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Osteoporosis Prevalence In Stable Patients With Chronic Obstructive Pulmonary Disease Dwi Handoko; Faisal Yunus; Budhi Antariksa; Rochsismandoko Rochsismandoko
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.19

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world. Comorbid diseases in COPD contributing to low health status, affecting the duration of treatment and even death. Osteoporosis is a quite often comorbid that found in COPD. In Indonesia, there are no data of prevalence on osteoporosis in patient with stable COPD. The aim this research to get the data of osteoporosis in patients with stable COPD at Persahabatan Hospital. Method: The studie’s design was cross-sectional. Patients with stable COPD who came to the Asthma/COPD policlinic at Persahabatan Hospital who meet the criteria of inclusion and exclusion. Subjects had an examined of bone mineral density using dual energy x-ray absorptiometry (DXA) and had an examined of vitamin D blood level. At the time of visit, conducted anamnesis of symptoms, exacerbations, history of smoking, used of corticosteroid (oral or inhaled), comorbid, assessment of nutritional status. Results: Subjects were dominated with male (90.6%) in the age group 65-75 years old (53.1%), and smoking history (84.4%). The most degree of COPD were GOLD II (46.9%) and group B (50%) that using corticosteroid (65.7%). Prevalence of osteoporosis was 37.5%. There were no statistically significant between COPD group, the degree of COPD, sex, smoking history, history of corticosteroid, age, levels of 25-OHD, pulmonary function with the occurrence of osteoporosis in patients with stable COPD. There were a statistically significant on low BMI as a risk factor for osteoporosis in stable COPD. Conclusion: The prevalence of osteoporosis in patients with stable COPD in the Persahabatan Hospital is 37.5%. There are a statistically significant relationship between BMI with osteoporosis in patients with stable COPD.

Chest Wall Syndrome Isti Mardiana Soetartio; Agus Dwi Susanto; Dicky Soehardiman; Budhi Antariksa
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.34

Chest wall syndrome is the most frequent cause of chest pain complained by patients admitted to the physician’s office, in outward as well as in emergency department. It may affect all ages with sex ratio of 1:1 between man and woman. History of illness and sensibility to palpation or tenderness were the keys to the diagnostic approach. Pain was generally moderate, well localized, continuous or intermittent over a number of hours to days or weeks and was amplified by position or movement that was commonly located on the left side of the chest. Chest wall syndrome is usually a common and benign condition, but it leads to anxiety and frequent recurrence. Definitive treatment is not yet confirmed and treatment for the different condition causing isolated musculoskeletal chest pain is poor. Therefore, some options to avoid aggravating physical activities, stretching, and simple analgesics as needed are the best choices of current management.

Preoperative Assessment Prior to Lung Resection: How to Eliminate the Risk Dian Megawati; Menaldi Rasmin; Budhi Antariksa; Faisal Yunus
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.48

Lung resection is part of the treatment of various lung diseases, both malignancy and infection. Although it has great benefits, lung resection can result in a variety of functional disorders that can affect the whole cardiopulmonary system. The mortality of these procedures is 2-4% in segmentectomy and 6-8% in lobectomy, while the mortality of pneumonectomy in the world is 11%. Good preoperative assessment of patients has been reported to have reduced mortality and morbidity after lung resection. Things that need to be considered to assess preoperative eligibility include age, lung function, cardiovascular fitness, nutrition, and performance status. The preoperative pulmonary tolerance assessment is divided into three stages: the first stage is the assessment of lung function and blood gas analysis, the second stage is to assess postoperative prediction of pulmonary function, and the third stage is to assess the maximum oxygen consumption per minute by doing a cardiopulmonary exercise test. Patients who have a good tolerance for lung resection are patients who have predictive postoperative force expiration volume one second (ppoFEV1) values more than 40%, predictive postoperative diffusion capacity of the lung for carbon monoxide (ppoDLCO) more than 50%, and maximum oxygen consumption (VO2 max) more than 15ml/kg/min.

