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Journal : Althea Medical Journal

Effect of Topical Application of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Paste in Wound Healing Process in Mice a/p Gurcharan Singh, Gurwinder Kaur; Utami, Novi Vicahyani; Usman, Hermin Aminah
Althea Medical Journa Vol 1, No 1 (2014)
Publisher : Althea Medical Journa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (549.093 KB)

Abstract

Background: Wound caused by trauma poses challenging daily clinical problems for physicians in hospitals and other health services. It has high risk for mortality and morbidity. Binahong [Anredera Cordifolia (Ten.) Steenis] plant originates from China and can be found abundantly in Indonesia. The objective of this research is to investigate the effect of topical application of Binahong leaf paste on wound healing process.Methods: A laboratory experimental study was conducted at the Pharmacology Laboratory, Universitas Padjadjaran, from October to December 2012 by using 27 Mus Muscularis mice which were divided into 3 groups: group 1 (sodium chloride 0.9%), group 2 (Binahong) and group 3 (povidone iodine 5%). Binahong leaves were crushed and were mixed with water to make a paste. The application was given for 12 days. On day zero, 1.0 cm2 of wound was incised at the back of the mice, and further on day 1, 4, 8 and 12, the percentage of wound contraction was measured. The data was analyzed using Mann-Whitney test.Results: The study indicated that the percentage of wound contraction in group 2 on day 4 (1.17%), day 8 (23.7%) and day 12 (76.14%) is the highest among all groups. The result showed that the comparison between binahong and NaCl was highly significant on day 12, p= 0.001 (p < 0.05) and the data for comparison between Binahong and povidone iodine on day 12 was significant with p= 0.003 (p < 0.05).Conclusions: Topical application of Binahong leaf paste shows better result in wound healing process of Mus muscularis mice. From this study it can be concluded that binahong promotes wound healing and can be used for home remedies for wound care and as an alternative traditional way to treat wound.[AMJ.2014;1(1):6–11]Keywords: Binahong [Anredera Cordifolia (Ten.) Steenis], povidone iodine, wound healingEfek Aplikasi pasta daun Binahong [AnrederaCordifolia (Ten.) Steenis] secara topikal dalam proses penyembuhan luka pada tikus jenis MusmuscularisLatar Belakang: Luka yang disebabkan oleh trauma menjadi masalah klinis yang menantang bagi para dokter di rumah sakit maupun bagi petugas kesehatan lainnya dalam melakukan pekerjaan sehari-hari. Luka yang timbul tersebut memiliki risiko yang tinggi terhadap mortalitas dan morbiditas. Tanaman Binahong [AnrederaCordifolia (Ten.) Steenis] berasal dari Cina dan banyak ditemukan di Indonesia. Tujuan dari penelitian untuk mengetahui efek dari aplikasi pasta daun Binahong secara topikal terhadap proses penyembuhan luka.Metode: Penelitian eksperimental ini dilakukan di Laboratorium Farmakologi, Universitas Padjadjaran, mulai Oktober–Desember 2012, menggunakan tikus jenis MusMuscularis sebanyak 27 ekor, dibagi menjadi 3 kelompok: kelompok 1 (natrium klorida 0,9%), kelompok 2 (pasta daun Binahong) dan kelompok 3 (povidone iodine 5%). Daun Binahong dihancurkan dan ditambahkan sedikit air sehingga menjadi bentuk pasta. Perlakuan diberikan selama 12 hari. Pada hari 0 dilakukan insisi pada punggung tikus untuk membuat luka sebesar 1,0 cm2. Persentase kontraksi luka akan dinilai pada hari ke-1, 4, 8, dan 12. Kontraksi luka adalah pengurangan luas pada area luka. Hasil penilaian tersebut akan dibandingkan pada tiap kelompok untuk melihat efektivitas aplikasi topikal pasta daun Binahong. Data akan dianalisis dengan uji Mann-Whitney.Hasil: Hasil penelitian menunjukkan bahwa persentase kontraksi luka kelompok 2 pada hari ke-4 (1,17%), hari ke-8 (23,7%), dan hari ke-12 (76,14%) adalah lebih tinggi dibandingkan dengan kelompok lainnya. Hasil juga menunjukkan bahwa terdapat perbedaan sangat signifikan antara perbandingan Binahong dan natrium klorida pada hari ke-12, dengan p=0,001 (p<0,05). Perbandingan antara Binahong dan povidone iodine pada hari ke-12 juga menunjukkan hasil signifikan dengan p=0,003 (p<0,05).Simpulan: Aplikasi pasta daun Binahong secara topikal menunjukkan hasil yang lebih baik dalam proses penyembuhan luka pada tikus jenis Musmuscularis. Dari penelitian ini dapat disimpulkan bahwa Binahong mempercepat penyembuhan luka serta dapat digunakan untuk perawatan luka di rumah dan sebagai cara alternatif yang bersifat tradisional untuk mengobati luka.Kata kunci: Binahong [AnrederaCordifolia (Ten.) Steenis], penyembuhan luka, povidone iodine
Association between Patient’s Basic Characteristic and Clark Level in Cutaneous Malignant Melanoma Rahmalaelani, Egie; Usman, Hermin Aminah; Agusni, Jono Hadi
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.806 KB)

