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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Sciences of Pharmacy Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Administrative and Clinical Pharmacy
S.Farm., M.Farm., Apt, Sondang Khairani
Fakultas Farmasi Unniversitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Analysis of Antibiotic Therapy Accuracy and Drug Interaction in Pneumonia Inpatients at The Islamic Hospital Jakarta Cempaka Putih Khairani, Sondang; Manninda, Reise; Ariani, Lusiana; Iskandar, Benni; Hidayati, Nabila Nur
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404456

Abstract

Polypharmacy may increase the risk of drug interactions affecting toxicity and therapeutic efficacy in pneumonia patients. This study aimed to analyse evaluation of pneumonia management, polypharmacy, relationship between polypharmacy and occurrence of drug-drug interactions, and relationship between drug-drug interactions and length of hospital stay of pneumonia patients. The study design used a quantitative descriptive approach with cross-sectional and retrospective data collection and a total sample of 113 samples that met the criteria. Analyses were performed using Spearman's rho correlation test to assess the association of polypharmacy with drug interactions, and the association of drug interactions with length of hospital stay. Medication accuracy was measured using PDPI (The Indonesian Lung Doctors Assosiaciation) guidelines, drug interactions using drugs.com and/or Medscape.com. Results showed 59.29% of patients were female, with the majority aged over 65 (55.65%). Most patients (91.15%) paid with BPJS, 62.61% were hospitalised for 1-5 days and 81.74% had comorbidities. Treatment accuracy in this study was 49.56%. 106 drug interactions were identified in a total of 226 cases. 66% of the interactions were pharmacodynamic with moderate severity (79%), such as the interaction between combivent and ondansetron. Mild pharmacokinetic interactions were common, especially between ranitidine and paracetamol (22 cases). There is a correlation between polypharmacy and drug interactions with a p-value 0.000 and there is a correlation between the number of drug interactions and length of hospitalisation with p-value 0.000. Conclusion of this study is polypharmacy increases the risk of drug interactions and affects the length of hospital stay in pneumonia patients.
Co-Authors Anggriani, Yusi Anita Rahmi Pradani Antasya, Vaylia Ariani, Lusiana BENNI ISKANDAR Desi Nadya Aulena Erna Kristin Fauzia Noprima Okta Fitri Nurhayati Gressty F Swandiny Hidayati, Nabila Nur Ika Permata Sari Ira Ningtiyas Purpranoto Isti Atika Ita Rahmawati Kurnia, Mala Lestari Rahayu Manninda, Reise Reise Manninda Meyke Afrianty Mita Restinia Mohamad Rega Satria Ramadhan Moordiani Moordiani Mulatsari, Esti Nasution, Musyirna Rahmah Neni Frimayanti Ni Made Dwi Sandhiutami Nurita Andayani Nurul Azizah Peng-Wei, Ching Raharjo, Lalu Joko Ramadaniati, Hesty Utami Reise Manninda Rika Sari Dewi RIKA SARI DEWI Rina Rosdiana Ros Sumarny ROS SUMARNY Rulliani Bianca Wijaya Safira Nafisa Sang Ayu Made Widyadari Sarah, Mutia Sarnianto, Prih Sesilia A Keban Shirly Kumala Wanda Ditan Arvandi Widodo, Akhmad Fajri Wijaya, Rulliani Bianca Wijayanti, Bitya Aulia Yeshika Krispansis Maelissa Yurista Elystra Yusi Anggriani Zainur Rahman Hakim