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Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non Formularium Nasional Rizki Amalia Nashuha; Satryo Waspodo; Yani Triyani
Cermin Dunia Kedokteran Vol 48, No 12 (2021): General Medicine
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i12.1581

Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Di antara sebelas faktor yang bisa memengaruhi prevalensi skabies di komunitas, salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional, yaitu Permethrin dan Salep 2–4 dengan Non Formularium Nasional seperti Benzyl Benzoate, Ivermectin, Gamma Benzene Hexachloride, Crotamiton, dan Tinospora cordifolia. Metode penelitian ini adalah scoping review dari September 2020–Desember 2020. Pencarian sistematis melalui database elektronik PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane sesuai kriteria inklusi dan eksklusi; skrining menggunakan kriteria PICOS (Pasien, Intervention, Comparison, Outcome, dan Study). Hasil pencarian adalah 15 artikel; 11 artikel menunjukkan bahwa Permethrin memiliki cure rate lebih tinggi daripada Benzyl Benzoate, Ivermectin, Gamma benzene hexachloride dan Crotamiton. Dua artikel menunjukkan Ivermectin memiliki cure rate lebih tinggi daripada Lindane dan Sulfur. Satu artikel menunjukkan terapi kombinasi sulfur lebih baik daripada terapi tunggal. Satu artikel menunjukkan bahwa Tinospora cordifolia memiliki cure rate yang tinggi. Disimpulkan bahwa Permethrin sebagai salah satu obat antiskabies yang terdapat di Formularium Nasional, memiliki cure rate lebih tinggi daripada obat-obat antiskabies Non Formularium NasionalScabies is the third most common skin disease in Indonesia; it is caused by Sarcoptes scabiei var hominis mite. This study aims to compare the cure rate of antiscabietic drugs in the National Formulary, namely Permethrin and 2–4 ointment with the Non-National Formularies such as Benzyl Benzoate, Ivermectin, Gamma Benzene Hexachloride, Crotamiton, and Tinospora cordifolia.. The systematic search was done in September 2020–December 2020 from electronic databases i.e. PubMed, Science Direct, Springerlink, Google Scholar, and Cochrane; using the inclusion and exclusion criteria and PICOS (Patient, Intervention, Comparison, Outcome, and Study) criteria, The search resulted in 15 articles; 11 articles show that Permethrin has better cure rate than Benzyl Benzoate, Ivermectin, Gamma benzene hexachloride and Crotamiton. Two articles show that Ivermectin has higher cure rate than Lindane and Sulfur. One article suggests sulfur combination therapy is preferable to single therapy. One article shows that Tinospora cordifolia has a high cure rate. The conclusion is that Permethrin as one of antiscabietic drug in National Formulary has higher cure rate than Non-National Formulary antiscabietic drugs.

Protective Effect of the T1212C Macrophage Mannose Receptor Gene Polymorphism on Pulmonary Tuberculosis Yani Triyani; Julia Hartati; Budiman Budiman; Ida Parwati; Bachti Alisjahbana
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.10706

The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor (MMR) gene, and the most virulent antigen (the mannose-capped lipoarabinomannan) cell wall of virulent strains of Mycobacterium tuberculosis trigger an innate and adaptive immune response. It also produces pro and anti-inflammatory cytokines, which play a role in the pathogenesis of tuberculosis (TB) infection. Therefore, MMR gene polymorphism is a risk factor associated with the prognosis for active pulmonary TB. This study aimed to determine the correlation between MMR gene polymorphism and active or latent pulmonary tuberculosis. In this phase, MMR gene polymorphism was analyzed using a case-control design consisting of 74 control group subjects (patients with latent TB) and 74 case groups (patients with active pulmonary TB). The subject’s MMR gene DNA sequencing examination. The study was conducted at the Teaching Hospital, Faculty of Medicine, Universitas Padjadjaran Bandung, from February 2014 to January 2015. The statistical analysis used chi-square and odds ratio. The study’s result has shown the MMR gene polymorphism factor that correlated to the incidence of active pulmonary TB was T1212C (OR=0.253; 95% CI=0.111−0.575; p=0.001). There was an MMR gene in one SNP in the control group (C1323T) only and five single nucleotide polymorphisms (SNPs) in both groups (C1303T, C1221, T1212C, G1186A, and G1195A). Therefore, it can be concluded that MMR gene polymorphism on the T1212C site correlated with the incidence of active pulmonary tuberculosis and was protective.

