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All Journal Nurse Media Journal of Nursing MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kesehatan FKUB Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Manuju : Malahayati Nursing Journal Jurnal Respirologi Indonesia Heart Science Journal MAHESA : Malahayati Health Student Journal Narra J Cermin Dunia Kedokteran Indonesian Nursing Journal of Education and Clinic (Jurnal Pendidikan dan Praktik Keperawatan Indonesia) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Bambang Budi Siswanto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, University Of Indonesia, And National Cardiovascular Center Harapan Kita, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Exploring the Relationship Between Comprehensive Respiratory Assessment and Intra-Extracardiac Biomarkers in Heart Failure Rehabilitation Triangto, Kevin; Radi, Basuni; Siswanto, Bambang B.; Tambunan, Tresia FU.; Heriansyah, Teuku; Harahap, Alida R.; Kekalih, Aria; Katsukawa, Hajime; Santoso, Anwar
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.248

Abstract

Introduction: Heart failure with reduced ejection fraction (HFrEF) is well-known as a systemic disease that involves cardiac and extracardiac issues, with respiratory function playing on of the key role in rehabilitation prognosis. Biomarkers such as soluble suppression of tumorigenicity 2 (sST2), myostatin, miRNA-133, and NT-proBNP indicate disease progression. Notably, sST2, which is also produced by the lungs, predicts heart failure outcomes. This study examines the relationship between comprehensive respiratory assessments (e.g., diaphragmatic ultrasonography, spirometry) and intra-extracardiac biomarkers to improve rehabilitation strategies. Methods: Sixty-nine HFrEF patients underwent respiratory evaluations, including diaphragmatic ultrasonography, spirometry, chest expansion measurements, and a six-minute walking test (6MWT). Biomarkers assessed were sST2, myostatin, miRNA-133, and NT-proBNP. Associations between respiratory parameters and biomarkers were analyzed using t-tests and correlation analyses. Results: The median age was 56 years, and 33 (47.82%) of the subjects had diaphragmatic dysfunction, resulting in poorer 6MWT performance (378.03±58.15 m vs 409.75±63.65 m, p=0.017) and other parameters. Superior chest expansion negatively correlated with sST2 (r=−0.387, p=0.001) and positively with miRNA-133 (r=0.442, p<0.001). Similar results were found for inferior chest expansion. No significant correlations were observed for other biomarkers. Conclusion: This study highlights strong associations between chest expansion and sST2/miRNA-133, suggesting that incorporating respiratory assessments and training into HFrEF rehabilitation could enhance outcomes by addressing cardiorespiratory insufficiencies. Given sST2's predictive value for heart failure prognosis, these findings support a multi-component rehabilitation strategy incorporating respiratory training, such as aerobic and inspiratory muscle exercises, to enhance cardiopulmonary outcomes. This integrated approach offers promise for future HFrEF rehabilitation protocols.
Co-Authors Achir Yani S. Hamid Adi, Andi Wahjono Agung Waluyo Ambari, Ade Meidian Amiliana M Soesanto Amiliana M. Soesanto Andi Mahavira Andy Kristyagita Anna Ulfah Rahajoe Anwar Santoso Aria Kekalih Asrory, Virna Dwi Oktariana Astari Pranindya Sari Basuni Radi BRM Ario S. Kuncoro Budhi Antariksa Budhi S. Purwowiyoto Dedi Afandi Desandri, Dwita Rian Dewi H Suprobo Dewi H Suprobo Dewi Irawati Dewi Irawati DEWI IRAWATI Diana Septiyanti Doni Firman Dwiputra, Bambang Emir Yonas Endang Ratnaningsih Erwin Mulia Fatoni, Mukhamad Ganesja M Harimurti Ganesja M Harimurti Gipta Galih Widodo Hadrian Deka Hananto Andriantoro Harahap, Alida R. Harahap, Alida Rosita Hari Utomo Hariadi Hariawan Harmani Kalim Herliana , Rini Huda , Khoirul I Made Putra Swi Antara Idrus Alwi Ikhda Ulya, Ikhda Indarto, Malik Jantra Indriwanto Sakidjan Januar W Martha Jaya, Irvantri Aji Junaiti Sahar Jusup Endang Juzni Alkatiri Katsukawa, Hajime Kusuma, Nico Listyaningsih, Erlin Lukman H. Makmun Muhammad Munawar Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nico Kusuma Nico Kusuma Nitia A. Asbarinsyah Nur Haryono Nurhay Abdurachman Nusanti, Synthia Oktarina, Virna Dwi Pius Almindu Leki Berek Poppy S Roebiono Pranata, Raymond Pratama, Erlan Anugrah Prima Almazini Purwowiyoto, Budhi S. Rachel Vania Rachel Vania Radityo Prakoso Raja Adil C Siregar Rarsari S. Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Raymond Pranata Retna Dewayani Rif'ati, Lutfah Rizki Rizki Rony Mario Candrasatria, S Taofan Sadikaningtya, Lirasati Sekarsari, Rita Seskoati Prayitnaningsih Siska Sulistiowati Sri Yona Syntia Nusanti Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Teuku Heriansyah, Teuku Tony Suharsono, Tony Triangto, Kevin Vania, Rachel Vidya Gilang Rejeki Wahju Aniwidyaningsih Wendy M. Saragih Wienta Diarsvitri William Sanjaya Wisnu Jatmiko Yoga Yuniadi Yonas, Emir