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All Journal Dentika Dental Journal Jurnal Teknosains The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Mutiara Medika: Jurnal Kedokteran dan Kesehatan INDONESIAN JOURNAL OF PHARMACY Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Chemistry B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Material Kedokteran Gigi Journal of Material Processing and Characterization (JMPC) Odonto dental journal Indonesian Journal of Dentistry Jurnal Akuntansi Kontemporer
W. Widjijono
Departemen Biomaterial, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Engineering Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health

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Journal : ODONTO Dental Journal

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The effect of casein and lactoferrin of bovine's milk on nestin expression of the exposed dental pulp Endah Ariyati Eko Ningtyas; Widjijono Widjijono; Siti Sunarintyas
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.2.273-278

Abstract

Background: Pulp tissue can regenerate if damage occurs. The pulp differentiates into new odontoblast-like cells in Progenitor cells. Nestin is a marker of the presence of new dontoblast-like and expressed in pathological conditions. Bovine's milk casein and lactoferrin contain proteins that accelerate cell growth. This study aimed to determine the effect of casein and lactoferrin on the expression of nested cells in the exposed dental pulp.Method: The research method is an experimental laboratory with male 30 Spraque Dawley rats. Rats were grouped as : casein, lactoferrin, casein-lactoferrin, and Ca-(OH)2. Each group consisted of 15 samples of molars which were divided into 5 samples of teeth for observation on the 7, 14, and 21 days. The first molars of rats were prepared until the pulp was exposed. The data of nestin quantity with immunohistochemical (IHC) analysis on histological preparations were analyzed using two-way ANOVA then the least significance difference (LSD) test.Result: The results of the average number of nested cells on 7,14 and 21 days were highest on combination of casein and lactoferrin. Two-way ANOVA statistical proved that there was a significant difference (p<0.05) in each observation period and group and the number of expressions of nestin cells. LSD test showed that there was a significant difference (p<0.05) between groups compared to the control group.Conclusion: Combination casein and lactoferrin extracts affect the expression of the number of nestin cells as a marker of new odontoblast-like cells in the exposed dental pulp.
Co-Authors Adella Syvia Maharani Agustin Wulan Agustin Wulan Akhmad Kharis Nugroho Ariyani Faizah Budiono Budiono Catur Septommy Dana Ardianata Dendy Murdiyanto Dewi Arsih Sulistiani Diatri Nari Ratih Diyah Fatmasari Dwi Aji Nugroho, Dwi Dyah Irnawati Eko Hadianto Eko Hadianto, Eko Eko Sri Kunarti Endah Ariyati Eko Ningtyas Endang Wahyuningtyas Erna Prawita Setyowati Etny Dyah Harniati Gustina, Mara Harsini Harsini, Harsini Ikmal Hafizi Iwan Dwi Prahasto Iwan Dwi Prahasto Izfan Yulviansyah Karna Wijaya Leny Yuliatun Leny Yuliatun M.K. Herliansya M.K. Herliansya, M.K. Marsetyawan HNE Soesatyo N Nuryono N. Nuryono Nisaa, Khairun Nuryono Nuryono Nuryono Nuryono Nuryono Nuryono Pramudya Aditama Prihashinta Uswatun Hasanah Purwanti, Sari Purwanto Agustiono Purwanto Agustiono Raphael Tri Endra Untara Resti Efrata Eka Rethy Den Rini Dharmastiti Rini Dharmastiti S. Sunarintyas S. Sunarintyas, S. Sari Purwanti Siti Sunarintyas Siti Sunarintyas Soesatyo, Marsetyawan Heparis Nur Ekandaru Suryono Suryono . Tri Windarti Verani, Dhea Maurilla Wehartaty, Tineke Wibowo, Diva Agrita Dentisia Widowati Siswomihardjo Widya Asmara Widya Asmara Widya Asmara Widyapramana Widyapramana Widyapramana Widyapramana, Widyapramana Wijayanti Dwi Aastuti Yasnawi, Mohammad Imanuddin Yoga Yuniadi Yosaphat Bayu Rosanto Zwista Yulia Dewi