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Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form Nerdy Nerdy; Linda Margata; Dian Ika Perbina Meliala; Bunga Mari Sembiring; Selamat Ginting; Effendy De Lux Putra; Atika Mulyati; Tedy Kurniawan Bakri
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 2, November 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i2.22158

Abstract

The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry method to identify and determine metformin hydrochloride in marketed tablet dosage form. This research included preparation of standard, analysis of samples, and validation of method. The specific wavenumber obtained for qualitative analysis was 1645.68 cm–1 and 1574.8 cm–1. The specific area obtained for quantitative analysis with a single baseline ranged from 1701.53 cm–1 to 1535.66 cm–1. All metformin hydrochloride marketed tablet dosage forms were analyzed and met all of the qualitative and quantitative requirements. The methods met the requirements of method validation for accuracy with a percentage of recovery of 100.22 %, precision with relative standard deviation of 0.48 %, linearity with a correlation coefficient of 0.9992, limit of detection of 11.17 mg per mL, limit of quantitation of 33.84 mg per mL, and good specificity results. In this study, the Fourier Transform Infrared spectrophotometry method was successfully developed and validated for application in identification and determination of metformin hydrochloride in marketed tablet dosage form.
HUBUNGAN PENDAPATAN DAN PENGETAHUAN KEPALA KELUARGA DENGAN KETERSEDIAAN JAMBAN SEHAT DI DESA GUNUNG MERLAWAN KECAMATAN TIGANDERKET KABUPATEN KARO TAHUN 2019 Bunga Mari Sembiring; Desi Veronika; Fithri Handayani Lubis
Jurnal Penelitian Kesmasy Vol 2 No 1 (2019): Jurnal Penelitian Kesmasy
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Deli Husada Delitua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpksy.v2i1.153

Abstract

To improve public health in the form of disease prevention, and health recovery by the government and society is the development of basic sanitation. Any of them has access to basic sanitation that is healthy latrines. The purpose of this study was to determine the relationship of income and knowledge of family heads with the availability of healthy latrines . The method of this study used observational analytics with a cross sectional study design. The population in this study was the family Head of the gunung merlawan village as much as 60 households in Tiganderket District Karo Regency. Samples were taken according to the number of samples of 60 households with 230 inhabitants. with this sampling technique is total sampling. Statistical tests using the chi square test using SPSS 20. The results of the study showed that there was a relationship between the level of income of family heads with the availability of family latrines. And that there is a relationship of knowledge with the availability of healthy latrines. It is recommended to health officer in the working area of Puskesmas Tiga Nderket and the Head of Gunung Merlawan village to increase their role in counseling the community in the use of healthy latrines in Gunung Merlawan village, Tiganderket .
PENETAPAN KADAR VITAMIN C PADA BEBERAPA JENIS CABE (CAPSICUM ANNUM L.) DAN PAPRIKA (CAPSICUM ANNUM L. VAR. GROSUM) DENGAN METODE TITRASI IODIMETRI Bunga Mari Sembiring; Anggi Pramono Siregar
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.219

Abstract

Ascorbic acid is one of the nutrients that acts as an antioxidant to effectively overcome free radicals that can damage cells or tissues, including protecting the lens from oxidative damage caused by radiation. Ascorbic acid is abundant in fruits and vegetables, one of which is chili and pappers.The purpose of this study was to determine the content of the content and differences in levels of ascorbic acid content in several types of chillies and peppers. The method used in this study is the Iodimetry method, because ascorbic acid is a reducing agent which is strong enough, easily oxidized and iodine is easily reduced. This is one of the requirements of the compound can be done by the Iodimetry method. This research included descriptive research, with samples of red chili, cayenne pepper, curly green chili, red peppers, yellow peppers and green peppers obtained in the market of the old deli and its surroundings. This research begins with making samples, then performs qualitative tests, making standard solutions and determining ascorbic acid levels. During the titration process replication is done 6 times to compare the results of each titration. The results showed levels of ascorbic acid Red Chilli = 0.1856%, Cayenne pepper = 0.0739%, Curly green Chili = 0.0882%, Red peppers = 0.1945%, Yellow paprika = 0.1886%, and Green peppers = 0.1631%. Conclusions showed that the highest ascorbic acid levels were found in red pappers samples which were 0.1945% and the lowest ascorbic acid levels were in the cayenne sample which was 0.0739%. Suggestions for future researchers should be continued with other parameters and samples.
UJI EFEKTIVITAS EKSTRAK ETANOL DARI KULIT PISANG KEPOK (Musa Paradisiaca) UNTUK PENYEMBUHAN LUKA SAYAT PADA TIKUS bunga mari sembiring
Jurnal Penelitian Farmasi & Herbal Vol 3 No 1 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i1.361

