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All Journal Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Nusantara (JPN) Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy
Yamin, Y
Fakultas Farmasi, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Karakterisasi dan Uji Aktivitas Antioksidan serta Penetapan Kadar Fenolik Total Ekstrak Etanol Kulit Batang Kapuk Randu (Ceiba petandra L. Gaertn) Yamin, Y; Hamsidi, Rini; Nasria, N; Sabarudin, S
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 4, No 2 (2018): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.78 KB) | DOI: 10.33772/pharmauho.v4i2.6277

Abstract

Antioksidan merupakan senyawa penting dalam menjaga kesehatan tubuh karena berfungsi sebagai penangkap radikal bebas dalam tubuh. Radikal    bebas    dapat    menginduksi    penyakit kanker, aterosklerosis, dan penuaan dini. Penelitian ini bertujuan untuk mengkarakterisasi ekstrak, serta menguji potensi antioksidan dan menentukan kadar fenolik total ekstrak etanol kulit batang kapuk randu (Ceiba petandra L Graetn). Aktivitas antioksida ditentukan dengan uji penangkal radikal bebas DPPH (2,2-diphenyl-1-pikrilhidrazil). Kandungan fenolik total ditentukan dengan metode Folin-Ciocalteau menggunakan spektrofotometri UV-Vis. Hasilnya menunjukkan bahwa ekstrak etanol kulit batang C. petandra L Graetn mengandung metabolit sekunder yang terdiri dari alkaloid, flavonoid, fenol tannin dan saponin, memiliki potensi antioksidan yang kuat dengan nilai IC50 sebesar 26,06 µg/mL, serta memiliki kadar fenolik total sebesar 43,063 µg/mLKata kunci: Antioksidan, kulit batang Kapuk Randu, DPPH
METODE PENGUATAN WARGA DALAM MELAKUKAN MITIGASI PADA MASA PANDEMI COVID-19 DI KABUPATEN MUNA BARAT Yamin Yamin; Ruslin Ruslin; Rina Andriyani; Syahabudin Syahabudin; La Aba
Jurnal Pengabdian NUSANTARA Vol 1, No 1 (2021): Januari-Juni
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.558 KB) | DOI: 10.33772/jpnus.v1i1.17845

Abstract

Corona virus disease (COVID-19) is an infectious disease caused by the recently discovered corona virus. Common signs and symptoms of COVID-19 infection include acute respiratory symptoms such as fever, cough and shortness of breath. The average incubation period is 5-6 days with the longest incubation period of 14 days. Severe cases of COVID-19 can cause pneumonia, acute respiratory syndrome, kidney failure and even death. The purpose of this activity is to provide strengthening of Community Strengthening in Mitigation against the COVID-19 Outbreak in West Muna Regency. The implementation of activities is carried out by providing outreach to the community through both online and offline. Online activities are carried out by communicating through the WhatsApp application while suspiciously by socializing with direct meetings or distributing leaflets with the material of the Healthy Living Community Movement (GERMAS), Clean and Healthy Lifestyle (PHBS), Movement Using Masks (GEMAS), Family Medicinal Plants (TOGA) ) and the use of disinfectants and antiseptics.------------------------------------------------------------------------------------------------------------------Penyakit virus corona (COVID-19) adalah penyakit menular yang disebabkan oleh virus corona yang baru-baru ini ditemukan. Tanda dan gejala umum infeksi COVID-19 antara lain gejala gangguan pernapasan akut seperti demam, batuk dan sesak napas. Masa inkubasi rata-rata 5-6 hari dengan masa inkubasi terpanjang 14 hari. Pada kasus COVID-19 yang berat dapat menyebabkan pneumonia, sindrom pernapasan akut, gagal ginjal, dan bahkan kematian. Tujuan kegiatan ini adalah untuk memberikan penguatan Penguatan Masyarakat dalam Mitigasi Menghadapi Wabah COVID-19 di Kabupaten Muna Barat. Pelaksanaan kegiatan dilakukan dengan memberikan penyuluhan kepada masyarakat melalui baik daring  maupun luring. Kegiatan daring dilakukan dengan komunikasi melalui aplikasi whattsApp sedangkan secara lurig dengan sosialisasi dengan pertemuan langsung maupun penyebaran leaflet dengan materi Gerakan Masyarakat Hidup Sehat (GERMAS), Pola Hidup Bersih dan Sehat (PHBS), Gerakan Menggunakan Masker (GEMAS), Tanaman Obat Keluarga (TOGA) dan Penggunaan disinfektas dan Antiseptik.
PENINGKATAN KUALITAS KESEHATAN MASYARAKAT ERA PANDEMIC COVID-19 MELALUI PEMANFAATAN TANAMAN OBAT KELUARGA SEBAGAI SUMBER IMMUNOMODULATOR Sunandar Ihsan; Yamin Yamin; Muhammad Handoyo Sahumena; Wa Ode Sitti Zubaydah; Arfan Arfan
Jurnal Pengabdian NUSANTARA Vol 2, No 2 (2022): Juli - Desember
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jpnus.v2i2.28443

