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Journal : Majalah Farmaseutik

Network Pharmacology Analysis of Secondary Metabolites of Ciplukan (Physalis angulata L.) Against Lung Cancer Khoirunnisa, Azka; Jamil, Ahmad Shobrun; Muchlisin, Muhammad Artabah
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.96275

Abstract

Lung cancer is the most common and high-risk type of cancer. Ciplukan (Physalis angulata L.) has antibacterial, anti-inflammatory, and anticancer activities, as well as cytotoxic ability and inhibits cancer cell growth. Research that discusses the molecular cellular mechanism of P. angulata's potential as an anti-lung cancer has not been widely informed, especially on the network pharmacology aspect of this plant's active compounds. This study reveals the prediction of the molecular mechanism of active compounds of P. angulata as anti-lung cancer using several tools including: Compound database retrieval with Knapsack and PubChem. Absorption Distribution Metabolism and Excretion (ADME) screening with SwissADME. Target protein identification with Gene Card, SwissTargetPrediction and Venny Diagram. Network pharmacology construction with String-DB and Cytoscape. Network pharmacology analysis using Gene Ontology (GO), and Cellular Component and Molecular Function. Based on the results of the analysis of P. angulata protein potential based on Maximal Clique Centrality (MCC) on CytoHubba in Cytoscape application, it shows that the Protein-protein Interaction (PPI) network has 10 main targets, namely ERBB2, KRAS, TP53, PTEN, CDKN2A, NRAS, PIK3CA, BRAF, NF1, and EGFR which interact with each other to regulate cell growth, differentiation, and survival. The results of this study can be concluded that the secondary metabolite compounds of P. angulata have the potential to control and alternative for lung cancer therapy.
Co-Authors Ahyana Fitrian, S.Farm. Apt Ahyana Fitrian, S.Farm. Apt, Ahyana Fitrian, Alamsyah, Fakhruddin Almutahrihan, Irsan Fahmi Amaliyah Dina Anggraeni Andika Aliviameita Aris Soewondo Astri Ariani Astri Ariani, Astri Asyhari, Firda Nuri Azka Khoirunnisa Bayu Prasaja Bayu Prasaja, Bayu Buhari Adi, Buhari Buhari Buhari Burhanuddin Burhanuddin Burhanuddin Burhanuddin Dikky Syadqamullah Dina Siti Rahma M. Hentu Dinda Farida Dliyauddin, Moh Dra. Uswatun Chasanah, Apt. Dra. Uswatun Chasanah, Apt., Dra. Uswatun Drs. Ahmad Inoni, Apt Drs. Ahmad Inoni, Apt, Drs. Ahmad Dwi Retno Nur Syahida Eko Budi Cahyono Engrid Juni Astuti Faiznanda Awwaluddin Fakhruddin Alamsyah Fath, Dwi Hanif Muluqul Fitria Dwi Damayanti Hentu, Dina Siti Rahma M. Hidayaturrahman Hidayaturrahman Hidayaturrahman, Hidayaturrahman Hilmy, Fauzan Irsan Fahmi Almuhtarihan Irsan Fahmi Almutahrihan Izuddin Karim Karim, Izuddin Khasna Shafwatul Jihan Lely Mauliana Lena, Nour Lilik Yusetyani Luqman Hakim Luqman Hakim M Artabah Muchlisin M. Artabah Muchlisin M. Artabah Muchlisin M. Helmi Mansur Ibrahim Miftahul Mushlih Moch Sasmito Djati Muchlisin, M. Artabah Muhammad Halim Natsir Mujahidin Ahmad Nabilatul Auliyana Nour Lena Nurul Amalia Azhari Nuryasin, Ilyas Pertiwi, Cinta Junaidi Putri Puspitasari Puspitasari Putri, Nenis Try Melani Rafikayanti, Agustin Resi Puguh Prihantono Rifa’i, Muhaimin Risma Ayu Setiawan Satriawan, Herland Siti Rofida Solly Aryza SRI RAHAYU Sumadi, Firasti Agung Nugrahening Syabana, Nada Laela Syadqamullah, Dikky Thoat Stiawan Tri Luthfiana Maretha Trikxy Viori Andhani Trimianti Hidahyatun Nazah Veda, Adella Infia Helga wahyuni, reni sri Zulfatim, Heni Sukma Zulkipli Hardi Zulkipli Hardi, Zulkipli