Abstract

Banana peel turns out to have many benefits, one of which is that it can be used to accelerate the wound healing process. Banana peel (Musa Paradisiaca L.) ripe yellow skin is rich in flavonoid compounds, as well as other phenolic compounds, besides containing a lot of carbohydrates, minerals such as potassium and sodium and cellulose. This study aims to determine the wound healing effect of cuts using the Ethanol Extract of Kepok Banana Skins in Rats. Determine the concentration of ethanol extract of Kepok banana peel which is the most effective in healing wound cuts in mice. Knowing a significant difference to the acceleration of wound healing between ethanol extracts of Kepok banana peel and betadin. Research methods conducted included characterization, effectiveness test of ethanol extract of Kepok banana peel, manufacture of extract by maceration using ethanol 96% solvent, test of effectiveness of ethanol extract of kepok banana peel on cut wounds in mice. Data analysis using SPSS is Anova One Way Test. From the results of this study the ethanol extract of Kepok banana peel can have an effect on wound healing in mice. Ethanol extract of Kepok banana peel is faster than betadin in healing wound cuts in mice. Ethanol extract of Kepok banana peel with a dose of 750 Mg / kg BW is the most effective in healing wound cuts in rats.
FORMULASI SEDIAAN MASKER GEL Peel-off EKSTRAK DAUN KECOMBRANG (Etlingera elatior) SEBAGAI PERAWATAN PADA KULIT WAJAH Bunga Mari Sembiring
Jurnal Penelitian Farmasi & Herbal Vol 3 No 2 (2021): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v3i2.656

Abstract

Kecombrang (Etlingera elatior) leaves contain flavonoid compounds, saponins, alkoloid, and tannins. Based on the compounds owned kecombrang leaves can be used as a peel off gel mask. The purpose of this study was to make a peel off gel mask formulation of kecombrang (Etlingera elatior) leaf extract as a treatment for facial skin. The gel peel off mask formulation was made with 4 formulations, F0 = 0%, FI = 10%, FII = 15%, FIII = 20%. Extraction method is done using maceration method with 96% ethanol solvent. Evaluation of peel off gel mask preparations, including organoleptic tests (color, odor, shape), pH measurement of preparations, homogeneity test, dry time test, spreadability test. Peel off gel mask preparations that have effectiveness as treatments for facial skin are FIII formulations with a concentration of 15% that meet the evaluation test requirements, and positive control (Naturgo) which has had better effectiveness test results. The results of the evaluation test of peel off gel mask preparation, including organoleptic test (color, odor, shape), pH measurement of the preparation, homogeneity test, dry time test, dispersion test according to the gel preparation parameters.
PENYULUHAN TENTANG PENCEGAHAN KEJADIAN KECACINGAN PADA ANAK DI DESA PENEN KECAMATAN BIRU-BIRU Bunga Mari Sembiring; Fithri Handayani Lubis
Jurnal Pengabdian Masyarakat Putri Hijau Vol 1 No 3 (2021): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.583 KB) | DOI: 10.36656/jpmph.v1i3.708

