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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina E-Jurnal Medika Udayana E-Jurnal Udayana Medica WMJ (Warmadewa Medical Journal) JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Indonesian Journal of Obstetrics & Gynecology Science ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Ilmiah Sangkareang Mataram Indonesian Journal of Perinatology Public Health and Preventive Medicine Archive Journal Research of Social Science, Economics, and Management Journal of Global Pharma Technology
I Nyoman Hariyasa Sanjaya
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Udayana University
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Perinatology

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Pregnancy with choriangioma: a placental disorder that causes fetal death I Nyoman Hariyasa Sanjaya; Cokorda Istri Mirayani Pemayun; Ni Komang Anik Pirgantari; Made Diah Vendita Sakuntari; Ni Wayan Dewi Purwanti; NI Putu Nining Gianni; Ni Luh Made Diah Mas Cahyani Putri; Ni Luh Md Dwi Laxmi Satriani; Firsta Sesarina Mintariani; Anak Agung Wahyu Putri Agustini
Indonesian Journal of Perinatology Vol. 3 No. 2 (2022): (Available online: 1 December 2022)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v3i2.26

Abstract

Introduction: Chorioangioma is the most common non-trophoblastic vascular tumor of the placenta. It was estimated that the incidence of chorioangioma was 1%. Although the incidence was not widely large, it has high mortality and morbidity. Commonly, chorioangiomas is a small asymptomatic lesion found only after birth after careful excision of the placenta. In making it easier to visualize the food vessels entering the placental mass and peritumoral diffuse vasculature we could use the color doppler. The wide range of outcomes and limited studies related to this case makes it quite difficult to handle. Thus, this study aimed to provide information on chorioangioma from diagnosis to the management. Case description: Mother A is our referral patient who was recommended to do an ultrasound, with a diagnosis of 20 weeks gestation with suspected IUFD and a cyst in the placenta measuring 6.5cm x 4.1cm x 5.4 cm, the mother has not felt fetal movement. Ultrasound examination revealed a hematoma at the time of insertion of the umbilical cord in the placenta. The location of the placenta in the corpus anterior grade 1. No heartbeat was found in the baby, and the baby's weight was 529 grams. Conclusion: The adverse outcome is known to be associated with chorioangioma. It depends on the mass size, and the existence of fetal hydrops. The worst prognosis that we found in this case was no heartbeat when the baby was born.
Relationship between total 25(OH)D and interleukin-2 contents in preterm conversion patients Sanjaya, I Nyoman Hariyasa; Mulyana, Ryan Saktika; Kamajaya, I Gusti Ngurah Agung Trisnu
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.37

Abstract

The most essential nutrient for pregnant women is vitamin D. A lack of vitamin D can cause preterm labor and other issues like low birth weight, preeclampsia, and issues with the baby's bones. According to some research, there is no safe top level and a 75–80 nmol/L range. According to additional studies, an ideal range is between 75 and 110 nmol/L and a daily dosage of 1800 to 4000 IU of vitamin D3. In both early and late pregnancies, women with sufficient vitamin D levels (at least 30 ng/mL) exhibited a significant decrease in the incidence of preeclampsia. It is also known that vitamin D modulates the immune system in several ways. T-cell proliferation can be suppressed, and pro-inflammatory cytokines, including IL-2, IFN-, and IL-17, can be produced less frequently when vitamin D is present. A lack of vitamin D may lead to a rise in cytokines that promote inflammation, such as IL-2. This paper will, therefore, examine the relationship between vitamin D, IL-2 levels, and the risk of premature labor.
The effect of maternal diabetes on the formation of fetal surfactant Sanjaya, I Nyoman Hariyasa; Sutandi, Chatrine
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.42

