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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Sciences of Pharmacy Enrichment: Journal of Multidisciplinary Research and Development Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Administrative and Clinical Pharmacy
S.Farm., M.Farm., Apt, Sondang Khairani
Fakultas Farmasi Unniversitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Analysis of Antibiotic Therapy Accuracy and Drug Interaction in Pneumonia Inpatients at The Islamic Hospital Jakarta Cempaka Putih Khairani, Sondang; Manninda, Reise; Ariani, Lusiana; Iskandar, Benni; Hidayati, Nabila Nur
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404456

Abstract

Polypharmacy may increase the risk of drug interactions affecting toxicity and therapeutic efficacy in pneumonia patients. This study aimed to analyse evaluation of pneumonia management, polypharmacy, relationship between polypharmacy and occurrence of drug-drug interactions, and relationship between drug-drug interactions and length of hospital stay of pneumonia patients. The study design used a quantitative descriptive approach with cross-sectional and retrospective data collection and a total sample of 113 samples that met the criteria. Analyses were performed using Spearman's rho correlation test to assess the association of polypharmacy with drug interactions, and the association of drug interactions with length of hospital stay. Medication accuracy was measured using PDPI (The Indonesian Lung Doctors Assosiaciation) guidelines, drug interactions using drugs.com and/or Medscape.com. Results showed 59.29% of patients were female, with the majority aged over 65 (55.65%). Most patients (91.15%) paid with BPJS, 62.61% were hospitalised for 1-5 days and 81.74% had comorbidities. Treatment accuracy in this study was 49.56%. 106 drug interactions were identified in a total of 226 cases. 66% of the interactions were pharmacodynamic with moderate severity (79%), such as the interaction between combivent and ondansetron. Mild pharmacokinetic interactions were common, especially between ranitidine and paracetamol (22 cases). There is a correlation between polypharmacy and drug interactions with a p-value 0.000 and there is a correlation between the number of drug interactions and length of hospitalisation with p-value 0.000. Conclusion of this study is polypharmacy increases the risk of drug interactions and affects the length of hospital stay in pneumonia patients.
Analysis of the Rationality of Antibiotic Use in Pediatric Bronchopneumonia Patients and its Impact on Clinical Outcomes and Costs at RS Columbia Asia Pulomas Jakarta Period April 2024–April 2025 Yuwono, Wahyu Agung; Khairani, Sondang; Lizikri, Assajadda; Sandhiutami, Ni Made Dwi
Enrichment: Journal of Multidisciplinary Research and Development Vol. 3 No. 11 (2026): Enrichment: Journal of Multidisciplinary Research and Development
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/enrichment.v3i11.612

Abstract

Bronchopneumonia is one of the leading causes of morbidity and mortality in the pediatric population, especially in developing countries such as Indonesia. This condition also imposes a considerable economic burden due to the long duration of treatment and the frequent use of antibiotics, which are often inappropriate. This study aimed to evaluate the rationality of antibiotic administration in pediatric patients hospitalized with a diagnosis of bronchopneumonia at Columbia Asia Pulomas Hospital Jakarta during the period from April 2024 to April 2025, and to analyze its effect on clinical outcomes and treatment costs. This study used a retrospective cross-sectional design with a total sampling approach of 164 patients through a review of medical records and cost data. The rationality of antibiotic therapy was assessed using the Gyssens method, and the relationship between variables was analyzed using bivariate statistical tests. The study found that 71.9% of rational antibiotic use correlated with a higher clinical improvement rate of 80.5% compared to 52.2% for irrational antibiotic use (p = 0.000). However, there was no significant difference in the duration of hospitalization between rational antibiotic use (4.70 ± 0.82 days) and irrational antibiotic use (5.41 ± 2.25 days) (p = 0.612), nor in the total cost of hospitalization (rational use: Rp 15,956,032.66 ± Rp 5,568,892.10 vs. irrational use: Rp 18,801,283.94 ± Rp 11,292,810.87) (p = 0.658). These results emphasize the importance of antibiotic rationality analysis as an effort to improve clinical outcomes without having a significant impact on cost efficiency or treatment duration.
Co-Authors Anggriani, Yusi Anita Rahmi Pradani Antasya, Vaylia Ariani, Lusiana Assajadda Lizikri, Assajadda BENNI ISKANDAR Desi Nadya Aulena Erna Kristin Fauzia Noprima Okta Fitri Nurhayati Gressty F Swandiny Hidayati, Nabila Nur Ika Permata Sari Ira Ningtiyas Purpranoto Isti Atika Ita Rahmawati Kurnia, Mala Lestari Rahayu Manninda, Reise Reise Manninda Meyke Afrianty Mita Restinia Mohamad Rega Satria Ramadhan Moordiani Moordiani Mulatsari, Esti Musyirna Rahmah Nst Neni Frimayanti Ni Made Dwi Sandhiutami Nurita Andayani Nurul Azizah Peng-Wei, Ching Raharjo, Lalu Joko Ramadaniati, Hesty Utami Reise Manninda Rika Sari Dewi RIKA SARI DEWI Rina Rosdiana Ros Sumarny ROS SUMARNY Rulliani Bianca Wijaya Safira Nafisa Sang Ayu Made Widyadari Sarah, Mutia Sarnianto, Prih Sesilia A Keban Shirly Kumala Wanda Ditan Arvandi Widodo, Akhmad Fajri Wijaya, Rulliani Bianca Wijayanti, Bitya Aulia Yeshika Krispansis Maelissa Yurista Elystra Yusi Anggriani Yuwono, Wahyu Agung Zainur Rahman Hakim