Pengaruh Penyakit Penyerta Asma dan PPOK Terhadap Derajat Keparahan Pasien Covid-19 Di Rsup Persahabatan Periode April 2021 - Agustus 2021 dan Tinjauannya Menurut Pandangan Islam Sekar Kirana Anggarani; Marisa Riliani; M. Arsyad; Budhi Antariksa
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 12 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Virus corona pada manusia atau sindrom pernafasan akut parah coronavirus 2 (SARS-CoV-2), pertama kali diidentifikasi di Wuhan, Cina, pada Desember 2019. Sejak saat itu, virus corona menyebar ke seluruh dunia. SARS-CoV-2 telah menginfeksi manusia dari semua kelompok masyarakat dan menyebar luas dalam tingkat yang mengkhawatirkan. Faktor risiko tepapar COVID-19 meliputi kondisi kesehatan atau komorbiditas yang menyertainya yang akan mengakibatkan perkembangan penyakit yang semakin cepat dan parah, seringkali bahkan menyebabkan kematian. Salah satu penyakit penyerta COVID-19 yang ditemukan di beberapa orang adalah asma dan PPOK. Dalam islam sudah diajarkan bagaimana caranya mencegah tertular dan mencegah menularkannya ke orang sekitar. Penelitian ini bertujuan untuk mengetahui Untuk mengetahui pengaruh antara penyakit penyerta asma dan PPOK dengan derajat keparahan pasien COVID-19 di RSUP Persahabatan periode April 2021-Agustus 2021 dan tinjauannya menurut pandangan Islam. Metode pada penelitian ini adalah deskriptif analitik dengan rancangan penelitian yang digunakan adalah cross-sectional. Penelitian dilakukan dengan cara mengambil data dari rekam medis dari RSUP Persahabatan. Sampel ditetapkan dengan cara saturation sampling yang kemudian ditetapkan besar sampel yang diambil dengan total quota sampling. Data dianalisis menggunakan lima tahapan, yaitu editing, coding, entry, cleaning, saving dan penarikan kesimpulan menggunakan uji chi square. Pada penelitian didapatkan bahwa pasien COVID-19 paling banyak (64,7%) berjenis kelamin wanita. Sebanyak 12 pasien (70,5%) berusia > 50 tahun. Pasien dengan penyakit penyerta asma paling banyak mengidap COVID-19 dengan derajat keparahan berat, terdapat 6 pasien (35,3%) dan hanya 1 pasien yang meninggal (5,9%). Sedangkan pasien dengan penyakit penyerta PPOK paling banyak mengidap COVID-19 dengan derajat keparahan berat, terdapat 3 pasien (17,6%).

Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age.

Exploring Epigenetic Landscapes in COPD: Therapeutic Implications and Recent Insights Wirawan, Aditya; Kinasih, Tutug; Imaniar, Rania; Baskoro, Hario; Antariksa, Budhi; Matsumoto, Naohisa
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.166

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, primarily driven by an abnormal inflammatory response to harmful particles and gases. This review explores the epigenetic mechanisms underlying COPD pathogenesis and their therapeutic implications. A comprehensive literature review was conducted, analyzing recent findings on DNA methylation, histone modifications, and noncoding RNAs (ncRNAs) in COPD. Key studies highlighting the impact of these epigenetic changes on inflammation, cellular responses, and disease progression were evaluated. Our review highlights that epigenetic modifications, such as DNA methylation and histone modifications, significantly impact gene expression without altering the DNA sequence. Cigarette smoking has been shown to influence both DNA methylation and histone acetylation, leading to inflammatory responses and the the exacerbation of COPD. These modifications contribute to chronic inflammation and disease progression, with alterations in histone acetylation, methylation, and phosphorylation playing critical roles in COPD pathogenesis. The interplay between epigenetic changes and environmental factors, particularly tobacco smoke, reveals a complex mechanism driving COPD progression. Aberrant gene expression linked to these epigenetic modifications suggests potential disease severity and progression biomarkers. Targeting these alterations offers novel therapeutic strategies. Emerging treatments, such as quercetin and theophylline, promise to restore normal cellular functions and effectively manage COPD. Future research should focus on elucidating these mechanisms further and developing targeted therapies to mitigate the impact of epigenetic modifications on COPD.

Optimizing chest X-rays as a leading diagnostic modality for handling COVID-19: a diagnostic study Purbasari, Utami; Prihartono, Nurhayati Adnan; Helda, Helda; Antariksa, Budhi; Audita, Fatira R.
International Journal of Public Health Science (IJPHS) Vol 14, No 2: June 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i2.24653

Recent studies have highlighted that chest CT scans are crucial for accurately diagnosing COVID-19. However, in rural areas of Indonesia, people may have difficulty assessing CT scans, leading to increased undetected cases. To address this issue, we investigated whether chest X-rays (CXR) could replace CT scans in diagnosing COVID-19 patients. A diagnostic cross-sectional-based study was conducted at Fatmawati General Hospital from January to September 2021. The study included suspected COVID-19 patients in isolation wards and ICU who were over 18, with or without comorbidities, and had complete clinical data and laboratory tests. We analyzed imaging data through reverse transcription-polymerase chain reaction (RT-PCR) tests, CXR, and chest CT scans. This study enrolled 150 eligible patients. With RT-PCR as the gold standard, we found that CXR had a sensitivity of 86.6% (95% CI: 78.9-92.3%) and chest CT scan had a sensitivity of 91.1% (95% CI: 84.2-95.6%). Similar performance was observed when detecting ground glass opacities (GGO), bilateral laterobasal, and influenza-like syndrome and dyspnea (ILI) between CXR and CT scans. Receiver operating characteristic (ROC) curves demonstrated that CXR is comparable to CT scan, especially in ground glass opacity (GGO) and consolidation (AUC=0.72; 95% CI: 0.61-0.83 and AUC=0.710; 95% CI: 0.64-0.78). The proposed CXR method can be a reliable primary imaging tool for diagnosing COVID-19 by considering ILI. However, chest CT scans remain the most effective diagnostic method for COVID-19. These findings may be useful for the utilization of CXR for diagnosing COVID-19 in areas with limited access to CT scans.