Abstract

Background: Malignant melanoma is  a cancer that begins in the melanocytes. Melanoma is commonly happened on older people, male and located on sun exposure body area, such as face, neck and lower limb. Melanoma cases occur less than 5% of skin cancer but cause a majority of skin cancer deaths because melanoma has an aggressive behavior. Age, sex, location of lesion, and type of melanoma influences the melanoma invasion. The cutaneous melanoma invasion could be assessed with the Clark level. This study is aimed to determine the association between patient’s basic characteristic and Clark level in cutaneous malignant melanoma.Methods: This study used cross sectional analytic design. The medical records and histopathology slide from the Department of Anatomic Pathology Dr. Hasan Sadikin General Hospital from 2008−2012 took as a sample. Forty one data were meet the inclusion criteria.  Furthermore, those data were analyzed using chi-square test.Result: Overall, patient’s characteristic in this study, commonly occurred on female (66%), 50−59 years group age (35%), non-cephalic/acral location (71%), and the level V in Clark level (73%). Location of lesion showed an association with Clark level (p=0.023), whereas, age and sex was not significant (p=0.679 and p=0.389).Conclusions: There is an association between location of lesion and Clark level [AMJ.2017;4(1):25–9]DOI: 10.15850/amj.v4n1.1015 
Five Years Data of Clinical and Histopathological Characteristics of Skin Adnexal Tumors in Dr. Hasan Sadikin General Hospital Bandung Trisaputra, Jessica Oktavianus; Usman, Hermin Aminah; Hindritiani, Reti
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.609 KB)

Abstract

Background: Skin adnexal tumors arise from skin adnexal differentiation. Very limited number of study has been performed on their clinical and histopathological characteristics in Dr. Hasan Sadikin General Hospital. The objectives of this study was to identify the clinical and histopathological characteristic of skin adnexal tumors during the period of 2009 to 2013.Methods: AA descriptive study performed on 79 medical records of patients with skin adnexal tumors at the Department of Anatomic Pathology in Dr. Hasan Sadikin General Hospital Bandung from 2009 to 2013. Data were collected during the period of September to October 2014. The inclusion criteria were medical records containing information on skin adnexal tumors confirmed by histopathological examination results, patient characteristics (age and gender), and the tumor characteristics (size, location, malignancy, type, and histopathological origin). Collected data were processed using computer and presented in tables.Results: This study showed that tumors occured during productive age with male to female ratio was 1.2:1. Most skin adnexal tumors were ≤5 cm in size and were distributed in the head-neck region. Most of the tumors were benign and arised from hair follicle differentiation with pilomatricoma type while the malignant tumors commonly arised from sebaceous gland differentiation with sebaceous carcinoma type.Conclusions: Most skin adnexal tumors occur in productive age with no gender prediclation. They are small in size and are distributed in the cephalic region. Most are benign tumors arising from hair follicle differentiation with some malignant tumors arising from sebaceous gland differentiation. [AMJ.2016;3(4):514–9] DOI: 10.15850/amj.v3n4.933
Association between Patient’s Basic Characteristic and Clark Level in Cutaneous Malignant Melanoma Egie Rahmalaelani; Hermin Aminah Usman; Jono Hadi Agusni
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (544.806 KB)

