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All Journal Jurnal Farmasi Andalas JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Pendidikan IPA (JPPIPA) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Stamina Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Journal of Pharmaceutical and Sciences. Journal of Health Economic and Policy Research (JHEPR) Borneo Journal of Pharmacy
Rahmi Yosmar
Fakultas Farmasi Universitas Andalas
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Effect of Drug Information Service on Clinical Outcome of Patients with Type 2 Diabetes Mellitus in Padang, Indonesia Lailaturrahmi Lailaturrahmi; Fuji Araswati; Armenia Armenia; Rahmi Yosmar
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3301

Abstract

Type 2 diabetes mellitus (T2DM) has been a health burden worldwide, including Indonesia. However, T2DM therapy needs a long and complex process, which patients often do not favor, thus making them does not take medications as instructed and negatively affecting clinical outcomes. This study aimed to understand the effect of Drug Information Service provision on the clinical outcome of T2DM patients. This quasi-experimental study was conducted using one group pre-post-test design. As the clinical outcome, the fasting blood glucose levels were measured before and after the intervention. A drug information service was provided through direct explanation to the patients. Sociodemographic data were analyzed descriptively. The difference in fasting blood glucose before and after the intervention was assessed using Wilcoxon signed-rank test. Forty patients participated in this study. Most participants are female (N=34; 85%) and receive two-drugs combination therapy of metformin and sulfonylureas (N=32; 77.5%). Although there is a decrease in mean fasting blood glucose level after intervention (174.92±59.561 vs. 184.20±49.768), there is no significant difference between fasting blood glucose levels pre-intervention and post-intervention (p>0.05). It is concluded that despite the noticeable decline of blood glucose level after drug information service, its effect on blood glucose control is not significant.
Aspirin-clopidogrel combination therapy for ischemic stroke patients: Clinical efficacy and cost-effectiveness analyses in low-resource setting Fitria, Najmiatul; Febiana, Dian; Akram, Muhammad; Yosmar, Rahmi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.758

Abstract

Understanding the cost-effectiveness of aspirin-clopidogrel combination therapy is crucial in determining its influence on coagulation parameters, specifically prothrombin time (PT) and activated partial thromboplastin time (APTT). The aim of this study was to assess the cost-effectiveness and clinical impact of using the aspirin-clopidogrel combination compared to aspirin alone in managing ischemic stroke. Employing an observational research design, inpatient ischemic stroke cases receiving the aspirin-clopidogrel combination were compared to those treated with aspirin alone. Focusing on the hospital's perspective on costs, the research specifically analyzed medical expenses without discounting costs or effects. The analysis involved comparing the direct medical costs and coagulation parameters between the two treatment groups. Our data revealed that the aspirin-clopidogrel combination demonstrated superior cost-effectiveness over aspirin alone, indicated by the incremental cost-effectiveness ratio (ICER) values for PT (IDR -246,930/second) and APTT (IDR -119,270/second). This indicated that the combination therapy was associated with lower costs while yielding better clinical parameter values. The ICER analysis placed the aspirin-clopidogrel combination in the southeast quadrant, marking its dominance over aspirin monotherapy by demonstrating higher effectiveness at lower costs. These results suggest that combination therapy might be a favorable alternative for managing ischemic stroke, presenting a viable option for consideration in clinical practice. The findings underscore the potential economic and clinical advantages of employing the aspirin-clopidogrel combination in routine stroke management protocols.
Evaluating Economic Outcomes: Single-Use Aspirin vs. Aspirin-Clopidogrel in Ischemic Stroke Patients Based on Barthel Index Scores Yosmar, Rahmi; Febiana, Dian; Fitria, Najmiatul
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.293-299.2023

