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All Journal Journal of Food and Pharmaceutical Science Alchemy : Journal of Chemistry SAINSTIS Indonesian Journal of Cancer Chemoprevention Erudio: Journal of Educational Innovation Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Pharmascience Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB FITOFARMAKA: Jurnal Ilmiah Farmasi Farmasis: Jurnal Sains Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry

Arief Suryadinata

Universitas Islam Negeri Maulana Malik Ibrahim Malang

Author-ID : 394947

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Potensi Senyawa Nitazoxanide dan Arbidol sebagai Antivirus SARS-CoV-2 terhadap Reseptor NSP5 (7BQY dan 2GZ7) dan ACE2 (3D0G dan 1R4L) Ami Fini Faqiha; Yen Yen Ari Indrawijaya; Arief Suryadinata; Muhammad Amiruddin; Roihatul Mutiah
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3393

Nitazoxanide merupakan obat pro-drug untuk tizoxanide. Obat tersebut diketahui memiliki aktivitas antivirus pada MERS-CoV. Arbidol memiliki aktivitas antivirus pada H3N2 HA yang memiliki kesamaan struktur dengan SARS-CoV-2. Reseptor target spesifik untuk obat-obat Anti SARS-CoV-2 saat ini adalah NSP5 (Nonstructural protein) dan ACE2 (Angiotensin-converting enzyme 2). NSP5 memediasi replikasi dan transkripsi protein-protein virus sedangkan ACE2 sebagai fasilitator transport asam amino dan reseptor tempat terikatnya SARS-CoV maupun SARS-CoV-2. Tujuan penelitian ini adalah untuk mengetahui aktivitas antivirus SARS-CoV-2 dari senyawa Nitazoxanide dan Arbidol secara in silico. Senyawa Nitazoxanide dan Arbidol dipreparasi terlebih dahulu dengan melakukan pengunduhan kode PDB ID, penyiapan struktur 2D dan 3D, penentuan minimal energy, pembuatan kode SMILES serta prediksi sifat fisikokimia dan toksisitas. Setelah dipreparasi, dilanjutkan proses penambatan molekul menggunakan aplikasi PyRx-Vina®. Hasil docking dianalisis dengan perangkat lunak PyMOL® dan Discovery Studio Visualizer®. Hasil profil fisikokimia menunjukkan bahwa senyawa Arbidol dan Nitazoxanide telah memenuhi hukum Lima Lipinski dan masing-masing memiliki nilai LD50 sebesar 1350 mg/kg dan 340 mg/kg. Hasil penambatan senyawa uji dengan reseptor menghasilkan interaksi yaitu ikatan hidrogen, interaksi hidrofobik dan interaksi elektrostatik. Interaksi Nitazoxanide pada reseptor 2GZ7 serta Arbidol pada reseptor 3D0G dan 1R4L menunjukkan perbedaan yang signifikan masing-masing terhadap Lopinavir dan Chloroquine dengan nilai p < 0.05, sehingga senyawa tersebut diprediksi memiliki potensi antivirus lebih baik.

Anticancer Activity of Combination of Benalu Belimbing (Macrosolen cochinensis) Extract and Sabrang Onion (Eleutherine palmifolia (L) Merr) on Cervical Cancer Hela Cell Line Roihatul Mutiah; Anik Listiyana; Arief Suryadinata
Majalah Obat Tradisional Vol 22, No 3 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Benalu belimbing (Macrosolen cochinensis) and onion sabrang / onion dayak (Eleutherine palmifolia (L) Merr.) is a traditional medicinal plant that has been used by the community as a cancer drug from generation to generation. This study aims to prove scientifically about the anticancer potential from combination of both plants. Anticancer potential of the plant has been proven by testing the extract both in single form and in combination with Hela cells. While to know the selectivity of the extract to HeLa cell then extract is tested on normal cell Vero cell line. Furthermore, a combination test of both extracts was done using variation dose under IC50. The method used to determine anticancer activity was the MTT method. The results obtained in this study showed that ethanolic extract onion sabrang selectively able to inhibit the growth of cervical cancer cells HeLa on IC50: 40.36 μg / ml with 4.06 for the SI (selectivity index) value. While ethanolic extract of benalu belimbing bselectively can inhibit the growth of cervical cancer cells HeLa on IC50: 217.72 μg / ml with 5.77 for the SI (selectivity Index) value. The combination test of sabrang onion extract and extract of benalu belimbing showed that the combination was highly synergistic in combination dose of EBS 22.62 μg / ml and EBB 23.3 ug / ml with combination index 0.15. Whereas the combination doses having synergistic effects on combination doses 23.3 μg / ml for EBB and 11.31 μg / ml for EBS; 23.3 μg / ml EBB and 16.96 μg / ml EBS with a consecutive combination index; 0.51 and 0.64. From these results it can be concluded that the onion sabrang extract has anticancer effect on HeLa cells and selectively killing HeLa cells because the value of selectivity index is greater than 3. The result of the combination test of both extracts shows that the combination dose having strong synergistic effect, so that combination can be recommended for further research.

Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N) Roihatul Mutiah; Chamlah Ayatillah; Yen yen Ari Indrawijaya; Arief Suryadinata
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.70124

Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV. These considerations are used in this study using Non-structural Protein (NSP), namely NSP3 and NSP5 in SARS CoV-2, which have a role in viral replication and transcription. This study aims to predict the physicochemical properties according to the five rules of Lipinski's using swissADME. Prediction of toxicity with LD50 classification using the Protox II online tool. Catechin compound activity based on ligand interaction with NSP3 (PDB ID: 6W6Y) and NSP5 (PDB ID: 6M2N) receptors using Molegro Virtual Docker (MVD) 6.0. The results showed the predictions of physicochemical properties of the (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG), and (-)-epicatechin (EC) compounds fulfilled the five rules of Lipinski's. Catechin compounds have toxicity at levels 4 and 6. The activity of catechin compounds on NSP3 (PDB ID: 6W6Y) and NSP5 (PDB ID: 6M2N) receptors indicated that all catechin compounds had inhibitory activity. The best potential activity compound is (-)-epigallocatechin-3-gallate (EGCG) with a rerank score of -102.8200 and -134.1800 Kcal/mol so that EGCG can be recommended as a candidate for the SARS CoV-2 antiviral compound.

Metabolite Profiling Bagian Akar, Batang, Daun, dan Biji Helianthus annuus L. Menggunakan Instrumen UPLC-MS Fitrotun Nasikhatul Maslakhah; Roihatul Mutiah; Abdul Hakim; Risma Aprinda; Arief Suryadinata
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Sunflower (Helianthus annuus L.) is one of the plants that can be used for herbal medicine as antimalaria and antioxidant. To control the quality of plant as raw material of herbal medicine, we need to analyze the metabolites or chemical compounds found in the plant. One of the techniques for this purpose is the metabolite profiling. Chemical compounds in the plants are obtained from different metabolic processes in each plant organs. The purpose of this study was to obtain the metabolite profile data, to identify the marker and major compound of roots, stems, leaves and seeds of sunflower using UPLC-MS. Each plant organ was extracted using 96% ethanol by the Ultrasound Assisted Extraction (UAE) method. Each extracts were then analyzed using the UPLC-MS instrument. The interpretation of the UPLC-MS chromatograms were then classified using multivariate Principal Component Analysis (PCA) to determine the grouping effects and characteristic compounds in each organ. Based on the research, it is known that metabolite profiles of roots, stems, leaves and seeds of sunflower were different and the concentration of major compounds in each part are 5.9490%; 5.5558%; 8.6758%; and 9.2150%, respectively.

