmawati, Ismi
East Asian Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i9.10945

Abstract

Acne is experienced by 90% of teenagers due to infection with the bacteria Staphylococcus epidermidis. Bacterial infections are treated with antibiotics, but excessive use causes resistance, so medicinal plants are used that do not have side effects. (Aloe vera L.) have antibacterial activity because contain anthraquinone compounds. The aim of research is update the optimization of aloe vera leaf gel to increase the effectiveness of use. The research method uses Simplex Laticce Design with HPMC, Karbopol and TEA. The optimum formula concentration of 1.3379% HPMC, 2.540% Carbopol and 0.481% TEA produced predicted and experimental values for adhesion power (7.977 and 7.5 seconds), spreadability (7 and 6.87 cm), pH (6.128 and 6 ), viscosity (246.775 and 265.3 dPa.S) and inhibition zone (23.772 and 22.66mm). The results of the Paired Sample Test for verification data show a p value of 0.430 > 0.05, is not significant difference between the predicted and the experimental.
Antibacterial Activity and Fractional Antibiofilm Black Mulberry Leaf (Morus Nigra. L) against Bacterial Staphylococcus Aureus ATCC 25923 Niva, Oktiva Cheria Kairul; Rahmawati, Ismi; Indrayati, Ana
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11213

Abstract

The purpose of this study is to determine the antibacterial activity of extracts and fractions against S. aureus bacteria, the most active fraction of black mulberry leaves has antibiofilm activity against S. aureus bacteria, the most active fraction is located in the cell membrane wall  of S. aureus bacteria. The leakage of K+ metal ions and Ca2+ was carried out using the AAS  method and the morphology  of S. aureus  bacterial colonies was observed using the SEM method. The test result of the concentration inhibition % of 12.5 mg/ml had the highest average percentage, which was 40.01. The average IC50 value of inhibition is 24.57. The biofilm degradation test had with an average of 34.98. EC50 value 48.98.
Evaluation of BPJS Drug Planning Controls in Regional General IFRS dr. Soehadi Prijonegoro Sragen Tongkonoo, Mutiah; Rahmawati, Ismi; Dewi, Lucia Vita Inandha
International Journal of Science and Society Vol 6 No 2 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i2.1129

Abstract

Service in the pharmaceutical sector at hospitals is one that must be carried out in a timely and high-quality manner in order to support good service. Controlling drug supplies has a major impact on the quality of service to patients. The aim of this research is to evaluate the BPJS drug inventory control system for the planning and procurement stages with ABC, VEN, ABC-VEN, EOQ. The research design is a type of non-experimental descriptive research with retrospective data collection. The data used for the period January-December 2021. The drugs analyzed are oral drugs and the most needed drugs are included in the ABC, VEN categories so that the BPJS ABC-VEN drug group is obtained. The results of ABC analysis with a total of 464 drugs were classified into groups. Group A 19%, group B 25.4% and group 55.6%. The VEN group analysis was Vital 19.4%, Essential 77.8% and non-Essential 2.8%. Based on the results of EOQ with a total of 113 items.
Antibacterial Activity Test of Ethanol Extract and Fraction of Carrot Leaf (Daucus Carota L.) Against Staphylococcus Aureus Akune, Nadia Ayuwanda S; Rahmawati, Ismi; Sulaiman, Saifullah
Jurnal Multidisiplin Madani Vol. 4 No. 3 (2024): March, 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i3.8604

Abstract

Staphylococcus aureus is one of the bacteria that cause acne and can cause skin and organ damage because bacteria can defeat the body's defences. Carrot leaf extract has antibacterial power or inhibitory activity against S. aureus. This study aims to determine the inhibition value and antibacterial activity of ethanol extract and n-hexane fraction of carrot leaves. The research method consists of extraction using 96% ethanol and fractionation using water, ethyl acetate, and n-hexane. The antibacterial activity of carrot leaf extracts and fractions was carried out using the pitting method as well as the use of gentamicin positive control and DMSO negative control. The results showed that 96% ethanol extract of carrot leaves with a concentration of 30% had inhibition against S. aureus bacteria with a value of 7.8 mm or weak inhibitory activity, and the ethyl acetate fraction of carrot leaves with a concentration of 20% had inhibition against S. aureus bacteria with a value of 11.27 mm or strong inhibitory activity. Therefore, ethyl acetate fraction of carrot leaves have inhibition against S. aureus bacteria with strong inhibitory activity compared to other test solutions and is equivalent to gentamicin positive control
Antibacterial and Antibiofilm Activity of Papaya Leaf Fractions (Carica Papaya L.) Against Staphylococcus Aureus ATCC 25923 Pranata, Yovi; Rahmawati, Ismi; Saptarini, Opstaria
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9879

