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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal SOLMA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JFIOnline Borneo Journal of Pharmacy
Kori Yati
Universitas Muhammadiyah Prof. Dr. HAMKA
Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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UJI DIFUSI MIKROEMULSI NITROGLISERIN MENGGUNAKAN TWEEN 80 SEBAGAI SURFAKTAN Yati, Kori; Situmorang, Almawati; Umoro, Ani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 9, No 1 (2017): Punica Granatum
Publisher : Indonesian Research Gateway

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Abstract

ABSTRACT: Nitroglycerine is a drug of choice in the treatment of angina pectoris. Nitroglycerine has low dose, short time of plasma half life and liver metabolizing. This study used the formulation of microemulsion. The advantages of microemulsion transparent form, stable and has better skin penetration due to the smaller size of its droplet. This study aims at determining concentration of Tween 80 as surfactant as penetration in the nitroglycerine microemulsion. Tween 80 concentrations used were 40% (F1), 42,5% (F2) and 45% (F3). Penetration ability was tested by invitro using Franz diffusion cells. The results showed that 42,5% of the concentration of Tween 80 produces good penetration. F2 shows the measurement result of droplet size is 69,0 nm and diffusion test on the minutes of 180 for 86,00% ± 3,65. It can be concluded that the concentration of Tween 80 as surfactant of 42,5% gives microemulsion nitroglycerine with good penetration.
UJI DIFUSI MIKROEMULSI NITROGLISERIN MENGGUNAKAN TWEEN 80 SEBAGAI SURFAKTAN Yati, Kori; Situmorang, Almawati; Umoro, Ani
Jurnal Farmasi Indonesia Vol 9, No 1 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (9030.693 KB) | DOI: 10.35617/jfi.v9i1.557

Abstract

ABSTRACT: Nitroglycerine is a drug of choice in the treatment of angina pectoris. Nitroglycerine has low dose, short time of plasma half life and liver metabolizing. This study used the formulation of microemulsion. The advantages of microemulsion transparent form, stable and has better skin penetration due to the smaller size of its droplet. This study aims at determining concentration of Tween 80 as surfactant as penetration in the nitroglycerine microemulsion. Tween 80 concentrations used were 40% (F1), 42,5% (F2) and 45% (F3). Penetration ability was tested by invitro using Franz diffusion cells. The results showed that 42,5% of the concentration of Tween 80 produces good penetration. F2 shows the measurement result of droplet size is 69,0 nm and diffusion test on the minutes of 180 for 86,00% ± 3,65. It can be concluded that the concentration of Tween 80 as surfactant of 42,5% gives microemulsion nitroglycerine with good penetration.
PERBANDINGAN VCO, MINYAK ZAITUN DAN MINYAK JAGUNG TERHADAP SIFAT FISIK BALSEM STIK DENGAN PENGIKAT VASELIN ALBA ATAU ADEPS LANAE Lestari, Pramulani Mulya; Yati, Kori; Rosanti, Mimil
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.671

Abstract

The use of balm by applying it to the affected part of the body can cause heat and stickiness in the fingers. Making balm sticks is one solution to overcome this problem. Balm sticks are influenced by the components used are oils, waxs and fats. Oils and fats have different fat acid and molecul weight will affect the physical properties of balm stick. Selection of the proper components are excepted to good melting point and hardness and in accordance with requirments. This study aimed at compare of VCO, olive oil and corn oil with variation between Adeps lanae and Vaselin albaon the physical properties of stick balm. All balm sticks prepared by the same method and evaluated included organoleptic test, homogenity, hardness and melting point. The result showed that difference in melting point and hardness, but all formula meet the requirment of physical preparation balm stick. Formula with VCO and Adeps lanae shows higest melting point and hardness. Statistical result of Kruskal Wallis shows sig <0,05 which means that there were difference of each formula. It could be concluded that VCO with Adeps lanae in combination Carnauba wax and Cera alba g a ve a high melting poin , hardenss and yield value.
Co-Authors Abdulloh Abdulloh Almawati Situmorang, Almawati Ari Widayanti Bariroh, Tahyatul Dessy Ayu Permatasari, Dessy Ayu Dwitiyanti Dwitiyanti Endang Sulistyaningsih Fatmawati, Sofia Harahap, Roito Elmina Gogo Intan, Annisa khoirunisa, irbah Kriana Efendi Ladeska, Vera Lestari, Pramulani Mulya Mawanti, Wening Tri Melinda, Rika Nugrahaeni, Fitria Prisiska, Fahjar Rahmah Elfiyani Rindita, Rindita Riyanti, Hurip Budi Rosanti, Mimil Setiawan, Abdul Aziz Siska Siska Siska Siska Umoro, Ani Umoro, Ani Wati, Lilis Rokimah Wirawan, Adi Putra