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All Journal Jurnal Keperawatan Indonesia Timur (East Indonesian Nursing Journal) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Pengabdian Ilmu Kesehatan Jurnal Rumpun Ilmu Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan Jurnal Katalisator Usada Nusantara: Jurnal Kesehatan Tradisional Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Aulia Debby Pelu
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Agriculture, Biological Sciences & Forestry Chemistry Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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UJI AKTIVITAS ANTIFUNGI EKSTRAK ANGGUR LAUT (Caulerpa sp.) ASAL PULAU GESER KABUPATEN SERAM BAGIAN TIMUR TERHADAP FUNGI Candida albicans Aulia Debby Pelu; Maryam Lihi; Moh. Nurul Iman Wokas
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 2 No. 2 (2022): JULI : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v2i2.1177

Abstract

Sea Grape (Caulerpa sp.) is a group of seaweed which is a macroalgae belonging to the Caulerpaceae family . Sea Grape very potential as a new antifungal drug because it contains secondary metabolites of saponins and flavonoids that can inhibit the growth of the fungus Candida albicans . The purpose of this study was to determine the content of secondary metabolites present in sea grapes and antifungal activity test of sea grapes (Caulerpa sp.) which was extracted using 70% ethanol as a solvent against the fungus Candida albicans. The antifungal activity was tested using the disc diffusion method with several concentrations of 5%, 10%, 25%, 50%, 85, 130%, 185%, and 250%, ketoconazole as a positive control and aquadest as a negative control. The results showed that the extraction of sea grapes contains secondary metabolites, namely: Saponins, Flavonoids, Tannins and Steroids capable of inhibiting the growth of the fungus Candida albicans, at a concentration of 25% with an inhibition zone diameter of 12.5 mm, 50% diameter of the inhibition zone 14.5 mm, 130% the diameter of the inhibition zone is 17.5 mm, 185% the diameter of the inhibition zone is 19 mm and 250% with the diameter of the inhibition zone is 22mm. The test results showed that the effective and very strong concentration of inhibiting the growth of Candida albicans was at a concentration of 250% with an inhibition zone of 22 mm.
Α-GLUCOSIDASE ENZYME INHIBITOR ACTIVITY OF ETLINGERA ELATIOR LEAF EXTRACT WITH SOLVENT VARIATION Imrawati Imrawati; Yuri Pratiwi Utami; Yuniar Dwi Yanti; Tuti Handayani; Nurzadrina wahyuddin; Zahira Amody; Aulia Debby Pelu; Rahmah Mustarin; Indri Indri
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3462

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin production or utilization. The increasing prevalence of diabetes, especially type 2, is a global concern due to the risk of complications it poses. One approach in treating type 2 diabetes is to inhibit the α-glucosidase enzyme to slow down glucose absorption. This research aims to identify the potential of patikala leaf extract as an α-glucosidase enzyme inhibitor. Using an experimental method with patikala leaf samples collected from Mariri Hamlet, Banyuurip Village, Bone-bone District, North Luwu Regency. Extraction was performed using the maceration method with variations in solvents: 70% ethanol, ethyl acetate, and n-hexane. The α-glucosidase enzyme inhibition activity was measured using a microplate reader and analyzed to determine the IC50 value. From the percentage inhibition data, the IC50 values obtained for 30% ethanol extract of patikala leaves were 351.95 µg/mL, for 70% ethanol extract of patikala leaves were 444.83 µg/mL, for 96% ethanol extract of patikala leaves were 362.27 µg/mL, for ethyl acetate extract of patikala leaves were 163.59 µg/mL, and for n-hexane extract of patikala leaves were 294.90 µg/mL, indicating that patikala leaf extracts with variations in solvent or extraction method exhibited very weak α-glucosidase enzyme inhibition activity. In conclusion, based on the research results obtained, the extract with variations in the solvent or extractant. Patikala leaf extract has an inhibitory activity against the α-glucosidase enzyme, which is categorized as very weak because it has an IC50 value > 100 µg/mL. In comparison, the control (acarbose) is in the weak category with an IC50 value of 50-100 µg/mL.
Co-Authors Astin Buton Astuti Tuharea Cut Bidara Panita Umar Hikmawati Hikmawati Imrawati Imrawati Indri Indri Irma Yanty Larajasi Jayanti Djarami Marasabessy, Nur Baharia Maryam Lihi Moh. Nurul Iman Wokas Muhammad Azril Hardiman Mahulauw Nadhira Fahreza Patimahu Nur Hardianti.Walalayo Nurzadrina Wahyuddin Nur’in Aihena Pia Batmomolin Rahmah Mustarin Rokia Latuamury Sahril Sillehu Sultina Syari Tunny, Risman Tuti Handayani Yuni Widiastuti Hayoto Yuniar Dwi Yanti Yuri Pratiwi Utami Zahira Amody