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All Journal AL KAUNIYAH e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Kesehatan Masyarakat STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UNDIKMA International Journal of Islamic and Complementary Medicine Journal of Agropharmacy

Lina Winarti

Bagian Farmasetika Program Studi Farmasi Universitas Jember

Author-ID : 418315

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Optimasi Hydroxypropyl Methylcellulose dan Chitosan pada Tablet Floating-Mucoadhesive Diltiazem Hidroklorida Menggunakan Desain Faktorial Irsalina Triastutik; Lusia Oktora Ruma Kumala Sari; Lina Winarti
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.11419

Diltiazem HCl is one of the drugs used for hypertension treatment. It requires frequent dosing, which is why diltiazem HCl needs to be formulated into preparations using a controlled release drug delivery system. The combination of floating and the mucoadhesive system is expected to increase the stomach's retention of the dosage form. This study aimed to determine the optimum composition of hydroxypropyl methylcellulose (HPMC K100M) and chitosan for floating mucoadhesive diltiazem HCl tablet. Tablets that have been prepared were evaluated for the tablet's physical characterization, powder flowability test, dissolution test, floating ability, and mucoadhesive test. Tablets were optimized using a factorial design, and the data were analyzed using design expert 11.0.0. The results showed that the optimum formula for polymer combination in diltiazem HCl tablet was 175 mg for HPMC K100M and 50 mg for chitosan. The combination of polymers with this amount can produce a floating lag time of 45,333 seconds, floating duration time >12 hours, and the strength of mucoadhesive is 81,633 grams.

Preparasi dan Karakterisasi Nanopartikel Kitosan-Naringenin dengan Variasi Rasio Massa Kitosan-Natrium Tripolifosfat (Preparation and Caracterization of Naringenin-Chitosan Nanoparticles with Various Mass Ratio of Chitosan-Sodium Tripolyphosphat) Helmi Nur Laili; Lina Winarti; Lusia Oktora Ruma Kumala Sari
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Naringenin has a wide pharmacological activities. Low bioavailability of naringenin caused the under-developed utilization. Preparation of naringenin nanoparticles can improve the bioavailability. Chitosan as polymer for nanoparticles has ideal properties such as nontoxic, biocompatible, biodegradable. Sodium tripolyphosphat (NaTPP) used as an crosslinker to form nanoparticles by ionic gelation method. The aim of this research is to know the optimum formula of chitosan and NaTPP in naringenin-chitosan nanoparticles based on entrapment efficiency (EE) using factorial design. In this research, naringenin-chitosan nanoparticles were prepared with various mass ratio, 6:1, 10:1, 3:1, 5:1 and then EE each formulas measured by UV spectrophotometer. The optimum formula of naringenin-chitosan nanoparticles were characterized by PSA, TEM, and FTIR. The optimum formula (3:1) showed EE >42.12%. The consentration of chitosan and NaTPP to get final optimum formula were 0.06-0.0606777% for chitosan and 0.0970833-0.1% for NaTPP. The result of characterizations showed that size of naringenin-chitosan nanoparticles 13.2 ± 2.6 nm, PDI 0.443, zeta potensial 15.23 mV, complex chitosan-TPP formed. The results demostrated naringenin nanoparticles have successfully prepared. Keywords: naringenin, nanoparticle, chitosan, sodium tripolyphosphat

UJI EFEK ANALGETIKA EKSTRAK RIMPANG TEMU KUNCI (Boesenbergia pandurata (Roxb.) Schlechter PADA MENCIT JANTAN GALUR SWISS Lina Winarti; Wantiyah Wantiyah
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

