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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Sciences of Pharmacy Enrichment: Journal of Multidisciplinary Research and Development Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Administrative and Clinical Pharmacy
S.Farm., M.Farm., Apt, Sondang Khairani
Fakultas Farmasi Unniversitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Comparative study of DOTS treatment outcomes among pulmonary tuberculosis patients at Bondongan and Bogor Timur primary health centers Khairani, Sondang; Reise Manninda; Lusiana Ariani; Sabina Radya Harumi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI In Press
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2105

Abstract

Tuberculosis (TB) remains a major infectious disease and a significant public health concern in Indonesia. The Directly Observed Treatment Short-course (DOTS) strategy has been widely implemented to improve treatment adherence and outcomes among patients with TB. This study aimed to compare the treatment outcomes of patients with pulmonary tuberculosis undergoing DOTS therapy at Bondongan Primary Health Center and Bogor Timur Primary Health Center. This study used a descriptive and inferential research design with retrospective data collection conducted in 2024. A total of 159 patients with pulmonary TB were included in the study. Data were analyzed based on patient characteristics, including age, sex, comorbidities, type of diagnosis, duration of treatment, and treatment outcomes. The results showed that the majority of patients at Bondongan Primary Health Center were aged 38–47 years (30.13%), whereas most patients at Bogor Timur Primary Health Center were aged 18–27 years (36.03%). Female patients accounted for 54.10% of the total population. Most patients received six months of treatment (84.91%), were bacteriologically confirmed (76.10%), and all patients received fixed-dose combination (FDC) therapy. At Bondongan Primary Health Center, the comorbidity status of diabetes mellitus (DM) was largely unknown (80.82%), whereas most patients at Bogor Timur Primary Health Center had no DM comorbidity (87.21%). The treatment success rates were 83.56% and 97.67% at the Bondongan and Bogor Timur Primary Health Centers, respectively. Statistical analysis indicated that patient characteristics were not significantly associated with treatment success (p≥0.05).
INCREASING ANTIOXIDANT ACTIVITY OF SUPEROXIDE DISMUTASE AND DECREASING MALONDIALDEHYD LEVELS FROM Ethanol Extract of Radish (Raphanus Sativus L.) LEAVES IN SWIMMING MICE Khairani, Sondang; Sandhiutami, Ni Made Dwi; Sari, Ika Permata
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 10 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v10i1.8261

Abstract

Daun lobak (Raphanus sativus L.) mengandung senyawa flavonoid yang memiliki aktivitas sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek antioksidan ekstrak etanol 70% daun lobak (Raphanus sativus L.) berdasarkan parameter kadar malondialdehid (MDA) dan aktivitas superoksida dismutase (SOD). Penelitian menggunakan mencit dibagi menjadi 6 kelompok yaitu: kelompok kontrol normal (I), kelompok kontrol negative (II), kelompok kontrol positif (III) (vitamin C 2,6 mg/20 gBB), dan 3 kelompok (IV,V,VI)dosis ekstrak etanol 70% daun lobak (Raphanus sativus L.) (5,6; 11,2; 22,4 mg/20 gBB). Pengukuran kadar MDA dilakukan dengan metode Wills dan pengukuran aktivitas SOD dilakukan dengan metode Adrenochrome Assay dan Analisa menggunakan uji ANOVA. Hasil pengukuran kadar MDA pada kelompok normal, kelompok kontrol negatif, kelompok kontrol negatif, kelompok kontrol positif, kelompok dosis 5,6 mg/20 gBB; 11,2 mg/20 gBB; 22,4 mg/20 gBB secara berturut-turut adalah 2,1617 nmol/mL; 5,3075 nmol/mL; 2,3331 nmol/mL; 4,5583 nmol/mL; 3,5957 nmol/mL; 2,6702 nmol/mL sedangkan untuk hasil pengukuran aktivitas SOD hati mencit adalah 124,2383 U/mL; 65,64 U/mL; 176,7583 U/mL; 106,045 U/mL; 134,34 U/mL; 153,53 U/mL. Kesimpulan penelitian ini adalah terdapat perbedaan bermakna antara kelompok III dengan kelompok IV,V,VI  dalam peningkatan aktivitas SOD dan penurunan kadar MDA (p<0,05) yaitu memiliki potensi antioksidan yang sama seperti vitamin C.
Co-Authors Anggriani, Yusi Anita Rahmi Pradani Antasya, Vaylia Ariani, Lusiana Assajadda Lizikri, Assajadda BENNI ISKANDAR Desi Nadya Aulena Erna Kristin Fauzia Noprima Okta Fitri Nurhayati Gressty F Swandiny Hidayati, Nabila Nur Ika Permata Sari Ika Permata Sari, Ika Permata Ira Ningtiyas Purpranoto Isti Atika Kurnia, Mala Lestari Rahayu Lusiana Ariani Manninda, Reise Reise Manninda Meyke Afrianty Mita Restinia Mohamad Rega Satria Ramadhan Moordiani Moordiani Mulatsari, Esti Musyirna Rahmah Nst Neni Frimayanti Ni Made Dwi Sandhiutami Nurita Andayani Nurul Azizah Peng-Wei, Ching Raharjo, Lalu Joko Ramadaniati, Hesty Utami Reise Manninda RIKA SARI DEWI Rika Sari Dewi Rina Rosdiana ROS SUMARNY Ros Sumarny Rulliani Bianca Wijaya Sabina Radya Harumi Safira Nafisa Sang Ayu Made Widyadari Sarah, Mutia Sarnianto, Prih Sesilia A Keban Shirly Kumala Wanda Ditan Arvandi Widodo, Akhmad Fajri Wijaya, Rulliani Bianca Wijayanti, Bitya Aulia Yeshika Krispansis Maelissa Yurista Elystra Yusi Anggriani Yuwono, Wahyu Agung Zainur Rahman Hakim