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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease Global Medical and Health Communication Universa Medicina Jurnal SOLMA Jurnal Kreativitas PKM Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Public Health and Preventive Medicine Archive Jurnal Lintas Keperawatan Media Penelitian dan Pengembangan Kesehatan
Edhyana Sahiratmadja
Department of Biochemistry, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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ABCB1 rs1045642 Genotypes and Clinical Response in Indonesian Patients with Systemic Lupus Erythematosus Pratama, Muhammad Syawal; Afifah, Nadya Nurul; Permatasari, Lany Indah; Kennardi, Gabriel Bagus; Hamijoyo, Laniyati; Sahiratmadja, Edhyana; Barliana, Melisa Intan
Indonesian Journal of Clinical Pharmacy Vol 13, No 3 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.3.62273

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often managed with immunosuppressants such as methylprednisolone (MP) and azathioprine (AZA), although therapeutic responses vary among individuals. Genetic variation, including polymorphisms in the ATP-Binding Cassette Subfamily B Member 1 (ABCB1) gene encoding the P-glycoprotein drug transporter, may influence treatment outcomes. The rs1045642 polymorphism has been linked to variable responses in SLE, but data in Indonesian populations are scarce. This study aimed to describe the distribution of the ABCB1 rs1045642 polymorphism in SLE patients from Bandung, Indonesia, and to explore its potential association with therapy outcomes using MP and/or AZA. We conducted a cross-sectional study of 84 SLE patients, collecting clinical data from medical records. Treatment outcome was defined as achievement of lupus low disease activity state (LLDAS). Genomic DNA was extracted and sequenced to determine rs1045642 genotypes. A total of 84 SLE patients were included, predominantly aged 26–35 years (34%). Almost half had a disease duration of 6–10 years (49%). The majority achieved LLDAS (69%), and all patients were receiving methylprednisolone, with 78.6% also receiving azathioprine. The genotype distribution of ABCB1 rs1045642 was AA 10.71%, AG 61.91%, and TT 27.38%, which deviated from Hardy–Weinberg equilibrium (p < 0.05). However, genetic variations were observed among patients with SLE. Further studies on other possible polymorphisms related to the outcome of SLE therapy are needed.
Anemia Postpartum dan Dampaknya terhadap Kualitas Hidup Ibu Nifas: Scoping Review Rokhimawaty, Afita; Rachmawati, Anita; Pramatirta, Akhmad Yogi; Anwar, Ruswana; Tarawan, Vita Murniati; Sahiratmadja, Edhyana
Jurnal Lintas Keperawatan Vol. 6 No. 2 (2025): OKTOBER 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlk.v6i2.14000

Abstract

ABSTRAK Latar belakang : Anemia postpartum masih menjadi masalah kesehatan global yang berdampak pada pemulihan fisik dan psikologis ibu setelah melahirkan. Penurunan kadar hemoglobin dapat menurunkan kualitas hidup ibu nifas dan menghambat proses adaptasi terhadap peran keibuan. Kajian ini diperlukan untuk memahami sejauh mana kadar hemoglobin berpengaruh terhadap kesejahteraan ibu pascapersalinan. Metode : Penelitian ini merupakan scoping review berdasarkan pedoman PRISMA-ScR. Pencarian literatur dilakukan pada PubMed, Scopus, ScienceDirect, dan Google Scholar untuk periode 2015–2025. Sebanyak 10 artikel memenuhi kriteria inklusi dan dianalisis secara tematik. Hasil : Analisis menghasilkan tiga tema utama, yaitu kesehatan fisik, kesejahteraan psikologis, dan adaptasi peran ibu. Kadar hemoglobin rendah berhubungan dengan kelelahan, penyembuhan luka yang lambat, depresi postpartum, serta penurunan kepercayaan diri dan kelekatan ibu–bayi. Kesimpulan : Kadar hemoglobin postpartum memengaruhi kualitas hidup ibu secara multidimensi. Pemantauan hemoglobin dan intervensi gizi serta dukungan psikososial perlu diintegrasikan dalam pelayanan kebidanan pascapersalinan. Kata Kunci: anemia postpartum; hemoglobin; kualitas hidup; ibu nifas
Pengetahuan Tentang Talasemia pada Mahasiswa Kedokteran dan Dokter Umum di Bandung serta Prevalensi Karir β-Thalassemia Sahiratmadja, Edhyana; Wijaya, Michelle Angelica; Widjajakusuma, Anggraini; Maskoen, Ani Melani; Dewantoro, Julius Broto; Panigoro, Ramdan
Majalah Kedokteran Indonesia Vol 70 No 4 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.4-2020-232