Correlation between NLR and PLR with the Severity of COVID-19 Inpatients Fitriana Andiani; Rita Herawati; Yani Triyani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 29, No 1 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i1.1924

When the COVID-19 outbreak is ongoing, the classification of COVID-19 patients based on the severity assessment is necessary to optimize the allocation of existing resources and early management interventions to improve prognosis. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are two of the most common, simple, inexpensive, rapid, and widely available tests in all health facilities, which indirectly indicate the inflammatory status of COVID-19 patients. This study aimed to analyze the correlation between NLR and PLR with the severity of COVID-19 inpatients. This cross-sectional study was conducted retrospectively using medical record data of COVID-19 patients hospitalized at Al Islam Hospital, Bandung, from January to March 2021. COVID-19 patients involved in this study were classified into moderate, severe, and critical degrees. Statistical analysis was carried out using ANOVA or Kruskal-Wallis and Spearman with a significant value of p < 0.05. The median NLR and PLR results based on the severity were 3.49; 6.27; 8.4 (p<0.001) and 159.2; 202.6; 250.9 (p<0001), respectively. There was a correlation between NLR and PLR and the severity with r= 0.415 (p<0.001) and r=0.216 (p<0.001), respectively. The correlation between NLR and the severity was stronger than PLR. Therefore, it was concluded that there was a correlation between NLR and PLR with the severity of COVID-19 patients.

Kejadian Hiperglikemia Baru Akibat Infeksi Covid-19 Lukman Hakim Muttaqien; Yani Triyani; Wida Purbaningsih
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5564

Abstract. Coronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The SARS-CoV-2 virus has a spike-like protein (S) structure, which will bind to the angiotensin converting enzyme 2 (ACE2) receptor. The number of tissues that express ACE2 receptors causes varied symptoms, ranging from mild symptoms such as coughing, to severe symptoms such as digestive disorders, heart failure, hypertension, and other systemic disorders such as hyperglycemia. So that there are many cases of increased blood sugar levels in COVID-19 patients which cause hyperglycemia. This study aims to determine the relationship between the incidence of new hyperglycemia and COVID-19. This study was conducted by taking medical record data at Al-Islam Hospital in the January-September 2021 period to obtain data on COVID-19 hospitalized patients and data on current blood sugar. This study used an analytical observational method with a case control design and the sampling technique was carried out using the total sampling method and analysis using the chi-square test. The medical record samples studied were 171 medical records at Al-Islam Bandung Hospital. The results showed that most of the subjects experienced hyperglycemia as many as 44 people (51.8%), and there was a significant relationship between COVID-19 infection and the incidence of hyperglycemia (P=0.038). COVID-19 infection is one of the causes of hyperglycemia. Abstrak. Penyakit Coronavirus (COVID-19) adalah penyakit infeksius yang disebabkan oleh virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Virus SARS-CoV-2 memiliki struktur protein seperti spike protein (S), yang akan berikatan dengan reseptor angiotensin converting enzyme 2 (ACE2). Banyaknya jaringan yang mengekspresikan reseptor ACE2 menimbulkan gejala yang bervariasi, berawal dari gejala ringan seperti batuk, hingga gejala berat seperti gangguan pencernaan, gagal jantung, hipertensi, dan gangguan sistemik lain seperti hiperglikemia. Sehingga banyak kasus kenaikan kadar gula darah pada pasien COVID-19 yang menyebabkan hiperglikemia. Penelitian ini bertujuan untuk mengetahui hubungan antara kejadian hiperglikemia baru dengan COVID-19. Penelitian ini dilakukan dengan mengambil data rekam medis di RS Al-Islam pada periode Januari–September 2021 untuk mendapatkan data pasien rawat inap COVID-19 dan data gula darah sewaktu. Penelitian ini menggunakan metode observasional analitik dengan rancangan kasus control dan Teknik pengambilan sample dilakukan dengan metode total sampling serta analisis menggunakan uji chi-square. Sampel rekam medis yang diteliti sebanyak 171 rekam medis di RS Al-Islam Bandung. Hasil penelitian didapatkan Sebagian besar subjek mengalami hiperglikemia sebanyak 44 orang (51,8%), dan terdapat hubungan yang signifikan antara infeksi COVID-19 dengan kejadian hiperglikemia (P=0,038). Infeksi COVID-19 menjadi salah satu penyebab hiperglikemia.