Abstract

Background: Malignant melanoma is  a cancer that begins in the melanocytes. Melanoma is commonly happened on older people, male and located on sun exposure body area, such as face, neck and lower limb. Melanoma cases occur less than 5% of skin cancer but cause a majority of skin cancer deaths because melanoma has an aggressive behavior. Age, sex, location of lesion, and type of melanoma influences the melanoma invasion. The cutaneous melanoma invasion could be assessed with the Clark level. This study is aimed to determine the association between patient’s basic characteristic and Clark level in cutaneous malignant melanoma.Methods: This study used cross sectional analytic design. The medical records and histopathology slide from the Department of Anatomic Pathology Dr. Hasan Sadikin General Hospital from 2008−2012 took as a sample. Forty one data were meet the inclusion criteria.  Furthermore, those data were analyzed using chi-square test.Result: Overall, patient’s characteristic in this study, commonly occurred on female (66%), 50−59 years group age (35%), non-cephalic/acral location (71%), and the level V in Clark level (73%). Location of lesion showed an association with Clark level (p=0.023), whereas, age and sex was not significant (p=0.679 and p=0.389).Conclusions: There is an association between location of lesion and Clark level [AMJ.2017;4(1):25–9]DOI: 10.15850/amj.v4n1.1015 
Pathological Findings of the Lung at Neonatal Autopsy in Dr. Hasan Sadikin General Hospital Bandung Period 2016-2019 Rania Azzahra Salsazayasya Parikesit; Nita Novita; Hermin Aminah Usman
Althea Medical Journal Vol 8, No 3 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n3.2337

Abstract

Background: Infanticide is a criminal act when a mother kills her child at or soon after birth. Considering whether a case has been decided as infanticide, determination of the life of the neonate at birth is imperative. Breath signs from macroscopic and microscopic approacesh and hydrostatic test are useful indicators. This study aimed to explore the lungs pathological findings at autopsy of neonates.Methods: This study was a retrospective descriptive observational study, using medical records of neonatal deaths in the Department of Forensics and Medicolegal Dr. Hasan Sadikin General Hospital, Bandung for the period 2016–2019. Total sampling method was used. Inclusion criteria were neonatal death with presumptive infanticide, had autopsied and microscopic examination as well as neonatal death without putrefaction. Data on macroscopic and microscopic findings as well as the hydrostatic test were presented.Result: In total, 12 of the 42 medical records with data on presumptive infanticide met the inclusion criteria. For macroscopic findings, 7 of the 12 samples had positive results, meaning the lungs had sign of breath. Meanwhile, in microscopic findings 8 of the 12 samples had positive results. For the hydrostatic test, 8 out of 12 samples had positive results. Of the 12 samples, there were four samples that had different results, at least on one variable. Conclusions: Most of the cases are matched with macroscopic, microscopic, and hydrostatic test, but some unmatched data are also found. In order to improve reliability, especially for legal purposes in infanticide, it is necessary to conduct all the examination.
Histopathological Findings in Sudden Cardiac Death: 5-years Autopsy Experience in a Tertiary Hospital in Bandung, Indonesia Gian Nugraha; Nita Novita; Hermin Aminah Usman
Althea Medical Journal Vol 8, No 2 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n2.2324

