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Hamsidar Hasan
Universitas Negeri Gorontalo
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Building an mandiri village of herbal medicine in an effort to improve the health of the Taula'a village Gorontalo District Hamsidar Hasan; Madania Madania
Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Vol 11, No 3 (2022): Jurnal Sibermas (Sinergi Bersama Masyarakat)
Publisher : Univeristas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/sibermas.v11i3.12237

Abstract

Herbal medicine is a medicine made from natural ingredients, either plants, animals, or minerals. Herbal medicines are widely used by the people of Indonesia to treat certain symptoms or diseases. Although this medicine is made from natural ingredients and has been used for a long time, it is necessary to know how to take safe herbal medicines to avoid side effects. This service aims to build the independence of the Taula'a Village community in terms of treatment using herbal medicines. Independent in terms of sources of herbal medicines, independent in terms of management, and independent in terms of their use. The methods used are lectures, education, and direct practice on how to cultivate medicinal plants in the yard, how to cultivate, and how to use herbal medicines. Evaluation of the success of community service based on increasing knowledge after education and being able to process herbal medicines with raw materials based on spices to improve health.
Uji Aktivitas Antidiabetes Ekstrak Etil Asetat Daun Lamun (Enhalus acoroides) Pada Mencit (Mus musculus) Hamsidar Hasan; A.Mu'thi Andy Suryadi; Zulfianto Djufri
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15379

Abstract

Diabetes mellitus is a severe condition, chronic in nature, that occurs when there is an increase in blood glucose levels (GDS) 200 mg/dL or hyperglycemic conditions. Some plants are reported to have anti-diabetic effects. One of the examples is seagrass (Enhalus acoroides), which has α-glucosidase enzyme inhibitory effects in vitro. The community often uses it as traditional medicine. This present work explores the anti-diabetic activity of ethyl acetate extract of seagrass (Enhalus acoroides) leaves against male mice (Mus musculus) charged with 90% sucrose solution. It employed the oral sucrose tolerance test (OSTT) methodology. Activity tests on mice were carried out in five treatment groups, namely: group I or a negative control (Na-CMC 1% w/v); group II or a positive control (acarbose); group III (ethyl acetate extract dose 50 mg/kg BW); group IV ( ethyl acetate extract at a dose of 150 mg/kg BW), and; group V (ethyl acetate extract at a dose of 250 mg/kg BW). All data were analyzed by using a one-way ANOVA statistical test. The results show that the ethyl acetate extract of seagrass leaves can inhibit the absorption of sucrose, in which the most significant total inhibition occurred at a dose of 250 mg/kg BW, i.e., 68 mg/dL. A substantial inhibition was also found at a dose of 150 mg/kg BW, which was 82 mg/dL and at a dose of 50 mg/dL or 103 mg/dL. In conclusion, the ethyl acetate extract of seagrass leaves has anti-diabetic activity.
Senyawa Antidiabetes Fraksi Aktif Daun Ketapang (Terminalia catappa L.) Hamsidar Hasan; Endah Nurrohwinta Djuwarno; Hasrita Samudi; Widy Susanti Abdulkadir; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15656

Abstract

Antidiabetic is a compound that has a vital role in treating diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder that is characterized by an increase in blood sugar levels. The use of traditional medicine is relatively cheaper and safer compared to synthetic drugs. One of the plants that is often used in traditional herbal medicine is ketapang (Terminalia catappa L.) because it contains a secondary metabolite compound that acts as an antidiabetic. Thus, this present study aimed to determine the n-hexane, ethyl acetate, and methanol extracts that had antidiabetic efficacy on blood sugar levels and compound group that acts as antidiabetic. The research employed mehods of multiple maceration, phytochemical screening, thin layer chromatography, and antidiabetic test, while the most effective antidiabetic efficacy was then continued to the fractionation stage using vacuum liquid chromatography and gravity column chromatography. Furthermore, the preparative thin layer chromatography (PTLC) analysi, UV-Vis zspectrometry and FTIR were carried out. The research findings revealed that the maximum wavelength of active fraction in ketapang (Terminalia catappa L.) leaves was 410.50 nm, and FTIR spectrum had functional groups of O-H (hydroxyl) C=O (carbonyl Co (aliphatic), C-O (ether) and CH3. Based on the finding, it could be concluded, that antidiabetic compound that plays a role in active fraction of ketapang (Terminalia Cappy L.) leaves was a flavonoid compound.
Isolasi dan Uji Aktivitas Antiinflamasi Ekstrak Daun Andong (Cordyline fructicosa (L) A.Chev) Endah Nurrohwinta Djuwarno; Hamsidar Hasan; Mahdalena Sy. Pakaya; Faramita Hiola; Dewa Ayu Puspita
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15740

