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All Journal Pharmascience JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Ilmiah Medicamento Jurnal Insan Farmasi Indonesia Jurnal INKOFAR Jurnal Bakti Untuk Negeri Sinteza Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy
Akbar, Nabila Hadiah
Program Studi Farmasi Universitas Lambung Mangkurat, Kalimatan Selatan
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Bioactive Compound Profiling of Ethyl Acetate Fraction from Oil Palm (Elaeis guineensis Jacq.) Leaves using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Setiawan, Deni; Hadi, Samsul; Mahdi, Nur; Mardiati, Nurul; Normaidah; Hadiah Akbar, Nabila; Rasyid Ridha, Muhammad; Apriliany, Fitri
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30147

Abstract

Oil palm leaves could yield various health benefits, potentially leading to innovative applications in natural remedies, supplements, and dietary products. Targeted extraction and sophisticated analytical methods have become necessary for investigating bioactive compounds in plant materials. The combination of liquid chromatography and high-resolution mass spectrometry (LC–HRMS) makes for a potent technique for analyzing a wide range of metabolites, allowing for the precise and sensitive identification of various plant compounds. This investigation aimed to examine the active compounds in the ethyl acetate fraction of Elaeis guineensis leaves using LC–HRMS to identify potential new avenues for drug research. The simplicia was extracted by completely immersing 500 g of granules in acetone for three days. The crude extract was fractionated with n-hexane, ethyl acetate, and n-butanol solvents to separate components according to their polarity. The ethyl acetate part was analyzed using LC–HRMS with specific settings, including a temperature of 30°C and a gas flow rate of 11.01 L/min. The extract yield from dense oil palm leaves was 32.5 g, equivalent to 6.5%. Subsequently, the components were separated by fractionating the complete yield. The n-hexane fraction yield was 7.085 g or 21.83%, the ethyl acetate fraction yield was 3.38 g or 10.4%, the n-butanol fraction yield was 8.84 g or 27.2%, and the remaining fraction yield was 3.93 g or 12.1%. In conclusion, oil palm leaves are a prospective source of zingerol compounds, suggesting potential to be used as an alternative to rhizomes.
Co-Authors Alfandani, Gina Alif Vera Aprilianes Arnida Arnida Candra Wijaya Candra Wijaya, Candra DENI SETIAWAN Deni Setiawan Farendina Suarantika Fitri Apriliany, Fitri Herningtyas Nautika Lingga Khalid, Ega Rezkyan Khoirunnisa Muslimawati Khumaira Sari, Anna Liling Triyasmono Muhammad Ikhwan Rizki Muhammad Muhatadin Jamil Muhammad Rasyid Ridha Muhammad Zaini Muliyani Muliyani Muliyani Nani Kartinah Nani Kartinah Nashrul Wathan Nazhipah Isnani Normaidah, Normaidah Nur Mahdi Nurul Mardiati Okta Muthia Sari Okta Sari, Okta Putra, Aditya Maulana Perdana Rizkiyah, Noor Annisa Salsabila, Risma Zahra Salwa, Helmina Samsul Hadi Sandi, Dita Ayulia Dwi Sari, Risa Purnama Sutomo Sutomo Vinda Maharani Patricia