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All Journal HAYATI Journal of Biosciences Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Biotropika Research Journal of Life Science Natural B Edu Geography Jurnal Pengembangan Teknologi Informasi dan Ilmu Komputer Indonesian Journal of Cardiology Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Jamu Indonesia Nusantara Science and Technology Proceedings Berkala Penelitian Hayati Makara Journal of Science Indonesian Journal of Jamu
Sri Widyarti
Biology Department, Faculty Of Mathematics And Natural Sciences Brawijaya University, Malang Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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FORMULASI MASKER ALAMI BERBAHAN DASAR BENGKOANG DAN JINTAN HITAM UNTUK MENGURANGI KERUTAN PADA KULIT WAJAH Swaidatul Masluhiya AF; Widodo Widodo; Sri Widyarti
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 4, No 2 (2016)
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.426 KB) | DOI: 10.33366/cr.v4i2.466

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pemakaian masker alami untuk mengurangi kerutan pada kulit wajah dan untuk mendapatkan formulasi masker pasta yang tepat dari campuran bubuk bengkoang, minyak jintan hitam, cokelat bubuk, dan madu. Bahan yang digunakan untuk membuat formulasi masker alami ini adalah 2 gram bubuk bengkoang, 1 gram bubuk cokelat, 0.6 ml minyak jintan hitam, dan 5 ml madu. Bahan-bahan tersebut dicampurkan sehingga dihasilkan masker dengan struktur pasta yang siap digunakan. Masker digunakan setiap tiga hari sekali hingga 12 kali pemakaian masker. Masker diberikan pada sepuluh probandus wanita yang memenuhi kriteria inklusi yang ditentukan. Karakteristik yang diamati meliputi adanya kerutan pada kulit wajah. Data kerutan diambil secara visual dengan difoto menggunakan camera DSLR 1000D pada tiga sisi wajah (depan, kanan, kiri). Hasil persepsi data kerutan wajah menunjukkan adanya perubahan kerutan sebanyak 100%.
Distribusi Nrf2 dan Enzim GST pada Sel Granulosa Ovarium Tikus Putih Premenopause setelah Pemberian Serbuk Rimpang Kunyit Teguh Suprihatin; Sri Rahayu; Muhaimin Rifa'i; Sri Widyarti
Buletin Anatomi dan Fisiologi Volume 6, Nomor 1, Tahun 2021
Publisher : Departemen Biologi Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/baf.6.1.2021.66-73

Abstract

Kurkumin pada tanaman kunyit dapat mengaktivasi agen transkripsi yaitu Nuclear related factor 2 (Nrf2). Nrf2 berperan dalam transkripsi kelompok enzim detosifikasi fase II, seperti glutathione S-transferase (GST). Enzim GST dapat berfungsi sebagai antioksidan dengan melindungi sel dari radikal bebas terutama dari kelompok ROS. Penelitian bertujuan mengetahui distribusi Nrf2 dan enzim GST pada sel granulosa ovarium tikus putih premenopause, setelah pemberian serbuk rimpang kunyit. Hewan uji yang digunakan adalah 30 ekor tikus putih betina, strain wistar, usia 12 bulan, dengan bobot 200-250 g. Enam kelompok perlakuan, yaitu P0; kontrol negatif, diberi akuades 4 ml, P1; kontrol positif, diberi serbuk kurkumin dosis 6,75 mg/kg BB, P2; diberi serbuk rimpang kunyit dosis 100 mg/kg BB, P3; diberi serbuk rimpang kunyit dosis 200 mg/kg BB, P4; diberi serbuk rimpang kunyit dosis 400 mg/kg BB, dan P5; diberi serbuk rimpang kunyit dosis 800 mg/kg BB. Perlakuan per oral setiap hari selama 27 hari. Penelitian menggunakan Rancangan Acak Lengkap, data distribusi Nrf2 dan GST dianalisis menggunakan ANOVA dan dilanjutkan dengan BNJ. Hasil penelitian menunjukkan bahwa pemberian serbuk rimpang kunyit dosis 200mg/kg BB, merupakan dosis optimal dalam meningkatkan distribusi Nrf2 dan enzim GST pada sel granulosa ovarium tikus putih premenopause.
Pengaruh Pemberian Serbuk Rimpang Kunyit (Curcuma longa L.) terhadap Jumlah Folikel Ovarium Tikus Putih (Ratus norvegicus) Premenopause Teguh Suprihatin; Sri Rahayu; Muhaimin Rifa'i; Sri Widyarti
Buletin Anatomi dan Fisiologi Volume 5, Nomor 2, Tahun 2020
Publisher : Departemen Biologi Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/baf.5.2.2020.190-197

