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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences AGRIKA Jurnal Mahasiswa Teknologi Hasil Perikanan Research Journal of Life Science Jurnal Pembangunan dan Alam Lestari Jurnal Perikanan dan Kelautan JURNAL IPTEKS PEMANFAATAN SUMBERDAYA PERIKANAN Science and Technology Indonesia JFMR (Journal of Fisheries and Marine Research) Jurnal Penelitian Pendidikan IPA (JPPIPA) Khadimul Ummah Journal of Social Dedication FaST : Jurnal Sains dan Teknologi Jurnal Nutrisi Ternak Tropis (JNT) Jurnal Abdi Insani Prosiding Konferensi Nasional PKM-CSR Journal of Fisheries & Marine
Eddy Suprayitno
Universitas Brawijaya
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Journal : Science and Technology Indonesia

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Potential Analysis of Snakehead Fish Albumin Extract (Channa striata) as Immunostimulant and Anti-Inflammatory in Indomethacin-Induced Inflammatory Bowel Disease (IBD) Rats Panjaitan, Tina Fransiskha Carolyn; Fiddaroini, Saidun; Suprayitno, Eddy; Aulanni’am, Aulanni’am; Hardoko, Hardoko
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.725-740

Abstract

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal disorder driven by oxidative stress and immune dysregulation, often exacerbated by prolonged non-steroidal anti-inflammatory drug (NSAID) use. Conventional therapies provide symptomatic relief but are limited by severe adverse effects, necessitating safer alternatives. Channa striata (snakehead fish) is a rich source of albumin, essential amino acids, and bioactive compounds with potential immunomodulatory and anti-inflammatory effects. This study investigates the therapeutic efficacy of purified Channa striata albumin extract in an indomethacin-induced IBD rat model. Albumin was isolated via ammonium sulfate precipitation and characterized by SDS-PAGE, antioxidant activity (DPPH assay), and amino acid profiling. Rats were treated with Channa striata albumin (100-300 mg/kg BW) for 14 days post-indomethacin induction. Compared to controls and diclofenac-treated groups, the extract significantly reduced malondialdehyde (MDA) levels (up to 90.69%), improved jejunal histoarchitecture, and enhanced occludin expression. Immunohistochemistry showed a marked reduction in CD4+T cell infiltration, indicating immunomodulatory activity. These findings establish Channa striata albumin as a potent natural antioxidant and immunomodulator, offering a safer alternative to NSAIDs for IBD management.
Co-Authors Ahmad, Mirza Gulam Ahmad, Nurul Hawa Alfin Adam Arifin Anggira W, I Putu A Anies Chamidah Anies Chamidah Arifin, Alfin Adam Asep Awaludin Prihanto Attaftazani, Adam Rasyidi Aulanni’am, Aulanni’am Bambang Budi Sasmito Bambang Budi Sasmito Bambang Budi Sasmito Desi Tri Anggita Desy Arisandi Dewi Sinta Wati Dewinta, Dastiana Ajeng Djamaluddin, Heder Djamaludin, Heder Dwi Sulistiyati, Titik E Ernawati, E Efendi, Yessi Renita Endang Yuli Herawati Fiddaroini, Saidun Firdaus, Shelina Innasa Happy Nursyam Hardoko Hardoko Hardoko Hardoko Hardoko Hardoko Hardoko Hardoko Hardoko, Mr. Hariati, Anik Martinah Heder Djamaludin Hidayat, Audiava Happy Kenthida Vanezza Kartika, Aprilia Dwi Kartikaningsih, Hartati Kayanti, Nadila Putri Dwi Kiki Riski Arisandy Kusmartono Kusuma, Zulfia Rifka Ayu Lestari, Santi Dwi Luh Ayu Hesa Frida Nanda Putri Mashudi Mikchaell Alfanov Pardamean Panjaitan Mikchaell Alfanov Pardamean Panjaitan Mohammad Bisri Mr. Hardoko Muhamad Firdaus Mujibur Rahman Khairul Muluk Nursinah Amir, Nursinah Panjaitan, Mickhael A.P. Panjaitan, Mikchaell Alfanov Pardamean Poespitasari Hazanah Ndaru Putri, Luh Ayu Hesa Frida Nanda Ramli, Nurul Shazini Rohmatuzzahro, Umi Sasmita, Bambang Budi Setiawan, Daniel Wahyu Siti Tsaniyatul Miratis Sulthoniyah Sulistiati, Titik Dwi Sulistiyati, Titik Dwi Tambunan, Jenny E. Tambunan, Jenny Ernawati Tambunan, Jeny Ernawati Tian Nur Ma’rifat Tina Fransiskha Carolyn Panjaitan, Tina Fransiskha Carolyn Titik Dwi Sulistiyati Titik Dwi Sulistiyati Yahya Yahya Yanuhar, Uun Yulindra, T Trisnawati Yuniarti, Desy Windia Yunita Eka Puspitasari Yunita Yunita Zulfia Rifka Ayu Kusuma