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All Journal AL KAUNIYAH e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat (IKESMA) STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia Jurnal Pengabdian UNDIKMA Journal of Agropharmacy
Lina Winarti
Bagian Farmasetika Program Studi Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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UJI TERATOGENIK CAMPURAN SERBUK BIJI JINTEN HITAM (Nigella sativa L.), BIJI KELABET (Trigonella foenum-graecum L.), DAN GINSENG (Panax ginseng C. A. Mey.) PADA TIKUS PUTIH GALUR WISTAR Fransiska Maria Christianty; Lina Winarti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 9 No 3 (2012)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

One of the empirical effects of black cumin seed or jinten hitam (Nigella sativa L.) is the agent of abortivum. Feenugreek seeds should not be prescribed medicinally for pregnant women since they can induce uterine contraction. The objectives of this study are to know whether the flavour mixture of black cumin seed, fenugreek, and ginseng can cause abnormalities or congenital malformation to the rat foetus and also whether the congenital malformation or birth defect have relationship significantly with the dosage given. The mixing was given orally to pregnant rats on the 7th day until 15th day of pregnancy to observe the sum of foetus, living foetus, fetal death, resorption (foetus biometric) and congenital malformation (gross morphology). The results indicated that there were many effects of the mixture toward rat foetus, such as the decrease of weight and length, increase of resorption and fetal death, but statistically not significant, except weight of foetus. The dosage of 520; 1697,8; 5543,3 mg/kg of body weight didn’t show abnormalities or congenital malformation.
POTENSI PENGGUNAAN KITOSAN RANTAI PENDEK SEBAGAI PEMBAWA DALAM PENGHANTARAN GEN; EVALUASI IN VITRO Lina Winarti; Ronny Martien; S Sismindari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 10 No 2 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Gene therapy involves the introduction of DNA or ribonucleic acid (RNA) into the target cell either to express or suppress the biosynthesis of proteins. The success of gene therapy is highly dependent on a suitable carrier system that can efficiently deliver genes in to specific desired cell with minimum cytotoxicity on target cells. Chitosan is interesting to be used as a gene carrier because it has a high positive charge and low toxicity to cells. Positive charge chitosan can form complexes with the plasmid. DNA complexes provide protection against enzymes degradation and promote internalization of plasmids that have been condensed. In this study the complex formation of chitosan-pEFneo-GFP and chitosan / TPP-pEFneo-GFP is by complex coaservation method. The results of complex analysis with a 0.8% agarose gel electrophoresis for 30 minutes 100Volt showed that the complex was stayed in the well and the plasmids did not migrate like plasmids which were dissolved in the water and buffer solvent. Stability evaluation in storage at room temperature for 14 days showed that the complex with chitosan concentration 0.02%-0.04% were the most stable, so that transfection analysis performed for the complex with chitosan concentration of 0.02%-0.04%. Transfection results showed that chitosan is able to protect plasmid and promote the internalization of plasmid into the nucleus and then expressed as a green luminescence. From these results chitosan potentially be developed as a carrier system in gene delivery.
Use of bitter melon seed oil (Momordica Charantia) to Improve the photoprotective effect of Sunscreen Formulations Winarti, Lina; Refayani , Ema Prastiwi
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.28208

Abstract

Bitter melon seed oil (BMSO) was identified as having potential as an anti-UV radiation agent due to alpha-oleo stearic acid, flavonoids, tannins, polyphenols, and phytosterols, which have the potential as antioxidants. Antioxidants are the main protection for the skin from the dangers of solar radiation, making BMSO a good quality if developed in sunscreen cream. This research aims to determine the effect of adding variations in the concentration of BMSO on the physical characteristics and in vitro photoprotective effectiveness of cream of oxybenzone and octyl methoxycinnamate. Sunscreen creams are made with each BMSO concentration of 0%, 6%, 8%, 10%, and 12%. The result shows that the greater the concentration of BMSO added, the lower the viscosity and pH values, the spreadability and SPF (sun protection factor) values of the cream increase, and the %TP (percentage of transmission pigmentation) and %TE (percentage of transmission erythema) become smaller. The best formula is the formula that contains the highest concentration of BMSO (12%). The characteristics of the best formula are a slightly yellowish, soft cream appearance and a slight smell typical of bitter melon. The spreadability value of the best formula cream is 6.6 ± 0.1 cm, pH of 6.57 ± 0.01, and viscosity of 88.3 ± 4.1 dPa.s, SPF value of 24.27 ± 0.28, %TE of 0.931 ±0.084, and %TP of 0.981±0.0001. These results show that BMSO has the potential to be an active ingredient in sunscreen to reduce the negative effects of using synthetic sunscreen, such as allergenic and irritant.
Optimization study on palm fat base (HAMIN®) and purified water proportion in diphenhydramine hydrochloride cream formulation Winarti, Lina; Gazzali, Amirah Mohd; Arafika, Whendy Waliya; Ameliana, Lidya; Ulfa, Evi Umayah; Nurahmanto, Dwi; Paramayuda, Farukh
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30790