This research is conducted to evaluate analgetics effect of Boesenbergia pandurata (Roxb.) Schlechter extract using Witkin et al method. This method is conducted to see the elimination effect of pain after the administration of acetate acid by intraperitoneal injection to swiss furrow male mice. Pain effect by the administration of acetate acid causing stomach wall contraction, till the head and feet pulled rear and abdomen touch the cage room base. This symptom is named by writhing reflex and this symptom can be eliminated with an analgesic. Analysis was done by comparing the amount of writhe that happened after the giving of Boesenbergia pandurata (Roxb.) Schlechter extract with acetosal as positive comparator and aquadest as negative control. Writhing effect calculated during 30 minute after the administration of acetate acid by intraperitoneal injection. Boesenbergia pandurata (Roxb.) Schlechter extract between dose 15; 30 and 60 mg / kgBW have significant difference ( P<0.05). In the dose-effect relation it can be seen that more higher the dose give more higher effect. The amount of writhing in Boesenbergia pandurata (Roxb.) Schlechter extract dose 30 mg / kgBW not significantly differ with Acetosal, while Boesenbergia pandurata (Roxb.) Schlechter extract dose 15 mg / kgBW and 60 mg / kgBW have significant difference with Acetosal. Boesenbergia pandurata (Roxb.) Schlechter extract dose 15 mg / kgBB showing the amount of writhing larger than Acetosal and Boesenbergia pandurata (Roxb.) Schlechter extract dose 60 mg / kgBB has amount of writhing fewer than Acetosal. From the calculation of protection percentage administration significant difference between group. Boesenbergia pandurata (Roxb.) Schlechter extract dose 30 mg / kgBW and 60 mg / kgBW do not show significant difference with Acetosal. While from effectiveness percentage analysis also showing significant difference between group except Boesenbergia pandurata (Roxb.) Schlechter extract dose 30 mg / kgBW with Acetosal 130 mg / kgBW. So from overall of analysis resulting that analgetics activity of Boesenbergia pandurata (Roxb.) Schlechter extract start from dose 30 mg / kgBW have effective effect to reduce the pain induced with acetatic acid which equivalent with Acetosal as positive control. More great the dose give higher activity. From this research the dose of Boesenbergia pandurata (Roxb.) Schlechter extract 60 mg / kgBW have analgetics activity stronger than Acetosal

UJI ANTIINFLAMASI EKSTRAK METANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav ) PADA TIKUS PUTIH Atik Fitriyani; Lina Winarti; Siti Muslichah; Nuri Nuri
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Inflammation is a natural respon for tissue damage. To reduce inflammation, people used a NSAID (Non Steroid Antiinflammatory Drugs). This agent caused many side effects. One of medicinal plant empirically used for traditional medicine is Piper Crocatum Ruiz & Pav. This plant is potential to be developed as medicine for anti-inflammatory because its contains flavonoid, saponin, tannin, and alkaloid. The aim of this study was to investigate the anti-inflammatory effect of the P.Crocatum extract using carrageenan-induced rat oedema test. For the anti-inflammatory activity measurement, five different groups were established and piper extract was administered in three different doses : 25, 50 and 100 mg/kgBW. Acetosal was used as a reference agent. It was found that reduction in the flammation was 77.58% for acetosal, 72.37% for 25 mg/kg extract, 85.60% for 50mg/kg, and 81.02% mg/kg for 100mg/kg extract. Extract of P. Crocatum at 50 mg/kg showed the strongest anti-inflammatory activity among the doses used. The results showed that P. Crocatum extract posseses promising anti-inflammatory effect.

Radical Scavenging Activity and Acute Toxicity of Bitter Melon (Momordica Charantia L.) Seed Oil Lina Winarti; Lusia Oktora Ruma Kumalasari; Evi Umayah Ulfa
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.52743

Bitter Gourd or bitter melon (Momordica Charantia L.) is a common type of vegetable and safe for daily consumption. The seeds are part of bitter gourd that useless. Research on bitter melon seed oil has promising commercial applications. This study aims to determine the antioxidant potential and safety of bitter melon seed oil through acute toxicity study. The content of phenols, flavonoids, and antioxidant activity was analyzed. The antioxidant activity was evaluated using the DPPH method. Antioxidant activity is expressed as an IC-50 value. The results showed that the phenol content of bitter melon seed oil was 0.0118 ±0.0006%, the flavonoid content was 0.0127±0.0004%. From the antioxidant activity study, the IC-50 of vitamin C was 2.41 μg / ml, while an IC-50 of bitter melon seed oil was 11.31 ± 0.77 mg/ml. The results of this antioxidant activity study showed very weak activity. The results of the acute-toxicity study show LD-50 cannot be determined precisely because up to the highest dose of 100 ml/kg does not cause death even though it causes toxic symptoms such as diarrhea. Overall, test results indicate that bitter melon seed oil is a compound that is categorized as practically non-toxic with low antioxidant activity.