Abstract

Andong (Cordyline fructicosa (L) A. Chev) is used as traditional medicine, the use of this traditional medicine is related to the content of secondary metabolites contained in the andong plant. Empirically people use this plant as an antioxidant, the compound that acts as an antoixidant is related to antiinflamasi. The purpose of this study was to isolate secondary metabolites from the extracts of N-Hexane, Ethyl Acetate, and Methanol from Andong (Cordyline fructicosa (L) A. Chev) leaves and to determine the anti-inflamatory effect of the isolated secondary metabolites of Andong (Cordyline fructicosa (L) A. Chev) leaves through in vitro with red blood cell stabilization method. Several methods are used in the isolation of these compounds, namely extraction, identification of compound, fractionation of KCV and KKG, KLT,KLTP, and characterizationof compounds using UV-VIS spectrophotometry and FTIR. The results of UV-VIS characterization show a maximum wavelength of 434 nm, and the results of  FTIR characterization indicate the presence of a functional groups namely O-H (Hidroxyl) at a wave number of 3448,72 cm-1, C-H (Aliphatic) at a wave number of 2954,95 cm-1, 2920,23 cm-1, and 2852,72 cm-1, aliphatic compounds are supported by the presence of CH2 and CH3 at wave number of 1463,97 cm-1 and 1379,10 cm-1, C=O (conjugated carbonyl) at wave number of 1721,79 cm-1, C=C at wave number of 1633,71 cm-1, C-O at wave number of 1294,24 cm-1. So it is very likely that the compounds in Andong leaves isolate are flavonoid compounds. Furthermore, the activity of results of the isolation is tested where the isolate whit a concentration of 100 ppm signifies the highest anti-inflamatory activity, with the ability to stabilize red blood cell membranes of 80,142 %.
Pelatihan Pembuatan Produk Kesehatan Berbasis Ikan Layang Sebagai Upaya Mencegah Stunting Di Desa Langge Kabupaten Bone Bolango Gorontalo Hamsidar Hasan; Ekawaty Prasetya; Cindy Puspita Sari
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 2, No 1 (2023): Volume 2, Edisi 1, 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (932.174 KB) | DOI: 10.3731/phar.soc.v2i1.18606

Abstract

Stunting atau sering disebut kerdil atau pendek adalah kondisi gagal tumbuh pada anak berusia di bawah lima tahun (balita) akibat kekurangan gizi kronis dan infeksi berulang terutama dalam 1.000 Hari Pertama Kehidupan (HPK), yaitu dari janin hingga anak berusia 23 bulan, dan kondisi stunting baru nampak setelah bayi berusia 2 tahun. Stunting disebabkan oleh beberapa faktor seperti asupan makanan, berat lahir, pendidikan orang tua, usia balita dan ekonomi keluarga. Pemerintah berupaya menanggulangi permasalahan stunting melalui program suplementasi, upaya perubahan perilaku konsumsi masyarakat agar mengkonsumsi sumber makanan yang beragam dan kaya akan kandungan gizi termasuk zat gizi mikro serta sehat dan aman, serta fortifikasi pangan. Solusi yang paling dekat adalah mengupayakan konsumsi ikan karena Indonesia mempunyai potensi perikanan yang sedemikian besar. Untuk meningkatkan daya konsumsi masyarakat, akan dibuat dalam bentuk produk menarik yang disukai anak anak seperti nugget, bakso, abon. Metode yang digunakan adalah edukasi tentang stunting, faktor penyebabnya, dampak, gejala dan cara mengatasinya. Selanjtnya melakukan praktek secara langsung dengan melibatkan masyarakat. Program ini melibatkan 12 mahasiswa, 3 dosen pemdamping lapangan dengan latar belakang keilmuan adalah prodi kesehatan. Sebelum edukasi diberikan free test untuk melihat sejauh mana pengetahuan masyarakat tentang stunting dan produk yang akan disajikan. Hasil free test menunjukkan 30 % masyarakat mengetahui tentang potensi ikan dalam mencegah stunting (A) dan juga 30 % mengetahui bahwa ikan bisa dibuat menjadi nugget (B). Tapi pengetahuan tentang bahan baku nugget (C) dan cara membuatnya (D) menunjukkan 0%.  Evaluasi dilanjutkan dengan wawancara terbuka setelah pelaksanaan program utama dan menunjukkan ada peningkatan pengetahuan sebesar  40 % untuk A, 35 % untuk B, 80 % untuk C dan 80 % untuk D.
Pemanfaatan Lidah Buaya (Aloe vera) dalam pembuatan Hand Sanitaizer pada Masyarakat Desa Ulapato A Juliyanty Akuba; Hamsidar Hasan
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 1 (2022): Vol 1 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.021 KB) | DOI: 10.3731/phar.soc.v1i1.13996

