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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) ALKIMIA : Jurnal Ilmu Kimia dan Terapan JURNAL FARMASIMED (JFM) Jurnal Kefarmasian AKFARINDO Suluah Bendang: Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Kesmas Asclepius Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Abdimas Bina Bangsa Medical Sains : Jurnal Ilmiah Kefarmasian Sinteza Indonesian Journal of Cosmetics Medical Sains : Jurnal Ilmiah Kefarmasian Lentera Negeri JPEPT
Puspawan Hariadi
Universitas Hamzanwadi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Aktivitas Antioksidan Buah Sawo Manila (Manilkara zapota L) Sebagai Kandidat Produk Perawatan Kulit Azim, Muhlisun; Saputra, Dani; Hariadi, Puspawan
Sinteza Vol. 2 No. 2 (2022): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.594 KB) | DOI: 10.29408/sinteza.v2i2.7662

Abstract

Antioksidan merupakan senyawa-senyawa yang dapat mencegah terbentuknya radikal bebas yang akan menyerang dinding sel. Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan pada buah sawo manila (Manilkara zapota L). Senyawa antioksidan yang ditemukan pada buah sawo manila adalah senyawa alkaloid, flavonoid, tanin, dan saponin. Desain penelitian ini menggunakan desain eksperimental di laboratorium farmasi Universitas Hamzanwadi. Sampel diekstraksi dengan etanol 96%, dilanjutkan dengan proses fraksinasi menggunakan kolom kromatografi. Eluen yang digunakan pada proses fraksinasi yaitu etil asetat, etil asetat-metanol, dan metanol. Pengujian aktivitas antioksidan dilakukan secara kualitatif dan kuantitatif. Hasil pengujian  secara kualitatif menunjukkan semua sampel mengandung antioksidan karena terlihat warna kuning ketika disemprotkan DPPH pada plat KLT. Sedangkan hasil pengujian secara kuantitatif menunjukkan bahwa nilai IC50 fraksi I 46 ppm dengan kategori sangat kuat, nilai IC50 fraksi II 97 ppm dengan kategori kuat, nilai IC50 fraksi III 149 ppm dengan kategori sedang, dan nilai IC50 vitamin C 29 ppm dengan kategori sangat kuat. Kesimpulannya yaitu fraksi buah sawo manila (Manilkara zapota L) memiliki aktivitas antioksidan dengan kategori sangat kuat, kuat dan sedang.
Uji Minyak Atsiri Daun Mengkudu (Morinda citrifolia L) terhadap Diameter Zona Hambat Staphylococcus aureus Wardani, Evi; Hariadi, Puspawan; Yuliana, Tri Puspita
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.25237

Abstract

Infeksi merupakan salah satu masalah kesehatan yang banyak disebabkan oleh virus, jamur, bakteri atau parasit. Bakteri Staphylococcus aureus merupakan bakteri penyebab infeksi pada manusia. Penggunaaan obat antibiotik dalam terapi infeksi yang tidak terkontrol dapat meningkatkan jumlah resistensi bakteri terhadap antibiotik, oleh karena itu perlu adanya terapi alternatif dari bahan alam yang memiliki potensi dalam menghambat pertumbuhan bakteri. Daun mengkudu (Morinda citrifolia L) merupakan salah satu tanaman yang dapat digunakan sebagai antibakteri dengan kandungan metabolit sekunder seperti flavonoid, alkaloid, saponin, steroid dan terpenoid. Tujuan penelitian ini untuk mengetahui pengaruh uji aktivitas minyak atsiri daun mengkudu terhadap pertumbuhan bakteri Staphylococcus aureus dan mengetahui konsentrasi optimum minyak atsiri daun mengkudu yang efektif dapat menghambat pertumbuhan bakteri Staphylococcus aureus. Daun mengkudu diekstraksi secara destilasi dengan pelarut aquades. Destilat minyak atsiri daun mengkudu lalu diuji aktivitas antibakteri dengan menggunakan metode difusi kertas cakram dengan konsentrasi 15%, 25%, dan 35% (b/v). Kontrol positif yang digunakan yaitu ciprofloxacin dengan kontrol negatif DMSO. Hasil penelitian menunjukkan bahwa minyak atsiri daun mengkudu memiliki aktivitas antibakteri pada bakteri Staphylococcus aureus dibuktikan dengan adanya zona bening disekitar kertas cakram. Aktivitas antbakteri tertinggi yaitu pada konsentrasi 35%. Diketahui bahwa semakin tinggi konsentrasi yang digunakan hasil diameter zona hambat bakteri yang dihasilkan juga akan semakin besar.
FRAP REDUCING ACTIVITY OF PROTIUM JAVANICUM BURM.FIL LEAVES: A SCREENING ANTIOXIDANT POTENCY OF NATURAL COSMETIC INGREDIENT Sulastri, Novi; Gemantari, Baiq Maylinda; Hayaza, Azzam Hafid; Azim, Muhlisun; Hariadi, Puspawan; Pratiwi, Puspa Dwi
Indonesian Journal of Cosmetics Vol. 3 No. 2 (2025): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v3i2.2373

