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All Journal Dentika Dental Journal Jurnal Kesehatan Masyarakat Folia Medica Indonesiana Jurnal Biosains Pascasarjana Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Jurnal Riset Kesehatan Poltekkes Depkes Bandung Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Dental Medicine Jurnal Pengabdian UNDIKMA Indian Journal of Forensic Medicine & Toxicology Strada Jurnal Ilmiah Kesehatan (SJIK)
Theresia Indah Budhy Sulisetyawati
Departemen Imunologi, Sekolah Pascasarjana,Universitas Airlangga
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Jurnal Biosains Pascasarjana

 1 
Penentuan Grading Tumor Ganas Oral Squamous Cell Carcinoma Berdasarkan Gambaran Histopatologi Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 17 No. 1 (2015): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (812.418 KB) | DOI: 10.20473/jbp.v17i1.2015.46-51

Abstract

AbstrakLatar Belakang: Sekitar 95% dari tumor ganas diklasifikassikan secara histologis sebagai Oral Squamous Cell Carcinoma (OSCC). Secara mikroskopis OSCC diklasifikasikan berdasarkan pada metode yang mempehitungkan penilaian subjektif, tingkat keratinisasi, pleomorfik nukleus dan seluler, dan aktivitas mitosis. Tingkatan tersebut meliputi well differentiated (grade I-II), moderately differentiated (grade III), dan poorly differentiated (grade IV). Well dan moderately differentiated dapat dikelompokkan sebagai low grade sedangkan poorly differentiated tumor sebagai high grade. Standar yang paling baik untuk menegakkan diagnosis OSCC adalah pemeriksaan histopatologis dan biopsi jaringan lesi tersebut. Tujuan: Penelitian ini bertujuan untuk menentukan grading tumor ganas OSCC berdasarkan gambaran histopatologi. Metode: Sampel terdiri dari 6 jenis OSCC kemudian dilakukan pembuatan sediaan jaringan tumor ganas OSCC kedalam blok paraffin dan dilakukan pengecatan menggunakan hematoxilin eosin (HE). Gambaran histopatologi dari keenam sampel diamati dibawah mikroskop cahaya dengan pembesaran 100x dan 400x.   Hasil: Dari 6 kasus yang ditemukan satu terdiagnosa sebagai well differentiated (stage I), dua kasus terdiagnosa well differentiated(sstage II),  dua kasus terdiagnosa moderately differentiated (stage III), dan poorly differentiated (stage IV). Kesimpulan: OSCC diklasifikasikan berdasarkan gambaran histopatologi kedalam well differentiated (stage I-II), moderately differentiated (stage III), dan poorly differentiated (stage IV)Kata Kunci : OSCC, well differentiated, moderately differentiated, poorly differentiated
The Role Of Moringa Leaf Extract (Moringa Oleifera) On Interleukin-10 Levels In Chronic Inflammation Of The Dermis Of White Wistar Rats (Rattus Norvegicus) Nurwinda Enni Rosyidah; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 24 No. 1 (2022): VOL 24, NO 1 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i1.2022.23-28

