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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Gizi dan Pangan Jurnal Teknologi Dan Industri Pangan Jurnal Teknologi Industri Pertanian Jurnal Pengolahan Hasil Perikanan Indonesia Jurnal Veteriner Perspektif : Review Penelitian Tanaman Industri agriTECH Indonesian Journal of Biotechnology Jurnal Bioteknologi & Biosains Indonesia (JBBI) Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Indonesian Journal of Chemistry ANNALES BOGORIENSES Biosaintifika: Journal of Biology & Biology Education JURNAL SELULOSA Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Mutu Pangan : Indonesian Journal of Food Quality Perspektif, Review Penelitian Tanaman Industri Annales Bogorienses
Maggy Thenawidjaja Suhartono
Departemen Ilmu Dan Teknologi Pangan, Fakultas Teknologi Pertanian, IPB University, Kampus IPB Dramaga, Bogor 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Journal : agriTECH

 1 
Isolasi dan Identifikasi Bakteri Asam Laktat Penghasil Inhibitor Enzim HMG-KoA Reduktase dari Bekasam Sebagai Agen Pereduksi Kolesterol Rinto Rinto; Ratih Dewanti; Sedarnawati Yasni; Maggy Thenawidjaja Suhartono
agriTECH Vol 35, No 3 (2015)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (637.273 KB) | DOI: 10.22146/agritech.9342

Abstract

The purpose of this research was to obtain statins producer bacteria as a HMG-CoA reductase (HMGR) enzyme inhibitor to reduced cholesterol biosynthesis. Stages of this research were the isolation of compactin and lovastatin resistant bacteria, statin production, analysis of culture extracts to inhibition of HMG-CoA reductase and identification of bacteria. The results showed that the 20 isolates of compactin and lovastatin resistant bacteria, there are 5 bacterial isolates produced statins. They were L3.3.4; C3.4.2; C3.3.5; C3.4.4 and L3.3.3; with the statins content were 9.491; 1.536; 0.065; 0.060; and 0.040 ppm. Selection of the 5 bacterial isolates resulted 2 bacteria which had inhibition ability to HMGR enzyme activity. They were Lactobacillus acidophilus and Lactobacillus delbruckii sp. delbruckii with inhibitory ability were 66.67% and 58.33%, respectively.ABSTRAKPenelitian ini bertujuan memperoleh bakteri penghasil statin sebagai inhibitor enzim HMG-KoA reduktase (HMGR), penghambat sintesis kolesterol. Tahapan penelitian yang dilakukan adalah isolasi bakteri yang resisten terhadap compactin dan lovastatin, produksi statin, uji penghambatan ekstrak dari kultur bakteri terhadap HMG-KoA reduktase dan identifikasi bakteri. Hasil penelitian menunjukan bahwa dari 20 isolat bakteri yang resisten terhadap compactin maupun lovastatin, terdapat 5 isolat bakteri yang potensial menghasilkan statin, yaitu isolat L3.3.4; C3.4.2; C3.3.5; C3.4.4 dan L3.3.3; dengan kandungan statin berturut-turut adalah 9.491; 1,536; 0,065, 0,060, dan 0,040 ppm. Seleksi terhadap 5 isolat menghasilkan 2 bakteri yang mempunyai kemampuan penghambatan terhadap aktivitas enzim ¸Â•ÝWtu Lactobacillus acidophilus dan Lactobacillus delbruckii sp. delbruckii dengan kemampuan penghambatan  berturut-turut adalah 66,67% dan 58,33%.
Co-Authors , Widodo Abd. Rauf Patong Agnes Imelda Manurung Ahyar Ahmad ALBERTA RIKA PRATIWI Anja Meryandini Anja Meryandini Apon Zaenal Mustopa Apon Zaenal Mustopa Ardiansyah, Romadhony Aris Tri Wahyudi Bambang Prasetya DAHRUL SYAH Dedi Fardiaz Diana Lestari, Diana Diana Nur Afifah Efi Toding Tondok Ekowati Chasanah Elvira Syamsir Endang Yuli Purwani Eni Kusumaningtyas Eni Kusumaningtyas Enny Rimita Sembiring Evy Damayanthi Fitriyana, Intan Nur Fransisca Rungkat Zakaria Fransiska Rungkat Zakaria Fransiska Rungkat Zakaria Fransiska Rungkat Zakaria Haliza, Winda Hana Fitria Navratilova Hanifah Nuryani Lioe Harsi D. Kusumaningrum Hartati Chairunnisa Hasnah Natsir I Gusti Ngurah Kade Mahardika I wayan Teguh Wibawan Joshua Evan Katarina Aninda Karisma Palupi Kusmajadi Suradi Kusmajadi Suradi Laras Cempaka Laurentia Stephani Lilis Nuraida LILY MARIA GORETTI PANGGABEAN LINAWATI HARDJITO Meda Canti Meity Suradji Sinaga Muhammad Hanafi Palupi, Nurheni Sri Purwani, Endang Yuli Puspo Edi Giriwono R Susanti Raphaella Widiastuti Ratih Dewanti -Hariyadi Raymond R. Tjandrawinata Retno Damajanti Soejoedono Retno Damayanti Soejoedono Rinto . Rizki Maryam Astuti Rosmawati Perangiangin Rosmawaty Peranginangin Rosmawaty Peranginangin Rosmawaty Peranginangin Satya Nugroho SEDARNAWATI YASNI Setyani Budiari SHANTI RATNAKOMALA Sherly Valentina Sipriyadi Sipriyadi Sipriyadi Sri Budiarti Poerwanto Sri Sugiwati Subaryono Subaryono Subaryono Subaryono Subaryono Subaryono TATI NURHAYATI Wangsa Tirta Ismaya Wendry Setiyadi Putranto Winda Haliza Yanti Lim YOPI YOPI YULIN LESTARI Yuwanita Ardilasari