Abstract

Tenggulun (Protium javanicum Burm.fil) has been traditionally used to treat various ailments such as cough, stomachache, diarrhea, inflammation and headache. The leaves have therapeutic roles in the treatment and prevention of illnesses acting as antibacterial, antidiabetic and antiinflammation agents. It is also reported that tenggulun leaves can be used for insecticides, cosmetics and food additives. This research aimed to determine antioxidant activity by reducing FRAP of the tenggulun leaves methanol extract using Trolox as the standard solution. The result showed that the tenggulun leaves extract contained secondary metabolites of flavonoid and polyphenolic. The extract showed the FRAP reducing activity at 0,008634±0.00043 μmol TE/g DW. These results indicated the ability of tenggulun methanolic extract to reduce Fe (III) into Fe (II) equivalent to Trolox by the presence of secondary metabolites confirmed.
2,2-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging Analysis and Antibacterial Activities of Renggak Seed (Amomum Dealbatum Roxb) Muhlisun Azim; Puspawan Hariadi; Baiq Risma Fatmayanti; Yuyun Febriani; Annisa Rizqita Wazni; Virta Dwi Anggraini
Sinteza Vol. 5 No. 1 (2025): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i1.28683

Abstract

Natural sources have complex interaction mechanisms in providing inhibitory effects against various radical reactions and multi-drug resistance (MDR). Amomum dealbatum (Renggak in Lombok) seed phytochemistry and bioactivities have the potential to be investigated. This study aims to explore the bioactivity of extracts and fractions of renggak seeds in reducing reactive oxygen species and inhibiting bacterial growth to overcome MDR. The methods used to determine the level of free radical scavenging and antibacterial activity in this study were the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and agar diffusion methods. The results of the phytochemical tests of the ethanolic extract of Renggak seeds contain triterpenoids, alkaloids, saponins, and phenolics. Meanwhile, in the hexane fraction were found alkaloids, saponins, and phenolics. The results of antibacterial tests on Staphylococcus aureus using the agar diffusion method for ethanol and hexane extracts at concentrations of 20, 40 and 60% were 12.50±1.00, 19.00±0.00, and 21.8±0.76 for ethanol extracts, respectively. The hexane fraction was 5.33±0.57, 10.83±0.57, and 14.33±0.28 mm. For Salmonella sp bacteria, it was 9.00±1.00, 14.16±0.29, and 18.16±1.04 mm for ethanol extracts than was 7.50±0.50, 12.67±0.76, and 15.67±0.76 mm for hexane fractions. Moreover, the ethyl acetate fraction contains triterpenoids, alkaloids, saponins and phenolics which are responsible for giving antioxidant effects with an IC50 value of 66.515±2.37 ppm and is classified as a strong antioxidant to scavenging free radicals of DPPH. The higher the concentration of the fraction, the higher the inhibition of the growth of Salmonella sp and Staphylococcus aureus bacteria. The ability of the extract and fraction to inhibit bacterial growth and reduce free radicals makes renggak seeds very potential for further investigation.
Pengetahuan masyarakat dan pemanfaatan tanaman obat keluarga di desa toya aikmel utara Muhlisun Azim; Arief Rafsanjani; Tripuspita Yuliana; Puspawan Hariadi
Lentera Negeri Vol. 2 No. 1 (2021): Lentera Negeri
Publisher : Indonesian Institute For Counseling, Education and Therapy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/99330