PENGARUH KONSUMSI OBAT OLEH IBU HAMIL TERHADAP JANIN YANG DIKANDUNG Lina Winarti; Budipratiwi Wisudyaningsih
Jurnal Ilmu Kesehatan Masyarakat Vol 3 No 2 (2007)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Pregnant woman is possible to expose with disease which need to cure by using drugs. Sometimes a woman suffer from chronic disease should take some medicine, even in pregnant condition. Risk of harm effect happened on consuming drug at pregnant condition depend on type & when the drug given. In first two week, growth of fetus embryo is known by the most critical effect of teratogenic defect because of drug administration. Most critical period of growth of embryo started about 17 day of post impregnation when system organ expanding. It is last until 60 -70 days. Administration of certain drugs on that period can give teratogenic effect. Administration of drug on pregnant woman should be carried with extra attention, because of the possible risk that can occur during a period of pregnancy. If pregnant woman can’t avoid not taking drug therapy, she has to counsel with physician to decide what kind of drug she should take. On the other side, before giving drug therapy physician has to consider about drug safety, dosage, usage duration, type of drug & way the drug should given.

Formulation of nanoparticles from short chain chitosan as gene delivery system and transfection against T47D cell line Lina Winarti; Ronny Martien; Sismindari .
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Recently numerous prototype DNA-based biopharmaceuticals can be used to control disease progression by induction and inhibitin the overexpression of genes. Since there are poor cellular uptake and rapid in vivo degradation of DNA-based therapeutics therefore the use of delivery systems to facilitate cellular internalization and preserve their activity is necessary. Cationic polymers commonly used as carriers to delivery gene because of easy to form complexes and higher stability compared to that lipoplexs. Chitosan, a cationic, are polymer most widely used in gene delivery systems because of the low toxicity, and biocompatible. The aim of this study was to formulate nanoparticles of short chain chitosan-pEGFP-C1 and short chain chitosan/TPP-pEGFP-C1 by coaservation complex method. Stability test of the formula was performed by incubating the nanoparticles complex with DNase I and Artificial Intestinal Fluid. Cytotoxicity and transfection studies were evaluated against T47D cell line. The diameter of Chitosan-pEGFP-C1 and chitosan/TPP-pEGFP-C1 nanoparticles were on the range of 56–282.8 nm. The zeta potential wasdetermined to be +14.03 - +16.6 mV. Stability studies showed that chitosan-pEGFP-C1 and chitosan/TPPpEGFP-C1 nanoparticles were stable, undegradable by DNase I and artificial intestinal fluid. Cytotoxic Assay of Chitosan-pEGFP-C1 and chitosan/TPP-pEGFPC1 nanoparticles (pH 4.0) showed that the viability of cell was > 90% for all formulas. EGFP-C1 plasmid gene delivered by chitosan nanoparticles can be expressed in T47D cell culture. According to these results chitosan and chitosan/TPP nanoparticles had potentially to be used as a non-viral vector system delivery for gene therapy.Key words:Chitosan, Nanoparticles, Plasmid EGFP-C1, Cell culture T47D

Formulation of Insulin Self Nanoemulsifying Drug Delivery System and Its In Vitro-In Vivo Study Lina Winarti; Suwaldi Suwaldi; Ronny Martien; Lukman Hakim
Indonesian Journal of Pharmacy Vol 29 No 3, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Particulate delivery system can be used for improving the efficacy of protein and peptide drug. In addition to a polymer-based particulate delivery system, self-nanoemulsifying drug delivery system (SNEDDS), a lipid-based delivery system, is currently developed for either less water-soluble or soluble drugs. This study aims to design SNEDDS for oral insulin administration and its in vitro-in vivo study. The SNEDDS template was designed using D-optimal mixture design and was analyzed using software Design Expert 7.1.5. The obtained optimum template was loaded with insulin and evaluated for its transmittance percentage, emulsification time, particle size, zeta potential, stability, the amount of insulin in vitro diffused across rat intestine, and insulin serum concentration after oral administration. The study results revealed that the optimum template of SNEDDS formula consisted of 10% (w/w) Miglyol 812N, 65% (w/w) Tween 80, and 25% (w/w) propylene glycol. These optimum template then was loaded with insulin and characterized. SNEDDS insulin has particle size of 12.0±1.7 nm, zeta potential of +0.16mV, transmittance of >90%, and emulsification time of < 60 seconds. The stability study showed that SNEDDS insulin was stable from both precipitation and phase separation. The amount of insulin transported from SNEDDS formula in vitro was 32.45±2.03% and non-SNEDDS formula was 10.44±5.04%. In vivo study of SNEDDS insulin produced a significantly increased Cmax, AUC, and F value than insulin non SNEDDS (p < 0.05). In brief, SNEDDS formulation in this study is a promising approach to increase the effectiveness of oral insulin. Insulin is better given orally in SNEDDS formulation than in non SNEDDS formulation.

