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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Bionatura Chimica et Natura Acta Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
Ace Tatang Hidayat
Departemen Kimia, FMIPA, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology

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Journal : Makara Journal of Science

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Activity of Cytotoxic Flavanoids against a P-388 Murine Leukemia Cell Line from the Stem Bark of Aglaia elliptica (Meliaceae) Hidayat, Ace Tatang; Farabi, Kindi; Harneti, Desi; Maharani, Rani; Nurlelasari,; Supratman, Unang; Shiono, Yoshihito
Makara Journal of Science Vol. 21, No. 4
Publisher : UI Scholars Hub

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Two mixtures of flavanoid compounds (1 and 2), a mixture of catechin (1a) and epicatechin (1b), and a mixture of gallocatechin (2a) and epigallocatechin (2b), were isolated from the active fraction of the stem bark of Aglaia elliptica methanol extract. The chemical structure of the compounds was identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and additionally compared with previously reported spectral data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compound 2 showed cytotoxicity against the P-388 murine leukemia cell, with an IC50 value of 7.79 µg/mL, but compound 1 was found not to be active (more than 100 µg/mL).
Limonoids Isolated from Chisocheton pentandrus (Meliaceae) Stembarks and its Cytotoxicity Towards MCF-7 Breast Cancer Cell Line Runadi, Dudi; Anjari, Intan Hawina; Purnama, Purnama; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Harizon, Harizon; Hidayat, Ace Tatang; Salam, Supriatno; Azmi, Mohamad Nurul; Supratman, Unang
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Chisocheton is a large source of limonoids with various pharmacological effects, such as antiviral, antibacterial, antimalarial, antifungal, and cytotoxic activities. This study aimed to isolate, elucidate, and evaluate the cytotoxicity of limonoids from C. pentandrus stembarks. Isolation was carried out using various separation methods including extraction and column chromatography. Spectral data were analyzed by FT-IR, UV, DEPT 135°, 1H, 13C-NMR, and HRTOF-MS and compared with those previously reported to determine the chemical structure.The obtained limonoids were lasiocarpine (1), lasiocarpine B (2), pentandricine (3), and 16β-hydroxydysobinin (4); all of which were successfully isolated from C. pentandrus for the first time. The cytotoxic activity of these limonoids were also evaluated against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells using PrestoBlue method. Lasiocarpine A revealed the strongest cytotoxicity with an IC50 of 42.62 µM in moderate level.
Co-Authors Achmad Zainuddin Achmad Zainuddin Ade Sholeh Hidayat Andi Rahim Anjari, Intan Hawina Astrid, Dewi Azmi, Mohamad Nurul Christina Marpaung Dadan Sumiarsa Darwati Darwati Darwati Darwati Desi Harnet Desi Harneti Putri Huspa Dessy Yulyani Kurnia Dewa Gede Katja Dewi Astrid DUDI RUNADI Euis Julaeha Fajar Fauzi Abdullah Fajar Fauzi Abdullah Farabi, Kindi Febrianti, Inky Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Gunawan Gunawan Gunawan, Latifah Harizon Harizon Hasbilla, Raihan Fathurrahman Herdanu Rizqullah Hersa Milawati Hersa Milawati Hidayat, Ade Sholeh Hilmayanti, Erina Hutagaol, Ricson Pemimpin Ida Nur Farida Ida Nurfarida Ihsan Rahadian Ika Wiani Iman Permana Maksum IMAN PERMANA MAKSUM Iman Rahayu Inky Febrianti Jamaludin Al-Anshori Kansy Haikal Khadijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Mohamad Fajar Mohamad Nurul Azmi Mohamad Nurul Azmi Muchlis, Handi Nugraha Mulyasari, Rita Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Nadya Thufaila Naini, Al Arofatus Nunung Kurniasih Nur Muhammad Miftah Nurlelasari Nurlelasari Nuruzzahra Ammatillah O. Suprijana - Ponis Tarigan Primahana, Gian Purnama Purnama R. Ukun M.S. Soedjanaatmadja Rachman, Saadah Diana Rani Maharani Rani Maharani Rani Maharani Rani Maharani Rani Maharani Rani Maharani Rani Maharani Rani Maharani Rani Maharani Ricson Pemimpin Hutagaol Rita Mulyasari Rizky Abdulah Ronny Lesmana Rurini Retnowati Saadah Diana Rachman Safriansyah, Wahyu Salam, Supriatno Salam, Supriyanto Sandra Amalia Riyadi Shiono, Yoshihito Siska Mulya Octavia Siska Mulya Octavia Sofa Fajriah Srikandi, Srikandi Supriatno Supriatno Supriyatna, - Susianti, Susianti Tati Herlina TATI NURHAYATI Tjandrawati Mozef Tri Mayanti Tri Mayanti Unang Supratman Winda Sukmawati Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito shiono Yoshihito Shiono