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All Journal Medical Journal of Indonesia Damianus Journal of Medicine Medicinus : Jurnal Kedokteran Cermin Dunia Kedokteran
Arini Setiawati
Departemen Farmakologi dan Terapi, Fakultas Kedokteran Universitas Indonesia
Health Professions Medicine & Pharmacology Public Health

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Journal : Medicinus : Jurnal Kedokteran

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Randomized Trial Comparing Adjuvant Intravitreal Triamcinolone Acetonide 2mg and Bevacizumab 12,5mg for Diabetic Macular Edema Larasati, maria; Setiawati, Arini; Djatikusumo, Ari
Medicinus Vol. 7 No. 2 (2018): February 2018 - May 2018
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v7i2.1792

Abstract

ObjectivesTo evaluate the efficacy and safety of Intravitreal Triamcinolone Acetonide (IVTA) 2 mg and Bevacizumab (IVB) 12,5 mg for adjuvant therapy of Diabetic Macular Edema (DME)DesignThis was a prospective, randomized clinical trial. Each participants with DME was randomized to received single intravitreal injection of IVTA or IVB  and then being followed until fourth week after injection. The efficacy parameters were the improvement in Best Corrected Visual Acuity (BCVA) in logMAR and Standardized Central Macular Thickness (SCMT) by Optical Coherence Tomography. The safety parameters were the Intra Ocular Pressure (IOP) and Posterior Capsular cataract progression using LOCSIII criteria.ResultsTwenty five eyes of 20 participants were randomly assigned to receive IVTA 2 mg (n=12) and IVB (n=13). At 4 weeks, mean BCVA was better in IVTA group than in IVB group -0,39 logMAR (p<0,05). CMT reduction were significant in all visits of both groups. The SCMT showed 78,37%  at final follow-up for IVTA group. There were no statistic significant difference in the mean IOP and posterior capsular cataract changes among two groups. (p>0,05)ConclusionAdjuvant IVTA injections were more effective than IVB injections in patients with DME. However, it was associated with higher increment in IOP, despite not reaching statistical significance.
Co-Authors Ali Baziad Andhika Rachman Arif Abdillah Diah Ambarwati, Fransisca Dian Saraswati Djatikusumo, Ari Dwi R. Parwati Elise Kasakeyan Errol U. Hutagalung Faiz Faiz Fatimah Eliana, Fatimah Fitriyadi Kusuma Franciscus D. Suyatna Frans D. Suyatna Hadiarto Mangunnegoro Handoko, Iwan Surjadi Harmani Kalim HENI RACHMAWATI Ifran Saleh Ikhwan Rinaldi Iwan Darmansjah Iwin Sumarman Jan Susilo Jessie S. Pamudji Juan T. Sion Junita Indarti Karmel L Tambunan, Karmel L Karmel L. Tambunan Kris Pranarka Lugyanti Sukrisman Lukman H. Makmun Maria Marietta Bali Larasati Marina Hamadian Melva Louisa Metta S.S. Wiria Mulyarjo Mulyarjo Nafrialdi Nafrialdi Nina Irawati Nur A. Aroeman Rianto Setiabudy Robby Zulkarnain Roestiniadi D. Soemantri S. B. Gunawan Samsirun Halim Shufrie Effendi, Shufrie Sidartawan Soegondo Sofyanuddin Sofyanuddin Sri W.A. Jusman T. Djumhana Atmakusuma, T. Djumhana Tety H. Rahim Theresia G Kurniawan, Theresia G Wiguno Prodjosudjadi Yeyet C. Sumirtapura Zita Arieselia Zulkifli Alkaf