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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Jurnal Kesehatan Melayu Jurnal Gizi Klinik Indonesia Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Narra J Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Dani Rosdiana
Department Of Internal Medicine, Faculty Of Medicine University Of Riau/Arifin Achmad General Hospital, Pekanbaru, Riau
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hemokonsentrasi dan Trombositopenia pada COVID-19, Pembelajaran dari Ruang Instalasi Gawat Darurat Dani Rosdiana; Marlina Tasril; M Firdaus J Karimi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.84-89

Abstract

Coronavirus disease 2019 (COVID-19) has become a pandemic since January 2020 and caused the death of 6 million people by April 2022. Exponential human-to-human transmission and the wide variety of clinical and laboratory manifestations of COVID-19 were challenging. Hematological abnormalities such as thrombocytopenia and hemoconcentration in COVID-19 are difficult to distinguish from dengue fever in the ER. Misdiagnosis would impact patient outcomes, health workers, and community safety as well as its transmission. We report a suspected case of dengue fever in admission in X Pekanbaru hospital, Riau which is confirmed as COVID-19. The patient was observed in the isolation ward and treated accordingly to the COVID-19 protocol and heparin due to coagulopathy related to COVID-19. The Proper initial assessment of acute febrile, especially Dengue fever at the emergency room, and the availability of modalities in diagnosing COVID-19 are of paramount importance in the era of the COVID-19 pandemic, even more, it become endemic status.
Kejadian Breakthrough Infection Pasca Vaksinasi Dosis 2 Sinovac pada Tenaga Kesehatan RSUD Arifin Achmad Agung Ramadhan; Eka Bebasari; Dani Rosdiana; Ligat Pribadi Sembiring; Rahmat Azhari Kemal
Majalah Kedokteran Andalas Vol 46, No 2 (2023): Online April 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i2.p348-357.2023

Abstract

Tujuan: untuk mengetahui prevalensi dan karakteristik responden breakthrough infection pasca vaksinasi dosis 2 Sinovac. Metode: penelitian deskriptif observasional dengan pendekatan cross sectional, pengambilan data dilakukan menggunakan metode consecutive sampling dengan besar sampel adalah 120 orang. Hasil: menunjukkan bahwa sebanyak 11 orang (9,2%) tenaga kesehatan di RSUD Arifin Achmad Provinsi Riau terkonfirmasi mengalami breakthrough infection. Mayoritas subjek penelitian yang mengalami breakthrough infection adalah laki-laki (63,6%), pada kelompok usia 40-49 tahun (36,4%), berprofesi sebagai dokter (40%), kelompok obesitas (81,8%), tanpa penyakit komorbid (54,5%), mempunyai riwayat kontak erat (63,6%), dan belum pernah terinfeksi COVID-19 sebelum vaksinasi (90,9%). Sebagian besar kasus merupakan kasus asimtomatis/tanpa gejala sebanyak 6 orang (54,5%), dan terdapat 5 orang (45,5%) yang memiliki gejala yaitu pada 3 orang (27,3%) dengan gejala sedang, dan pada 2 orang (18,2%) dengan gejala ringan. Kesimpulan: kejadian breakthrough infection pasca vaksinasi Sinovac dosis dua pada tenaga kesehatan di RSUD Arifin Achmad Provinsi Riau tidak ditemukan adanya kasus dengan gejala berat. 
Gambaran KIPI Vaksin Booster mRNA Heterolog Pada Tenaga Kesehatan RSUD Arifin Achmad Provinsi Riau Carlo Manuel Perangin-angin; Eka Bebasari; Dani Rosdiana; Ligat Pribadi Sembiring; Rahmat Azhari Kemal
Majalah Kedokteran Andalas Vol 46, No 2 (2023): Online April 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i2.p394-404.2023