Abstract

Ischemic stroke is a catastrophic disease that causes large costs in Indonesia. The high prevalence of stroke results in  increased morbidity and mortality rates, which will impact the socioeconomic status of stroke patients. Cost Effectiveness Analysis  (CEA) is a method in pharmaco-economics that aims to make decisions regarding the rational choice of therapy and evaluate  the economic impact on ischemic stroke patients. This study aims to determine the Incremental Cost Effectiveness Ratio (ICER)  value of antiplatelet therapy in the aspirin-clopidogrel combination group and the single aspirin group in ischemic stroke patients  treated at the Regional General Hospital. Dr. M. Djamil Padang. The clinical parameter observed was the Barthel Index (BI) value.  This research is a descriptive study with retrospective data collection using medical record data and the Hospital Management  Information System (SIMRS) at RSUD Dr. M.Djamil Padang. The cost data shows the total direct medical costs incurred in treating  ischemic stroke. Based on the results obtained, the Incremental Cost Effectiveness Ratio (ICER) value is IDR (-) 401,302. 71 per  1% increase. In this study it can be concluded that the aspirin-clopidogrel combination has better cost effectiveness than aspirin  alone.
Uji Efek Teratogenik Infusa Daun Kopi Arabika (Coffea arabica L.) Terhadap Fetus Mencit Afriyeni, Helmice; Yosmar, Rahmi; Rizal, Rosiana; Fikri, Zahiya Afifah
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 4 No 1 (2025): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v4i1.1852

Abstract

Arabica coffee leaves (Coffea arabica L.) are a herbal medicine used to treat hypertension, diarrhea, malaria, fever, diabetic and hypercholesterolemia. However, it is feared that the use of herbal medicines will cause side effects during pregnancy, especially defects in the fetus. This concern arises due to the lack of information regarding the side effects and toxicity of herbal medicines. Therefore, it is necessary to conduct research on the teratogenic effects of Arabica coffee leaf infusion (Coffea arabica L.) on test animals. This study used varying concentrations of Arabica coffee leaf infusion of 2.5%, 5%, and 10%, which were given orally during the organogenesis period of white mice (Mus Musculus) pregnancy, days 6-15 of pregnancy. On the 18th day, a laparotomy was performed, then the fetus was observed to see whether there were skeletal and external malformations. The statistical results of one-way ANOVA show that there is an abnormality in the fetus in the form of low birth weight (LBW), and the incidence of fetal death increases with each administration of a larger concentration/1 infusion. Statistical results of two-way ANOVA showed that the concentration and length of treatment significantly influenced the mother's body weight (P<0.05), while the interaction between the two had no significant effect (P>0.05). The research results show that Arabica coffee leaf infusion has the potential to have a teratogenic effect on the fetus.
Body Mist-Making Training and Socialization of Cosmetic Product Registration and Marketing Authorization to Youth Organisations in Kerinci Nova Syafni; Try Andy Sahputra; Saafrida Saafrida; Uswatul Hasanah; Rini Agustin; Rahmi Yosmar; Friardi Ismed; Erizal Zaini
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.336-342.2024

Abstract

Indonesia is an important country that produces essential oils that are widely used in fragrance cosmetic products. The use of local essential oils for cosmetics needs to be introduced to the youth generation with the aim that they do not just become consumers. Youth organisations in Kerinci have many activities to improve their skills and abilities for a better future. Collaboration between the university and the youth organisation was achieved by providing training on doing cosmetic product training on making cosmetic products. The product uses essential oils called body mist. Nowadays, the youth still know very little about the manufacturing process of cosmetics products. To provide further benefits, this community service activity collaborated with BBPOM in Padang, West Sumatra, to explain cosmetic safety and the registration process of cosmetic products. With this series topic in this training and outreach-related cosmetics, it is hoped that it can increase business ideas for young people who are members of the Sakti Alam Kerinci Organisation.
Hubungan Tingkat Kepatuhan Terapi Antihipertensi Dengan Kualitas Hidup Pasien Di Puskesmas Kota Padang Primadhini, Tessa Amanda; Sari, Yelly Oktavia; Yosmar, Rahmi; Syukra, Putri Salsabila Eka Ranti; Azzahra, Rafifah; Serdiani, Serdiani
Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta Vol 4 No 2 (2025): Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE
Publisher : LPPM Universitas Dharma Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47233/jppie.v4i2.2201

