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All Journal VALENSI Alchemy Jurnal Penelitian Kimia Indonesian Journal of Chemical Science ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia Bulletin of Chemical Reaction Engineering & Catalysis
Fajar Rakhman Wibowo
Departmen Of Chemistry, Faculty Of Mathematics And Natural Sciences, Sebelas Maret State University, Surakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology

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Journal : VALENSI

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Isolasi dan Identifikasi Senyawa Seskuiterpen dari Curcuma soloensis Val. (Temu Glenyeh) Soerya Dewi Marliyana; Muhamad Widyo Wartono; Fajar Rakhman Wibowo; Gesti Munasah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (729.169 KB) | DOI: 10.15408/jkv.v4i2.7443

Abstract

Curcuma soloensis Val. is a family plant Zingiberaceae and is known as "temu gelnyeh". This plant has been used as a medicinal plant but has not been widely reported about its chemical components. Therefore, this study was carried out to isolation and identification of the chemical components of the C. soloensis Val. rhizome. Isolation was done by extraction, fractionation, and purification. The fractionation and purification of the compound were carried out using chromatography methods. The identification of the compound was determined by spectroscopic methods including 1D-NMR (1H NMR, 13C NMR) and 2D-NMR (HSQC, HMBC). Based on NMR spectra data analysis and compared with literature, the compound obtained yellow liquid was ar-turmerone (2-methyl-6- (4-methylphenyl) hept-2-en-4-on) which was a terpenoid sesquiterpene. Ar-turmerone is the first compound that found from Curcuma soloensis Val. rhizome.  
Search for SARS-CoV-2 Inhibitors. Is it still needed?Molecular Docking Study of Teicoplanin Derivatives and Vancomycin against SARS-CoV-2 Mpro Mulyani, Sri; Lestari, Nova Dwi; Samodra, Imam; Wibowo, Fajar Rakhman; VH, Elfi Susanti; Ardyanto, Tonang Dwi
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 1, May 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.44709

Abstract

Coronaviruses have been known since 2002 in the case of SARS (Severe Acute Respiratory Syndrome). SARS-CoV-2, the cause of the COVID-19 pandemic, is believed to be an evolution of the SARS-causing coronavirus (SARS-CoV). This evolution shows the complex interaction dynamics between the virus and the host, which have characterized the emergence of new SARS-CoV-2 strain variations until now. Therefore, the search for these antiviral drugs is still critical. MPro is one of the important proteins for the life cycle of pathogenic coronaviruses, so it is an attractive target for developing drugs that inhibit this virus. This study examined the interaction of teicoplanin derivatives and vancomycin as SARS-CoV-2 MPro (6LU7) inhibitors through molecular docking with Autodock Vina. The smallest RMSD value was selected and stored to calculate the energy value. The image of atoms in the ligand and receptor was processed with Autodock Tools, LigPlus, and PyMOL. The study showed that teicoplanin derivatives such as teicoplanin aglycone, teicoplanin-A3-1, and vancomycin had the potential as SARS-CoV-2 Mpro inhibitors. Based on the interaction at the active site and the obtained ΔG values, even the teicoplanin aglycon had a more significant inhibitory potential than other potent inhibitors such as N3.
Co-Authors Ali Triambodo, Ali Angeline Prita C, Angeline Prita Annisa Istiqomah, Annisa Bambang Heru Susanto, Bambang Heru Desi Suci Handayani Elfi Susanti V. H. Elfrida Ratnawati Gesti Munasah Hilmi Amirul Haq Husna Habib Musthofa Irmawan, Muhammad Lestari, Nova Dwi Maulidan Firdaus Muhamad Widyo Wartono Muhammad Nursyam Maulana Nestri H, Nestri Nestri Handayani, Nestri Ozi Adi Saputra, Ozi Adi Puput Veronikasari Purwanti . Riandy Putra Rita Rakhmawati, Rita Rossalia Soraya Safitriono, Wahyu Nur Samodra, Imam Sari, Meiyanti Ratna Kumala Soerya Dewi M, Soerya Dewi Soerya Dewi Marliana, Soerya Dewi Soerya Dewi Marliyana Soerya Dewi Marliyana Sri Mulyani Tahara, Alfia Uke Teddy Prayoga, Teddy Tonang Dwi Ardyanto Triana Kusumaningsih Venty Suryanti Witri Wahyu Lestari