Abstract

Penurunan jumlah folikel ovarium secara drastis karena peningkatan kadar hormon FSH adalah kondisi umum pada wanita premenopause. Penelitian bertujuan mengetahui potensi serbuk rimpang kunyit dalam menghambat laju penurunan jumlah folikel ovarium pada tikus putih premenopause. Hewan uji adalah 30 ekor tikus putih betina, galur Wistar, usia 12 bulan, bobot 200-250 g. Hewan uji dibagi menjadi 6 kelompok, yaitu kelompok kontrol negatif (P0), diberi perlakuan akuades 4 ml/hari; kelompok kontrol positif (P1), diberi perlakukan serbuk kurkumin 6,75 mg/kg BB; kelompok perlakuan 1 (P2), diberi perlakukan serbuk kunyit 100 mg/kg BB; kelompok perlakuan 2 (P3), diberi perlakukan serbuk kunyit 200 mg/kg BB; kelompok perlakuan 3 (P4), diberi perlakukan serbuk kunyit 400 mg/kg BB; dan kelompok perlakuan 4 (P5), diberi perlakukan serbuk kunyit 800 mg/kg BB. Perlakuan per oral setiap hari selama 27 hari. Penelitian menggunakan Rancangan Acak Lengkap, data jumlah folikel ovarium dianalisis menggunakan ANOVA dan dilanjutkan dengan Uji BNJ. Kelompok perlakuan serbuk rimpang kunyit dengan dosis 200 mg/kg BB menunjukkan peningkatan jumlah folikel primer dan jumlah folikel antral tertinggi yaitu 9,7±1,52 atau sebesar 262,16% dan 6,7±0,57 atau sebesar 181,08% dibandingkan dengan kelompok kontrol negatif.Kata kunci: foikel primer, folikel antral, kurkumin, FSH.
Senyawa pada Serbuk Rimpang Kunyit (Curcuma longa L.) yang Berpotensi sebagai Antioksidan Teguh Suprihatin; Sri Rahayu; Muhaimin Rifa'i; Sri Widyarti
Buletin Anatomi dan Fisiologi Volume 5, Nomor 1, Tahun 2020
Publisher : Departemen Biologi Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/baf.5.1.2020.35-42

Abstract

Tanaman kunyit secara tradisional sudah sejak lama banyak digunakan sebagai tanaman obat. Negara India dan China menggunakan tanaman kunyit untuk mengobati penyakit empedu, selesma, batuk, diabetes, rematik, sinusitis, penyakit kulit, infeksi parasit, inflamasi, dan biliary disorders. Potensi tanaman kunyit sebagai tanaman obat menimbulkan ide untuk melakukan penelitian yang bertujuan mengetahui kandungan senyawa pada serbuk rimpang kunyit yang berpotensi sebagai antioksidan. Penelitian dilakukan dengan menganalisis kandungan senyawa pada serbuk rimpang kunyit (turmeric powder) menggunakan metode LC-MS dan dilanjutkan dengan menganalisis senyawa yang terkandung pada serbuk rimpang kunyit yang berpotensi sebagai antioksidan dengan metode in silico. Hasil penelitian menunjukkan bahwa terdapat 49 senyawa aktif yang ditemukan pada serbuk rimpang kunyit, kurkumin adalah senyawa dengan konsentrasi paling tinggi dibandingkan dengan senyawa yang lain yaitu sebesar 7,798%. Sedangkan senyawa yang berpotensi sebagai antioksidan berdasarkan analisis in silico diperoleh 11 senyawa yaitu Ascorbic acid, Quercetin, β Carotene, Arabinose, Bis Demethoxycurcumin, Demethoxycurcumin, Curcumin, Caffeic acid, Cinnamic acid, Letestuianin A, dan Calebin A. Kata kunci: turmeric powder, kurkumin, LC-MS, in silico
In silico study of active compounds ADMET Profiling in Curcuma xanthorrhiza Roxb and Tamarindus indica as Tuberculosis Treatment Sherry Aristyani; M. Irsyad Nur; Sri Widyarti; Sutiman B. Sumitro
Jurnal Jamu Indonesia Vol. 3 No. 3 (2018): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1111.446 KB) | DOI: 10.29244/jji.v3i3.67