Abstract

Family Medicinal Plants (TOGA) is an alternative in achieving GERMAS (Healthy Living Community Movement) as an effort to achieve traditional independent health. The success of the use of TOGA is strongly influenced by the level of public knowledge about the benefits of the type of medicinal plants which has been empirically investigated. The data obtained is qualitative data with descriptive approach analysis method. Data collection was carried out by conducting observations, interviews and technical training to the community in an effort to provide knowledge about TOGA and the creation of a TOGA demonstration plot. The results obtained from this activity are the emergence of public awareness of the use of home yard land for the manufacture of living pharmacies as an effort to achieve independent health and the emergence of public interest in the use of TOGA as a UMKM product in the form of packaged drink sachets as a pilot. The importance of public knowledge about TOGA is needed in supporting the success of achieving independent health and efforts to utilize local biological resources in initiating the manufacture of herbal plant-based UMKM products.
Antibacterial Activity of Tobacco Flower Extract Against Staphylococcus Aureus and Pseudomonas Aeruginosa Hariadi, Puspawan; Andhini Yasmina Hukmi; Baiq Maylinda Gemantari
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x219jd72

Abstract

Background: Tobacco is known contains secondary metabolites such as flavonoids, alkaloids, and phenolic compounds which has pharmacological activity. As a part of the plant, it flowers have not been widely explored but are potentially rich in bioactive compounds that may be utilized as natural antibacterial agents. Aim: this study aimed to determine the antibacterial potential of tobacco flower extract against Gram-positive and Gram-negative bacteria. Methods: The ethanolic extract of tobacco flowers was obtained using a graded maceration method. The experimental groups were divided into six groups, consisting of four treatment groups with extract concentrations of 20%, 30%, 40%, and 50%, as well as one positive control group and one negative control group. Antibacterial activity was evaluated using the disc diffusion method. Result: The results showed that tobacco flower extract at concentrations at 20%, 30%, 40%, and 50% revealed inhibition zone diameters against Staphylococcus aureus as 0.6 mm, 1.5 mm, 1.8 mm, and 3 mm respectively, while were 0.5 mm, 0.6 mm, 0.6 mm, and 2.8 mm, respectively against Pseudomonas aeruginosa the inhibition zones. The positive control exhibited inhibition zone diameters of 18.6 mm against Staphylococcus aureus and 15.8 mm against Pseudomonas aeruginosa, whereas the negative control showed no inhibition zone (0 mm) against both test bacteria. Those activities known related to secondary metabolites compound that could inhibit bacterial growth. Conclusion: Based on those findings, the potency of tobacco flower extract posses inferior in antibacterial activity.
Formulation and Evaluation of the Physical Properties of Clay Mask Containing Ethanol Extract of Kenikir (Cosmos caudatus) Leaves Puspawan Hariadi; Rina Sri Apriani; Baiq Maylinda Gemantari; Tri Puspita Yuliana; Erma Ewisa Oktresia; Fitriwati Sovia
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.19

Abstract

The demand for natural-based cosmetic products continues to increase due to their perceived safety and minimal side effects. Kenikir leaves (Cosmos caudatus Kunth) are known to contain active compounds such as flavonoids, tannins, and phenols, which have antioxidant potential and can be utilized in facial mask preparations. This study aims to formulate a clay mask preparation from the ethanol extract of kenikir leaves and evaluate its physical properties. The extract was obtained through maceration using 96% ethanol, and then formulated into three concentrations: F1 (0.5%), F2 (1%), and F3 (2%). The evaluation of the preparation included organoleptic tests, adhesion test, spreadability test, and pH measurement. The results showed that F1 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.3 cm. F2 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.2 cm. F3 had a pH of 6, adhesion time of 4.6 seconds, and spreadability of 5 cm. The evaluation results indicated that all clay mask formulations met the physical quality criteria for clay masks.
Co-Authors Abdul Rahim Andhini Yasmina Hukmi Annisa Rizqita Wazni Arief Rafsanjani Baiq Maylinda Gemantari Baiq Risma Fatmayanti Citra Ariani Elfasyari, Trie Yuni Erma Ewisa Oktresia Ersi Arviana Ihsan Ewisa Oktresia Fitriwati Sovia Hamidah, Laeli Aminatul Hanifah Karimatulhajj Hariani, Dia Isma Hartini Haritani Hasratul Kusuma Hayaza, Azzam Hafid Hidayati, Kartika Hikmah, Rani Anggraini Ihsan, Ersi Arviana Khairurrizki, Amanda Kintoko, Kintoko Kusumo, Rudy Harjo Minawati Minawati Minawati Minawati, Minawati Muhlisun Azim Nopita, Rati Astuti Dewi Novasari, Novasari Nurkhasanah Nurkhasanah Nurmayanti, Wiwit Putra Puspa Dwi Pratiwi Putra, Teguh Adiyas Rina Sri Apriani Saputra, Dani Shakila, Shakila Sulastri, Novi Tri Puspita Yuliana Ula, Fatin Bariatul Virta Dwi Anggraini Wardani, Evi Yuyun Febriani