Abstract

Elevated maternal blood glucose levels in pregnancy correlate with increased risk of pregnancy complications, labor, and pregnancy outcomes. Type II alveolus cells produce a combination of fat and protein called pulmonary surfactant. To assist in preserving lung stability, pulmonary surfactant plays a crucial function in lowering the propensity of the alveolus to recoil and preventing alveolus collapse. The hallmark of maternal diabetes is the malfunctioning of pancreatic β-cells, which results in insufficient insulin production to sustain proper blood glucose levels. Respiratory distress syndrome (RDS) in newborns is caused by surfactant lack of sufficiency, which is caused by fetal hyperglycemia and hyperinsulinism brought on by maternal diabetes. Appropriate treatments are required to improve glycemic management since maternal diabetes raises the risk of RDS in term newborns. These therapies include a deeper comprehension of the molecular mechanisms behind gestational diabetes mellitus that impact the surfactant system. Phosphatidylglycerol levels are either nonexistent or extremely low in infants with RDS. Phosphatidylglycerol synthesis during pregnancy in diabetics is known to be delayed in comparison to the non-diabetic control group. For this reason, proper care is essential to enhancing long-term health and neonatal outcomes. These findings underscore the need for early detection and management of maternal diabetes to mitigate the risk of RDS and improve neonatal health.
The Role of Cytokines, Hormones, and Cellular Regulation in Improving Maternal and Fetal Well-Being Hariyasa Sanjaya, I Nyoman; Sutandi, Chatrine; Syauta, Fetrisya
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.51

Abstract

Maternal and fetal well-being is a complex interplay of various factors. A key factor is that women receiving early and adequate pregnancy care are more likely to achieve positive pregnancy outcomes. Several studies have identified internal maternal factors as significant contributors to the well-being of both mother and fetus. However, scientific research and discussions on the role of cytokines, hormones, and cellular regulation in maternal and fetal well-being outcomes still need to be completed. Progesterone, a vital hormone for pregnancy and humans, influences immune function directly and through mediators by promoting the synthesis of T helper cell-type cytokines. The favorable benefits of dydrogesterone on repeated spontaneous miscarriages and impending miscarriages may be attributed to the regulating effects of these cytokines and the hormone's capacities. T helper cell-produced cytokines are linked to allograft rejection. Lastly, our finding of cellular regulatory mechanisms, including apoptosis, autophagy, and cellular senescence, highlights the multifaceted nature of maintaining maternal and fetal health during pregnancy. This review aims to delve deeper into the role of cytokines, hormones, and cellular regulation in enhancing maternal and fetal well-being.
Ethnopharmacological insights and clinical prospects of ten Indonesian medicinal plants for pregnancy, postpartum, and lactation: a systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Rahardjo, Theresia Monica; Suryawan, Aloysius; Rahardjo, Bambang; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.77

Abstract

Background: The perinatal period involves significant physiological and metabolic transitions, particularly concerning hypertensive disorders, preeclampsia, hemorrhage, lactation challenges, and oxidative stress. Although pharmacological therapies are available, their safety and accessibility remain inconsistent, especially in resource-limited settings. Indonesia’s extensive biodiversity and deep-rooted ethnomedicinal traditions offer promising yet underutilized botanical alternatives. This study aimed to review the efficacy of Indonesian medicinal plants used in pregnancy, postpartum, and lactation. Methods: This systematic review investigates ten Indonesian medicinal plants traditionally used during pregnancy, postpartum recovery, and lactation: Sauropus androgynus, Curcuma longa, Moringa oleifera, Nigella sativa, Centella asiatica, Orthosiphon aristatus, Syzygium polyanthum, Andrographis paniculata, Solanum nigrum, and Zingiber officinale. Literature from 2000 to 2025 was reviewed using PRISMA guidelines across global and regional databases. Phytochemical composition, mechanisms of action, therapeutic effects (e.g., antihypertensive, antidiabetic, galactagogue, hemostatic, antioxidant), and clinical relevance were critically evaluated. Results: All ten plants demonstrated pharmacological potential relevant to perinatal health challenges. Notably, Zingiber officinale offers antiemetic and anti-inflammatory benefits during early pregnancy, complementing the lactogenic, antihypertensive, and wound-healing properties of other species. However, gaps persist in human trials, dosage standardization, and regulatory oversight. Conclusion: The review highlights the importance of integrating validated traditional botanicals into perinatal care through interdisciplinary research, targeted clinical trials, and culturally responsive health policies. Bridging ethnopharmacology with maternal health systems offers a scalable, sustainable pathway toward maternal wellness and equity in Indonesia and comparable global settings.
Metastatic breast cancer during pregnancy: a case report Widi, Made Yudha Ganesa Wikantyas; Putra, Wayan Artana; Kusuma, Anak Agung Ngurah Jaya; Wiradnyana, Anak Agung Putra; Sanjaya, I Nyoman Hariyasa; Budiana, I Nyoman Gede; Mahayasa, Putu Doster; Marta, Kadek Fajar
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.73

