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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention Adi Widya : Jurnal Pengabdian Masyarakat Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Media Ilmu Kesehatan JFIOnline Jurnal Mandala Pharmacon Indonesia Science Midwifery Indonesian Journal of Global Health research Formosa Journal of Multidisciplinary Research (FJMR) Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Titik Sunarni
Faculty of Pharmacy Setia Budi University Jl. Letjen Sutoyo Mojosongo – Solo, 57127, Phone. 0271-852518, HP:08121520941
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Science Midwifery

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Literature review of the cytotoxic activity of faloak (sterculia quaddrifida r.br) against t47d and mcf-7 breast cancer cells and its active compounds Seran, Rumaldus; Herdwiani, Wiwin; Sunarni, Titik
Science Midwifery Vol 13 No 6 (2026): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2246

Abstract

Faloak (Sterculia quadrifida R.Br) is one of the plants used by the community as a multipurpose drug. Faloak bark herb has long been used by the people of East Nusa Tenggara as a medicinal plant. Empirically, boiled water from the bark of the faloak plant is used by the people of East Nusa Tenggara as a cure for hepatitis, typhus, ulcers, and stamina recovery. The data extraction method used is narrative by grouping similar data from the literature review results according to the size of the results to be presented. The flow of the journal search is about testing the cytotoxic activity of faloak (Sterculia quadrifida R.Br) against T47D and MCF-7 breast cancer cells and the content of their active compounds. From these data, screening, journal eligibility, and monitoring of conformity with inclusion and exclusion criteria were carried out to obtain appropriate journals to conclude the cytotoxic activity of faloak. The results of a literature review showed that faloak (Sterculia quadrifida R.Br) had cytotoxic activity against T47D and MCF-7 breast cancer cells. Chemical compounds that have cytotoxic activity are alkaloids, flavonoids, terpenoids, tannins, naphthoquinone, apigenin, and puerarin. Naptaquinone derivatives 2,3-dihydro-6hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione and 2-iminoethyl 2-(2-(1-hydroxypentan-2-yl) phenyl) acetate obtained from the extract or active fraction of faloak bark (Sterculia quadrifida R.Br) showed cytotoxic activity against T47D breast cancer cells. Apigenin compounds were found to be the most effective phytoestrogens in inhibiting the growth of breast cancer cells. Apigenin also has apoptotic effects and induces autophagy in breast cancer cells. an effective proteasome inhibitor in breast cancer cell culture and breast cancer xenografts, and puerarin can increase DUSP1 expression by increasing the expression level of miR-133a-3p in breast cancer cells.
Co-Authors Ahmad Suriyadi Muslim Ana Indrayati Daniel Happy Putra Doso, Tri Efrilia, Erin Fransiska Leviana Ika Purwidyaningrum Ilham Kuncahyo, Ilham Khairunnisa, Rizky Dila Mardiana, Lia Mardiyono Mardiyono, . Munawir Munawir Murukmihadi, Mimiek Opstaria saptarini Pacheco, Mergita Angela Pagal, Fajria Rezky Priyanti Amara Reslely Harjanti Rini Prastiwi Seran, Rumaldus Siti Aisiyah Suhartinah, Suhartinah Supriyadi Supriyadi Susilowati, Rizka Agustine Taena, Adriani Tri Murti Andayani Vivin Nopiyanti Wiwin Herdwiani Yudi Rinanto