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All Journal Jurnal Kartika Kimia Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Riset Inossa : Media Hasil Riset Pemerintahan, Ekonomi dan Sumber Daya Alam Jurnal Sains dan Kesehatan

Wisnu Cahyo Prabowo

Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295380

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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Pola Pengobatan Pada Pasien Infark Miokard Akut Di Rumah Sakit Abdul Wahab Sjahranie Samarinda Desta Winanda; Wisnu Cahyo Prabowo; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Acute myocardial infarction is a major health problem that needs special attention because of the mortality prevalence and costs is quite high. Generally caused by plaque rupture and thrombus of coronary arteries so that the oxygen-containing blood supply is reduced to the myocardium. The purpose of this study was to determine the characteristics of acute myocardial infarction patients and acutemiokardial infarction drug use pattern at Abdul Wahab Sjahranie Hospital, Samarinda City in the January-December 2018 period. This study was a non-experimental study with a retrospective method and analyzed descriptively. Sampling using a purposive sampling method. The results of the most characteristic study were obtained in patients with acute myocardial infarction in men, namely 7,4%, age characteristics 46-55 years 37,1%, private work 48,6%, and high school education 47,1%. The most treatment pattern used in STEMI patients out of 32 patients was Nitrate + DAPT + Anticoagulant + ACE-I + Statin for 6 patients (18.7%) and the most treatment pattern used in NSTEMI patients out of 38 patients was Nitrate + DAPT + Anticoagulant + ß-Blocker + Statins in 7 patients (18.4%). The use of most drugs ISDN (antiangina) as much as 90%, morphine and petidine (potency analgesic) 8.6%, aspirin (antiplatelet) 84.3%, fondaparinuks (anticoagulants) 68.6% and streptokinase (fibrinolytic agents) 5.7% . To prevent reinfarction the most used drug is bisoprolol (ß-Blocker) 28.6%. The most commonly used left ventricular damage inhibitor candesartan (ARB) is 22.8%. The most given antidislipidemia was simvastatin 47.1%.

Potensi Sari Kurma (Phoenix dactylifera) sebagai Peluruh Kristal Kalsium Oksalat Secara In Vitro Wilujeng Ayu; Wisnu Cahyo Prabowo; Niken Indriyanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Dates (Phoenix dactilyfera) contain chemical compositions that can be used as traditional medicine for Calcium oxalate of kidney stone decay. Compound in palm juice can make Calcium oxalate dissolving is flavonoid and calium . The purpose of this study was to determine the effect of Palm dates juice dissolving calcium oxalate to determine the relationship between the concentration of dates palm juice with calcium solubility in kidney stones. To test its activities carried out in vitro using calcium oxalate which incubated for 3 hours with shaken out every 20 minutes at 37oC Determination of the solubility of calcium in date palm juice is by weighs insoluble calcium oxalate. Palm's juice concentration is divided into 60%, 50%, 40%, 30% and 20%. The results of these concentrations can be concluded that the juice of dates has the activity of dissolving calcium oxalate from kidney stones with average result weight in sequence 0.02 + 0.005 g; 0.02 + 0.005 g; 0.03 + 0.005 g; 0.04 + 0.005 g and 0.05 + 0.005 g. Positive control (batugin elixir) 60%, 50%,40%, 30% and 20% with in sequence result 0.08 + 0.001 g; 0.08 + 0.001 g; 0.08 + 0.005 g; 0.09 + 0.005 g; and 0.1 + 0.005 g. Negative Control result 0.11 g. The results obtained from the standard deviation are 0.031. Calcium oxalate that is not dissolved at most in the sample is 20% with an average of 0.05 + 0.005 g and the positive control is 20% of the batugine with an average of 0.1 + 0.005 g.Based on the weighing of calcium oxalate from each concentration the higher the concentration will cause the least insoluble calcium oxalate.

