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All Journal INDONESIAN JOURNAL OF PHARMACY JFL : Jurnal Farmasi Lampung JI-KES (Jurnal Ilmu Kesehatan) AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Jurnal Riset Kefarmasian Indonesia Borneo Journal Of Pharmascientech Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Etam Jurnal Abdi Masyarakat Kita Jurnal Bakti Untuk Negeri Journal of Tropical Pharmacy and Chemistry Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JI-KES (Jurnal Ilmu Kesehatan) JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan) Jurnal Abdimas Mahakam
Hayatus Sa`adah
STIKES Samarinda
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Energy Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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FORMULASI KAPSUL ANTIDIABETES EKSTRAK UMBI BAWANG DAYAK (Eleuhterine palmifolia (L) Merr.) DENGAN VARIASI KONSENTRASI AVICEL 101 DAN PREGELATINIZED STARCH Indriawan, Kadek Agus; Sa'adah, Hayatus; Helmidanora, Rusdiati
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 3 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i3.402

Abstract

Diabetes Mellitus is a heterogeneous disease characterized by improvement glucose levels in the blood. Several studies have shown that Dayak onions have hypoglycemic activity or lowering blood glucose levels which may be very useful for treatment of diabetes mellitus. Flavonoids contained in Dayak onions are in position to restore the characteristics of pancreatic tissue by increasing insulin release through β cells, so that it can lower blood sugar levels and can also increase sensitivity peripheral cells to insulin. Given the great potential of Dayak onions as antidiabetic, it is very important to develop more practical preparations that can carrying out weight uniform measurements of the products used, of course, one of them is in pharmaceutical preparations capsule form. This examination aims to determine the physical properties and antioxidant activity of Dayak onion extract capsules in large quantities concentration of Avicel PH 101 and pregelatinized starch as fillers. Look was carried out experimentally using three formulas with various concentrations fillers with a ratio between Avicel PH 101 and pregelatinized starch, in particular formula I (1:0), formulation II (0.5:0.5) and method III (0:1). body residence and drug stability is checked and then tested for antioxidant hobby spectrophotometric use. The research results show that the formula with the composition of Avicel PH 101 and pregelatinized starch in the ratio (0:1) is given the best wet house physical test results were 3.4%, sliding houses 12.82 gram/second, angle of repose 29.85⁰, compressibility 8%, density 0.544 and destroyed time 3 minutes 37 seconds. along with antioxidant effects activity examination showed that the drug Dayak onion extract proved to be moderate antioxidant activity, specifically 228.78 ppm.  
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL dan FRAKSI DAUN SEMBUNG (Blumea balsamifera L.) TERHADAP BAKTERI Staphylococcus epidermidis Sa'adah, Hayatus; Pristanti, Ragilia; Warnida, Husnul
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.440

Abstract

Sembung Leaves (Blumea balsamifera L.) is a plant with many properties, one of which is antibacterial. Sembung leaves have several chemical compounds such as tannins, saponins, and flavonoids which function as antibacterials. This study aims to determine the diameter of inhibition zone, the value of Minimum Inhibition Concentration (MIC) dan the value of Minimum Bactericidal Concentration (MBC) of ethanol extract, n-hexane fraction, ethyl acetat fraction and water fraction of sembung leaves (Blumea balsamifera L.) against the staphylococcus epidermidis bacteria. Antibacterial testing by using disc diffusion dan solid dilution methods. Ethanol extract and fractions of sembung leaf (Blumea balsamifera L.) that has been obtained are diluted with a concentration of 10%, 25%, and 50%. The positive control as clindamycin 1% and DMSO as the negative control. The results showed that ethanol extract of sembung leaves (Blumea balsamifera L.) can inhibit the growth of Staphylococcus epidermidis bacteria at a concentration of 10% which is 8,1 mm, concentration of 25% which is 9,13 mm, concentration of 50% which is 10,1 mm. The n-hexane fraction can inhibit Staphylococcus epidermidis bacteria at a concentration of 10 % which is 6,1 mm, concentration of 25% which is 7,11 mm, concentrarion of 50% which is 7,21 mm. The ethyl acetate fraction can inhibit Staphylococcus epidermidis bacteria at a concentration of 10% which is 9,1 mm, concentration of 25% which is 11,16 mm, concentration of 50% which is 12,26 mm. The water fraction there is no inhibition zone diameter. The MIC of ethanol extract of sembung leaves is 10%, n-hexane fraction is 25% and ethyl acetate fraction is 10%. The MBC of ethanol extract was at a concentration of 25%, n-hexane fraction at a concentration of 50% and ethyl acetate fraction at a concentration of 10%.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BIJI BUAH NYIRIH (Xylocarpus granatum) DENGAN METODE DPPH SECARA SPEKTROFOTOMETRI UV-VIS Achmad Kadri Ansyori; Mutmainna Tamrin; Hayatus Sa'adah
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.527

