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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Tropical and Infectious Disease Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline Journal of Food and Pharmaceutical Sciences
Ratna Asmah Susidarti
Faculty Of Pharmacy, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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The Miracle from The Yard: Annona muricata as Cancer Chemo-Preventive and Co-Chemotherapy Rovik, Anwar; Jenie, Riris Istighfari; Susidarti, Ratna Asmah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 1 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i1.86516

Abstract

Cancer remains one of the biggest challenges to human health worldwide, with incidence and mortality rates continuing to rise. Popular cancer treatments to date include surgery, radiation-based therapy, chemotherapy, gene therapy, and hormone therapy. Chemotherapy is one of the primary treatment methods for cancer. However, it has unwanted side effects. It has prompted the search for new chemotherapeutic drugs with better efficacy, excellent selectivity, and fewer side effects. In recent years, there has been growing scientific interest in the potential of soursop leaf (Annona muricata) as an anticancer agent. This review paper discusses the phytochemical content of A. muricata and its potential as a co-chemotherapy against various types of cancer. Several bioactive compounds in soursop leaves have been reported, including annopentocin A, muricatetrocin A, annohexocin, isoannonacinone, annomuricin A, muricatin C, corossolin, and arianacin. Extracts from various parts of A. muricata have potential as co-chemotherapy in the treatment of breast cancer, colon cancer, prostate, lung, cervical, liver, and blood cancer. Studies concluded that A. muricata extracts have a good safety and tolerability profile. Its benefits as a co-chemotherapy agent will be even more significant when made into pharmaceutical dosage forms. A. muricata extracts or compounds packaged in pharmaceutical preparations are expected to improve patient's quality of life. However, more research is needed to determine the optimal dosage, route of administration, and potential side effects.
Co-Authors . Larasati . Sismindari . Warsinah Abdul Karim Zulkarnain Abdul Manaf Ali, Abdul Manaf Abdul Rohman Adam Hermawan Aditya Fitriasari Agung Endro Nugroho Agustina Setiawati Agustina Styawan, Anita Alfi Yasmina Aulia Katarina Edy Meiyanto Endah Puji Septisetyani, Endah Puji Fany Mutia Cahyani Fitria Rahmi Harsan, Hayfa Salsabila Herwandhani Putri Ika Puspitasari Indah Purwantini Indri Kusharyanti Inna Armandari Kartika Dyah Palupi Kholid Alfan Nur Marchaban, Marchaban Martono, Sudibyo Marvin Lambertus Meiyanto, Edy Meiyanto, Edy Mintarsih, Betty Mintarsih, Betty Muflikhasari, Haruma Anggraini Mustofa Mustofa Mustofa, Mustofa Muthi Ikawati Nasrudin, Nasrudin Octa Ujiantari, Navista Sri Pamungkas P, Dyaningtyas Dewi Pramono, Suwidjiyo Purwanto Rahmah, Inggita Hasi Rahman, Faaza Aulia Rahmani, Mawardi Rahmani, Mawardi Rahmawati, Desty Restia Rahmi Khamsita Raisatun Nisa Sugiyanto Rianti, Andrih Riris Istighfari Jenie Rohmad Yudi Utomo Rovik, Anwar Sarmoko Sarmoko Sendy Junedi Sofa Farida Sri Handayani Sukari, Mohd. Aspollah Sukari, Mohd. Aspollah Sunarni, Titik Triutomo, Devyanto Hadi Wahyono Wahyono Wahyono, Wahyono Wahyuono, Subagus Wibowo, Andy Eko Windarsih, Anjar Zufairo, Shofa Khamdanatuz