Abstract

HAMIN® is a self-emulsifying base composed of a mixture of hydrogenated palm kernel oil and hydrogenated palm kernel stearin. This formulation not only enhances the aesthetic quality of products but also simplifies the manufacturing process, as it eliminates the need for additional emulsifying agents to form a stable cream. Due to these properties, HAMIN® is considered highly suitable for the development of both pharmaceutical and cosmetic formulations. Despite its potential applications, no prior research has investigated the optimal ratio of HAMIN® palm fat base to distilled water distilled waterrequired to achieve desirable physical characteristics and drug release properties in cream formulations. Therefore, this study aims to determine the optimum composition of HAMIN® palm fat base and distilled water for the formulation of diphenhydramine hydrochloride cream. The optimization process was conducted using the simplex lattice design (SLD) method, a statistical approach commonly employed to evaluate and optimize multicomponent formulations. The experimental results demonstrated that increasing the concentration of HAMIN® palm fat base had a dominant effect on enhancing the pH, viscosity, adhesion, and stability of the cream. Conversely, a higher concentration of distilled water significantly improved spreadability, extrudability, and drug release flux. These findings indicate that the selection of base composition plays a crucial role in determining the overall performance of the cream formulation. The optimal formulation, as determined through SLD analysis, consisted of 41.667% HAMIN® palm fat base and 48.333% distilled water, achieving a desirability index of 0.649. This composition represents the most balanced formulation in terms of physical stability and drug release, making it a promising candidate for further pharmaceutical and cosmetic applications.
Penyuluhan Interaktif Tentang Pubertas dan Kesehatan Reproduksi Remaja bagi Siswa SMP Negeri 14 Jember Eryani, Mikhania Christiningtyas; Winarti, Lina; Wardhani, Firdha Aprilia
Jurnal Pengabdian UNDIKMA Vol. 5 No. 4 (2024): November
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v5i4.12879

Abstract

This community service activity aims to increase the knowledge of students of SMP Negeri 14 Jember regarding puberty and reproductive health in order to realize healthy adolescents for Indonesia Emas 2045. The method used in this activity is the interactive counseling method. The evaluation instrument for this community service is a questionnaire and is analyzed descriptively qualitatively and quantitatively. The results of the community service show that there is an increase in student knowledge which initially had a score of 41.4 before the counseling to 84.1 after the counseling. So that the increase in participant scores after the community service process was carried out was 42.7 or 103%. Through this community service activity, adolescents at SMP Negeri 14 Jember increased their knowledge, especially regarding puberty and reproductive health.
Optimasi Gliserin dan Propilen Glikol dalam Sediaan Antioksidan Essence Ekstrak Kayu Secang (Caesalpinia sappan L.) Ameliana, Lidya; Winarti, Lina; Roja, Talidah Alqibtiyah
Journal of Agropharmacy Vol. 1 No. 2 (2024)
Publisher : Faculty of Pharmacy, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/joa.v1i2.1320

