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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Medical Journal of Indonesia Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease Global Medical and Health Communication Universa Medicina Jurnal SOLMA Jurnal Kreativitas PKM Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Public Health and Preventive Medicine Archive Media Penelitian dan Pengembangan Kesehatan
Edhyana Sahiratmadja
Department of Biochemistry, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Efektivitas Media Presentasi dan Pamflet dalam Meningkatkan Pengetahuan Ibu Hamil di Desa Cileles tentang Tuberculosis dan Imunisasi BCG Salsabila, Fathiyyah; Ndaha Wungo, Sydney Immanuella Puteri; Aini, Intan Nur; Hudaya, Syahra Ramadhani; Nabilah, Kayla Shafa; Viansih, Helsy Murtry; Putra Sit, Ari Dwi; Tiyanto, Rizqi Deva; Samandari, Aquila Mozaffar; Sahiratmadja, Edhyana
Jurnal SOLMA Vol. 14 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i2.18750

Abstract

Background: Indonesia menempati peringkat kedua tertinggi di dunia dalam jumlah kasus Tuberculosis (TB). Imunisasi Bacillus Calmette-Guérin (BCG) merupakan langkah pencegahan utama yang diwajibkan bagi bayi baru lahir. Namun, masih terdapat kesenjangan pengetahuan di kalangan ibu hamil mengenai pentingnya imunisasi ini. Untuk itu, dilakukan program edukasi kepada 30 ibu hamil di Desa Cileles dengan tujuan meningkatkan pemahaman terkait imunisasi BCG dan imunisasi dasar lainnya. Metode: Kegiatan dilaksanakan melalui penyuluhan, pre-test dan post-test, serta permainan interaktif. Keberhasilan program diukur melalui dua indikator, yaitu jumlah peserta minimal 20 orang dan peningkatan skor rata-rata ≥10%. Hasil: Kegiatan dilaksanakan melalui penyuluhan, pre-test dan post-test, serta permainan interaktif. Keberhasilan program diukur melalui dua indikator, yaitu jumlah peserta minimal 20 orang dan peningkatan skor rata-rata ≥10%. Kesimpulan: Disarankan agar mitra, yaitu tenaga kesehatan dan kader desa, melanjutkan edukasi serupa secara berkala dan mengintegrasikannya dalam kegiatan posyandu untuk memperluas cakupan dan dampak edukasi. Program ini diharapkan dapat berkontribusi dalam meningkatkan cakupan imunisasi dan menurunkan risiko TB pada bayi baru lahir.
ABCB1 rs1045642 Genotypes and Clinical Response in Indonesian Patients with Systemic Lupus Erythematosus Pratama, Muhammad Syawal; Afifah, Nadya Nurul; Permatasari, Lany Indah; Kennardi, Gabriel Bagus; Hamijoyo, Laniyati; Sahiratmadja, Edhyana; Barliana, Melisa Intan
Indonesian Journal of Clinical Pharmacy Vol 13, No 3 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.3.62273

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often managed with immunosuppressants such as methylprednisolone (MP) and azathioprine (AZA), although therapeutic responses vary among individuals. Genetic variation, including polymorphisms in the ATP-Binding Cassette Subfamily B Member 1 (ABCB1) gene encoding the P-glycoprotein drug transporter, may influence treatment outcomes. The rs1045642 polymorphism has been linked to variable responses in SLE, but data in Indonesian populations are scarce. This study aimed to describe the distribution of the ABCB1 rs1045642 polymorphism in SLE patients from Bandung, Indonesia, and to explore its potential association with therapy outcomes using MP and/or AZA. We conducted a cross-sectional study of 84 SLE patients, collecting clinical data from medical records. Treatment outcome was defined as achievement of lupus low disease activity state (LLDAS). Genomic DNA was extracted and sequenced to determine rs1045642 genotypes. A total of 84 SLE patients were included, predominantly aged 26–35 years (34%). Almost half had a disease duration of 6–10 years (49%). The majority achieved LLDAS (69%), and all patients were receiving methylprednisolone, with 78.6% also receiving azathioprine. The genotype distribution of ABCB1 rs1045642 was AA 10.71%, AG 61.91%, and TT 27.38%, which deviated from Hardy–Weinberg equilibrium (p < 0.05). However, genetic variations were observed among patients with SLE. Further studies on other possible polymorphisms related to the outcome of SLE therapy are needed.
Co-Authors A, Muhammad Naufal Afandi Charles, Afandi Afifah, Nadya Nurul Aini, Intan Nur Akhmad Yogi Pramatirta, Akhmad Yogi Alfi, Mohammad Abyan Anandayu Pradita Ani Melani Ani Melani Maskoen Ari indra Susanti Astuti, Intan Widya Aulia Bramantyo Azzahra, Fadhilla Zakya Bayu A. P. Wilopo, Bayu A. P. Bethy Suryawathy Hernowo Birgitta M. Dewayani, Birgitta M. Cynthia Kurniawan Dewi, Vycke Yunivita Dhestina, Winnery Elsa Pudji Setiawati Elvina Karyadi Fadillah, Viki Faliq, Muhammad Faza Fitri Rahmi Fadhilah Gatot N.A. Winarno Gisrianti, Reina Syafira Gisrianti,, Reina Syafira Haryono Tansah, Haryono Helena Napitu, Helena Hendraswari, Chatrine Aprilia Herman Susanto Hudaya, Syahra Ramadhani Ikhwanuliman Putera Ikrar Syahmar Intan M. W. Dewi, Intan M. W. Jaya, Fidi Bhawana Julius Broto Dewanto, Julius Broto Kennardi, Gabriel Bagus Laniyati Hamijoyo, Laniyati Lelani Reniarti Lestari, Frida Dwi Maharani, Khalista Ismaya Mas Rizky A.A. Syamsunarno Melisa Intan Barliana, Melisa Intan Mugia Bayu Rahardja Mugia Bayu Raharja Muhammad Zulfikar Azhar, Muhammad Zulfikar Nabilah, Kayla Shafa Nagelkerke, Nico Ndaha Wungo, Sydney Immanuella Puteri Novi Vicahyani Utami Penggoam, Simeon Permatasari, Lany Indah Pramono, Alvinsyah Adhityo Pratama, Muhammad Syawal Prayudi Santoso Putra Sit, Ari Dwi Putri, Rahmania Devina R.M. Ryadi Fadil, R.M. Ryadi Ramdan Panigoro Ratu Safitri Salsabila, Fathiyyah Samandari, Aquila Mozaffar Sari Puspa Dewi Shadrina, Siti Azyyati Nur SONY SUHANDONO Sulistiyorini, Ifa Sumantri, Nur Imaniati Sunarjati Sudigdoadi Surbakti, Indra Murty Tear, Alveron Andreas Tiyanto, Rizqi Deva Trevino A. Pakasi Tri Hanggono Achmad Viansih, Helsy Murtry Yuliasti Eka Purnamaningrum