Abstract

Traumatic injury can cause chronic inflammation that lasts several months to years. Interleukin-10 plays an important role in the repair of tissue fibrosis and accelerates wound healing. The active compounds of secondary metabolites in Moringa leaves include flavonoids, saponins, alkaloids, and tannins that can accelerate wound closure and act as anti-inflammatory effect to help vasoconstriction in blood vessels so as to minimize signs of inflammation. The aim of this study was to analyze the role of Moringa leaf extract on Interleukin-10 levels in chronic dermis inflammation. This study used a true experimental research with a post-test only control group design. This experimental procedure using 20 male Wistar rats, aging 2-3 months, weighing 150-200 grams and divided into four groups, a negative control group and experiment group with treatment of Moringa leaf extract at concentration of 5%, 10% and 15%. The extract was administered for 3 days after the creation of chronic inflammation in the dermis. Blood serum were taken after 3 days administration of Moringa leaf extract. Analysis using Kruskal Wallis with 5% of error rate. The results showed p=0.040 (p<0.005), which means interleukin-10 levels in experiment group with treatment of Moringa leaf extract were significantly increased. The leaf extract of Moringa oleifera had a role in increasing Interleukin-10 levels in chronic dermis inflammation of male white Wistar rats (Rattus norvegicus) with the best concentration of 15%.
Differences in Total S-RBD Antibody SARS-CoV-2 Post-vaccination mRNA-1273 3rd Dosage (Heterologous Prime Booster) with Post-prime Vaccination Inactivated Whole Virus Two Doses (Homologous) in Health Personnel Surabaya H2LC Clinic Deddy Hartanto; Jusak A. Nugraha; Theresia Indah Budhy
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.107-114

Abstract

SARS-CoV-2 cases have increased to 463,182,124 reported worldwide as of March 16, 2022 with a death toll of 6,079,600. Indonesia on March 17, 2022 has increased by 5,939,082 with a death toll of 153,212 (KPCPEN, 2022). SARS-CoV-2 is closely related to the coronavirus. One of the efforts made to prevent the risk of severe infection and reduce the death rate from the SARS-CoV-2 virus in Indonesia is a vaccination program. According to IDI (2021) cases of Covid-19 deaths are dominated by men (84%) and women (16%). Clinical trials in China and Brazil have shown that, the immunogenicity of two doses of the vaccine decreases over time and there is a decrease in low antibody concentrations after 6 months of running time. To overcome this potential, the Indonesian government gives priority to the 3rd vaccine booster. The purpose of this study was to analyze the comparison between the total antibody titer for the Spike-RBD (Receptor Binding Domain) SARS-CoV-2 protein after the 3rd dose of mRNA-1273 booster vaccination and post-vaccination of two doses of primary inactivated whole virus in health workers. This research was conducted by observation with a cohort approach. It was concluded that the results of the Mann Whitney two-sided test with a significance value of 0.000, the antibody titer correlation test results with gender had a value of 0.702 and -0.366 for the relationship between antibody titer and age. There was a significant difference between the primary vaccination dose of 2 doses of CoronaVac and the 3rd vaccination (booster) mRNA-1273, gender was strongly associated with S-RBD antibody titer and age was not associated with S-RBD antibody titer.
The Potential of Mangrove Stem Extract (Aegiceras corniculatum) on the Haematocrit Value Gustiadi Saputra; Theresia Indah Budhy; Muji Rahayu; Budi Santosa
Jurnal Biosains Pascasarjana Vol. 24 No. 2 (2022): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v24i2.2022.122-127

Abstract

Hematocrit examination is an examination used to measure the concentration of red blood cells (erythrocytes) in the blood stated in percent (%). The usual hematocrit examination uses the anticoagulant EDTA, is expensive, and rarely distributed in remote area. Alternative anticoagulants are currently being studied, one of which is the extract of mangrove stems (Aegiceras corniculatum). This study aims to determine the difference in hematocrit values ​​using the anticoagulant EDTA and extract of mangrove stems (Aegiceras corniculatum). The type of this research was analytic observational with a cross-sectional research design. Samples were taken by non-random purposive sampling of 16 female students from a total of 31 students of class D semester VIII of Health Analyst Universitas Muhammadiyah Semarang. The results showed average hematocrit value using EDTA anticoagulant was 42.38% by using the microhematocrit method. Meanwhile, the average hematocrit value using mangrove stem extract (Aegiceras corniculatum) is 20.88%. The hematocrit examination using the EDTA anticoagulant were higher than using the extract of mangrove stems (Aegiceras corniculatum). It showed a value of 0.000 with a significant level of 0.05, which is 0.000 <0.05. Therefore, there is a difference in hematocrit value using EDTA anticoagulant and mangrove stem extract (Aegiceras corniculatum).
MORINGA OLEIFERA EXTRACT CAN INHIBIT GLOMERULUS DAMAGE OF RATTUS NOVERGICUS INJECTED CYCLOPHOSPHAMIDE Laurencia Dwiamanda Elizabeth; Budhy, Theresia Indah; Rahayu, Retno Pudji
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.8-14

