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All Journal Althea Medical Journal Journal of Dentistry Indonesia Jurnal Administrasi Kesehatan Indonesia Global Medical and Health Communication JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Dental Journal (Majalah Kedokteran Gigi) Jurnal Sistem Kesehatan Padjadjaran Journal of Dentistry Narra J Jurnal Penyakit Dalam Indonesia
Rudi Wisaksana
Department Of Internal Medicine, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Prevalence of major INSTI and HIV-1 drug resistance mutations in pre- and antiretroviral-treated patients in Indonesia Djojosugito, Fauzia A.; Arfianti, Arfianti; Wisaksana, Rudi; Siregar, Fajri M.; Nasronudin, Nasronudin; Rachman, Brian E.; Khairunisa, Siti Q.; Indrati, Agnes R.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1022

Abstract

Indonesia has one of the highest HIV infection rates in Southeast Asia. The use of dolutegravir, an integrase strand transfer inhibitor (INSTI), as a first-line treatment underscores the need for detailed data on INSTI drug resistance mutations (DRMs). Currently, there is a lack of comprehensive data on DRMs INSTI and other HIV drug resistance in Indonesian patients, both pre- and post-treatment. The aim of this study was to identify the subtypes and drug resistance mutations of the protease, reverse transcriptase, and integrase genes in both treatment-naive and ARV-treated patients in Bandung, West Java, Indonesia. A cross-sectional study was conducted involving HIV-positive patients at Hasan Sadikin Hospital, Bandung, Indonesia, from September 2022 to January 2023. The patients were categorized into two groups: ARV-treated and pre-treatment patients. Peripheral blood mononuclear cells (PBMCs) were processed for DNA extraction, followed by amplification and sequencing of the pol gene to detect mutations and subtypes. The study found that the predominant subtype was CRF01_AE, accounting for 85.4% and 69% of pre-treatment and treated patients, respectively, followed by recombinant forms such as A1/CRF01_AE, CRF01_AE/CRF02_AG, subtype B, and other subtypes. Among ARV-treated/INSTI-naive patients, major INSTI DRMs R263K and Y143H were identified, while pre-treatment patients exhibited accessory integrase DRMs. The most common DRMs detected were non-nucleoside reverse transcriptase inhibitor (NNRTI) DRMs, with prevalences of 14.6% and 7% in pre-treatment and ARV-treated patients, respectively. In conclusion, CRF01_AE emerged as the predominant subtype in both pre-treatment and ARV-treated patients in Bandung, underscoring the necessity for ongoing surveillance of integrase DRMs, particularly given the presence of major INSTI DRMs in patients undergoing INSTI treatment.
Oral manifestations of anemia in HIV/AIDS patients without ARV treatment Hidayat, Wahyu; Dewi, Tenny Setiani; Wisaksana, Rudi
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.792 KB) | DOI: 10.24198/pjd.vol29no1.11752

Abstract

AbstractIntroduction: Acquired immunodeficiency syndrome (AIDS) is  a set of symptoms caused by decreases of the immune system that was infected by human immunodeficiency virus (HIV). Blood disorders often found in patient with HIV and associated with HIV infection. Mostly found disorders is anemia of chronic disease. The prevalence of anemia in HIV/AIDS patients reaches 70%. Oral manifestations of anemia are atrophy of the papillae on tongue, glossodynia, pallor, angular cheilitis, glossitis, aphthous ulcers/erosive lesions, candidiasis, and geographic tongue. There are many publications that uses anemia as indicator to determine the prognosis of HIV infection, thus the description of oral manifestation of anemia in the non-ARV HIV/AIDS patients is a necessity. The purpose of this study was to describe the oral manifestation of anemia in the non-ARV HIV/AIDS patients. Methods: The methods used were purposive random sampling. Samples were new HIV/AIDS patients who have not got antiretroviral (ARV) treatment. The study included 40 patients in Teratai Clinic Hasan Sadikin Hospital Bandung. Results: Oral manifestations of anemia were found amongst non-ARV HIV/AIDS patients, which were candidiasis in  37 patients, glossodynia in 28 patients, glossitis in 10 patients, and angular cheilitis in 1 patient. Conclusion: From the study found that oral manifestations of anemia that found in non-ARV HIV/AIDS patients were candidiasis, glossodynia, glossitis and angular cheilitis. HIV/AIDS patients with anemia needed to treat more intensive for better prognosis and quality of life.Keywords: Anemia, HIV/AIDS, Candidiasis, Glossitis, Glossodynia
Co-Authors Ade Nea Adiatma Siregar, Adiatma Adiatma YM. Siregar, Adiatma YM. Agnes R Indrati, Agnes R Agnes R. Indrati Agnes Rengga Rendati Agung Firmansyah Sumantri Agustinawaty, Hervina Alessandro, Ariella Ali Djumhana Amalia, Riezki Andreas Jonathan Arfianti Arfianti Bachti Alisjabana, Bachti Bony Wiem Lestari Bony Wiem Lestari, Bony Wiem Dewi Puspasari Dewi Puspasari Dewi, Intan Mauli Warma Djojosugito, Fauzia A. Dolvy Girawan Donny Hardiawan Enny Rohmawaty Fauziah, Nisa Guntur Darmawan Handayani, Miasari Hervina Agustinawaty Hestia Nur Annisa Ida Parwati Igor van Laere Igor van Laere, Igor van Imam Megantara Indrati, Agnes R. Inriyana, Ria Insi Farisa Desy Arya Irna Sufiawati Isabellina Dwades Tampubolon Ivana Agnes Sulianto Ivana Agnes Sulianto, Ivana Agnes Juniati, Rianita Juwita, Mery Nurma Khairunisa, Siti Q. Kusman Ibrahim Munthe, Eliza Kristina M Nasronudin Nasronudin Nataprawira, Heda M Nenny Agustanti Nita Arisanti Noormartany Pande Putu Januraga Pipit Pitriyan Prawinegara, Rozar Prayudi Santoso Rachman, Brian E. Rachmat Sumantri Rachmat Sumantri Revi Nelonda Riezki Amalia Rovina Ruslami, Rovina Rudolf Andean S. Suniti Shifa Nadya Rahma Siregar, Fajri M. Soeroto, Arto Y Sulaiman, Nurjannah Teddy Hidayat Teddy Hidayat Tenny Setiani Dewi Wahyu Hidayat Yovita Hartantri