Systematic Review: Anti-Osteoporosis Potential Activities Of Phytoestrogen Compounds In Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L. Burhan Ma'arif; Suryanto Suryanto; Faisal Akhmal Muslikh; Arief Suryadinata; Begum Fauziyah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Phytoestrogens are compounds from plants that have a structure and function similar to estrogen (17β-estradiol). Phytoestrogens can be found in Chrysophyllum cainito L., Elaeis guineensis Jacq., Lannea acida Rich., Marsilea crenata Presl., and Medicago sativa L. This systematic review aimed to prove that all of these five plants have phytoestrogens which were observed with several instruments, and to assess activities and bone forming mechanisms from these five plants in the female mice (Mus musculus) and female rats (Rattus norvegicus). This systematic review was done by identifying articles in several databases (Google Scholar, PubMed, and Science Direct). The process of selecting the articles used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to create a flowchart with inclusion and exclusion study criteria. Meta-synthesis was done to analyze, identify, and interpret all of the data in the articles systematically. 31 articles in total were obtained from the selection process, with 27 articles containing a discussion about chemical compound content and 4 articles describing research results for in vivo testing of the plants that were reviewed. The results showed that these five plants have phytoestrogens and by in vivo testing have the activity in increasing trabecular bone density in the experimental animals.

Perbedaan Tingkat Pengetahuan Siswa SMA Darul Kholil Burneh Bangkalan tentang Obat Generik Antara Sebelum dan Setelah Edukasi Abdul Hakim; Arief Suryadinata; Pradita Fiqlyanur Isna Primadana
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13517

Obat generik merupakan program Pemerintah Indonesia untuk meningkatkan kualitas kesehatan di Indonesia. Namun, masih banyak yang belum mengetahui tentang obat generik, sehingga perlu adanya pemberian edukasi untuk meningkatkan pengetahuan tentang obat generik. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan tingkat pengetahuan siswa SMA Darul Kholil Burneh Bangkalan tentang obat generik antara sebelum dan sesudah edukasi. Penelitian ini menggunakan metode eksperimental one-group pretest postest design, pengambilan sampel dilakukan dengan teknik stratafied random sampling. Sampel yang digunakan pada penelitian ini sejumlah 72 responden. Penelitian ini dilakukan pada bulan Desember 2021-Januari 2022. Hasil pada penelitian ini diperoleh yaitu saat pretest terdapat 14% dengan tingkat pengetahuan baik, 65% dengan tingkat pengetahuan cukup dan 21% dengan tingkat pengetahuan kurang baik. Sedangkan saat postest diperoleh hasil 100% responden tergolong tingkat pengetahuan baik. Berdasarkan hasil penelitian ini terdapat perbedaan tingkat pengetahuan antara sebelum dan setelah edukasi, hal tersebut dibuktikan dengan hasil uji Wilcoxon yang diperoleh nilai Asymp.Sig (2-Tailed) 0,0001. Kata Kunci: Obat Generik, Tingkat Pengetahuan, Edukasi, One Group Pre-Post TestGeneric drugs are a program of the Indonesian government to improve the quality of health in Indonesia. However, there are still many who do not know about generic drugs, so there needs to be education to increase knowledge about generic drugs. The purpose of this study was to find out the difference in high school student Darul Kholil Burneh Bangkalan's knowledge level about generic drugs between before and after education. This study uses an experimental method of one-group pretest postest design, sampling is done with stratafied random sampling techniques. The sample used in this study was 72 respondents. The study was conducted in December 2021-January 2022. The results in this study were obtained when the pretest there was 14% with a good level of knowledge, 65% with a sufficient level of knowledge and 21% with a level of knowledge less good. While when postest obtained the results of 100% of respondents classified as a good level of knowledge. Based on the results of this study there is a difference in the level of knowledge between before and after education, it is evidenced by the results of the Wilcoxon test obtained asymp.Sig (2-Tailed) value of 0.0001.

Analisis Efektivitas Biaya Terapi Kombinasi Insulin dengan Obat Antidiabetes Oral pada Pasien Rawat Jalan Penderita Diabetes Melitus Tipe 2 di RSUD dr. Soehadi Prijonegoro Sragen Daffa Dhiya Ulhaq; Yen Yen Ari Indrawijaya; Arief Suryadinata
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.16376