Abstract

Coronavirus Diseases 2019 (COVID-19) is a disease caused by a new coronavirus strain (SARS-CoV-2) which then mutates into various variants including the omicron variant, alpha variant, beta variant, and gamma variant. Where, transmission will pose a high risk when the body's immunity is low. The purpose of this activity is to provide information on various "Family Medicine Gardens" that can function as Immunomodulators to the general public, as well as students, both junior high school (SMP) and elementary school (SD) students. The implementation of this activity is carried out face-to-face and is packaged in the form of socializing the benefits of the Family Medicinal Garden (TOGA) as a source of immunomodulators, together with the community practicing making Family Medicinal Plant gardens in the Poasia and Kambuh Districts as well as the School Environment. In addition, this is also done by distributing leaflets containing information on the types of plants that act as immunomodulators and how to make them.
The Potential of Clerodendrum paniculatum Leaves Fraction as a 3-Chymotrypsin-Like (3CL) Protease Inhibitor of SARS-CoV-2 Muhammad Arba; Arfan Arfan; Yamin Yamin; Muhammad Sulaiman Zubair
Indonesian Journal of Chemistry Vol 23, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.81447

Abstract

We described the biological activity of the Clerodendrum paniculatum leaf fraction against the SARS-CoV-2 3-Chymotrypsin-like 3CL protease at the molecular level. This study applied LC-MS/MS to identify bioactive compounds from fractions, computational studies, and fluorescence resonance energy transfer (FRET) assays to ascertain their inhibitory activity. LC-MS/MS analysis of the three samples revealed that sample 1 contained 18 compound peaks. In samples 2 and 3, there were 23 and 25 compounds with different molecular weights, respectively. Docking's study identified that the alkaloids (komarovicine and roemerine) have lower binding energies than other metabolites and standard compounds, with values of -33.47 and -32.63 kJ/mol, respectively. Roemerine demonstrated excellent stability based on dynamic simulation results and confirmed its affinity for 3CL protease predicted by the MM-PBSA approach of -89.44 kJ/mol. The FRET method for testing 3CL protease activity revealed that sample 2 had an enzyme inhibitory activity of 94.3%, which was close to that of GC376 (98.19%). Meanwhile, samples 1 and 3 yielded satisfactory inhibition activity by 89.64% and 85.24%, respectively. The antiviral activity of C. paniculatum leaves was discovered for the first time by inhibiting the 3CL protease SARS-CoV-2, providing an excellent opportunity for its development as an anti-SARS-CoV-2.
Determination of Antiradical Activity, Total Phenolic, and Total Flavonoid Contents of Extracts and Fractions of Langsat (Lansium domesticum Coor.) Seeds Yamin Yamin; Ruslin Ruslin; Sabarudin Sabarudin; Nurramadhani A Sida; Henny Kasmawati; La Ode Muhammad Diman
Borneo Journal of Pharmacy Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i4.1500

Abstract

Lansium domesticum Coor. is a fruit species from the Meliaceae family, which is a tropical plant native to Southeast Asia. Local citizens call it langsat, longkong, or duku and have used it as traditional medicine. The seeds of L. domesticum are used as a fever medicine, its bark is used to treat scorpion sting, and its leaves are used to repel mosquitoes. Because of its various uses, it is necessary to explore the antiradical potential of L. domesticum seeds. This study aims to determine the antiradical potential of L. domesticum seeds extract and fractions by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and to discover compounds that act as antiradical. Lansium domesticum seed powder was macerated with methanol, and then the extract was concentrated using a rotary evaporator and fractionated by n-hexane and ethyl acetate. The antiradical assay was conducted on extract and fractions by using DPPH radicals. Phenolic and flavonoid contents from extract and fractions were also tested. The ethyl acetate fraction obtained strong antiradical potential with an IC50 value of 8.938 ± 0.031 µg/mL. Total phenolic and flavonoid contents of ethyl acetate fraction were higher with values ​​of 58.25 ± 0.501 mgGAE/g sample and 75.123 ± 0.175 mgQE/g sample, respectively. Correlation of phenolic and flavonoid contents, which inhibited radicals had R2 values ​​of 0.9182 and 0.7658. Ethyl acetate fraction of L. domesticum seeds had very strong antiradical activity. Further isolation is expected to be conducted to discover which compounds are the most responsible as antiradical.
Acute Toxicity Determination and Compound Changing with Chemometric Procedures from Komba-Komba Leaf (Chromolaena odorata L.) Irvan Anwar; Yamin Yamin; Rachma Malina; Sabarudin Sabarudin
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.384