Abstract

   The nyirih plant (Xylocarpus granatum) is a type of mangrove that has been used for generations by coastal communities as traditional medicine. The flavonoid compounds contained in the nyirih plant are a group of polyphenols which have potential as antioxidants that can reduce free radicals. The aim of this research was to determine the antioxidant activity of ethanol extract of nyirih fruit seeds. The research carried out was non-experimental research, the stages of this research started from plant determination and sample collection, making simplicia, making extracts using the maceration method with 70% ethanol, phytochemical screening, and antioxidant activity testing using the DPPH method as free radicals which were measured using a spectrophotometer. UV-Vis. The research results obtained showed that the ethanol extract of nyirih fruit seeds positively contained secondary metabolites in the form of alkaloids, flavonoids, tannins and saponins. The results of the antioxidant activity test of the ethanol extract of nyirih fruit seeds obtained an IC50 value of 8.2729 ppm in the very strong antioxidant category.
KARAKTERISASI DAN SKRINING FITOKIMIA SIMPLISIA DAN ESKTRAK BUAH BAKAU HITAM (Rhizopora mucronata Poir) Sa'adah, Hayatus; Kavung, Clara Agatha; Supomo
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.608

Abstract

Black mangrove (Rhizopora mucronata Poir) is a species of mangrove plant that lives in mangrove forests which contains secondary metabolites and contains natural antioxidants and antibacterials which are widely used by coastal communities and consumed as food and medicine. The benefits of a natural ingredient with medicinal properties need to be scientifically proven through research. As a first step, characterization of simplicia and extracts was carried out as well as phytochemical screening. Characterization is intended to determine the quality of simplicia and black mangrove fruit extract as well as the content of secondary metabolite compounds. Characterization includes specific and non-specific parameters. In the first stage, black mangrove fruit was extracted by maceration using 96% ethanol solvent and a yield of 23.77% was obtained. Specific characterization test results include organoleptic tests with direct observation results on simplicia in the form of powder. dark brown color, slightly astringent taste, with a distinctive aroma and in the organoleptic test the ethanol extract is a thick extract, blackish brown in color, bitter taste with a characteristic aroma. The average level of dissolved compounds in simplicia water was 7.3% and the extract was 11.33%, while the average level of dissolved compounds in simplicia ethanol was 24% and the extract was 88.33%. The results of non-specific characterization tests include determining the average water content of the simplicia at 15% and the extract at 18%. The average total ash content test for simplicia was 8.3397% and the extract was 10.4976%, while the average acid insoluble ash content test for simplicia was 0.2329% and extract was 0.8144%. The average specific gravity of the extract was 0,98 g/mL and aquadest 0,94 g/mL, results of the microbial contamination test, the total plate number for simplicia was 4.6 x 10-3 colonies/g and the extract was 4.3 x 10-3 colonies/g, while the yeast mold number in simplicia 2.1 x 10-2 colonies/g and in extract 1.3 x 10-2 colonies/g. The results of the phytochemical screening test for simplicia and black mangrove fruit extract were positive for containing metabolite compounds, namely secondary alkaloids, flavonoids, tannins, steroids and terpenoids.
Antioxidant Activity Test of Tampoi Fruit Peel Extract (Baccaurea pyriformis Gage) using the DPPH (2,2-Difenil-1-Pkrihidrazil) Method Milasari, Novi; Reksi Sundu, Reksi Sundu; Hayatus Sa’adah, Hayatus Sa’adah; Stevani Olivia, Stevani Olivia; Adhila, Ghina; Fatimah, Nurul
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.908

Abstract

Excessive oxidation reactions in the body can cause various harmful effects, mainly due to the uncontrolled production of free radicals. Antioxidant compounds are needed to protect the body from free radical attacks. One natural source of antioxidants is the tampoi fruit (Baccaurea pyriformis Gage). This fruit is known to contain metabolites such as flavonoids, phenolics, tannins, and saponins, which act as natural antioxidants. The purpose of this study was to determine the antioxidant activity of tampoi fruit peel (Baccaurea pyriformis Gage) using the DPPH method. This was an experimental study with the independent variable being ethanol extract of tampoi fruit peel and the dependent variable being antioxidant activity. The research stages included plant determination, slimpisia preparation, maceration extraction, phytochemical screening, determination of extract moisture content, and antioxidant activity testing with DPPH. The results showed a drying shrinkage of 5.6%, an extract yield of 13%, and an extract moisture content of 14.77%, which is classified as a thick extract. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and saponins. Antioxidant test results showed that tampoi fruit peel ethanol extract had an average IC value of 11.8165 ppm (very strong category), and vitamin C as a comparison had an IC value of 7.5019 ppm. Thus, tampoi fruit peel ethanol extract has strong antioxidant activity.
AKTIVITAS ANTIBAKTERI EKSTRAK AIR KULIT BAWANG MERAH (Allium cepa L.) TERHADAP BAKTERI Propionibacterium acnes Sa`adah, Hayatus; Supomo, Supomo; Musaenah, Musaenah
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i2.73