Abstract

Tujuan: untuk mengetahui gambaran KIPI vaksin booster mRNA heterolog pada tenaga kesehatan di RSUD Arifin Achmad Provinsi Riau. Metode: penelitian deskriptif observasional, pengambilan data dilakukan menggunakan metode consecutive sampling dengan besar sampel adalah 117 orang. Hasil: menunjukkan bahwa mayoritas subjek penelitian berjenis kelamin perempuan (70,9%), pada kelompok usia 30-45 tahun (66,7%), dengan IMT overweight (46,2%), tanpa komorbid (71,8%), bukan penyintas (86,3%), dan memiliki riwayat kontak erat (54,7%).  Keluhan yang muncul terbanyak pada setiap kategori terdiri dari, keluhan umum berupa demam/meriang (82,9%), keluhan lokal/area penyuntikan berupa bengkak di daerah penyuntikan (55,6%), keluhan muskuloskeletal/otot berupa nyeri otot (88,9%), keluhan pencernaan berupa penurunan/peningkatan nafsu makan (24,8%), keluhan psikis berupa sering ngantuk/tidur lebih lama (23.9%), keluhan saraf berupa kebas pada tangan dan/atau kaki (11,1%), keluhan pada kepala/telinga/hidung/tenggorokan berupa hidung tersumbat (14,5%), dan keluhan pada jantung dan pembuluh darah dan pernapasan berupa batuk (8,5%). Kesimpulan: tenaga Kesehatan di RSUD Arifin Achmad Provinsi Riau mengalami Kejadian Ikutan Pasca Imunisasi (KIPI) yang terbagi kedalam beberapa kelompok.
Efficacy of pretomanid-containing regiments for drug-resistant tuberculosis: A systematic review and meta-analysis of clinical trials Simanjuntak, Arya M.; Daenansya, Raehan; Afladhanti, Putri M.; Yovi, Indra; Suyanto, Suyanto; Anggraini, Dewi; Rosdiana, Dani
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.402

Abstract

Concerns regarding the rise of drug-resistant tuberculosis (DR-TB) infections and the need for new drugs with shorter treatment time and fewer side effects have been voiced by the World Health Organization (WHO). The WHO revised its guideline to treat multi-drug resistant tuberculosis (MDR-TB) with a 6-month course of BPaLM (bedaquiline, pretomanid, linezolid and moxifloxacin) in 2022. However, a thorough study and meta-analysis of available evidence is required due to the limited confidence of the evidence confirming the effectiveness of pretomanid-containing regiments. The aim of this systematic review and meta-analysis was to evaluate the effectiveness of pretomanid-containing regiments in treating DR-TB patients. Data from six search engines were searched using inclusion criteria based on the PICOS framework. The keywords of pretomanid and tuberculosis or their alternatives were used. Using RoB2 Cochrane risk-of-bias tool for randomized clinical trials, data were independently extracted and the quality of the data was evaluated. Odds ratio (OR) and heterogeneity tests were used and the findings were presented in ORs and forest plots. A total of four studies with 237 patients was included in the final analysis and 204 (86%) patients had favorable outcome (cured) and 33 (14%) was not cured. Pretomanid-containing regimen (OR: 46.73; 95%CI: 11.76–185.7) and BPaLM/BPaL (OR: 41.67; 95%CI: 8.86–196.73) regimens were associated with favorable outcome (cured). This meta-analysis indicates that the pretomanid-containing regimen and the BPaLM/BPaL regimen could increase the chance to have favorable outcome in DR-TB patients.
PENGARUH EXTENDED-SPECTRUM BETA-LACTAMASE (ESBL) TERHADAP MORTALITAS PASIEN PNEUMONIA Raja Merlinda Veronica; Dani Rosdiana; Anwar Bet; Agustiawan
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 1 (2025): Januari 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i1.703