Abstract

Background: Sudden death (SD) is a sudden and unexpected death with an unknown cause. However, it has been assummed that the most common causes of sudden deaths are cardiovascular or non-cardiovascular causes such as gastrointestinal disease, respiratory disease, genitourinary disease, epilepsy, and trauma. This study aimed to portray histopathological findings and causes of sudden cardiac death (SCD) cases based on 5 year autopsy experience in a tertiary hospital in Bandung, Indonesia. Methods: This study was a descriptive cross-sectional study exploring causes of SCD from 2015 to 2019 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. All medical records with SCD and histopathology findings were retrieved from September to December 2020. Only cases with histopathological examination results were included.Results: SCD was found in 7 of 16 patients with sudden death. Coronary atherosclerosis was the most common (n=4), followed by myocardial infarction (n=2) and ruptured aortic aneurysm (n=1). Myocarditis and calcific aortic valve diseases were not found.Conclusions: In this study, the most common cause of SCD is coronary atherosclerosis, which is identified mainly in older and male patients.
Effect of Topical Application of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Paste in Wound Healing Process in Mice Gurwinder Kaur a/p Gurcharan Singh; Novi Vicahyani Utami; Hermin Aminah Usman
Althea Medical Journal Vol 1, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (549.093 KB)

Abstract

Background: Wound caused by trauma poses challenging daily clinical problems for physicians in hospitals and other health services. It has high risk for mortality and morbidity. Binahong [Anredera Cordifolia (Ten.) Steenis] plant originates from China and can be found abundantly in Indonesia. The objective of this research is to investigate the effect of topical application of Binahong leaf paste on wound healing process.Methods: A laboratory experimental study was conducted at the Pharmacology Laboratory, Universitas Padjadjaran, from October to December 2012 by using 27 Mus Muscularis mice which were divided into 3 groups: group 1 (sodium chloride 0.9%), group 2 (Binahong) and group 3 (povidone iodine 5%). Binahong leaves were crushed and were mixed with water to make a paste. The application was given for 12 days. On day zero, 1.0 cm2 of wound was incised at the back of the mice, and further on day 1, 4, 8 and 12, the percentage of wound contraction was measured. The data was analyzed using Mann-Whitney test.Results: The study indicated that the percentage of wound contraction in group 2 on day 4 (1.17%), day 8 (23.7%) and day 12 (76.14%) is the highest among all groups. The result showed that the comparison between binahong and NaCl was highly significant on day 12, p= 0.001 (p < 0.05) and the data for comparison between Binahong and povidone iodine on day 12 was significant with p= 0.003 (p < 0.05).Conclusions: Topical application of Binahong leaf paste shows better result in wound healing process of Mus muscularis mice. From this study it can be concluded that binahong promotes wound healing and can be used for home remedies for wound care and as an alternative traditional way to treat wound.[AMJ.2014;1(1):6–11]Keywords: Binahong [Anredera Cordifolia (Ten.) Steenis], povidone iodine, wound healingEfek Aplikasi pasta daun Binahong [AnrederaCordifolia (Ten.) Steenis] secara topikal dalam proses penyembuhan luka pada tikus jenis MusmuscularisLatar Belakang: Luka yang disebabkan oleh trauma menjadi masalah klinis yang menantang bagi para dokter di rumah sakit maupun bagi petugas kesehatan lainnya dalam melakukan pekerjaan sehari-hari. Luka yang timbul tersebut memiliki risiko yang tinggi terhadap mortalitas dan morbiditas. Tanaman Binahong [AnrederaCordifolia (Ten.) Steenis] berasal dari Cina dan banyak ditemukan di Indonesia. Tujuan dari penelitian untuk mengetahui efek dari aplikasi pasta daun Binahong secara topikal terhadap proses penyembuhan luka.Metode: Penelitian eksperimental ini dilakukan di Laboratorium Farmakologi, Universitas Padjadjaran, mulai Oktober–Desember 2012, menggunakan tikus jenis MusMuscularis sebanyak 27 ekor, dibagi menjadi 3 kelompok: kelompok 1 (natrium klorida 0,9%), kelompok 2 (pasta daun Binahong) dan kelompok 3 (povidone iodine 5%). Daun Binahong dihancurkan dan ditambahkan sedikit air sehingga menjadi bentuk pasta. Perlakuan diberikan selama 12 hari. Pada hari 0 dilakukan insisi pada punggung tikus untuk membuat luka sebesar 1,0 cm2. Persentase kontraksi luka akan dinilai pada hari ke-1, 4, 8, dan 12. Kontraksi luka adalah pengurangan luas pada area luka. Hasil penilaian tersebut akan dibandingkan pada tiap kelompok untuk melihat efektivitas aplikasi topikal pasta daun Binahong. Data akan dianalisis dengan uji Mann-Whitney.Hasil: Hasil penelitian menunjukkan bahwa persentase kontraksi luka kelompok 2 pada hari ke-4 (1,17%), hari ke-8 (23,7%), dan hari ke-12 (76,14%) adalah lebih tinggi dibandingkan dengan kelompok lainnya. Hasil juga menunjukkan bahwa terdapat perbedaan sangat signifikan antara perbandingan Binahong dan natrium klorida pada hari ke-12, dengan p=0,001 (p<0,05). Perbandingan antara Binahong dan povidone iodine pada hari ke-12 juga menunjukkan hasil signifikan dengan p=0,003 (p<0,05).Simpulan: Aplikasi pasta daun Binahong secara topikal menunjukkan hasil yang lebih baik dalam proses penyembuhan luka pada tikus jenis Musmuscularis. Dari penelitian ini dapat disimpulkan bahwa Binahong mempercepat penyembuhan luka serta dapat digunakan untuk perawatan luka di rumah dan sebagai cara alternatif yang bersifat tradisional untuk mengobati luka.Kata kunci: Binahong [AnrederaCordifolia (Ten.) Steenis], penyembuhan luka, povidone iodine DOI: dx.doi.org/10.15850/amj.v1n1.289
Five Years Data of Clinical and Histopathological Characteristics of Skin Adnexal Tumors in Dr. Hasan Sadikin General Hospital Bandung Jessica Oktavianus Trisaputra; Hermin Aminah Usman; Reti Hindritiani
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.609 KB)