Abstract

From the results of the study, it turns out that the prevalence of worm disease is still high, namely 60-70%. This parasite is found all over the world. The frequency of this worm disease in Jakarta is quite high. In Bekasi, 1083 school children show a frequency of 24.4%. The incidence rate in Indonesia is still very high, namely almost all children aged 1-10 years have Ascariasis infection, while in adults it is estimated that 60% (in Jakarta). Indonesia still thrives on worm disease, the reason is that the personal hygiene of the community is still lacking. There are still many people who defecate on the ground, in rivers, in ditches, and on rice fields. Worm eggs can also be attached to major vegetables, that is, if the major vegetables are not cleaned using ditch water, river water and water that has been contaminated by worm eggs. Various factors that support the high rate of stomach infection pain in Indonesia are Indonesia's geographical location in the tropics which has a hot but humid climate, which allows stomach worms to breed well.
PENYULUHAN TENTANG PERTUMBUHAN FISIK DAN PERKEMBANGAN MOTORIK ANAK DI KECAMATAN BIRU-BIRU Fithri Handayani Lubis; Bunga Mari Sembiring; Hengky Frengki Manulang; Herawati Bukit; Friska Ernita Sitorus; Alprindo Sembiring
Jurnal Pengabdian Masyarakat Putri Hijau Vol 1 No 4 (2021): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.891 KB) | DOI: 10.36656/jpmph.v1i4.726

Abstract

The physical and motor development of a child is influenced by many factors, one of which is the labor process. The labor process can be divided into two parts: natural delivery and caesarean section. During spontaneous labor, babies actively experience the labor reflex, but babies born by cesarean section do not experience the labor reflex. Early development of the adult infant brain is influenced by reflex mechanisms, including primitive intrauterine reflexes, birth reflexes, primitive postnatal reflexes, and natural reflexes. Indigenous reflexes, on average, were masked by functional exercise at 6 months of age. Persistent primitive reflexes indicate a developmental disorder. Motor development controls the development of body movements by coordinating the activities of the central nervous system, peripheral nerves, and muscles. This control of movement is due to the development of reflexes that begin in the womb. The development of athletic achievement can be divided into two types. In other words, thorough motor skills and fine motor skills. Overall movement is an aspect of motor (movement) and postural (positional) development, and fine motor skills include mature motor function, good neuromuscular coordination, accurate visual function, and non-verbal intellectual skills.
EDUKASI STANDAR PELAYANAN DI PUSKEMAS DAN KAITANNYA DENGAN PEMANFAATAN LAYANAN KESEHATAN DI PUSKEMAS NAMORAMBE KECAMATAN NAMBORAMBE KABUPATEN DELI SERDANG Jon Pitter Sinaga; Bachtiyar Wahab; Bunga Mari Sembiring
Jurnal Pengabdian Masyarakat Putri Hijau Vol 2 No 1 (2021): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.521 KB) | DOI: 10.36656/jpmph.v2i1.739

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Health services are a basic need for the community, therefore the Government is obliged to provide health service facilities in each region. Health services are increasingly needed in line with the high cases of sudden death and the occurrence of extraordinary diseases. In order to improve the health status of the community, the government must set clear and measurable standards to be easily implemented in every health service in the region. In avoiding problems, there must be a minimum service standard. With the minimum service standards, it is hoped that regional health services will be better. Utilization of health services is every effort carried out individually or jointly in an organization to maintain and improve health, prevent and cure disease and restore the health of individuals, families, groups and communities. Utilization of health services becomes a demand for consumers based on the need for pain, discomfort or desire for the prevention of a disease. In the Education of Service Standards at the Public Health Center and its Relation to the Utilization of Health Services, it is hoped that it can increase the knowledge of health workers at the Namorambe Health Center to improve health services and use health services properly.
Efektivitas Pasta Gigi Pemutih Ekstrak daun alang-alang (Imperata Cylindrica L. Beauv) Herviani Sari; Bunga Mari Sembiring
BEST Journal (Biology Education, Sains and Technology) Vol 4, No 2 (2021): September 2021
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v4i2.4559