Review Artikel: PENGGUNAAN FORMULASI NANOPARTIKEL KITOSAN SEBAGAI SISTEM PENGHANTARAN GEN NON VIRAL UNTUK TERAPI GEN Lina Winarti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 8 No 3 (2011)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Gene therapy is a method to repair damaged or defective genes that responsible for the onset of certain diseases. Now, numerous prototypes of DNA can control the progress of the disease through induction or inhibition of genes, but the bad cellular uptake and the rapid in vivo degradation of DNA-based therapy require the use of delivery system that can facilitate the cellular internalization and keep its activity. Cationic polymers are commonly used as gene carrier because it is easy to form complexes and it has higher stability compared with lipoplexes. Cationic polymer chitosan is the most widely used in gene delivery system because of the low toxicity andbiocompatible. Gene delivery system using viruses shows high transfection result but it has many disadvantages, such as oncogenic effects and immunogenicity. However, cationic polymers, such as chitosan have the potential for complexation of DNA that can be used as a non-viral vector for gene therapy. Chitosan provides a strongelectrostatic interaction with negative charge of DNA to form nanoparticles and effectively protect from nuclease degradation. Those properties make chitosan become a good candidate from non viral gene delivery.

SISTEM PENGHANTARAN OBAT TERTARGET, MACAM, JENIS-JENIS SISTEM PENGHANTARAN, DAN APLIKASINYA Lina Winarti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Development of methods to improve delivery of drugs for treating dangerous disease like cancer and viral infections are very important today. Selectivity in therapy is needed, hence capability to deliver drugs at specific site being studied in order to reduce toxicity and unwanted side effect at non target site. Many drugs delivery from passive targeting to active targeting delivery will be improved to reach that purpose. Because this system is very important for cancer therapy, many cytotoxic agent have been approved by clinical examination. Besides that targeting drug delivery is very useful for neurological diseases such as alzhemier, liver diseases, kidney, lung, and colon diseases.

Co-Authors Ameliana, Lidya Arafika, Whendy Waliya Atik Fitriyani Atik Fitriyani, Atik Barikah, Kuni Zu’aimah Dwi Nurahmanto Eka Deddy Irawan Erlia Narulita Eryani, Mikhania Christiningtyas Evi Umayah Ulfa Evi Umayah Ulfa Febrianti, Riska Ayu Fransiska Maria Christianty Gazzali, Amirah Mohd Hanif, Mohammad Ainul Fakhruddin Helmi Nur Laili Hery Diar Febryanto Irsalina Triastutik Khairunnisa, Icha Kiswara, Nur Hanifah Alim Kuswati Kuswati Ludfillah, Rayyan Zhafir Lukman Hakim Lusia Oktora Ruma Kumala Sari Lusia Oktora Ruma Kumalasari nafisah isnawati Nugroho, Agung Endro Nurahmanto, Dwi Nuri Nuri Nuri Nuri Paramayuda, Farukh Refayani , Ema Prastiwi Rohma, Hilda Khoirunnisa Roja, Talidah Alqibtiyah Ronny Martien Ronny Martien Ronny Martien Ronny Martien Ruma Kumala Sari, Lusia Oktora S Sismindari Sismindari . Sismindari . Siti Muslichah Suwaldi Suwaldi Viddy Agustian Rosyidi Wantiyah Wantiyah Wardhani, Firdha Aprillia Yulian, Ria

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