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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Higea JPK: Jurnal Proteksi Kesehatan Jurnal Pengabdian Masyarakat Bangsa Jurnal Kefarmasian Indonesia
Widya Kardela
Departemen Farmakologi Dan Farmasi Klinik, Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang
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Journal : JPK: Jurnal Proteksi Kesehatan

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Antihypertension Activity of Gynura procumbens (L.) Merr. Extract On Blood Pressure And Monoxide Nitrogen Levels In Male White Rats Rahimatul Uthia; Dina Yuliana; Widya Kardela
JURNAL PROTEKSI KESEHATAN Vol 9 No 2 (2020): JPK: Jurnal Proteksi Kesehatan
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v9i2.309

Abstract

Hypertension is closely related to vasodilation disorders because of the decreased availability of nitrogen monoxide (NO). The purpose of this study was to determine the decrease in blood pressure and nitrogen monoxide (NO) levels in rats after administration of Gynura procumbens leaves extract. The results showed that the administration of Gynura procumbens leaves extracts significantly reduced blood pressure and increased NO levels. From the results of Duncan's test, it was found that the dose of 300mg / Kg BW showed a better effect on increasing NO levels (p <0.05). From the results of the study, it can be concluded that the ethanol extract of Gynura procumbens leaves has an antihypertensive activity that can reduce blood pressure and increase the NO level.
Co-Authors Abdillah, Rahmad Annisa Rahmidasari Anzharni Fajrina Bellatasie, Rezlie Diah Witari Dina Yuliana Eriadi, Aried Erlina Rustam Fitra Fauziah Fitra Fauziah Fitra Fauziah Fitra Fauziah Fitra Fauziah Fitratul Wahyuni Garmi Handicka Helmi Arifin Ifora Ifora Ifora Ifora Ifora, Ifora Kukuh Bima Transida Kukuh Putri Lestari Makmur, Indra Mandala, Yoga Febrian Maria Dona Octavia Multi Silvi Nurayni Nurayni Oktavia, Sri Putri Ramadhani Putri Ramadhani, Putri Rahimatul Uthia Rahimatul Uthia Rahimatul Uthia Retnosari Andrajati Retnosari Andrajati Rezlie Bellatasie Rezlie Bellatasie Roslinda Rasyid Rozi Efendi Santi Nadia Sari Utami Sari, Yeni Novita Sinta Wahyuni Sofitriana, Lisa Solly Aryza Sonya Mayesri Sudibyo Supardi Sudibyo Supardi Uyun, Hendri Satria Kamal Wiliantari, Selvia Yana, Annissa Dwi Yoga Febrian Mandala Wijaya Yora Maideani H Yufri Aldi