Abstract

Pasta gigi merupakan salah satu bahan yang sudah lama digunakan untuk membersihkan gigi. Selain itu pasta gigi juga dapat menghilangkan atau mengurangi bau mulut, memoles permukaan gigi, memberikan rasa segar pada mulut serta memelihara kesehatan gigi. Pasta gigi yang mengandung bahan yang aman dan nyaman serta memiliki efek samping yang sedikit biasanya disebut pasta gigi herbal. Pembuatan pasta gigi dapat diinovasikan dengan penambahan bahan alami yang bermanfaat, aman dan efektif untuk menjaga kesehatan gigi. Bahan alami lain yang dapat ditambahkan pada pasta gigi yaitu tanaman obat. Salah satunya daun alangalang (Imperata cylindrica L.). Penelitian ini bertujuan untuk menganalisis Aktivitas Pasta Gigi Pemutih Ekstrak daun alang-alang (Imperata Cylindrica L. Beauv) Secara Invitro dan efektivitasnya. Rancangan penelitian yang akan digunakan adalah penelitian eksperimental laboratoris dan Observasional untuk menganalisis efektivitas. Pengumpulan data akan dilakukan melalui observasi pada 10 orang responden. Formula sediaan pasta gigi arang aktif yang dibuat merupakan formula pasta gigi yang telah dimodifikasi berdasarkan formula dari Harmely et aldengan memanfaatkan alang-alang yang dikeringkan lalu dijadikan arang aktif. Hasil penelitian menunjukkan mayoritas responden berusia 25 tahun dan 25-40 tahun. Berjenis kelamin laki-laki dan menyikat gigi 2 kali sehari. Terjadi perunbahan kadar plak gigi setelah dilakukannya intervensi, sebelum intervensi terdapat 3 orang (30%) responden dengan kategori plak baik dan meningkat menjadi 6 orang (60%) responden setelah intervensi, sebelum intervensi sebanyak 4 orang (40%) responden memiliki kategori plak buruk menurun menjadi 1 orang (10%) dengan kategori plak buruk setelah intervensi
Efektivitas Pemberian Ekstrak Daun Sisik Naga Terhadap Penyembuhan Diare Pada Anak di Desa Penen, Kecamatan Biru-Biru Tahun 2019 Bunga Mari Sembiring; Fithri Handayani Lubis
BEST Journal (Biology Education, Sains and Technology) Vol 3, No 2 (2020): September 2020
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v3i2.3331

Abstract

Latar Belakang: Walaupun persentase diare sebagai penyebab kematian pada anak di Indonesia cenderung menurun, namun angka kesakitan dan kematiannya masih tinggi. Badan Kesehatan Dunia (WHO) memprediksikan pada tahun 2025 masih terdapat lima juta kematian pada anak usia kurang dari 5 tahun, dimana 97% diantaranya terjadi di negara berkembang dengan penyakit infeksi sebagai penyebab utamanya, salah satunya diare. Pemanfaatan jamu berbasis kearifan lokal merupakan salah satu alternatif pengobatan diare yang diharapkan dapat menjadi terapi rasional yang dapat diterapkan oleh setiap keluarga. Sisik naga atau yang sering disebut ribuan di wilayah sumatera bisa dijadikan alternatif pengobatan herbal diare. Tujuan: Menganalisis pengaruh pemberian ekstrak daun sisik naga terhadap penyembuhan diare pada anak di Desa Penen Kecamatan Biru-Biru. Metode: Eksperimen semu dengan pendekatan sampel satu kelompok pada 95 anak usia 12 sampai 24 bulan. Hasil: Berdasarkan hasil penelitian diketahui bahwa dari 95 anak yang mengalami diare, 41 anak masih mengalami diare setelah diberikan ekstrak daun sisik naga dan sisanya 54 orang tidak lagi mengalami diare setelah diberikan ekstrak daun sisik naga. . Berdasarkan hasil analisis statistik dengan menggunakan uji Mc Nemar diketahui nilai sig. 000. Kesimpulan: Ada perbedaan kejadian diare pada anak yang menjadi responden sebelum dan sesudah pemberian ekstrak daun sisik naga.