Diabetes melitus tipe 2 (DM 2) adalah penyakit kronis menahun karena resistensi insulin atau akibat dari berkurangnya sekresi insulin oleh sel beta pankreas. Pengobatan DM 2 berupa terapi oral dan insulin. Cost-Effectiveness Analysis adalah metode analisis untuk mengambil keputusan alternatif terbaik dari terapi yang digunakan. Tujuan penelitian ini mengetahui efektivitas biaya terapi kombinasi insulin dengan antidiabetes oral (ADO) pada pasien rawat jalan di RSUD dr. Soehadi Prijonegoro Sragen tahun 2021. Metode penelitian ini non-eksperimental deskriptif dengan pengambilan data secara retrospektif. Data yang diambil yaitu data rekam medis pasien rawat jalan DM 2 di RSUD dr. Soehadi Prijonegoro Sragen tahun 2021. Parameter yang digunakan yaitu kadar gula darah puasa (GDP) dan biaya medis langsung meliputi biaya pendaftaran, biaya jasa dokter, biaya obat, dan biaya laboratorium. Pasien yang memenuhi kriteria inklusi sebanyak 49 pasien. Terdapat 5 macam kombinasi obat antidiabetes yang diberikan kepada pasien yaitu insulin + ADO (61,22%), insulin + 2 ADO (8,16%), 2 insulin + ADO (14,28%), 2 insulin + 2 ADO (4,08%), dan insulin + 3 ADO (4,08%). Efektivitas terapi dilihat dari jumlah GDP normal dibagi jumlah total pemeriksaan GDP dikali 100%. Efektivitas terapi tertinggi 100% dan terendah 0%. Biaya medis langsung tertinggi Rp. 1.066.520,- dengan terapi Apidra + Sansulin + Metformin + Pioglitazone. Terapi antidiabetes dengan biaya rendah dan paling efektif yaitu terapi dengan ACER terendah dan ICER negatif yaitu terapi Sansulin + Metformin dengan ACER sebesar Rp. 4.320,- dan ICER sebesar Rp. -13,381,-.

FORMULASI DAN KARAKTERISASI NANOEMULSI EKSTRAK ETANOL 70% DAUN SEMANGGI (Marsilea crenata C. Presl.) : FORMULATION AND CHARACTERIZATION OF 70% ETHANOL EXTRACT NANOEMULSION OF SEMANGGI (Marsilea crenata C. Presl.) LEAVES Burhan Ma'arif; Rani Azzahara; Fahrul Rizki; Arief Suryadinata; Abdul Wafi; Novia Maulina; Hajar Sugihantoro
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.731

Marsilea crenata C. Presl. mengandung fitoestrogen yang memiliki struktur atau fungsi seperti estrogen, sehingga berpotensi untuk digunakan sebagai neuroprotektor pada kondisi defisiensi estrogen. Namun, ada masalah yang mungkin timbul dari obat-obatan yang berasal dari bahan alam, salah satunya adalah kelarutan dan permeabilitas yang buruk. Penelitian ini bertujuan untuk memanfaatkan M. crenata dalam formulasi nanoemulsi sehingga dapat menjaga stabilitasnya. M. crenata diformulasikan menjadi dua formula kemudian dilakukan karakterisasi. Hasil karakterisasi menunjukkan bahwa kedua formula nanoemulsi memenuhi parameter yang meliputi nilai ukuran partikel, indeks polidispersitas, persen transmitan, sifat organoleptik, tipe nanoemulsi, dan pH. Hasil uji stabilitas menunjukkan adanya perubahan organoleptik pada formula B4 (75 ppm) dan B5 (100 ppm) serta terjadi penurunan pH pada semua formula. Formula nanoemulsi terbaik diperoleh dari formula A4 (75 ppm) yang ditandai dengan hasil karakterisasi yang memenuhi parameter sediaan nanoemulsi yang baik. Kata kunci : M.crenata, nanoemulsi, formulasi, karakterisasi.