Abstract

Facial skin problems are often caused by skin frequently exposed to free radicals, causing damage to skin cells. Usually, skin damage is characterized by a non-smooth skin structure, the appearance of dark spots, wrinkled skin, and dull skin. Antioxidants are one of the compounds that can protect cells from the influence of free radicals and slow down or prevent the oxidation process. To help reduce, stop, and slow down the adverse effects of free radical exposure, antioxidant essence preparations are used. In this study, glycerin and propylene glycol have been optimized in the preparation of sappan wood extract essence as an antioxidant. The purpose of this study is to determine the optimum concentration of glycerin and propylene glycol as a humectant in the essence preparation of sappan wood extract. In this study, the evaluation carried out includes pH tests, viscosity, and IC 50 antioxidant activity. In this study, essence characterization tests were also carried out including organoleptics, homogeneity, and dispersibility. From the results of the pH test, it was found that all essence formulas had a pH in the range of 5.5-6.0; viscosity in the range of 1.0-2.0 dPa.s; and IC50 test of antioxidant activity in the range of 100-125 μg/mL. The optimum essence formula has a propylene glycol concentration of 10% with a desirability of 0.871, with a predicted pH value of 5.658, a viscosity value of 1.256 dPa.s, and an IC50 value of 106.473 (μg/mL).
Optimasi Moringa Gum dan Hidroksi Propil Metil Selulosa dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida Sari, Lusia Oktora Ruma Kumala; Hanif, Mohammad Ainul Fakhruddin; Irawan, Eka Deddy; Winarti, Lina; Barikah, Kuni Zu’aimah; Rosyidi, Viddy Agustian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Moringa gum is a natural polymer obtained from Moringa oleifera plant and has been used as a stabilizer, binder, disintegrant, and controlled release matrix. Moringa gum has a polyuronide group, which can potentially be a mucoadhesive agent. This study used moringa gum as a mucoadhesive agent in diltiazem HCl mucoadhesive buccal film. This research aimed to determine the effect of the combination of moringa gum and HPMC on surface pH, swelling index, and in-vitro mucoadhesive residence time. Mucoadhesive buccal films were evaluated for weight and thickness uniformity, folding resistance, drug content, surface pH, swelling index, in-vitro mucoadhesive residence time, and characterization in the form of FTIR and release studies. All formulations met the tests of uniformity of weight and thickness, folding resistance, and drug content. The results showed FB as the optimum formula with a surface pH of 5.803±0.101, a swelling index of 7.031±0.134, and a residence time of 505.67±4.51 minutes. FTIR showed no interaction, and the release study showed 82.197±1.178% release at 480 minutes. In conclusion, a combination of moringa gum and HPMC mucoadhesive buccal film has been successfully prepared with moringa gum as a mucoadhesive agent that increases the residence time.
Bacteriophage-Based Wound Care Formulation for Diabetic Ulcers as A Growth Inhibitor of Alcaligenes faecalis Kiswara, Nur Hanifah Alim; Ludfillah, Rayyan Zhafir; Febrianti, Riska Ayu; Narulita, Erlia; Winarti, Lina
Al-Kauniyah: Jurnal Biologi Vol. 19 No. 1 (2026): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v19i1.44082

Abstract

Diabetic ulcers are frequently complicated by infections from multidrug-resistant bacteria such as Alcaligenes faecalis, necessitating the development of alternative therapeutic strategies. Bacteriophage therapy presents a promising approach due to its specificity and efficacy against antibiotic-resistant pathogens. This study aimed to formulate and evaluate a bacteriophage-based topical cleanser using the phage ϕAFaV1 for treating A. faecalis infections, focusing on high antibacterial efficacy and low dermal toxicity. Three suspension formulas (F1, F2, F3) were prepared with varying chitosan concentrations (0.5; 0.75, and 1.0%) as a suspending agent. These formulations underwent physical stability testing over 28 days, including assessments of viscosity, pH, zeta potential, and homogeneity. Antibacterial efficacy was determined through inhibition zone assays. All three formulations effectively inhibited bacterial growth, forming clear zones. The F2 formula (0.75% chitosan), containing 200 µL of active phage ingredient, was identified as the optimum formulation. It demonstrated superior physical stability and the most effective bactericidal activity against A. faecalis, as confirmed by statistical analysis. These results indicate that a bacteriophage suspension stabilized with 0.75% chitosan is a highly promising and stable topical agent for combating multidrug-resistant A. faecalis in diabetic wound care.
Optimization of Hydrolyzed Pumpkin (Cucurbita Moschata) Starch as Natural Superdisintegrant in Promethazine HCl Sublingual Tablets Winarti, Lina; Asrofi, Muhammad; Lubis, Maralodia Almira; Lestari, Tirtawati Putri; Sari, Lusia Oktora Ruma Kumala; Irawan, Eka Deddy; Febryanto, Hery Diar; Afthoni, Muhammad Hilmi; Eryani, Mikhania Christiningtyas
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.502-514