Abstract

Pendahuluan: Resistensi antimikroba merupakan krisis kesehatan global dalam beberapa tahun terakhir. Extended-spectrum beta-lactamase (ESBL) merupakan enzim yang diproduksi oleh bakteri yang mampu memghidrolisis golongan antibiotik beta laktam spektrum luas dan merupakan salah satu kelompok multi drug resitance (MDR). Penelitian ini bertujuan untuk mengetahui pengaruh ESBL terhadap tingkat kematian pasien pasien pneumonia. Metode: Studi observasional dengan pendekatan kohort retrospektif menggunakan data rekam medis. Pengambilan sampel dilakukan dengan consecutive sampling. Analisis bivariat dilakukan menggunakan uji chi square, dimana perbedaan signifikan jika nilai p <0,05. Hasil: Pasien dalam penelitian didominasi oleh laki-laki (59,5%) dan mereka dengan kategori usia <60 tahun (94,0%). Penderita pneumonia infeksi ESBL yang meninggal dunia sebanyak 41 orang (48,8% dari 84 orang sampel dan 89,1% dari total ESBL positif). Patogen Gram negatif terbanyak adalah Acinetobacter sp (16,7%), Escherichia coli (15,5%), Pseudomonas aeruginosa (10,7%), Stenoptrophomonas maltophilia (4,8%), Burkhoideria (24%), sedangkan patogen Gram positif yang ditemukan adalah Staphilococcus aureus (2,4%) dan Staphilococcus haemoliticus (2,4%). Sebanyak 89,1% pasien ESBL mengalami kematian, sedangkan sisanya tidak. Odds ratio (OR) mortalitas selama perawatan pada pasien dengan ESBL adalah 22,9 dengan interval kepercayaan (IK) 95% (7,1-74,4). Kesimpulan: Paparan infeksi bakteri ESBL dikaitkan dengan tingkat kematian yang lebih tinggi. Hal ini menunjukkan perlunya strategi pencegahan dan manajemen pasien dengan baik.
Frekuensi Karier Streptococcus pneumoniae pada Populasi Dewasa Suku Akit Provinsi Riau Rosdiana, Dani; Veronica, R. Merlinda; Harahap, Sari; Esha, Indi; Mardhatilah, Ashifa; Putri, Nabila; Safitri, Nuridha Audinia; Safari, Dodi; Sarassari, Rosantia; Ilmiawati, Cimi; Elliyanti, Aisyah
Jurnal Ilmu Kedokteran Vol 18, No 2 (2024): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v18i2.2024.137-143

Abstract

Stretococcus pneumoniae (S.pneumoniae) is a commonly colonized in healthy people that potentially to be transmitted directly to other individuals through droplets and as an invasive pathogen. The prevalence/ frequency of S. pneumoniae carriage in children is around 20-60%, while data of carriage’s frequency in adult population is still limited. Akit tribe is a tribe who lives in a group in the coastal rural area of Rupat Island. The high incidence of upper respiratory tract infection among Akit tribe and the location can be risk for S. pneumoniae carriage. Study aimed is to identify the frequency of carriage in the adult population of the Akit tribe. Nasopharyngeal swab was collected from healthy adults, then cultivated on agar media. Colonies suspected as S. pneumoniae then selected, then subjected to optochin test. S. pneumoniae confirmation were using automatic machine VITEK. We reported S. pneumoniae carriage rate was 7.8% (12 of 153 participants) among Akit tribe.
Risk Factors for Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae in Arifin Achmad Hospital Riau, Indonesia Anggraini, Dewi; Rosdiana, Dani; Kasih, Rani Rindang; Triani, Zhana Daisya
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3484

Abstract

Multidrug-Resistant (MDR) bacteria that produce Extended-Spectrum Beta-Lactamase (ESBL) isolates pose a global threat to human health, including in Indonesia. The availability of therapeutic options for ESBL-producing Klebsiella pneumoniae (ESBL-KP) is limited, making early recognition of patients with ESBL crucial to preventing the spread of these bacteria within the hospital. This study aimed to examine the risk factors associated with ESBL-KP in the Arifin Achmad General Hospital Riau, Indonesia. This prospective case-control study was performed from January to March 2018, with the diagnosis of ESBL established using the Vitek 2 compact automated tool. The risk factors examined were gender, age, specimen type, ward of origin, hospitalization exceeding seven days, history of antibiotic usage, presence of diabetes mellitus, chronic kidney disease, immunocompromised status, ICU care, and hospitalization within the past month. Patients hospitalized for more than seven days were 4.75 times more likely to develop ESBL-KP, while immunocompromised patients were 2.92 times more likely to develop ESBL-KP. However, the history of antibiotic use, diabetes mellitus, chronic kidney disease, ICU care, and hospitalization within the past month did not exhibit statistically significant associations with ESBL-KP infection. Therefore, ESBL-KP infection should be anticipated in patients hospitalized for more than seven days and those who are immunocompromised. It is crucial to implement infection prevention and control measures, as well as selecting appropriate antibiotic therapy.
Mortality and associated factors among community-acquired pneumonia patients: A cross-sectional study in a provincial referral hospital in Indonesia Rosdiana, Dani; Siregar, Fajri M.; Ediwi, Nabila C.; Putri, Rahmi T.; Nurrahma, Zuyyina ER.; Elisabet, Adinda; Sarassari, Rosantia; Safari, Dodi; Ilmiawati, Cimi; Elliyanti, Aisyah
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1649