Terapi Kombinasi Air Perasan Daging Buah Mengkudu (Morinda citrifolia L.) dan Mentimun (Cucumis sativus L.) untuk Menurunkan Tekanan Darah pada Pasien Hipertensi Novia Anggraini; Wisnu Cahyo Prabowo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Noni (Morinda citrifolia L.) and cucumber (Cucumis sativus L.) fruit are plants that have antihypertensive activity. The active ingredient scopoletin, anthosianin, xeronin in noni and high potassium in cucumber can lower blood pressure. This study aims to determine the characteristic description, hedonic quality test and the effect of giving a combination noni and cucumber squeezed water flesh of fruit on reduction in the systolic and diastolic blood pressure of hypertension patients in Muara Jawa District, East Kalimantan. The research method used was quasi experimental and research procedures measuring pre and post test being given treatment for 7 days. The highest percentage of respondents collected data obtained are aged 36-45 years as much as 45%, women70%, junior high school education 45%, family history 60%, frequent exercise habits 55% and normal BMI 45%. The highest percentage of sample hedonic quality test collected data obtained are the flavor test was sweet by 65%, the aroma test was sharp by 75% and the texture test was soft by 75%. The results of statistical tests using the paired sample t-test method showed a significant decrease in systolic blood pressure p = 0.000 < ? (0.05) of 12.3 mmHg and diastolic blood pressure p = 0.000 < ? (0.05) of 5.4 mmHg. Based on the results of the study, it can be concluded that giving a combination noni and cucumber squeezed water flesh of fruit can have reduced effect on systolic and diastolic blood pressure of hypertension patients.

Aktivitas Antibakteri Ekstrak Daun Lintut (Hemigraphis sp) Terhadap Bakteri Eschericia coli, Staphylococcus aureus, Staphylococcus epidermidis, dan Salmonella typhi: Antibacterial Activities of Lintut Leaves (Hemigraphis sp) Extract Against Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Salmonella typhi Bacteria?s Deva Ayudhia Septiani; Wisnu Cahyo Prabowo; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Lintut plants are herbaceous plants that can grow in soft or watery soil. Research on leaf extracts against Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Salmonella typhi has never been done. This study aims to determine the antibacterial activity of leaf extract against Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Salmonella typhi. The research stages began with the manufacture of simplicia, the manufacture of ethanol extract of lintut leaves, the ethanol extract phytochemical screening test, and the antibacterial activity test using the well diffusion method. The study was conducted using 3 groups of concentrations of lintut leaf extract, namely 7%, 9% and 10% with ampicillin 0.1% as a positive control and aquadest as a negative control. The results of the phytochemical screening test showed that the leaf extract positively contained triterpenoids / steroids and tannins. Antibacterial activity using the well diffusion method showed that the extracts of lintut leaves with a concentration of 7%, 9% and 10% were not significantly different. The best concentration in inhibiting the growth of Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Salmonella typhi was at a concentration of 7%. The positive control used, namely ampicillin, produced a larger diameter of the inhibition zone compared to the diameter of the extract inhibition zone.

Optimasi Basis Sabun Padat Transparan Menggunakan Minyak Zaitun dan Pengaruh Konsentrasi Sukrosa Terhadap Transparansi Sabun: Optimization of Transparent Solid Soap Base Using Olive Oil and the Effect of Sucrose Concentration on Soap Transparency Risma Dwi Novianti; Wisnu Cahyo Prabowo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Transparent solid soap has a luxurious, classy, and attractive appearance so it is often sold as a souvenir which is relatively expensive but still has a unique and exclusive appearance. In the process of making transparent soap, sugar (sucrose) functions to form transparency on the soap. Olive oil is one of the potential raw materials for soap making because it has a high content of oleic acid which is good for skin health. This study aims to formulate a transparent solid soap based on raw materials of olive oil and lintut leaf essential oil that meets the characteristics of transparent solid soap and soap quality requirements in accordance with SNI (1994). Sucrose as a transparent agent for soap is concentrated into 14%, 18%, and 22%. Then the base optimization was carried out by varying olive oil and 30% NaOH in three formulations. The results showed that the sucrose concentration was 22% which resulted in the most transparent preparation. Then the evaluation of base optimization shows that all formulas have good characteristics and only formula 2 (18% olive oil and 12% NaOH) fulfills all the soap quality requirements according to SNI (1994).