Abstract

Acid hydrolysis of pumpkin starch is a feasible strategy for developing novel pharmaceutical excipients, particularly natural superdisintegrants for sublingual and orally disintegrating tablet formulations. Given the requirement for extremely rapid tablet disintegration in sublingual dosage forms, selecting an efficient disintegrant is a critical formulation parameter. However, native pumpkin starch exhibits limited disintegration efficiency and generally requires high concentrations, which may adversely affect tablet hardness and friability. This study aimed to optimize the acid hydrolysis process of pumpkin starch and to evaluate the performance of the optimized hydrolyzed starch as a natural superdisintegrant in Promethazine HCl sublingual tablets. A factorial design was used to examine the impact of varying hydrolysis durations (3-9 days) and hydrochloric acid concentration (5-9%) on the physicochemical characteristics of the modified starch. The optimized hydrolyzed starch demonstrated a near-neutral pH (5.17 ± 0.03), acceptable moisture content (LOD 10.20 ± 0.44%), and excellent flow properties, as indicated by a low angle of repose (23.96°) and Carr’s index (9.99%). Scanning electron microscopy revealed increased surface irregularity and porosity, while FTIR analysis indicated enhanced exposure of hydroxyl groups, consistent with partial depolymerization of the starch polymer. The amylose content increased to 35.17%, accompanied by improved water uptake and swelling capacity. The effective pore radius (25.03 ± 0.35 µm) and swelling index (70.25 ± 0.57) were markedly higher than those of native pumpkin starch (12.27 µm and 44.30 ± 0.85, respectively), although slightly lower than crospovidone (27.65 µm and 99.97 ± 0.13). Incorporation of the hydrolyzed starch into Promethazine HCl sublingual tablets resulted in formulations with adequate mechanical strength (hardness 3.35 ± 0.05 kg), low friability (0.53 ± 0.04%), rapid disintegration (49.18 ± 0.75 s), and high drug release (96.79 ± 0.13%). These performances were comparable to those of crospovidone and superior to formulations containing native pumpkin starch. The improved tablet characteristics were primarily attributed to enhanced porosity and swelling capacity induced by acid hydrolysis. Overall, optimized hydrolyzed pumpkin starch demonstrates considerable potential as a sustainable, biodegradable, and cost-effective natural superdisintegrant for fast-disintegrating pharmaceutical tablet formulations.
Co-Authors Ameliana, Lidya Arafika, Whendy Waliya Atik Fitriyani Atik Fitriyani, Atik Barikah, Kuni Zu’aimah Dwi Nurahmanto Eka Deddy Irawan Erlia Narulita Eryani, Mikhania Christiningtyas Evi Umayah Ulfa Evi Umayah Ulfa Fransiska Maria Christianty Gazzali, Amirah Mohd Hanif, Mohammad Ainul Fakhruddin Helmi Nur Laili Hery Diar Febryanto Irsalina Triastutik Kiswara, Nur Hanifah Alim Lestari, Tirtawati Putri Lubis, Maralodia Almira Ludfillah, Rayyan Zhafir Lukman Hakim Lusia Oktora Ruma Kumala Sari Lusia Oktora Ruma Kumalasari Muhammad Asrofi, Muhammad Nugroho, Agung Endro Nurahmanto, Dwi Nuri Nuri Nuri Nuri Paramayuda, Farukh Refayani , Ema Prastiwi Riska Ayu Febrianti Roja, Talidah Alqibtiyah Ronny Martien Ronny Martien Ronny Martien Ronny Martien Ruma Kumala Sari, Lusia Oktora S Sismindari Sismindari . Sismindari . Siti Muslichah Suwaldi Suwaldi Viddy Agustian Rosyidi Wantiyah Wantiyah Wardhani, Firdha Aprillia