Abstract

Hypertension is a condition diagnosed when repeated blood pressure measurements show values ≥140/90 mmHg. Long-term treatment is required to control blood pressure, making patient adherence to therapy essential for achieving therapeutic targets. Non-adherence can negatively impact patients’ quality of life, as poor health-related quality of life may limit daily functioning. The Pill Count method and the SF-36 questionnaire were used to assess medication adherence and quality of life. This study aimed to determine the relationship between antihypertensive medication adherence and the quality of life in hypertensive patients. The research was conducted at Lubuk Buaya Public Health Center from February to March 2023. It was a non-experimental analytic study using a cross-sectional method. A total of 90 participants were selected using purposive sampling. The results showed that adherence to antihypertensive medication significantly influenced only certain domains, likely due to most respondents exhibiting good adherence and high awareness, which contributed to a better quality of life. Chi-square analysis revealed a significant relationship between medication adherence and health-related quality of life, particularly in the domains of bodily pain, social functioning, and mental health.
Dampak Terapi Antipsikotik terhadap Lama Rawat Inap dan Gejala Eksitasi pada Pasien Skizofrenia Yosmar, Rahmi; Almasdy, Dedy; Abdillah, Rahmad; Amni, Hudiyah
Jurnal Penelitian Pendidikan IPA Vol 11 No 9 (2025): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i9.12125

Abstract

Schizophrenia is a complex psychiatric disorder treated primarily with antipsychotics, yet their impact on clinical outcomes such as hospital stay and excitement symptoms, measured by the Positive and Negative Syndrome Scale–Excitement Component (PANSS-EC), remains uncertain. This study examined the association between antipsychotic therapy, hospital stay duration, and PANSS-EC scores in patients with schizophrenia. A retrospective, cross-sectional analysis was conducted on 271 patients. Sociodemographic data were analyzed descriptively, and the Kruskal–Wallis test was applied for bivariate analysis across treatment groups. The results showed that patients were predominantly male (72.7%), most frequently diagnosed with paranoid-type schizophrenia (42.8%), and commonly aged 26–35 years (33.9%). No significant differences were found in hospital stay or PANSS-EC scores among the antipsychotic treatment groups. However, gender was significantly associated with PANSS-EC score changes, and schizophrenia subtype correlated with hospital stay duration. Antipsychotic therapy demonstrated no direct association with hospital stay or PANSS-EC outcomes. Instead, demographic and clinical factors, particularly gender and schizophrenia subtype, influenced treatment outcomes. These findings underscore the need for further investigation into patient-specific variables to optimize therapeutic strategies in schizophrenia care.
Interaksi Obat dalam Terapi Insulin pada Pasien Diabetes Melitus Tipe 1: Studi Retrospektif Tungga , Intan Kumara; Juwita , Dian Ayu; Yosmar, Rahmi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1071

Abstract

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disorder resulting in the destruction of pancreatic β-cells, leading to absolute insulin deficiency and hyperglycemia. Insulin remains the cornerstone of therapy; however, its use may be complicated by drug interactions that alter treatment effectiveness through pharmacodynamic or pharmacokinetic mechanisms. This study aimed to evaluate the prevalence and mechanisms of potential insulin drug interactions in patients with T1DM. A retrospective, cross-sectional study was conducted using a total sampling method. The study was conducted at Dr. M. Djamil General Hospital Padang. The study population consisted of all hospitalized patients diagnosed with type 1 diabetes mellitus (T1DM) during the period 2019–2022. Patient characteristics, patterns of insulin therapy, and the occurrence of drug interactions were analyzed. The majority of patients were female (70%), and most were in the 0–18-year age group (83%). Insulin therapy was prescribed in 86.6% of cases. Potential drug–drug interactions were identified in 33.3% of hospitalized patients with type 1 diabetes mellitus, predominantly pharmacodynamic in nature. The basal–bolus insulin regimen constituted the most frequently prescribed therapeutic option among the patients. The Spearman correlation analysis indicated a statistically insignificant association between the metric of polypharmacy and the incidence of drug interactions. Systematic monitoring remains essential, and larger prospective studies are needed to confirm these findings.
Analisis Interaksi Obat-Obat Kardiovaskular pada Pasien Jantung Koroner dengan Riwayat Hipertensi Febriyenti, Amanda; Yosmar, Rahmi; Permatasari, Dita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1074