Abstract

Curcuma xanthorrhiza Roxb and Tamarindus indica L. have been used for a long time by Indonesia local societies as tuberculosis therapy. This study explores the active compounds of Curcuma xanthorrhiza Roxb and Tamarindus indica L that important for suppressing the survival of Mycobacterium tuberculosis and predicts the pharmacokinetics and toxicity of the compounds. stringApp of Cytoscape 3.6.0 was used for screening the compounds targeting mycobacteria proteins, then computational tools like SwissADME (http://swissadme.ch/) and admetSAR (http://lmmd.ecust.edu.cn/admetsar1/predict/) were applied for estimating absorption, distribution, metabolism, excretion, and toxicity (ADMET) of active compounds. The result has been shown that there were some active compounds could target proteins of Mycobacterium tuberculosis. According to the profiling result, these compounds had a various characteristic in gastrointestinal absorption, could pass the blood-brain barrier, and had drug-like properties. In toxicity term, the active compounds did not cause Ames toxicity.
Identification of Phenols and Triterpenoids Compounds in Michelia champaca for Treating Covid 19 Symptom by in Silico Khoirin Maghfiroh; Sri Widyarti; Sutiman B. Sumitro
Nusantara Science and Technology Proceedings Bioinformatics and Biodiversity Conferences (BBC)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0706

Abstract

Michelia champaca is used by the community to treat mild diseases in the population. The plant Michelia champaca produces anti-inflammatory compounds. Some anti-inflammatory classes of compounds include Phenols and Triterpenoids. In disease prevention and treatment mechanics, COVID 19 in particular, the ability of anti-inflammatory compounds is very significant. Coronaviruses are viruses that were first described in 2019 attack the human respiratory system. Cough, a runny nose, and shortness of breath for fever are typical signs of viral infection. In defense mechanisms from coronaviruses, ACE2 is one of the inflammatory mediators used by the body. This study aimed to determine the potential of each group of Phenols and Triterpenoids compounds in Michelia champaca in binding ACE2 in Silico. The method used is docking molecule to find out the potential of anti-inflammatory compound groups. The ligands used in the study were Taraxerol, Taraxeron, Ferulic Acid, and Galic Acid. The protein used in the study was ACE2. The results showed that docking molecules for the Phenols and Triterpenoids groups separately showed that native ligand ACE2 could not bind to ligand copies of the Phenols and Triterpenoids groups. However, there are similar amino acid residues in ligand copy of Gallic acid with NAG. Gallic acid is a compound of phenols. The conclusion of this analysis is the complete ability of treatments and disease prevention in the Michelia Champaca plant as a result of COVID 19. However, the mechanism of interaction of plant compounds with proteins that play a part in the COVID 19 mechanism must still be demonstrated in vitro and in vivo in this research.  
Antibacterial Activity of Pluchea indica Leaf Extract was Increased After Being Fermented with Saccharomyces cerevisiae and Added with its Cell-Free Supernatant Ria Rismawati; Yoga Dwi Jatmiko; Sri Widyarti
Biotropika: Journal of Tropical Biology Vol. 10 No. 2 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.02.04