Abstract

Cyclophosphamide is a cytostatic used in chemotherapy. Cyclophosphamide has a toxic effect that causes damage to the kidneys. Moringa oleifera is a plant with high antioxidant activity. Its antioxidant content in the form of flavonoids and vitamin C which can inhibit glomerulus damage. Many studies have proven that Moringa oleifera contains high antioxidant activity. However, there has been no research about the potential of Moringa oleifera in inhibiting glomerulus damage that was injected with cyclophosphamide. The purpose of this study was to determine the potential of Moringa oleifera in inhibiting glomerulus damage in Rattus novergicus due to cyclophosphamide injection. This was a laboratory experiment with a post-test only control group design. This study used 18 Rattus norvegicus as samples which was divided into 3 sample groups namely K1 is the group that was only given NaCl, K2 was the group that was given NaCl and injected by cyclophosphamide, and the treatment group was given Moringa oleifera extract. Glomerulus histopathological preparations were stained with Hematoxylin Eosin. Data were analyzed statistically by the Kruskall Wallis and Mann-Whitney tests. The Mann-Whitney test showed significant difference between groups K1 and K2 and groups of P and K2 (p<0.05). There were no significant differences between K1 and P (p>0.05). Giving Moringa oleifera extract can inhibit the glomerular damage of Rattus novergicus, which is injected with cyclophosphamide.
Co-Authors Adawiyah, Rabi’atul Akhmad Setyo Rahman Alexander Patera Nugraha Amalia, Nadya Rafika Ari Nuswantoro Aryati Aryati Azis, Zulfikran Moh Rizki Bambang Sumaryono Banerjee, Abhishek Bayu Indra Sukmana Budi Santosa Cinantya, Aulia Dian Cyuzuzo Callixte Deddy Hartanto Dominicus Husada Dwicha Rahma Nuriska Hartono Edhi Jularso Edith Frederika Puruhito, Edith Frederika Elizabeth, Laurencia Dwiamanda Erawati Wulandari Fadila, Okta Mulia Nur Firjani, Putri Nabila Fransiskus Andrianto Gustiadi Saputra I Ketut Sudana Indrasari, Yulia Nadar Ira Arundina Islamy, Azzahra Hasnur Jenny Sunariani Jusak A. Nugraha Jusak Nugraha Latief Mooduto, Latief Latifah, Maasyitoh Sari Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Ma`ruf, Anwar Muhammad Luthfi Muji Rahayu Nastiti Faradilla Ramadhani Noor, Tengku Natasha Eleena binti Tengku Ahmad Nugraha, Ilyas Yakob Nurul Nur Lailatul Fadhilah Nurwinda Enni Rosyidah Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Rahmah, Shafwa Aisha Rahmawati, Septyana Eka Ratri Maya Sitalaksmi Retno Indrawati Roestamadji Retno Palupi Retno Palupi Retno Pudji Rahayu Rezky, Muhammad Andyka Roni Handayani Roni Handayani S.Pd. M Kes I Ketut Sudiana . Salsabila, Alisya Rachel Sari, Arabella Vonia Sawitri Dwi Indah Pertami Setiawan, Kresna Erlangga Shahzad Shoukat Shallomitha, Aginta Gracia Shariff, Khairul Anuar Sisca Meida Wati Sunari, I Gusti Agung Ayu Eka Putri Supandji, Rafaelle Raditya Syahdiar, Aura Zalfa Ghassani Tika, Dian Tuyishimire Irene Vania Syahputri