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The Relationship between HbA1c Levels and Microalbuminuria in Patients with Diabetes Mellitus at Primary Health Care Centers in Malang City Abdullah, Ali Juwaidi; Yudha, Nyoman Satvika Dharma; Raras, Tri Yudani Mardining
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.01

Abstract

Background: Gender disparities in health-related behaviors have significant implications for public health interventions. Aim: This comprehensive analysis aims to explore variations in smoking, alcohol consumption, physical activity, nutrition, and blood pressure between genders. Methods: In the Inter-University Consortium for Political and Social Research Study (ICPSR146521), data that had been gathered prospectively were used to assess the prevalence of metabolic syndrome, its risk factors, and the linked lifestyle in adult Myanmar inhabitants. Results: The study revealed noteworthy gender disparities in various health-related behaviors. Among passive smokers, no significant gender differences were observed. However, in active smokers, males exhibited notably higher rates than females. In the category of individuals who had never smoked, females predominated. For past smokers, females were more likely to have quit smoking successfully. Concerning alcohol consumption, males reported higher rates of past and current drinking, while females were more likely never to have consumed alcohol. Regarding physical activity, females were less likely to engage in exercise activities. Sedentary lifestyle patterns showed no significant gender differences. Conclusion: This analysis underscores the importance of recognizing gender-specific health-related behaviors and their implications. Understanding these differences is essential for tailoring effective public health strategies that address the unique needs and challenges faced by each gender. By acknowledging and addressing these disparities, healthcare providers and policymakers can develop more targeted interventions to promote healthy behaviors and reduce health inequalities. These findings provide a valuable foundation for further research and the development of gender-sensitive public health initiatives.
Stem Cells and Exosomes Delivery via Collagen-Based Platform for Advanced Wound Healing: A Systematic Review of In Vivo Studies Ratih Paramita Suprapto; Raras, Tri Yudani Mardining; Kusuma, Ihda Dian
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Chronic wounds remain a global health challenge due to persistent inflammation and impaired cellular function that delay healing. Collagen-based hydrogels are promising delivery platforms for enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) and exosomes. This review aimed to evaluate the efficacy and molecular mechanisms of MSCs and/or their derived exosomes delivered in collagen-based hydrogels in accelerating wound healing in vivo. This review was managed following PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, and Europe PMC for original studies published between 2020 and 2025. Eligible studies provided sufficient data describing in vivo chronic wound models treated with collagen scaffolds loaded with MSCs or exosomes. Three in vivo studies using murine burn, diabetic rat, and diabetic rabbit models were included. Each of them used pullulan-collagen seeded with Adipocyte Stem Cells (ASCs), stem cell-derived exosomes combined with recombinant human collagen-methacrylate, and MSC-derived extracellular vesicles (EVs) loaded into collagen hydrogel. All platforms significantly accelerated wound closure versus controls. Histological analyses confirmed enhanced neovascularization, organized collagen deposition, mature granulation tissue formation, and re-epithelization. These effects were mediated by M1-to-M2 macrophage polarization and downregulation of pro-inflammatory cytokines. Cell-free exosome therapy loaded in collagen hydrogels represents a promising approach for chronic wound management.
Stem Cells and Exosomes Delivery via Collagen-Based Platform for Advanced Wound Healing: A Systematic Review of In Vivo Studies Ratih Paramita Suprapto; Raras, Tri Yudani Mardining; Kusuma, Ihda Dian
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.02.11

Abstract

Chronic wounds remain a global health challenge due to persistent inflammation and impaired cellular function that delay healing. Collagen-based hydrogels are promising delivery platforms for enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) and exosomes. This review aimed to evaluate the efficacy and molecular mechanisms of MSCs and/or their derived exosomes delivered in collagen-based hydrogels in accelerating wound healing in vivo. This review was managed following PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, and Europe PMC for original studies published between 2020 and 2025. Eligible studies provided sufficient data describing in vivo chronic wound models treated with collagen scaffolds loaded with MSCs or exosomes. Three in vivo studies using murine burn, diabetic rat, and diabetic rabbit models were included. Each of them used pullulan-collagen seeded with Adipocyte Stem Cells (ASCs), stem cell-derived exosomes combined with recombinant human collagen-methacrylate, and MSC-derived extracellular vesicles (EVs) loaded into collagen hydrogel. All platforms significantly accelerated wound closure versus controls. Histological analyses confirmed enhanced neovascularization, organized collagen deposition, mature granulation tissue formation, and re-epithelization. These effects were mediated by M1-to-M2 macrophage polarization and downregulation of pro-inflammatory cytokines. Cell-free exosome therapy loaded in collagen hydrogels represents a promising approach for chronic wound management.