Abstract

Multi Drug Resistance (MDR) is a global health problem that endangers public health and can lead to death. Therefore, novel antibacterial agents are required derived from medicinal plants, one of them is beluntas (Pluchea indica) which has high potential as an antibacterial. Fermentation or addition of cell-free supernatant of Saccharomyces cerevisiae is thought to increase the antibacterial content of an herb. This study aimed to evaluate the effect of fermentation and the addition of Cell-Free Supernatant (CFS) of S. cerevisiae to enhance antibacterial activity of P. indica leaf extract. Fresh and dried leaves of beluntas were used in this study. The dried leaves in the form of powder was boiled at 100oC for 45 minutes. Fresh leaves were homogenized by blending. The extract of P. indica was used for fermentation and addition of CFS of S. cerevisiae. CFS as much as 60 mL dan fermentation with cell density of 7.53x105 CFU/mL with 100 mL of P. indica leaf extract were centrifuged at 10,000 rpm for 20 minutes. The antibacterial test method used was the Kirby-Bauer method against Escherichia coli and Staphylococcus aureus. The results showed an increase in antibacterial activity as indicated by the increasing diameter of the inhibition zone either by fermentation or addition of CFS with inhibition zone diameter was 3.85 – 4.81 mm against E. coli and 4.63 – 5.12 mm against S. aureus. The fermented P. indica and addition of CFS was shown to be potentially developed as antibacterial agents. Keywords: Antibacterial, CFS, fermentation, Pluchea indica, Saccharomyces cerevisiae
Effect of Dietary Amorphophallus sp From East Java on LDL-C Rats (Rattus novergicus Wistar Strain) Nunung Harijati; Sri Widyarti; Rodiyati Azrianingsih
Journal of Tropical Life Science Vol. 1 No. 2 (2011)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of indication of obesity is high LDL-C . Obesity has serious risk to health, it can cause heart disease and stroke. Effort to lower obesity using drugs have significant side effects such as insomnia, increased blood pressure, dry mouth and so forth. Therefore using natural products that contain glucomannan to reduce obesity and LDL-C is good choise. Glucomannan in the global market derived from Amorphophallus konjac. In this study, we used glucomannan from Amorphophallus endemic East Java to reduce fattened Wistar rats. Amorphophallus that used include Amorphophallus muelleri, A.variabilis (variant: Brongkos 32; Brongkos 5; Wonorejo, Brangsi) and Amorphophallus campanulatus (Var Selopuro). Amorphophallus diet was given to white rats of Wistar strain that previously fattened using a mixture of cholesterol and lard, in addition to PARS (Chicken Feed Race Super) as a basic food. Amorphophallus konjac was used as control. Measurement of LDL-C was conducted in four different time points, namely 1). Prior to dietary cholesterol, 2). 24 days after the dietary cholesterol, 3) 11 days after Amorphophallus (+cholesterol) diet, 4). 25 days after Amorphophallus (+cholesterol) diet. The results showed that the diet of A.variabilis potentially lowered blood cholesterol levels for their respective 22.98%, 5.85% and 7.37% for consecutive variant Brongkos 32; Brongkos 5; Wonorejo. Diet from A.campanulatus and A.konjac had not been able to reduce cholesterol to the end of observation (25 days).Keywords: LDL-C, A.variabilis, A.muelleri, A.campanulatus, A.konjac
Accumulation of Calcium Crystal in Rat (Rattus norvegicus) Kidney A'liyatur Rosidah; Sri Widyarti; Sri Rahayu
Journal of Tropical Life Science Vol. 3 No. 1 (2013)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this research is to know the effect of tuber Porang flour (Amorphophallus muelleri) to the accumulation of calcium crystal. This research uses 2,5 months old male rats that are orally given by tuber Porang flour from three different location (Klangon, Sumber Baru, and Sumber Bendo) with doses 6 mg/100 gr BW/day for 3 months. Kidneys taken to analyzed distribution of crystal calcium accumulation. Observation of distribution crystal calsium accumulation with microscope of Olympus CX 31 at 400x magnification. The data to be analysed by using test of ANOVA with SPSS 16 for windows. The result of research known that the treatment of tuber Porang flour induce calcium crystal accumulation in rat kidneys. Using tuber porang flour from different location can generate different impact at accumulation of crystal calcium. The lowest calcium crystal accumulation in kidneys with giving Klangon Porang flour that is equal to 8,19±2,17 spot/ area. Consumption of the tuber Porang flour cause the accumulation of crystal calcium in rat kidney.
Formaldehyde And Benzo(Α)Pyrene induced Cells Necrotic in Mice Liver Ahmad Soni; sri Widyarti; Aris Suwondo
Journal of Tropical Life Science Vol. 3 No. 1 (2013)
Publisher : Journal of Tropical Life Science