Abstract

The employing of komba-komba leaves (Chromolaena odorata L.), a medicinal plant that can prevent and treat many ailments, is one example of the expanding use of traditional medicine in the health field. To increase their use as traditional medicine, Komba-komba leaves must have complete information about their safety due to the abundance of secondary metabolite substances they contain. The goal of this work was to classify the extract components and fractions of komba-komba leaves using FTIR spectra and a PCA chemometric technique, as well as to estimate the hazardous potential of komba-komba leaves, total flavonoid and phenolic levels from komba-komba leaves. The BSLT (Brine Shrimp Lethality Test) method was used for acute toxicity testing. The toxicity test results revealed that the LC50 values of the komba-komba leaves (Chromolaena odorata L.) n-hexane fraction, ethyl acetate fraction, and insoluble ethyl acetate fraction had LC50 values 1000 ppm, indicating that the extract and n-hexane fractions were poisonous. The total flavonoid concentration was determined to be 243.4 mgEQ/g in the methanol extract, 380.1 in the n-hexane fraction, 512.8 in the ethyl acetate fraction, and 189 mgEQ/g in the ethyl acetate insoluble fraction. The methanol extract's total phenolic content was 146.3 mgEAG/g, whereas that of the n-hexane, ethyl acetate, and insoluble ethyl acetate fractions was 269.6, 360.9, and 109.3 mgEAG/g, respectively. From the results of the score plot, it can be seen that the PCA analysis was successful in demonstrating group differences between extracts and fractions of komba-komba leaves. Extracts and fractions of C.odorata L. leaves have moderate toxicity due to the presence of flavonoid and phenolic content, making them potential candidates for development as natural antioxidants.
Moringa oleifera Linn: Extraction, Phytochemistry Constituent and Pharmacology Activity: A Review Yamin Yamin; Ruslin Ruslin; Ratna Asmah Susidarti; Abdul Rohman
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94004

Abstract

Moringa oleifera, commonly known as the “miracle tree”, belongs to the Moringaceae family and is a plant that has functional food and nutraceutical properties. Various parts of this plant are rich sources of carbohydrates, proteins, amino acids, lipids, vitamins, polyphenols and minerals. This review is a comprehensive summary of the extraction method, phytoconstituents, traditional uses, and pharmacological activity of this plant, namely as an antioxidant, antimicrobial and antifungal, anti-inflammatory, anti-diabetic and anti-obesity, antiviral. This is because Moringa leaves contain flavonoids and phenolics. In addition, Moringa leaves contain a large number of phytochemicals which are excellent for the development of functional products applied in various industries including pharmaceutical, cosmetic, nutraceutical and food.
Analysis of Phenolic, Flavonoid Content, and Antioxidant Activity of Combination of Pumpkin Leaves (Cucurbita moschata Durch.) and Aibika Leaves (Abelmoschus manihot L.) Fractions Ari Sartinah; Yamin Yamin; Hasnawati Hasnawati; Suryani Suryani; Nur Illiyyin Akib; Hikmawati Supu
Jurnal Kartika Kimia Vol 9 No 1 (2026): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v9i1.1058

Abstract

This study aims to determine the total phenolic and flavonoid content of ethyl acetate fractions from pumpkin (Cucurbita moschata Durch.) and aibika (Abelmoschus manihot L.) leaves, and to evaluate the antioxidant activity of their combined fractions. Analysis of total phenolics and flavonoids content was carried out using UV-Vis spectrophotometry with gallic acid (phenolics) and quercetin (flavonoids) as standards. Antioxidant potential testing was carried out using the DPPH method. The results showed that the phenolics content of the ethyl acetate fraction of PLand ALwas 60.81 and 56.47 mgEAG/g, respectively, while the total flavonoids content of the ethyl acetate fraction of PLand ALwas 64.54 and 55.07 mgEK/g, respectively. The IC50 value of the combination of ethyl acetate fractions of PLand ALwith a ratio of 3:2 was 4.686 μg/mL, while the single ethyl acetate fractions of PLand ALwere 7.040 and 7.549 μg/mL, respectively. This indicates that increasing antioxidant activity can be done by combining fractions from two or more types of plants.
Exploring the Anti-Inflammatory Activity of Purified Ficus septica Extracts: Insights from In Vitro and In Silico Studies Arfan Arfan; Ruslin Ruslin; Yamin Yamin; Finantha Annisa; Wa Ode Fitrawati Basrin
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.189-196.2024