Kajian In Silico Senyawa Turunan Pirazolina terhadap Bakteri Eschericia coli: In Silico Study of Pyrazoline Derivative Compounds against Eschericia coli Bacteria Tri Wulan Novi; Wisnu Cahyo Prabowo; Fajar Prasetya
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The development of antibiotics is needed to overcome drug resistance. Penicillin binding protein 5 (PBP5) Eschericia coli bacteria is one of the targets because it plays a role in maintaining cell shape. Pyrazolina is a compound that contains two nitrogen atoms where the two nitrogen atoms are close together and are responsible as an antibacterial agent that can disrupt the cell wall. The target molecule was downloaded from the Protein Data Bank (www.rcsb.org) (PDB ID: 6NTZ). The grid used is 20 ? x 26? x 32? with a center of 29,731?, -9,112 ? and 35,821 ?. Based on the results of the docking that has been carried out from 10 pyrazoline derivative test compounds, the resulting binding energy varies. There are 5 pyrazoline derivative compounds having binding energy lower than the natural ligands -6.27 kcal / mol. Compound P8 has the lowest value compared to other test compounds with a binding energy value of -7.69 kcal / mol. Based on the interaction, P2 and P3 compounds have interactions that are similar to the original ligands due to the presence of Pi-Donor hydrogen bonds with the amino acids SER 73 and SER 139. The results of molecular docking studies show that pyrazoline derivatives play a role in Eschericia coli bacteria.

Tingkat Pengetahuan dan Perilaku Swamedikasi pada Mahasiswa Universitas Mulawarman: Knowledge and Behavior of Swamedication in Mulawarman University Students Maria Simanjuntak; Wisnu Cahyo Prabowo; Adam M. Ramadhan
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Self-medication is the process of self-medication by a person without using a prescription from a doctor. Self-medication is one of the many efforts made by the community in overcoming minor illnesses. One of the factors that can influence self-medication behavior is knowledge about self-medication. This study was conducted to determine the level of knowledge and behavior of self-medication in students at Mulawarman University. This type of research is an observational research qualitatively and quantitatively using an online questionnaire. Respondents obtained as many as 929 respondents. The results of the research on the characteristics of respondents obtained the highest percentage of age 21 years (36.7%), class of 2017 (46.8%), and female gender (77.5%). The results showed that 43.4% of respondents had good self-medication knowledge and 60% of respondents had good self-medication behavior. The results of statistical tests using the Spearman Rank method show that there is a significant relationship between the level of knowledge and self-medication behavior. The significance value (p) obtained is 0.000, with a correlation coefficient of 0.270 in the health faculty student group and 0.212 in the non-health faculty student group which shows the close relationship between the two variables is weak.

Optimasi Konsentrasi VCO Terhadap Stabilitas Fisik Facewash dan Uji Antibakteri Ekstrak Daun Kelapa Sawit (Eleais Guineensis Jacq.) pada Bakteri Penyebab Jerawat: Optimization of VCO Concentration on Physical Stability of Facewash and Antibacterial Test of Oil Palm Leaf Extract (Eleais Guineensis Jacq.) on Acne-causing Bacteria Selin Cenora Aritonang; Wisnu Cahyo Prabowo; Angga Cipta Narsa; Riski Sulistiarini; Helmi Helmi
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Palm oil leaves (Elaeis guineensis Jacq.) is a waste from oil palm plantations which contain flavonoid, steroid, and alkaloid compounds that function as an antibacterial that causes acne. The purpose of this research was to identify determine the concentration of ethanolic extract of oil palm leaves which is effective in inhibiting acne-causing bacteria and to determine the best formulation that can produce a facewash base that fulfill the requirements for stability of the preparation according to SNI. Antibacterial test of oil palm leaf extract was using the pitting method against acne-causing bacteria. The results of the antibacterial test showed that the extract concentration of 75% had antibacterial activity against the growth of acne-causing bacteria. The facewash base was obtained by varying the VCO with concentrations of 17.5%, 20%, and 22.5%. The results of the evaluation of the facewash base formula for 28 days, namely F2 (20%) produced good characteristics and stability, namely a distinctive aroma, cream color, semi-solid form, pH 6,25 – 6,37, viscosity 0,904 -2,700 Pa.s, high foam stability. 89% - 100% and good homogeneity. The three base formulas have fulfill requirements for facewash according to SNI.