Abstract

The research on papaya leaves was aimed at determining antibacterial activity, antibiofilm activity, K+ and Ca2+ metal ion parameters, as well as the morphology of S.aureus bacteria from papaya leaf fractions and extracts. The average value of the test results for the diffusion method at 50% concentration was 20.66 ± 0.57 and the test results for the dilution method for Minimum Inhibitory Concentration at a concentration of 12.5%. Antibiofilm formation inhibitor test results at a concentration of 50 mg/ml with an average value of 72.37 ± 0.65, a concentration of 25 mg/ml 64.75 ± 0.83 and a concentration of 12.5 mg/ml with an average value of IC50 of 0.975 ± 0.012. Biofilm degradation testing at a concentration of 50 mg/ml resulted in an average value of 60.43 ± 1.11, a concentration of 25 mg/ml with an average value of 50.05 ± 0.87 and a concentration of 12.5 mg/ml with an average value -mean 35.86 ± 1.05. The average EC50 value was 26.731 ± 1.1874. Tests using AAS on K+ metal ions showed ion leakage or cell contents coming out was 1,805 mg/L, Ca2+ metal ions resulting from this leak were 3,884. Morphological observations using SEM showed that the samples experienced shrinkage and reduced size from being perfectly round to oval to S.aureus bacteria in samples with water fraction
Evaluation and Development of a Prescription Service Management Information System in the Pharmacy Installation of Puruk Cahu Hospital Aryani, Norsarida; Peranginangin, Jason Merari; Rahmawati, Ismi
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9960

Abstract

Information systems have an important role in supporting the health service process, to support the performance of hospital services using computerization. The purpose of this study is to evaluate the prescription service information system with the HOT-FIT (human, organization, technology and net benefit) method at Puruk Cahu Hospital. This study used a cross-sectional quantitative descriptive design  with a sample of 20 respondents. Data collection was carried out by direct observation, interviews with the Head of Pharmaceutical Installation, pharmacists, and pharmaceutical technical personnel, and data analysis by calculating SIM evaluation scores using the SPSS application. The results of the evaluation after development, the human  aspect results are good category with the effectiveness of the application of SIM application after development, the organization  aspect results are good category for the application of management information systems, the technology  aspect obtained good results after development for system implementation. The last aspect of net benefit has good category results. The results of information system development at the pharmaceutical installation of RSUD Puruk Cahu showed a significant increase in human, organizational, technology and net benefit aspects of 5.97; 10.31; 11.88 and 3.00% respectively
In-Silico Analysis And Molecular Dynamics Simulation Analysis of Sida rhombifolia Compounds as Candidate Antibacterial Agents Against Methicillin-Resistant Staphylococcus aureus firdaus, alshol; Herowati, Rina; Rahmawati, Ismi; Prasetiyo, Andri; Herman, Herman
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.646

Abstract

Antibiotic resistance has become a critical issue in global health, one of which is MRSA. The dynamic problem related to the increasing MRSA infections is clear evidence that the treatment and management of this disease have not been optimally resolved, requiring the development of effective antimicrobial agents against MRSA. An exploratory method was used to assess the antibacterial activity, interaction patterns, and stability of sidaguri compounds. A total of 15 potential compounds from sidaguri were docked onto four molecular targets: PBP2a (4JCN), MecR1 (609S), FtsZ (8HTB), and SCCmec (4FAK), using the molecular docking methods AutodockTools and PyMol, followed by analysis of the amino acid residue similarity of each test ligand. The molecular docking results predicted that the compounds with the best binding affinity and interaction patterns similar to the natural ligand for their respective molecular targets were quercetin, ecdysone, and 24-methylenecholesterol. The validation parameters are calculated from RMSD and RMSF based on the In-Silico predictions. MD simulations were performed using YASARA Dynamics. The MD simulation results showed that, from the RMSD and RMSF graphs of the MRSA target molecules, quercetin, ecdysone, and 24-methylenecholesterol exhibited binding stability close to that of the natural ligand. The predicted pharmacokinetic profiles show that all three compounds have a good ADMET profile, with optimal absorption potential, adequate distribution, appropriate metabolism, and relatively low toxicity, making them promising candidates for development as antibacterial drugs against MRSA
Co-Authors . Sardjiman Akune, Nadia Ayuwanda S Al-Mubarak, AgustiQori Ana Indrayati Andri Prasetiyo Arvian, Dias Wahyu Aryani, Norsarida Bambang Hartono Candra, Dhimas Tiya Claudius Hendraman B. Tobi Desi Purwaningsih Dewi Arum Sari Dewi, Lucia VIta Inandha Dewi, Nila Audri Risdiana Endang Diyah Ikasari Endang Sri Rejeki firdaus, alshol Ika Purwidyaningrum Ilham Kuncahyo, Ilham Jason Merari Peranginangin M. Yogi Riyantama Isjoni Niva, Oktiva Cheria Kairul Oetari, Oetari Opstaria saptarini Purnamasari, Nur Aini Dewi Puspitasari, Ismi Sari, Putri Rovita Setyaningrum, Dewi Anggraheni Sulaiman, Saifullah Sutrisno, Sahya Rania Tongkonoo, Mutiah Tri Wijayanti Triyani Triyani Youpita, Nyoman Yovi Pranata Zainudin Hasan