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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Belitung Nursing Journal Narra J
Bambang Supriyatno
Department Of Child Health, Faculty Of Medicine, Universitas Indonesia, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : The Indonesian Biomedical Journal

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Elevated Levels of Urinary Podocyte-Derived Microparticles in Nephrotic Syndrome Eka Laksmi Hidayati; Bambang Supriyatno; Sudung Oloan Pardede; Partini Pudjiastuti Trihono; Dewi Sukmawati; Dewi Wulandari; Oke Rina Ramayani
The Indonesian Biomedical Journal Vol 15, No 5 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i5.2553

Abstract

BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular disease in childhood. The proposed hypothesis for the pathogenesis of this disease has changed over time, from immune dysregulation theory and systemic circulating factors theory, to the growing recognition of podocytopathies’ role. The existance of podocytopathies is usually examined by using podocyte-derived microparticles (MPs), such as nephrin, podocin, and podocalyxin (PCX). Therefore in this study, the difference between nephrin, podocin, and PCX expressions in NS children and healthy children was investigated.METHODS: An observational cross-sectional study was conducted, involving 33 children with NS and 22 age-matched healthy children as controls. Urine samples were collected from each subject in the early morning, before being processed and incubated with antibodies to detect nephrin, podocin, and PCX. The processed samples were then analyzed with flow cytometer methods.RESULTS: NS subjects had significantly higher expression of all three urinary podocyte-derived MPs compared to the control subjetcs. Nephrin, podocin, and PCX showed good discrimination in NS subjects with the area under curve (AUC) of 0.895, 0.849, and 0.728, respectively.CONCLUSION: This study revealed the differential expression of podocyte proteins in NS subjects compared to healthy controls. This supports the role of podocytopathies in the pathogenesis of NS. Therefore, nephrin, podocin, and PCX might have potentials to be future non-invasive diagnostic tools in glomerular disease.KEYWORDS: nephrin, nephrotic syndrome, podocalyxin, podocin, podocyte, urinary microparticle
Co-Authors Adhi Teguh Perma Iskandar Ahmad Kautsar Ahmad Syafiq Alan R Tumbelaka Amir S. Madjid, Amir S. Anisa Rahmadhany Antonius H. Pudjiadi Aria Kekalih Arwin AP Akib Bambang Madiyono Bambang Tridjadja Bina Akura Chozie, Novie A. Citra Estetika Damayanti R. Syarif Damayanti Rusli Sjarif Darmawan B Setyanto Darmawan B. Setyanto Desy Dewi Saraswati Dewi I. Santoso Dewi Kartika Suryani Dewi Sukmawati Dewi Wulandari Dina Medina Dina Muktiarti, Dina Djajadiman Gatot Djer, Mulyadi Muhammad Eka Laksmi Hidayati, Eka Laksmi Ellen P. Gandaputra Endang Windiastuti Evita KB Ifran Faisal Yunus Finny Fitry Yani Fiolita I. Sutjipto Gunanti . Hanifah Oswari Hartono Gunardi Hartono Gunardi Heda Melinda D Nataprawira Heriandi Sutadi I Gusti Lanang Sidiartha I. Boediman Ida Bagus Subanada IGAN Partiwi Ika Karlina Idris Ina Rochayati Ina Susianti Timan Ina Susianti Timan Iqbal Zein Assyidiqie Irlisnia Irlisnia Irma Sapriani Iskandar, Adhi Teguh Perma Joedo Prihartono Joedo Prihartono Jose RL Batubara Kautsar, Ahmad Laila, Dewi S. Lisa Adhia Garina Mardjanis Said Matahari Harumdini Mulya Rahma Karyanti, Mulya Rahma Mulyadi M. Djer Mulyadi M. Djer Mulyadi M. Djer Munar Lubis Muzal Kadim Najib Advani Najib Advani Najib Advani Nalapraya , Widhy Yudistira Nani Nurhaeni Nastiti Kaswandani Nastiti N Rahajoe Nastiti N. Rahajoe Nia Kurniati Nia Kurniati Noenoeng Rahajoe Nyimas Heny Purwati Oke Rina Ramayani Partini Pudjiastuti Trihono Perdana, Andri Permatasari, Ruth K. Piprim Basarah Yanuarso, Piprim Basarah Rahmadhany, Anisa Rini Andriani Rini Andriani Rini Andriani Rini Asterina Rini Sekartini Risma Kerina Kaban Risma Kerina Kaban, Risma Kerina Rismala Dewi Riza Sahyuni Rusmala Deviani Rusmala Deviani Santoso, Dewi Irawati Soeria Sjawitri P Siregar Sri R.S. Hadinegoro Sudigdo Sastroasmoro Sudung O Pardede, Sudung O Sudung O. Pardede, Sudung O. Sudung Oloan Pardede Suhendro Sukman Tulus Putra Sutjipto, Fiolita Indranita Syahrial MH Tetty Yuniarti Tetty Yuniati Titis Prawitasari, Titis Wahyuni Indawati Yeni Rustina Yeni Rustina Yovita Ananta Zakiudin Munasir