Abstract

Propionibacterium acnes is one of the causes of acne. Shallot peels contain flavonoids, tannins, and saponins which potentially have antibacterial activity. The purpose of this study was to determine whether the water extracts of shallot peels have antibacterial activity against Propionibacterium acnes and determine the concentration which can inhibit the growth of bacteria Propionibacterium acnes. This research is an experimental study. The research stage begins with the extraction of shallot peels using in the foundation. Antibacterial activity was tested using the diffusion method with the Cup-plate technique. Propionibacterium acnes used as a sample of bacteria, with extract concentrations of 5%, 10%, 20%, and 40%. Positive controls used are clindamycin 150 mg and negative controls were used dimethyl sulfoxide 1% (v / v). Data were analyzed with a statistical test of the Kolmogorov-Smirnov method. The measurement results inhibition zone of shallot peels water extract with a concentration of 5%, 10%, 20%, and 40% of the bacteria Propionibacterium acnes sequentially by 12.8 mm, 13 mm, 14.33 mm and 15.50 mm in the strong category. The measurements of bacterial growth inhibition zone were statistically analyzed with the Kruskal-Wallis method gained 0,053 results indicating that the test has a significant effect (P > 0.05) with a decision that means that there is no significant difference between all concentrations.
Pelatihan Pembuatan Hand Sanitizer di Kantor Dinas Perindustrian Kota Samarinda Risa Supriningrum; Hayatus Sa’adah; Rusdiati Helmidanora
Jurnal Abdimas Mahakam Vol. 5 No. 01 (2021): Januari
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sejak terjadinya pandemi covid 19 ketersediaan hand sanitizer di Indonesia menjadi sangat langka di pasaran, dikarenakan banyak orang yang membeli barang tersebut secara berlebihan. Pemerintah menghimbau kepada masyarakat untuk selalu menjaga kebersihan tangan dengan rajin mencuci tangan menggunakan sabun atau menggunakan hand sanitizer sebagai salah satu upaya mencegah penularan covid 19. Pembersih tangan (hand sanitizer) memiliki kemampuan menghambat hingga membunuh bakteri. Tujuan dilakukannya pengabdian masyarakat ini adalah memberikan pelatihan kepada masyarakat cara membuat hand sanitizer dari bahan sintetis dan bahan alam. Formula hand sanitizer dari bahan sintetis berupa alkohol 96%, hydrogen peroksida, gliserin dan aquades. Sedangkan formula hand sanitizer dari bahan alam berupa daun sirih, jeruk nipis dan aquades. Kegiatan ini merupakan kerjasama antara Dinas Perindustrian, Perdagangan, Koperasi, Usaha Kecil dan Menengah Provinsi Kalimantan Timur dengan Sekolah Tinggi Ilmu Kesehatan Samarinda. Peserta pada kegiatan ini adalah perwakilan warga Kelurahan Karang Asam Ilir, Kelurahan Sempaja Utara dan Kelurahan Sungai Kapih. Metode yang digunakan pada pengabdian masyarakat meliputi ceramah tentang pentingnya menjaga kebersihan tangan, pengertian hand sanitizer, uraian bahan yang digunakan, dilanjutkan demonstrasi dan bimbingan. Kegiatan ini didanai oleh Desperidagkop UKM Provinsi Kalimantan Timur. Harapan dengan dilaksanakan pelatihan ini ialah masyarakat dari kelurahan yang menjadi peserta lebih peduli dengan kebersihan dan dapat memenuhi kebutuhan hand sanitizer untuk keluarga dan masyarakat sekitarnya.
Co-Authors Achmad Fudholi Achmad Kadri Ansyori Adhila, Ghina Akhmad Andy Sandra Andi Wijaya Ariyanti, Lusi Mardika Danang Yulianto Dayang Bella R.W Eka Siswanto Eka Siswanto Syamsul Fara Azzahra Hardi Astuti Witasari Hardi Astuti Witasari Henny Nurhasnawati Heri Wijaya Indriawan, Kadek Agus Kavung, Clara Agatha Kintoko Kintoko Kintoko Kintoko Kintoko, Kintoko Lusi Mardika Ariyanti Mangalik, Anastasia Reni Maria Elvina Tresia Butar-Butar Mexsi Mutia Rissa Milasari, Novi Musaenah, Musaenah Mutmainna Tamrin Nurul Fatimah Nurul Fatimah Octariana Sofyan Pristanti, Ragilia Rahmadani Rahmadani Reksi Sundu, Reksi Sundu Reni Anggraini Ria Indriyani Risa Supriningrum Rusdiati Helmidanora Sapri Sapri Sapri Siti Jubaidah Stevani Olivia, Stevani Olivia Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Supomo Syamrotul Muzdalifah Tri Marga Ningsih Tri Marginingsih Vivi Permatasari Warnida, Husnul Yulia Sukawaty Yulistia Budianti S. Yulistia Budianti Soemarie Yulistia Budianti Soemarie