Abstract

Background: Skin adnexal tumors arise from skin adnexal differentiation. Very limited number of study has been performed on their clinical and histopathological characteristics in Dr. Hasan Sadikin General Hospital. The objectives of this study was to identify the clinical and histopathological characteristic of skin adnexal tumors during the period of 2009 to 2013.Methods: AA descriptive study performed on 79 medical records of patients with skin adnexal tumors at the Department of Anatomic Pathology in Dr. Hasan Sadikin General Hospital Bandung from 2009 to 2013. Data were collected during the period of September to October 2014. The inclusion criteria were medical records containing information on skin adnexal tumors confirmed by histopathological examination results, patient characteristics (age and gender), and the tumor characteristics (size, location, malignancy, type, and histopathological origin). Collected data were processed using computer and presented in tables.Results: This study showed that tumors occured during productive age with male to female ratio was 1.2:1. Most skin adnexal tumors were ≤5 cm in size and were distributed in the head-neck region. Most of the tumors were benign and arised from hair follicle differentiation with pilomatricoma type while the malignant tumors commonly arised from sebaceous gland differentiation with sebaceous carcinoma type.Conclusions: Most skin adnexal tumors occur in productive age with no gender prediclation. They are small in size and are distributed in the cephalic region. Most are benign tumors arising from hair follicle differentiation with some malignant tumors arising from sebaceous gland differentiation. [AMJ.2016;3(4):514–9] DOI: 10.15850/amj.v3n4.933
Association of Nuclear VDR Immunoexpression with Breslow’s Thickness in Acral Melanoma Sholihah, Fitria; Usman, Hermin Aminah; Dewayani, Birgitta Maria
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2801