Abstract

Lidah Buaya merupakan tanaman hias yang dapat digunakan untuk mengobati beberapa penyakit, sebagai penumbuh rambut dan bisa sebagai antibakteri. Aktivitas antibakteri Lidah Buaya bisa di formulasikan menjadi Hand Sanitaizer. Penggunaan Hand Sanitaizer dimasa pandemic sangatlah penting dan sudah menjadi salah satu kebutuhan pokok. Pembuatan Hand Sanitaizer ini dibuat untuk membantu masyarakat desa untuk dapat memproduksi sendiri yang bisa digunakan sendiri, atau bisa dijual untuk meningkatkan perekonomian keluarga masyarakat di desa pada umumnya. 
Isolasi, Karakterisasi, dan Uji Antioksidan Fungi Endofit dari Tanaman Batang Kunyit (Curcuma domestica Val.,) Mahdalena Sy. Pakaya; Nur Ain Thomas; Hamsidar Hasan; Ariani H. Hutuba; Grasela Mbae
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20341

Abstract

Endophytic fungi live in mutualistic symbiosis and can produce secondary metabolites similar to their host. This research aims to isolate, characterize, and test the antioxidant activity of secondary metabolites from turmeric stems. This research is experimental research where the method used for endophytic fungi isolation is the direct planting method, and antioxidant activity is tested using qualitative and quantitative methods with DPPH (1.1-diphenyl-2-picylhydrazyl). One fungal isolate was obtained with the fungal isolate code (BK). Based on macroscopic and microscopic characterization, the BK fungal isolate indicates the Deuteromycota class's characteristics. The qualitative antioxidant test results indicate that the fraction of BK endophytic fungal isolate indicates antioxidant activity, indicated by the yellow color against a purple background on the TLC plate observed under visible light. The respective ICso values for the ethyl acetate and n-hexane fractions were 52.989 µg/ml and 89.725 µg/ml, categorized as strong antioxidants. The methanol fraction had an ICso value of 119.02 µg/ml, categorized as moderate, while the pure supernatant fraction had an ICso value of 156.86 µg/ml, categorized as weak antioxidant activity.
Penentuan Kadar Flavonoid Daun Rumput Knop (Hyptis capitata Jacq.) Menggunakan Spektrofotometri UV-Vis Hamsidar Hasan; A. Mu'thi Andy Suryadi; Syamsul Bahri; Ni Luh Widiastuti
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.19371

Abstract

Knop grass (Hyptis capitata Jacq.) is a weed used as a tradisional medicine, especially for the leaves. Flavonoids are one of the secondary metabolites contained in the Knop Grass (Hyptis capitata Jacq.) leaves, wich function as anti-inflammatory, analgesic, antipyretic and anti-diabetic. The amount of extracted flavonoids is optimized by choosing the right extraction method, as it will determine the amount of substance that can be attracted and obtain a high content of active substansces. This research aimed to compare the flavonoid levels in the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves in two different maceration methods: multilevel maceration and total maceration. Multilevel maceration employed n-hekxane, ethyl acetat and methanol solvents, while total maceration employed methanol solvent. In the meantime, the qualitative analysis in this reaserch used the color reagent test method, whereas the thin layer chromatography used the eluent, namely n-hexane : ethyl acetate with a ratio (7:3). In addition, the quantitative analysis used the UV-Vis spectrophotometry method at a maximum wavelength of 435 nm with standard quercetin as a comparison. The result signified that the average flavonoid level in the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves using the multilevel maceration method was 2,9750%. The total maceration method was 4,8822%. Furthermore, the total maceration method donated the highest concentration obtained from the methanol extract of Knop Grass (Hyptis capitata Jacq.) leaves.
Non-Linear Function Approximation for Predicting Binding Affinity of PPAR-Targeting Antidiabetic Compounds from Molecular Descriptors La Ode Aman; Widy Abdulkadir; Dizky Papeo; Ariani Hutuba; Teti Tuloli; Mohamad Mustapa; Yuszda Salimi; Hamsidar Hasan; Arfan; Aiyi Asnawi
Jambura Journal of Biomathematics (JJBM) Vol. 7 No. 1: March 2026
Publisher : Department of Mathematics, Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjbm.v7i1.18