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Abstract

Formaldehyde and benzo(α)pyrene are compounds that harmful for health. Misapplication of this compound have an impact in the form of organ damage in the body. This study aims to determine the impact of the treatment of the combined exposure of formaldehyde and benzo(α)pyrene to cell necrosis in the liver of mice (Mus musculus). Treatment of formaldehyde dose of 25 mg/kg BW to mice were given ​​orally every day for 60 days. Treatment of benzo(α)pyrene via intraperitoneal injection at a dose of 250 mg/kg BW were given after 30 days of incubation with four times injection with one day interval. Liver organ histological preparations were made through the HE staining. Observations were made by using a microscope for liver organ preparations. The data obtained that is the percentage of cells necrosis and necrotic foci. This research used Completely Randomized Design (CRD) with 95% confidence interval. Liver organ preparations observations indicate that the percentage of necrosis in the untreated control, benzo(α)pyrene 250 mg/kg BW, Formaldehyde 25 mg/kg BW, combination of formaldehyde 25 mg/kg BW with BaP in a row that is equal to 14.43% ± 0.91; 26.05% ± 3.75; 49.38% ± 2.66; 51.86 ± 1.73. The mean of necrotic foci in liver organ formed in the untreatment control, benzo(α)pyrene 250 mg/kg BW, Formaldehyde 25 mg/kg BW, and the combination of formaldehyde 25 mg/kg BW with BaP in a row, equal to 1.3 ± 0,07; 1.63 ± 0.61; 2 ± 0.51, and 3.4 ± 0.76. This suggests that the combined treatment had the highest level of toxicity compared with other treatments.
Co-Authors A'liyatur Rosidah A.A. Ketut Agung Cahyawan W A’liyatur Rosyidah Ahmad Soni Ahmad Soni Amandia Dewi Permana Shita Apik Budi Santoso Arief Azhary Aris Soewondo Aris Suwondo Askandar Tjokroprawiro Attabik Mukhammad Amrillah Bella Novinda Cholilia Abadiatul Masruroh Cholilia Abadiatul Masruroh Damayanti, Febriane Eka Daniar Kusumawati Dayu Nirwana Putri Dewi Parlina Ningrum Dian Siswanto Djanggan Sargowo Eko Puji Astuti Erly Nur Aisyah Estri Laras Arumingtyas Farida Rachmawati, Farida Fatinah, Arik Arubil Hafiedz Maulana Harits Amrulloh Intan Sartika Is Karima Jannah, Nur Karima, Is Khoirin Maghfiroh Linda Kartika Dewi Lulut Dwi Nurmamulyosari M. Irsyad Nur Maftuch Maftuch Marji Marji Moch Sasmito Djati Mochammad Pratama Viadi Mohammad Mabrur Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifai'i Muhamad Aris Widodo Naqiyah A. Mulachelah Noer Hasanah Nunung Harijati Nur Permatasari Nur Permatasari Nuzulul Hikmah Radita Intan Aisyah Pratiwi Rasjad Indra Retno Susilowati Retty Ratnawati Ria Rismawati Rifa'i, Muhaimin Rifa'i, Muhaimin Rike Wahyuningroom Rike Wahyuningroom Ririn Rochmawati Rizki Amalia Rochmatika, Lailiyavina Rodiyati Azrianingsih Rodiyati Azrianingsih Rosidah, A'liyatur Rosyidah, A’liyatur Sakti, Sefihara Paramitha Sari, Fikriya Novita Satuman Satuman Serafinah Indriyani Sherry Aristyani Siti Imama Khoiriyah Sofy Permana Soni, Ahmad Sri Rahayu SRI RAHAYU Sri Rahayu Sri Rahayu Sri Rahayu Sri Rahayu Suroso Suroso Sutiman B. Sumitro Sutiman B. Sumitro Sutiman B. Sumitro Sutiman B. Sumitro Sutiman Bambang Sumitro Suwondo, Aris Syahputra Wibowo Teguh Suprihatin Teguh Suprihatin Widodo Widodo Yayu Tsamrotul Fuadah, Yayu Tsamrotul Yoga Dwi Jatmiko YOGA DWI JATMIKO Yuni Kilawati Zauhani Kusnul