Abstract

Ficus septica is a plant that has demonstrated significant potential as an anti-inflammatory agent. This study evaluates the anti-inflammatory activity and molecular mechanisms of compounds from Ficus septica, focusing on their interactions with Bovine Serum Albumin (BSA) and Cyclooxygenase-2 (COX-2). The results show that the purified extracts from Kadia and Batalaiworu exhibited better anti-inflammatory activity, with IC50 values of 32.04 µg/mL and 32.06 µg/mL, respectively, compared to the crude extracts, which had IC50 values of 42.07 µg/mL and 42.44 µg/mL. Despite this, Diclofenac Sodium exhibited a significantly lower IC50 value of 7.99 µg/mL. Computational studies revealed that Genistein had the strongest binding affinity to BSA with a binding energy of -7.52 kcal/mol, comparable to Diclofenac Sodium (-7.51 kcal/mol). Furthermore, Ficuseptine B and Septicine demonstrated strong binding to COX-2, with binding energies of -9.51 kcal/mol and -9.45 kcal/mol, respectively, outperforming Diclofenac Sodium (-8.49 kcal/mol). These findings suggest that compounds from Ficus septica, particularly Genistein, Ficuseptine B, and Septicine, may serve as potential anti-inflammatory agents through their ability to bind to BSA and COX-2.
EDUKASI DAN PELAYANAN KESEHATAN MASYARAKAT DALAM KEGIATAN ROAD TO HARI KESEHATAN NASIONAL (HKN) KOTA KENDARI TAHUN 2025 Parawansah Parawansah; Henny Kasmawati; Yamin Yamin; Tridamayanti Fataraing; Hutamy Viranda Rahman; Muh Aidil Adha; Ghina Salsabila Awandhaputri; Rahimah Nurfadilah Dahlan; Dias Tama; Sherly Intan Ardani; Wandarsih Juniarti Akbar
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Januari 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i1.2165

Abstract

Road to Hari Kesehatan Nasional (HKN) Kota Kendari Tahun 2025 merupakan kegiatan promotif dan preventif yang bertujuan meningkatkan derajat kesehatan masyarakat melalui pelayanan kesehatan dan edukasi langsung. Kegiatan ini melibatkan Dinas Kesehatan Kota Kendari dan mahasiswa Program Studi Pendidikan Profesi Apoteker Universitas Halu Oleo sebagai bentuk implementasi Tri Dharma Perguruan Tinggi. Tujuan kegiatan pengabdian masyarakat ini adalah menjalin kemitraan antara Tim Pengabdian Masyarakat Mahasiswa Profesi Apoteker UHO dan Dinas Kesehatan Kota Kendari, berpartisipasi aktif dalam rangkaian Road to HKN Kota Kendari 2025 melalui pelaksanaan Cek Kesehatan Gratis, mendukung kelancaran kegiatan dengan bantuan tenaga dan dokumentasi, serta meningkatkan kesadaran mahasiswa akan pentingnya peran tenaga kesehatan dalam kegiatan sosial dan edukatif. Metode pelaksanaan meliputi edukasi kesehatan secara langsung, pendampingan pelayanan cek kesehatan gratis, serta dokumentasi kegiatan. Sasaran kegiatan adalah masyarakat umum yang hadir di lokasi kegiatan Road to HKN. Hasil kegiatan menunjukkan antusiasme masyarakat yang tinggi terhadap pelayanan kesehatan dan edukasi kefarmasian. Masyarakat memperoleh pemahaman terkait kesehatan mata, tuberkulosis, Beyond Use Date (BUD), prinsip DAGUSIBU serta Pencegahan Penyakit Tidak Menular (PTM). Kegiatan ini memberikan kontribusi positif dalam meningkatkan literasi kesehatan masyarakat. Kesimpulan dari kegiatan ini adalah bahwa keterlibatan mahasiswa profesi apoteker dalam pengabdian masyarakat mampu mendukung peningkatan derajat kesehatan masyarakat secara nyata.
Co-Authors ,, Suryani Abdul Rohman Anwar, Irvan Arfan Arfan Ari Sartinah Dias Tama Finantha Annisa Ghina Salsabila Awandhaputri Hasnawati Hasnawati Hikmawati Supu Hutamy Viranda Rahman Kasmawati, Henny La Aba La Ode Muhammad Diman Muh Aidil Adha Muhammad Arba Muhammad Handoyo Sahumena Muhammad Sulaiman Zubair Nasria, N Nur Illiyyin Akib Nurramadhani A. Sida Parawansah, P Rachma Malina Rahimah Nurfadilah Dahlan Ratna Asmah Susidarti Rina Andriyani Rini Hamsidi Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Sabarudin Sabarudin Sherly Intan Ardani Sunandar Ihsan Syahabudin Syahabudin Tridamayanti Fataraing Wa Ode Fitrawati Basrin Wa Ode Sitti Zubaydah Wandarsih Juniarti Akbar