Abstract

Coronary heart disease (CHD) accompanied by hypertension often necessitates the use of multiple cardiovascular agents. The concurrent use of multiple drugs increases the risk of drug-drug interactions (DDIs), which may alter drug metabolism, reduce therapeutic efficacy, or cause adverse effects. This study aimed to characterize the potential, mechanisms, and severity of drug interactions; to assess differences in the average number of drugs used per day in relation to the potential for drug interactions; and to assess the clinical profile based on DDI severity levels. A retrospective, analytic, observational method was applied, utilizing secondary data from hospital medical records. Statistical analysis included the Mann–Whitney test to compare the mean number of drugs per day between the interaction potential groups. A total of 52 patients met the inclusion criteria through purposive sampling. The results showed that most CHD patients with a history of hypertension were male (75%) and aged 18–64 years (73.1%). A total of 405 potential DDIs were identified. From these, 80 unique drug-pair interactions were selected for detailed analysis of their mechanisms and severity. Most were pharmacodynamic (77.5%), with aspirin–nitroglycerin the most frequent (7.6%). Among the 80 interactions analyzed in detail, those with moderate severity predominated (58.8%), followed by minor (35%) and major (6.2%). Polypharmacy (defined as the use of three or more medications) was observed in all patients who experienced DDIs. There was a significant difference in the average number of medications per day between patients with potential drug interactions and those without, p = 0.023 (p < 0.05).
Formulation and Physical Characterization of Chewable Gummy from Galangal Rhizome Extract (Kaempferia galanga L.) as a Nutraceutical Product Andarifera, Alya Zahira; Zaini, Erizal; Yosmar, Rahmi; Fitriani, Lili
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.145-155.2025

Abstract

The Kaempferia galanga L rizhome (kencur) extract, known in traditional use as an appetite enhancer, was developed into chewable gummy preparations as a nutraceutical product. Due to the taste and odor of extract from natural plants caused less preferable to consume. Therefore the formulation of chewable gummy was addressed to overcome this problem. This study formulated gummy with a concentration of 2% galangal extract and gelatin as gelling agent with concentration variations of 10% (F1), 12.5% (F2), and 15% (F3). The evaluation of the physical properties of galangal rhizome extract chewable gummy included swelling ratio, syneresis, organoleptic, weight diversity, and texture profile analysis (TPA). In addition, a hedonic test was conducted to determine the level of panelist preference. The results revealed that the higher the gelatin concentration, the more significant the changes in the physical properties of gummies. An increase in gelatin plays a crucial role in forming a denser and more stable preparation structure. This impacts the texture regarding chewiness and increase the hardness. The result of TPA showed a significant differences (p<0.05) in the parameters of hardness, gumminess, and chewiness between the three formulations. The results of the hedonic test showed that F3 was the most preferred by the panelists. Based on these results, a gelatin concentration of 15% is recommended for the formulation of chewable gummy galangal rhizome extract.
Co-Authors Ade Fitriani, Ade Almahdy A Amni, Hudiyah Andarifera, Alya Zahira Annisa Nurbuana Putri Armenia, Armenia Delva Yeni Dian Ayu Juwita Dita Permatasari Dita Permatasari Erizal Zaini Febiana, Dian Febriyenti, Amanda Fifi Yuliagus Fikri, Zahiya Afifah Fitria Rahma Friardi Ismed Fuji Araswati Helmi Arifin Helmice Afriyeni Jayawarsa, A.A. Ketut Julio Fajar Rahmat Illahi Juwita , Dian Ayu Lailaturrahmi Lailaturrahmi Meri Andani Muhammad Akram Nadia Putri Inanta Najmiatul Fitria Netty Marusin Netty Suharti Nova Syafni Primadhini, Tessa Amanda Rafifah Azzahra Rahmad Abdillah Rini Agustin Rizal, Rosiana Roslinda Rasyid Saafrida Saafrida Sari, Yelly Oktavia Serdiani, Serdiani Suhatri Suhatri Surya Dharma Syukra, Putri Salsabila Eka Ranti Try Andy Sahputra Tungga , Intan Kumara Uswatul Hasanah Yelly Oktavia Sari Zulkarni R