Abstract

Background: Thalassemia major ranks 5th among catastrophic diseases according to the National Health Insurance, BPJS. Health workers are expected to have good knowledge about thalassemia to raise public awareness for thalassemia carrier early detection. Aim: To explore the knowledge about thalassemia among medical students and general practitioners (GPs) in Bandung, and the prevalence of β-thalassemia carrier.Methods: Analytic study was designed using questionnaire to compare knowledge. The prevalence of anemia due to iron deficiency or β-thalassemia carrier was described using Mentzer Index (MCV/RBC) and Shine and Lal index (MCV*MCV*MCH/100). Results: The knowledge about thalassemia among medical students (n597) and GPs (n171) was moderate, however, there was a significant difference; GPs greater than 30 years old had lower knowledge compared to students. Students attended blood examination had better knowledge (p 0.036). Type of anemia among students (7.9%) was different according to Mentzer index vs. Shine and Lal index; iron deficiciency anemia (5.3% % vs. 3.2%) dan β-thalassemia carrier (2.6% vs. 4.7%). Conclusions: Knowledge of thalassemia among medical students and GPs need to be enhanced, since 6-10% of Indonesian population are thalassemia carriers. Further examination is needed to confirm thalassemia carriership.
Co-Authors A, Muhammad Naufal Afandi Charles, Afandi Afifah, Nadya Nurul Aini, Intan Nur Akhmad Yogi Pramatirta, Akhmad Yogi Alfi, Mohammad Abyan Anandayu Pradita Anggraini Widjajakusuma, Anggraini Ani Melani Ani Melani Maskoen Ari indra Susanti Astuti, Intan Widya Aulia Bramantyo Azzahra, Fadhilla Zakya Bayu A. P. Wilopo, Bayu A. P. Bethy Suryawathy Hernowo Birgitta M. Dewayani, Birgitta M. Cynthia Kurniawan Dewantoro, Julius Broto Dewi, Vycke Yunivita Dhestina, Winnery Elsa Pudji Setiawati Elvina Karyadi Fadillah, Viki Faliq, Muhammad Faza Fitri Rahmi Fadhilah Gatot N.A. Winarno Gisrianti, Reina Syafira Gisrianti,, Reina Syafira Haryono Tansah, Haryono Helena Napitu, Helena Hendraswari, Chatrine Aprilia Herman Susanto Hudaya, Syahra Ramadhani Ikhwanuliman Putera Ikrar Syahmar Intan M. W. Dewi, Intan M. W. Jaya, Fidi Bhawana Julius Broto Dewanto, Julius Broto Kennardi, Gabriel Bagus Laniyati Hamijoyo, Laniyati Lelani Reniarti Lestari, Frida Dwi Maharani, Khalista Ismaya Mas Rizky A.A. Syamsunarno Melisa Intan Barliana, Melisa Intan Mugia Bayu Rahardja Mugia Bayu Raharja Muhammad Zulfikar Azhar, Muhammad Zulfikar Nabilah, Kayla Shafa Nagelkerke, Nico Ndaha Wungo, Sydney Immanuella Puteri Novi Vicahyani Utami Penggoam, Simeon Permatasari, Lany Indah Pramono, Alvinsyah Adhityo Pratama, Muhammad Syawal Prayudi Santoso Putra Sit, Ari Dwi Putri, Rahmania Devina R.M. Ryadi Fadil, R.M. Ryadi Rachmawati, Anita Ramdan Panigoro Ratu Safitri Rokhimawaty, Afita Ruswana Anwar Salsabila, Fathiyyah Samandari, Aquila Mozaffar Sari Puspa Dewi Shadrina, Siti Azyyati Nur SONY SUHANDONO Sulistiyorini, Ifa Sumantri, Nur Imaniati Sunarjati Sudigdoadi Surbakti, Indra Murty Tear, Alveron Andreas Tiyanto, Rizqi Deva Trevino A. Pakasi Tri Hanggono Achmad Viansih, Helsy Murtry Vita Murniati Tarawan Wijaya, Michelle Angelica Yuliasti Eka Purnamaningrum