Standardization of Semanggi (Marsilea crenata C. Presl.) Leaves from Benowo District, Surabaya for Standardized Herbal Raw Material Burhan Ma'arif; Almay Abidzar Elpasha; Arief Suryadinata; Tanaya Jati Dharma Dewi; Novia Maulina; Mangestuti Agil
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 1 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i1.7459

Semanggi (Marsilea crenata C. Presl.) is a unique plant that grows in East Java, Indonesia. Its leaves are widely used as ingredients for traditional food. Semanggi leaves contain phytoestrogen compounds that can be used for their antineuroinflammatory, antiosteoporosis, and antioxidant properties. This effect is believed to be caused by kaempferol as an active marker. This study aims to determine the specific and non-specific parameters of semanggi leaves from Benowo District of Surabaya. The standardization results for specific parameters revealed the macroscopic characteristics of the leaves in radius ± 2 cm, pale green to yellowish-green color, smooth surface, obdeltoid shape, and four leaves. The microscopic features are stomata on the epidermis, crystal sand calcium oxalate, bone leaves with vascular bundle, and no space between the epidermis. The organoleptic characteristics are yellowish-green color, tasteless, astringent smell. The physicochemical of water-soluble content result was 7.4566 ± 0.1173% and soluble ethanol was 7.7466 ± 0.4083%. The phytochemical positive test results for the identification of alkaloids, flavonoids, and terpenoids. Based on UHPLC-HRMS analysis, semanggi leaves contain 0,41% kaempferol with a retention time of 6.88 ± 0.2 minute. The results for non-specific parameters indicated that the content of total ash, acid-insoluble ash, moisture, and drying shrinkage content was 0.8136 ± 0.0171%; 7.9700 ± 0.1044%; 6.2547 ± 0.2864%; and 9.0936 ± 0.1305% respectively. The results indicate that the semanggi leaves sample have been assessed and found to meet the established standards.

The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java Roihatul Mutiah; Fina Luthfiana; Arief Suryadinata; Wirda Anggraini; Anik Listiyana
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.647

Sambiloto (Andrographis paniculata Nees) contains andrographolid compound which has potentialas an anticancer. The difference of growth location has affected the distinction of metabolite content. Thisstudy aims to determine the profile of anticancer activities of A. paniculata extract from several locations inEast Java. The extracts from several locations were tested for activity on T47D cancer cell using MTT assaymethod. Thus, the result of this study describes that A. paniculata extract from several different locations doesnot provide significantly different anticancer activities with the amount of (p>0.05). The extracts which havemoderate anticancer activity were A. paniculata extracts from Selopuro Subdistrict Blitar Regency, SingosariSubdistrict Malang Regency, Lowokwaru Subdistrict Malang City, Klojen Subdistrict Malang City,Purwodadi Subdistrict Pasuruan Regency, Purwosari Subdistrict Pasuruan Regency, and PandaanSubdistrict Pasuruan Regency

Co-Authors AA Sudharmawan, AA Abdul Hakim Abdul Hakim Abdul Wafi Ach. Nashichuddin Ahmad, Ananda Rizkia Azizah Akyunul Jannah Almay Abidzar Elpasha Ami Fini Faqiha Amrulloh, Muhammad Firman Anik Listiyana Arrijal, Imam Malikul Hadi Artabah Begum Fauziyah Begum Fauziyah Briliana, Malich Septi Diajeng Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Chamlah Ayatillah Daffa Dhiya Ulhaq Denis Dewi Annisa, Dewi Diana Candra Dewi Fahrul Rizki Faisal Akhmal Muslikh Fina Luthfiana Fitria Rahma Fauzia Fitrotun Nasikhatul Maslakhah Fransiska Rosari Dewi Fuadi, Muhammad Nauval Nadhirul Hening Laswati Putra Janaloka, Nandana Adyuta Karawid, Galih Elsy Ma'arif , Burhan Ma'arif, Burhan Ma'arif, Burhan Mangestuti Agil Meilina Ratna Dianti Muhammad Afif Muhammad Amiruddin Muti'ah, Roihatul Mutiah, Roihatul Nafisa, Belia Bima Ni Nyoman Sri Budayanti Novia Maulina Nurani, Prasasti Swara Nurwijayanti Pradita Fiqlyanur Isna Primadana Qonita, Kesimira Rani Azzahara Risma Aprinda Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Sholekhah, Syafirda Arma'atu Suryanto Suryanto Tanaya Jati Dharma Dewi Ulfah, Jauza Wirda Anggraini Wirda Anggraini Yen Yen Ari Indrawijaya

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