Abstract

Background: Acral melanoma (AM) is a subtype of malignant melanoma (MM) that has a predilection for glabrous skin and is the most common type of melanoma among Asians. Depth of invasion is one of the prognostic factors in AM. VDR may have an association with depth of invasion in AM. However, reports from Asian patients are still lacking. The aim of this study was to explore the association between VDR immunoexpression and depth of invasion in AM patients in Bandung, Indonesia.Methods: This study was a retrospective cross-sectional study that analyzed the nuclear and cytoplasm VDR expression of melanoma cells and its association with Breslow’s thickness in patients with AM in Dr. Hasan Sadikin General Hospital Bandung. VDR immunostaining was performed on paraffin blocks. The Breslow thickness was measured using dot slide software. Chi square statistical analysis was done to determine the results.Results: Of the 30 patients, 73% had a Breslow thickness of >4 mm.  There was a significant inverse association between nuclear VDR immunoexpression and Breslow thickness of AM (p<0.001), but not for cytoplasmic VDR immunoexpression (p=0.914). Conclusion: Low nuclear VDR immunoexpression is associated with the depth of invasion in AM. Nuclear VDR immunoexpression possibly affect progression and should be considered before administration of vitamin D therapy in AM. 
Co-Authors . Afiati, . Abdul Hadi Hassan, Abdul Hadi Afiati Afiati Afiati Afiati Ahmad Faried Akbar Maulana Andi Kurniadi, Andi Anglita Yantisetiasti Anjani, Gebby Reviana Apriliani, Ardhia Rizki Arif, Izhar Muhammad Arif, Izhar Muhammad Arima Kurnia Sari Dewi Nurcahyani Astrid Feinisa Khairani Atika Hana Ilyasa Aviscena Fahmi Ali Bashari, Muhammad Hasan Bethy Hernowo Bethy S Hernowo, Bethy Bethy Surjawathy Hernowo Bethy Surjawathy Hernowo Bethy Suryawathy Hernowo Billy Parulian Lubis Defi Ardia Pramesti Dewayani, Birgitta Maria Dewi Yulianti Bisri Dika Widia Nur Azizah Dimas Erlangga Luftimas Dimas Erlangga Luftimas Dodi Suardi Dolvy Girawan Dwi Andini Dwi Putri, Riska Edward Jaya Hadi Egie Rahmalaelani Eka Surya Nugraha Endang Sutedja Erida, Yulie Eva Krishna Sutedja Fauzan Ali Zainal Abidin Fauzan Ali Zainal Abidin Gatot Nyarumenteng Adhipurnawan Winarno Gian Nugraha Gurwinder Kaur a/p Gurcharan Singh Gurwinder Kaur a/p Gurcharan Singh Handayani, Astri Hasrayanti Agustina Hasrayati Agustina Hendra Gunawan HENDRA GUNAWAN B11211055 Hendrikus Bolly Herry Yulianti Husain, Okky Jessica Oktavianus Trisaputra Jono Hadi Agusni Jono Hadi Agusni, Jono Hadi Khafifah, Dinda Salsa Kiki Akhmad Rizki Labibah, Salma Nur Lala Yuliani Laraswita, Sarah Maman Abdurahman Maria Meildi Meinarni, Retno Misuari Sabirin, Muhammad Syah Monty Priosodewo Soemitro Muhammad Begawan Bestari Nadiah, Zahra Nadifah Diana Zalia Nadila Ayu Karisa Naura Mardhiyah Nenny Agustanti Nita Novita Noor Fitriana, Maya Novi Vicahyani Utami Nugraha, Marwan Agung Nurhasanah Nurhasanah Nurhidayat, Ade Apon Oki Suwarsa Putri Halleyana Raden Yohana Rahmalaelani, Egie Rahman, Putri Halleyana A Ramdhani, Muhammad Farid Rani Septriana Rani Septrina Rania Azzahra Salsazayasya Parikesit Rasdianto, Devi Novianto Reiva Farah Dwiyana Reti Hindritiani Rianty, Fathia Rika Mustika Risqi Dwi Putra Sholihah, Fitria Siska Dwiyantie Wahyuni Siti Aminah Abdurachman Sri Suryanti Sunardi, Mas Adi Titing Nurhayati Trisaputra, Jessica Oktavianus Yudi Wahyudi Yunnica Yunnica Zahra Nurusshofa