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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Cancer Chemoprevention The Journal of Pure and Applied Chemistry Research Alchemy Jurnal Penelitian Kimia Majalah Obat Tradisional Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Pharmacology and Therapy
Rita Rakhmawati, Rita
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Journal : Jurnal Ilmiah Farmasi

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Review: Isolasi, Peningkatan Kadar, dan Analisis Calophyllolide dalam Minyak Calophyllum inophyllum Linn. serta Potensinya untuk Terapi Luka Bakar Herawati, Zainab; Rakhmawati, Rita
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art10

Abstract

Background: Calophyllolide is a dipyranocoumarin compound found in Calophyllum inophyllum L., known for its antimicrobial and anti-inflammatory properties, which are beneficial for burn wound healing. However, variability in its content and lack of standardized methods remain challenges.Objective: This review aims to present a literature study on calophyllolide, including its sources, isolation techniques, bioactive content optimization, analytical methods, and pharmacological potential in burn wound healing.Method: Data were retrieved from Scopus and PubMed using predefined keywords. Articles published in English between 2001 and 2021 and classified as original research were selected. Relevant studies were assessed for quality using the SYRCLE tool (animal studies) and the Young & Solomon checklist (non-clinical research).Results: Seeds harvested in September had the highest calophyllolide content (0.23%). Enhancement through tissue culture using 2 mg/L IBA yielded up to 45.23 mg/100 g callus. Among analytical techniques, a validated GC-MS method showed high precision and recovery. Pharmacological studies confirmed its activity against Staphylococcus aureus and its ability to modulate inflammatory responses.Conclusion: Calophyllolide shows strong potential as a natural agent for burn wound therapy. Standardized extraction, quantification, and production approaches are essential for further development.
Co-Authors Ahmad Ainurofiq, Ahmad Anastacia, Laura Anif Nur Artanti, Anif Nur Arko Jatmiko Wicaksono, Arko Jatmiko Azizah, Salma Nur Dinar Sari Cahyaningrum Wahyuni ESTU RETNANINGTYAS N Fajar Rakhman W, Fajar Fajar Rakhman W, Fajar Rakhman Fea Prihapsara, Fea Herawati, Zainab Mae Sri Hartati Wahyuningsih Nestri H, Nestri Nestri Handayani, Nestri Pratama, Tiara Dewi S. Pratama, Tiara Dewi Salindri Pujiastuti, Umi Hanik Rul Afiyah Syarif Saptono Hadi, Saptono Soerya Dewi Marliyana Syaiful Choiri Wahyuni, Dinar Sari C Wahyuni, Dinar Sari C. Yacobus Christian Prasetyo