Penggunaan Soy wax dan Beeswax sebagai Basis Lilin Aromaterapi: Use of Soy wax and Beeswax as Aromatherapy Candle Base Theresia Fenny Oktarina; Wisnu Cahyo Prabowo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The continuous use of paraffin wax produces pollutants that have a negative impact on health and the environment. Soy wax and beeswax candles are environmentally friendly materials because they produce fewer pollutants. This study aims to determine the best formula in the manufacture of aromatherapy candle preparations. This research was conducted using an experimental method. Aromatherapy candles are made by melting soy wax, beeswax, and stearic acid. Apply optimization based on the ratio formula of 75%:25% (F1), 50%:50% (F2), 25%:75% (F3) by evaluating physical properties such as organoleptic, melting point test, and burning time test to get the base The best aromatherapy candles from the use of soy wax and beeswax ingredients with the addition of stearic acid. The results of optimization of soy wax based on an organoleptic test, F1 and F2 have an even color and do not crack, F3 has an uneven color and does not crack. The melting point of wax preparations is 48°C-52°C, burning time 373 minutes-463 minutes. On the basis of the organoleptic test beeswax, F1 and F2 had an even color and did not crack, F3 had an even color and cracks. The melting point of the basic wax is 53°C-54°C, and the burning time is 443 minutes-499 minutes. From the results, it was found that the best formulas, namely F1 and F2, met the standards according to SNI, namely the color was uniform and not cracked and the melting point ranged from 42°C-60°C.

Skrining Fitokimia dan Profil KLT Ekstrak dan Fraksi dari Daun Berenuk (Cresentia cujete L.) serta Uji DPPH: Phytochemical Screening and TLC Profile of Extracts and Fractions from Leaves of Berenuk (Cresentia cujete L.) and DPPH Test Brigita Olivia Intan Kinam; Wisnu Cahyo Prabowo; Supriatno Supriatno; Rolan Rusli
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Berenuk or Maja Leaves (Cresentia cujete L.) is a plant that grows in the tropics. In Indonesia, the use of Berenuk Leaves for health is not utilized optimally, and there is still a lack of research on this plant. To be able to be developed as a traditional medicinal ingredient, it is necessary to know the content of secondary metabolites contained in berenuk leaf extract. This study aims to determine the secondary metabolites contained in berenuk leaf extract through phytochemical screening, TLC profile in C. cujete L. leaves. Extraction was carried out using methanol by maceration. After fractionation were carried out by using n-hexane and ethyl acetate as solvents. Then, a phytochemical analysis was screened and a TLC bioautography. Secondary metabolites by the compounds contained in C. cujete L. are alkaloids, tannins, saponins and steroids. C. cujete L. which has antioxidant activity was marked with yellow spots on TLC plates that had been sprayed with DPPH.

Co-Authors Adam M. Ramadhan Ade Nurlian Aisyah Anasia Apriani Anasda Amal Fathullah Angga Cipta Narsa Arsyik Ibrahim Brigita Olivia Intan Kinam Desta Winanda Deva Ayudhia Septiani Dina Sofia Dita Paramitha Dwi Agustina Dyan Ayu Lestari Fajar Prasetya Farida Anggraeni Hadi Kuncoro Hawa Ode Liya Wati Helmi Helmi Jaka Fadraersada Jenny Thalia Karundeng Josanti Pitri Sagala Kiki Vera Yasmina Laode Rijai Lilis Pania Anugrah M Arifuddin Mahfuzun Bone Maria Simanjuntak Mirhansyah Ardana MUHAMMAD AMIR MASRUHIM Mulia Indah Kusuma Dewi Nia Oktaviani Niken Indriyanti Novalia Debora Novia Anggraini Nurul Annisa Petrina Febrianti Risma Dwi Novianti Risna Agustina Rolan Rusli Selin Cenora Aritonang Sibarani Evy Morita Sulistiarini, Riski Supriatno Salam Synthia Defriana Theresia Fenny Oktarina Tiurliana Octavia Simarmata Tri Wulan Novi Ulfa Wahyu Wahyu Widayat Wilujeng Ayu

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