Pengaruh Penyakit Penyerta Asma dan PPOK Terhadap Derajat Keparahan Pasien Covid-19 Di Rsup Persahabatan Periode April 2021 - Agustus 2021 dan Tinjauannya Menurut Pandangan Islam Kirana Anggarani, Sekar; Riliani, Marisa; Arsyad, M.; Antariksa, Budhi
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 12 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v2i12.493

Virus corona pada manusia atau sindrom pernafasan akut parah coronavirus 2 (SARS-CoV-2), pertama kali diidentifikasi di Wuhan, Cina, pada Desember 2019. Sejak saat itu, virus corona menyebar ke seluruh dunia. SARS-CoV-2 telah menginfeksi manusia dari semua kelompok masyarakat dan menyebar luas dalam tingkat yang mengkhawatirkan. Faktor risiko tepapar COVID-19 meliputi kondisi kesehatan atau komorbiditas yang menyertainya yang akan mengakibatkan perkembangan penyakit yang semakin cepat dan parah, seringkali bahkan menyebabkan kematian. Salah satu penyakit penyerta COVID-19 yang ditemukan di beberapa orang adalah asma dan PPOK. Dalam islam sudah diajarkan bagaimana caranya mencegah tertular dan mencegah menularkannya ke orang sekitar. Penelitian ini bertujuan untuk mengetahui Untuk mengetahui pengaruh antara penyakit penyerta asma dan PPOK dengan derajat keparahan pasien COVID-19 di RSUP Persahabatan periode April 2021-Agustus 2021 dan tinjauannya menurut pandangan Islam. Metode pada penelitian ini adalah deskriptif analitik dengan rancangan penelitian yang digunakan adalah cross-sectional. Penelitian dilakukan dengan cara mengambil data dari rekam medis dari RSUP Persahabatan. Sampel ditetapkan dengan cara saturation sampling yang kemudian ditetapkan besar sampel yang diambil dengan total quota sampling. Data dianalisis menggunakan lima tahapan, yaitu editing, coding, entry, cleaning, saving dan penarikan kesimpulan menggunakan uji chi square. Pada penelitian didapatkan bahwa pasien COVID-19 paling banyak (64,7%) berjenis kelamin wanita. Sebanyak 12 pasien (70,5%) berusia > 50 tahun. Pasien dengan penyakit penyerta asma paling banyak mengidap COVID-19 dengan derajat keparahan berat, terdapat 6 pasien (35,3%) dan hanya 1 pasien yang meninggal (5,9%). Sedangkan pasien dengan penyakit penyerta PPOK paling banyak mengidap COVID-19 dengan derajat keparahan berat, terdapat 3 pasien (17,6%).

Proportions of Hypertension in Stable COPD Patients at the National Respiratory Center Persahabatan Hospital Dewantoro, Luhur; Wiyono, Wiwien Heru; Yunus, Faisal; Agustin, Heidy; Damayanti, Triya; Antariksa, Budhi; Fachrucha, Fanny; Samoedro, Erlang; Elhidsi, Mia
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.774

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most of these deaths are related to cardiovascular disease. This is due to systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead to poor quality of life, low exercise tolerance, and an increased risk of hospitalization. This study aims to report the proportion of hypertension among stable COPD patients in the Indonesian population.Methods: This cross-sectional study was conducted at the National Respiratory Center Persahabatan Hospital between February and March 2023. Stable COPD patients admitted to the Asthma and COPD Polyclinic who met the criteria were enrolled. Clinical information, vital signs, spirometry results, and DLCO measurements were collected.Results: There were 84 subjects participating in this study. The result of this study shows a 60.7% proportion of hypertension in stable COPD patients. Hypertension has a significant correlation with pulmonary functional values (P=0.021), severity degree of clinical COPD (P=0.004), Brinkman index (P=0.008), and age (P=0.0001). However, hypertension association with COPD duration (P=0.505) and DLCO (P=0.122) were not significant.Conclusion: The hypertension proportion in stable COPD Indonesian patients is 60.7%. Hypertension shows a significant association with pulmonary function values, severity degree of clinical COPD, Brinkman index, and age.

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