Abstract

Introduction: Breast cancer is the most prevalent malignancy among women and a notable comorbidity during pregnancy. Pregnancy-associated breast cancer (PABC) presents unique challenges due to physiological breast changes that complicate early diagnosis. This case report aimed to present a 31-year-old female with a diagnosis of bilateral breast tumors, pleural effusion, and multiple thoracic soft tissue tumors during her second pregnancy, highlighting the complexities and treatment considerations involved. Case presentation: A 31-year-old female patient, referred to Prof. Dr. I. G.N.G Ngoerah General Hospital, Denpasar, was in her second pregnancy at 20-21 weeks of gestation. She presented with bilateral breast lumps, worsening pain, and shortness of breath. Her obstetric history included a previous cesarean delivery and two abortions. Clinical examination revealed pleural effusion and multiple nodules suggestive of metastases. Biopsies confirmed tubular adenoma in the right breast and invasive breast carcinoma in the left breast. Ultrasound and chest x-ray findings indicated metastases to the liver and lungs. The patient was diagnosed with G4P1021 at 20 weeks of gestation with pregnancy-associated bilateral breast cancer and metastases. Conclusion: PABC diagnosis and treatment are fraught with challenges due to the need to balance maternal and fetal health. Delays in diagnosis, limited antenatal care, and the aggressive nature of PABC contribute to poor outcomes. This case underscores the necessity of early detection, prompt multidisciplinary intervention, and tailored treatment strategies to improve PABC patients' prognoses.
Co-Authors Adhi Pribadi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Aloysius Suryawan Anak Agung Ngurah Anantasika Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Andonotopo, Wiku Bachnas, Muhammad Adrianes Bambang Rahardjo Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cut Meurah Yeni Daniel H. Susanto Denni Prasetyo Dyah Pradnyaparmita Duarsa Eka Setiawan, Putu Pandu Endang Sri Widiyanti Evert Solomon Pangkahila Firsta Sesarina Mintariani Firsta Sesarina Mintariani Firsta Sesarina Mintariani Hartanto Hartanto I G A A Novya Dewi I Gede Ngurah Harry Wijaya Surya I Gusti Kamasan Arijana I Ketut Surya Negara I Made Gede Widnyana I Made Mahardika I Nyoman Gede Budiana I Nyoman Wirata I Wayan Murdita Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ida Bagus Putra Adnyana, Ida Bagus IGP Surya, IGP Julian Dewantiningrum Kadek Budi Juliantari Kamajaya, I Gusti Ngurah Agung Trisnu Ketut Widyani Astuti Kurjak, Asim Kusuma, Anak Agung Ngurah Jaya luh sudiarmini Made Adi Kusuma Made Diah Vendita Sakuntari Made Diah Vendita Sakuntari Made Diah Vendita Sakuntari Made Wiryana Marta, Kadek Fajar Murdita, I Wayan Ni Kadek Mulyantari Ni Komang Anik Pirgantari Ni Komang Anik Pirgantari Ni Komang Anik Pirgantari Ni Komang Erny Astiti Ni Luh Made Diah Mas Cahyani Putri Ni Luh Made Diah Mas Cahyani Putri Ni Luh Made Diah Mas Cahyani Putri Ni Luh Md Dwi Laxmi Satriani Ni Luh Md Dwi Laxmi Satriani Ni Luh Md Dwi Laxmi Satriani Ni Luh Putu Yulia Padmawati Ni Nyoman Dewi Purwanti Ni Nyoman Sri Budayanti Ni Putu Nining Gianni Ni Putu Nining Gianni Ni Putu Nining Gianni Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Nuswil Bernolian Pramono, Mochammad Besari Adi Putra, Wayan Artana Putu Doster Mahayasa Putu Pandu Eka Setiawan Rey Jauwerissa Ryan S. Mulyana Ryan Saktika Mulyana Sri Sulistyowati Stanojevic, Milan Sutandi, Chatrine Syauta, Fetrisya Tasa Riszkia Theresia Monica Rahardjo Tjokorda Gde Agung Suwardewa Utarini, Gusti Ayu Eka Widi, Made Yudha Ganesa Wikantyas Wijaya Surya, I Gede Ngurah Harry Wiradnyana, Anak Agung Gede Putra Wiradnyana, Anak Agung Putra