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All Journal Jurnal Tumbuhan Obat Indonesia Jurnal Farmasi Klinik Indonesia Pharmacon INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Indonesian Journal of Hospital Administration Academic Hospital Journal
Ika Puspitasari
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : indonesian journal of pharmacy

 1 
THE EFFECT OF GIVING DELTAMETHRIN AND CYPERMETHRIN INSECTICIDES ON THE LEVEL OF INTRATESTICULAR TESTOSTERONE IN MALE WISTAR STRAIN RATS Triutomo, Devyanto Hadi; Puspitasari, Ika; Susidarti, Ratna Asmah
Indonesian Journal of Pharmacy Vol 31 No 2, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss2pp116

Abstract

The use of deltamethrin and cypermethrin insecticides to control pests has been implemented in Indonesia. Irregular and excessive use of insecticides can have toxic effects on the male reproduction system. Deltamethrin and cypermethrin insecticides can inhibit androgen biosynthesis and disrupt the growth of sperm. Therefore, this research is conducted to find out the effect of deltamethrin and cypermethrin insecticides toward the level of intratesticular testosterone in male Wistar strain rats. This research is conducted in vivo using male Wistar strain rats. Nine rats are divided into three groups of treatment, namely control group, deltamethrin group with 0.26 mg/kg of weight, and cypermethrin group with 0.26 mg/kg of weight. Treatment is conducted every day for 15 days orally, and then the rats are dissected to take their testicles. Testicles are chopped and their intratesticular homogenates are taken by adding the medium of DMEM and collagenase (0.25 mg/mL). The measurement of the level of testosterone is conducted by using Electrochemiluminescence immunoassay (ECLIA) method. Data on the change of the increase of body weight, organ weight, and the level of testosterone is analyzed statistically using the one-way ANOVA test. The research result shows that giving 0.26 mg/kg of weight of deltamethrin and 0.26 mg/kg of weight of cypermethrin does not affect the increase in body weight, relative weight of the reproductive organ, and the level of intratesticular testosterone of male Wistar strain rats.
Effect of Platelet-rich Plasma on Caspase-3 and IGF-1 mRNA expression in the diabetic rat testis Evi Istiqamah; Dicky Moch. Rizal; Ika Puspitasari
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (953.325 KB) | DOI: 10.14499/indonesianjpharm30iss2pp98-104

Abstract

Testicular damage is a serious complication of diabetes mellitus resulting in male infertility, which is associated with caspase-3 and IGF-1 mRNA expression. Platelet-rich plasma (PRP), with its rich growth factor composition, has proven beneficial in regenerative therapy. It is believed that PRP has not been studied in testes for diabetes mellitus and there are no studies in the literature concerning the influence of PRP on expressions of growth factors in testes.The aim of this study was to investigate the efficacy of adjunctive PRP in insulin treatment for repair of testicular damage in a diabetic rat model. Diabetes was induced by administering single dose 60 mg/kg streptozotocin. Twenty Wistar male rats were divided into four groups: group 1, control group; group 2, diabetes without treatment; group 3, diabetes with treated insulin; and group 4, diabetes with treated insulin and PRP. Rats were euthanized after two weeks of treatment, and testes were taken for caspase-3 and IGF-1 mRNA expression measurements.Diabetes mellitus induction caused a significant increase in caspase-3 mRNA expression with p=0.049 and significant decrease in IGF-1 mRNA expression with p=0.004. There was no difference in caspase-3 and IGF-1 mRNA expression of the diabetic rat testis given insulin and PRP compared to without PRP.
Co-Authors Akhmad Kharis Nugroho Anggraini Citra Ryshang Bathari Annafi' Nanda Rohmah Utami Annisa Aulia Savitri Anton Bahtiar Antonia Adeleide Anutopi Arief Nurrochmad Atik Nuryah Avanilla Fany Septyasari Bambang Sigit Riyanto Bani Adlina Shabrina Chrisna Wardhani Daru Estiningsih Dhannia Fitratiara Dicky Moch Rizal Dicky Moch Rizal Dita Amalia Diyan Ajeng Rossetyowati Djoko Wahyono Dwi Nurahmanto Elma Viorentina Sembiring Endang Lukitaningsih Evi Istiqamah Farahdina Chairani Firdhani Satia Primasari Fita Rahmawati Fita Rahmawati Ganjar Taufik Hemi Sinorita Hemi Sinorita Hemi Sinorita Ida Safitri Laksanawati Ika Yuni Astuti Indah Hastuti Juniarto Mende Kris Kurniawan Linda Dimyati Maya Ramadhani Indarto Mayada Rakhmima Karizki Minar Paskah Lianti Manik Nanang Fakhrudin, Nanang Nanang Munif Yasin Nanang Munif Yasin Novrilia Atika Nabila Nunung Yuniarti Nunung Yuniarti Nuri Nuri Pebriati Sumarningsih Putri Dina Mahera Laily Ratna Asmah Susidarti Retnosari Andrajati Rinanto Prabowo Rizal Fauzi Rizka Humardewayanti Asdie Rizka Humardewayanti Asdie Rizki Rahmawati Rizqi Nurul Khasanah Rosylianti Rosylianti Sabrina Handayani Tambun Sisri Novrita Suhardjo Pawiroranu Suharjo Suharjo Taufiq Ramadhan Titik Nuryastuti Titik Rahayu Tri Hartati Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Tristina Devi Azzahra Triutomo, Devyanto Hadi Widya Adhitama Wihda Yanuar Yessy Resi Maharani Zita Dhirani Pramono