Abstract

Community-acquired pneumonia (CAP) poses a significant impact on the healthcare system due to rehospitalization and mortality. About one-third of hospitalized CAP patients died within one year. In addition to advanced age, vulnerable groups with comorbidities such as cancer, diabetes, and cerebrovascular disease (CVD) are more likely to suffer from severe CAP. The aim of this study was to investigate the factors linked to mortality in adult hospitalized CAP patients. The study extracted the medical records of patients aged ≥18 years, admitted to a referral hospital in Riau Province, who were diagnosed with CAP between January and December 2023. Multiple logistic regression step-wise analysis was employed to determine the factors associated with mortality in CAP patients. The study involved 334 patients with a median age of 58 years. Based on the confusion, urea, respiratory rate, blood pressure, and age ≥65 years (CURB-65) score, 11.9% of patients had severe CAP (CURB-65 scores 3 and 4). Age was a significant predictor of severe CAP (p≤0.001). The most prevalent comorbidities were malignancy (33.2%), CVD (30.2%), and diabetes (28.4%). Mortality incidence during hospitalization reached 35.9%. Significant factors associated with mortality in hospitalized CAP patients included renal dysfunction/elevated serum urea levels (p=0.031), CURB-65 score (p=0.023), vasopressor use (p≤0.001), mechanical ventilator use (p≤0.01) and steroid use (p=0.029). However, CVD was associated with a decreased risk of mortality (p=0.019). Gram-negative bacteria predominated, accounting for 50.6% of all positive isolates.  Several significant factors were associated with mortality in adult patients hospitalized with CAP at referral Hospital in Riau, including renal dysfunction, CURB-65 score, vasopressor use, mechanical ventilator use, and steroid use. This finding underscored the importance of early identification factors in CAP patients.
Co-Authors Abd. Rasyid Syamsuri Afladhanti, Putri M. Agung Ramadhan Agustiawan Aisyah Elliyanti Anwar Bet Ardini, Nadiah Yamanza Arfianti Arfianti Armi, Wahyuli Bet, Anwar Carlo Manuel Perangin-angin Cimi Ilmiawati, Cimi Daenansya, Raehan Darmawi Darmawi Dedi Afandi Dewi Anggraini Deyana, Frilly Dina Br Nababan Ediwi, Nabila C. Effendi, Dasril Eka Bebasari Elisabet, Adinda Elsa Sundari Erwin Christianto Esha, Indi Faradini " Fifia Chandra Harahap, Sari Hendra Asputra Hetty Hirfawaty Huriatul Masdar Huriatul Masdar Indra Fakhreza INDRA YOVI Kasih, Rani Rindang Kesumah, Dewi Iramayana Sandra Ligat Pribadi Sembiring Ligat Pribadi Sembiring M Firdaus J Karimi Mardhatilah, Ashifa Marlina Tasril Muhammad Arif Mukhyarjon Nisa Faradisa Hernita Nurrahma, Zuyyina ER. Olivia Makmur Pragita Ayu Saputri Prayogo Prayogo Puji Artanti Putri, Nabila Putri, Rahmi T. Rahmat Azhari Kemal Raja Merlinda Veronica Riezky Valentina Astari Safari, Dodi Safitri, Nuridha Audinia Saputri, Pragita Ayu Sarassari, Rosantia Simanjuntak, Arya M. Siregar, Fajri M. Suryani ", Suryani Suyanto Suyanto Tami Endriani Pardede Triani, Zhana Daisya Utami, Yurika Utami1 Marthalia Veronica, R. Merlinda Viona Ayu Safitri Yanti Ernalia yurika marthalia utami