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Journal : Dentika Dental Journal

THE POTENTIAL OF HEDYOTIS CORYMBOSA (L.) LAMK EXTRACT TO INHIBIT THE PROGRESSIVITY OF ORAL CANCER CELL IN RATS INDUCED WITH BENZOPYRENE Budhy, Theresia Indah
Dentika: Dental Journal Vol. 19 No. 1 (2016): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.501 KB) | DOI: 10.32734/dentika.v19i1.142

Abstract

Cancer is still ranked as the fifth cause of mortality and morbidityin Indonesia.Hedyotis corymbosa (L.) Lamk has ursolat acid as anti-proliferative cancer cell. This research is aimed to determine the potency of Hedyotis corymbosa (L.) Lamk at different doses, namely 375, 750, and 1500 mg/kg, used as an inhibitor for the progressivity of oral cancer, such as proliferation, angiogenesis, and apoptosis of cancer cells. Post test only control group design was used in this research. There were 24 Rattus novergicus used as research samples. Those were divided into four groups, namely control, treatment group 1 with a dose of 375mg/kg, treatment group 2 with a dose of 750 mg/kg, and treatment group 3 with a dose of 1500mg/kg. Their oral cavity was induced intramusculary by benzopyrene with a dose of 8mg/kg for 4 weeks (twice a week) to create cancer. Hedyotis corymbosa (L.) Lamk was given orally for 10 days. All samples were aclimatitation to perform Histo Pathology Anatomi among groups. Haematoxillin Eosin for proliferation cancer cell and capilary. Immunohistochemistry for expression of caspase3. Data were tabulated andanalyzed statistically by ANOVA. There was significant difference of cancer cell proliferation and capilary between control and treatment groups. The most significant decreasing of cancer cell proliferation was in those samples given with a dose of 750 mg/kg. Meanwhile, the highest apoptosis of caspase3 expression was in those samples given with a dose of 750 mg/kg. It can be concluded that Hedyotis corymbosa (L.) Lamk extract could decrease cancer cell proliferation and capilary as well as could increase apoptosis.
Co-Authors Adawiyah, Rabi’atul Akhmad Setyo Rahman Alexander Patera Nugraha Amalia, Nadya Rafika Ari Nuswantoro Aryati Aryati Azis, Zulfikran Moh Rizki Bambang Sumaryono Banerjee, Abhishek Bayu Indra Sukmana Budi Santosa Cinantya, Aulia Dian Cyuzuzo Callixte Deddy Hartanto Dominicus Husada Dwicha Rahma Nuriska Hartono Edhi Jularso Edith Frederika Puruhito, Edith Frederika Elizabeth, Laurencia Dwiamanda Erawati Wulandari Fadila, Okta Mulia Nur Firjani, Putri Nabila Fransiskus Andrianto Gustiadi Saputra I Ketut Sudana Indrasari, Yulia Nadar Ira Arundina Ira Arundina Islamy, Azzahra Hasnur Jenny Sunariani Jusak A. Nugraha Jusak Nugraha Latief Mooduto, Latief Latifah, Maasyitoh Sari Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Ma`ruf, Anwar Muhammad Luthfi Muji Rahayu Nastiti Faradilla Ramadhani Noor, Tengku Natasha Eleena binti Tengku Ahmad Nugraha, Ilyas Yakob Nurul Nur Lailatul Fadhilah Nurwinda Enni Rosyidah Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Rahmah, Shafwa Aisha Rahmawati, Septyana Eka Ratri Maya Sitalaksmi Retno Indrawati Roestamadji Retno Palupi Retno Palupi Retno Pudji Rahayu Rezky, Muhammad Andyka Roni Handayani Roni Handayani S.Pd. M Kes I Ketut Sudiana . Salsabila, Alisya Rachel Sari, Arabella Vonia Sawitri Dwi Indah Pertami Setiawan, Kresna Erlangga Shahzad Shoukat Shallomitha, Aginta Gracia Shariff, Khairul Anuar Sisca Meida Wati Sunari, I Gusti Agung Ayu Eka Putri Supandji, Rafaelle Raditya Syahdiar, Aura Zalfa Ghassani Tika, Dian Tuyishimire Irene Vania Syahputri