Abstract

Diabetes mellitus remains a major global health challenge, necessitating the development of more effective therapeutic agents. The PPAR family plays a crucial role in regulating glucose and lipid metabolism, making it an important target for antidiabetic drug discovery. However, the identification of potent PPAR-targeting compounds is often limited by the high cost and time-consuming nature of experimental approaches. This study aims to develop a non-linear function approximation model to predict docking-derived binding affinity of antidiabetic compounds targeting PPAR using 2D molecular descriptors. A dataset of 3,764 small molecules with IC50 values was curated from the ChEMBL database, followed by data preprocessing to remove duplicates and incomplete entries. Molecular docking simulations were performed using AutoDock Vina to obtain binding affinity scores (kcal/mol), which were used as the target variable. Subsequently, 2D molecular descriptors were calculated from SMILES representations to capture key structural and physicochemical properties of the compounds. These descriptors were used as input features for a Multi-Layer Perceptron (MLP) regression model to approximate the complex non-linear relationship between molecular structure and binding affinity. The model achieved R² values of 0.853 for the training set and 0.632 for the test set, indicating moderate predictive performance and acceptable generalizability. Overall, this approach demonstrates the potential of machine learning as a cost-effective and scalable tool to support early-stage discovery of antidiabetic compounds targeting the PPAR family.
Sosialisasi Konsep 5T Dalam Swamedikasi Sebagai Strategi Peningkatan Literasi Penggunaan Obat Pada Masyarakat Desa Bua, Kabupaten Gorontalo Madania Madania; Nur Rasdianah; Hamsidar Hasan; Faradila Ratu Cindana Moo
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 5, No 2 (2026)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v5i2.36654

Abstract

Swamedikasi merupakan praktik kesehatan yang umum dilakukan masyarakat untuk menangani keluhan ringan secara mandiri, namun praktik ini sering disertai risiko penggunaan obat yang tidak tepat akibat rendahnya literasi obat, keterbatasan pemahaman terhadap aturan pakai, dan kurangnya kewaspadaan terhadap efek samping. Kondisi tersebut dapat berdampak pada kegagalan terapi, munculnya reaksi obat yang merugikan, serta keterlambatan rujukan ke fasilitas kesehatan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pemahaman masyarakat mengenai penggunaan obat yang aman dan bertanggung jawab melalui sosialisasi konsep 5T dalam swamedikasi, meliputi Tahu Obatnya, Tahu Dosisnya, Tahu Aturannya, Tahu Efeknya, dan Tahu Waktunya. Metode pelaksanaan dilakukan melalui edukasi partisipatif di Desa Bua, Kecamatan Batudaa, Kabupaten Gorontalo, dengan melibatkan 30 peserta, berupa ceramah interaktif, diskusi, dan simulasi membaca informasi pada kemasan obat selama ±1 jam, serta penguatan pesan melalui leaflet dan poster. Evaluasi dilakukan melalui sesi tanya jawab pada akhir kegiatan untuk menilai pemahaman peserta serta mengidentifikasi isu praktis swamedikasi yang muncul.. Hasil kegiatan menunjukkan bahwa masyarakat memberikan respons positif dan terlibat aktif dalam diskusi, terutama terkait pemilihan obat untuk keluhan umum, batasan penggunaan obat bebas dan obat bebas terbatas, serta pengenalan risiko efek samping dan tanda bahaya yang memerlukan pemeriksaan tenaga kesehatan. Sosialisasi konsep 5T dinilai aplikatif dan mudah dipahami karena menyederhanakan prinsip penggunaan obat rasional ke dalam kerangka praktis yang relevan dengan kehidupan masyarakat. Dengan demikian, edukasi 5T berpotensi menjadi strategi efektif untuk memperkuat literasi penggunaan obat dan mendorong praktik swamedikasi yang lebih rasional pada komunitas pedesaan.
Co-Authors A. Mu'thi Andy Suryadi A.Mu'thi Andy Suryadi Abdul Rahman A. Djakaria Abdulrahman Daud Aiyi Asnawi Annisa Sabunge Arfan Ariani H. Hutuba Ariani Hutuba Cindy Puspita Sari Dewa Ayu Puspita Dizky Papeo Ekawaty Prasetya Endah Nurrohwinta Djuwarno Faradila Ratu Cindana Fika Nuzul Ramadani Fika Nuzul Ramadhani Grasela Mbae Hasrita Samudi Hiola, Faramita Ishak Isa La Ode Aman Madania, Madania Mahdalena Sy Pakaya Moh. Arya Avrilio Isa Mohamad Mustapa Mohamad Reski Manno Muhammad Taupik Multiani S Latif Ni Luh Widiastuti Nur Ain Thomas Nur Rasdianah Nur Rasdianah Papeo, Dizky Ramadani Putri Reski Manno Riduansyah Buchari Rifka Anggraini Anggai Rifka Anggraini Anggai Robert Tungadi Salyatulwalidaini Putri Hakim Sri Budiarti Utami sri Syamsul Bahri Teti Tuloli Widy Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Wiwit Zuriati Uno Yuszda K Salimi Zulfianto Djufri