Diabetes Melitus sebagai Komorbiditas Utama terhadap Mortalitas Pasien COVID-19 Zahra Salsabila; Yani Triyani; Sadiah Achmad
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6721

Abstract. Cases of COVID-19 are rapidly increasing and spreading throughout Indonesia and have an impact on the degree of severity and the number of deaths in the population that are affected by the presence of comorbidities. The purpose of this study was to analyze the relationship between comorbidities and mortality in COVID-19 patients. This study uses analytic methods with a cross-sectional research design. Data were obtained from the medical records of inpatients with confirmed COVID-19 at Al-Islam Hospital Bandung for the 2021 period. The statistical test used a univariate data test by looking at the characteristics of COVID-19 patients based on age, sex, and length of stay and using the Chi test -Square to analyze whether there is a relationship between the independent and dependent variables. The number of respondents in this study was 2,047 people, with the most age being ≥60 years (39.5%), male sex (51.3%), with the highest comorbidity diabetes mellitus (41.9%), followed by hypertension (35.7%) and renal disease (12.4%) which have CFR values of 10.1%, 5.9%, and 5.2% respectively. Patients with comorbid diseases have a decreased immune response and the location of ACE-2 receptors is found not only in the respiratory tract but also in other organs such as the pancreas and kidneys. The conclusion shows that there is a relationship between comorbidities and mortality of COVID-19 patients at Al-Islam Hospital Bandung in 2021 with a p-value <0.001 (p <0.05) Abstrak. Kasus COVID-19 dengan cepat meningkat dan menyebar ke seluruh Indonesia serta berdampak pada derajat keparahan dan jumlah kematian populasi yang dipengaruhi oleh adanya komorbiditas. Tujuan penelitian ini adalah menganalisis hubungan komorbiditas dengan mortalitas pasien COVID-19. Penelitian ini menggunakan metode analitik dengan rancangan penelitian cross sectional. Data diperoleh dari rekam medis pasien rawat inap yang terkonfirmasi COVID-19 di Rumah Sakit Al-Islam Bandung Periode 2021. Uji Statistik menggunakan uji data univariat dengan melihat karakteristik pasien COVID-19 berdasarkan usia, jenis kelamin, dan lama rawat inap serta menggunakan uji Chi-Square untuk menganalisis ada tidaknya hubungan antara variable bebas dan terikat. Jumlah responden pada penelitian ini sebanyak 2.047 orang, dengan usia yang paling banyak ≥60 tahun (39,5%), jenis kelamin laki-laki (51,3%), dengan komorbiditas tertinggi diabetes melitus (41,9%), disusul dengan hipertensi (35,7%) dan renal disease (12,4%) yang memiliki nilai CFR berturut-turut 10,1%, 5,9%, dan 5,2%. Pasien dengan penyakit komorbid berada dalam penurunan respon imun serta lokasi reseptor ACE-2 yang ditemukan tidak hanya di saluran respirasi, tetapi juga didapatkan di organ lain seperti pankreas dan ginjal. Kesimpulan menunjukkan terdapat hubungan komorbiditas dengan mortalitas pasien COVID-19 di RS Al-Islam Bandung tahun 2021 dengan nilai p <0.001 (p<0.05)

Pengaruh Gambaran Radiografi Thoraks dan Trombosit dengan Keparahan Pasien Covid-19 Fauzan Rahman Latama; Sadeli Masria; Yani Triyani
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6443

Abstract. Coronavirus Disease 2019 (COVID-19) is a disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). There is some way to diagnose Covid-19 patient, one of which is thrombocyte and imaging of Chest X-ray. The purpose of this study is to determine the relationship between thrombocyte value and imaging of Chest x-ray in severity of Covid-19 patients. This research uses total sampling method. The subject of this study was medical records of patients diagnosed Covid-19 who were hospitalized at Al-Islam Hospiital Bandung for the time period between January-March 2021. Data analysis used the chi square test. The result of this study showed that thrombocyte value has no significant relationship with severity in Covid-19 patients (p-value = 0.392) and Chest x-ray imaging has significant relationship with severity in Covid-19 Patients (p-value = 0.0001.). This study concluded that thrombocyte value has no significant relationshop with severity in Covid-19 patients and chest x-ray imaging has significant relationship with severity in Covid-19 patients. Abstrak. Coronavirus disease 2019 (Covid-19) merupakan penyakit infeksi virus yang penyebabnya adalah virus yang bernama severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ada berbagai cara untuk melakukan diagnosis pasien Covid-19, seperti menggunakan jumlah trombosit dan gambaran Radiografi thoraks. Tujuan penelitian ini untuk mengetahui hubungan jumlah trombosit dan gambaran radiografi thoraks dengan tingkat keparahan pada pasien Covid-19. Penelitian ini menggunakan metode total sampling. Subjek penelitian ini adalah rekam medis pasien terkonfirmasi Covid-19 yang dirawat inap di Rumah Sakit Al-Islam Bandung periode Januari-Maret 2021. Analisis data menggunakan uji chi square. Hasil dari penelitian ini menyatakan nilai trombosit dengan tingkat keparahan pasien Covid-19 tidak memiliki hubungan (p-value = 0.392) dan menyatakan gambaran chest x-ray dengan tingkat keparahan pasien Covid-19 memiliki hubungan (p-value = 0.0001). kesimpulan dari penelitian ini adalah nilai trombosit dan tingkat keparahan pasien Covid-19 tidak memiliki hubungan dan gambaran radiografi toraks memiliki hubungan dengan tingkat keparahan pasien Covid-19.

Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non-Formularium Nasional Rizki Amalia Nashuha; Satryo Waspodo; Yani Triyani
Cermin Dunia Kedokteran Vol 48 No 12 (2021): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i12.173

Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Di antara sebelas faktor yang bisa memengaruhi prevalensi skabies di komunitas, salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional, yaitu permethrin dan salep 2–4, dengan Non-Formularium Nasional seperti benzyl benzoate, ivermectin, gamma benzene hexachloride, crotamiton, dan Tinospora cordifolia. Metode penelitian ini adalah scoping review dari September 2020–Desember 2020. Pencarian sistematis melalui database elektronik PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane sesuai kriteria inklusi dan eksklusi; skrining menggunakan kriteria PICOS (Patient, Intervention, Comparison, Outcome, dan Study). Hasil pencarian adalah 15 artikel; 11 artikel menunjukkan bahwa permethrin memiliki cure rate lebih tinggi daripada benzyl benzoate, ivermectin, gamma benzene hexachloride, dan crotamiton. Dua artikel menunjukkan ivermectin memiliki cure rate lebih tinggi daripada lindane dan sulfur. Satu artikel menunjukkan terapi kombinasi sulfur lebih baik daripada terapi tunggal. Satu artikel menunjukkan bahwa Tinospora cordifolia memiliki cure rate yang tinggi. Disimpulkan bahwa permethrin sebagai salah satu obat antiskabies yang terdapat di Formularium Nasional, memiliki cure rate lebih tinggi daripada obat-obat antiskabies Non-Formularium Nasional. Scabies is the third most common skin disease in Indonesia; it is caused by Sarcoptes scabiei var hominis mite. This study aims to compare the cure rate of antiscabietic drugs in the National Formulary, namely permethrin and 2–4 ointment with the Non-National Formularies such as benzyl benzoate, ivermectin, gamma benzene hexachloride, crotamiton, and Tinospora cordifolia. The systematic search was done in September 2020–December 2020 from electronic databases i.e. PubMed, Science Direct, Springerlink, Google Scholar, and Cochrane; using the inclusion and exclusion criteria and PICOS (Patient, Intervention, Comparison, Outcome, and Study) criteria, The search resulted in 15 articles; 11 articles show that permethrin has better cure rate than benzyl benzoate, ivermectin, gamma benzene hexachloride, and crotamiton. Two articles show that Ivermectin has higher cure rate than lindane and sulfur. One article suggests sulfur combination therapy is preferable to single therapy. One article shows that Tinospora cordifolia has a high cure rate. The conclusion is that permethrin as one of antiscabietic drug in National Formulary has higher cure rate than Non-National Formulary antiscabietic drugs.

PEMBERDAYAAN TOKOH MASYARAKAT DALAM PENDAMPINGAN PENCEGAHAN PENYAKIT REUMATIK DEGENERATIF DI KAMPUNG PERENG DESA PANGAUBAN KECAMATAN PACET KABUPATEN BANDUNG Muhammad Iqbal; Dede Setiapriagung; Nuri Amalia; Yani Triyani
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 7, No 1 (2023): March
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v7i1.13166

ABSTRAKHasil survey masyarakat di kampung Pereng, Desa Pangauban Kecamatan Pacet Kabupaten Bandung sekitar 70% terdiri dari orang tua yang sering mengeluhkan penyakit degeneratif terutama reumatik, namun jarang berobat ke puskesmas. Kegiatan pengabdian di daerah tersebut bertujuan memberikan solusi permasalahan dengan pendampingan tokoh masyarakat untuk mengenal cara hidup sehat islami sebagai salah satu pencegahan penyakit yang sering dikeluhkan warga. Metode yang dilakukan pada tahapan awal adalah penjaringan kesehatan warga untuk mengetahui jenis penyakit yang paling banyak ditemukan. Tahapan selanjutnya adalah melakukan pendampingan berupa dialog interaktif kepada para tokoh masyarakat sebagai corong kesehatan masyarakat, dan dilakukan pre dan post test untuk menilai pengetahuan tentang penyakit degeneratif. Kegiatan dilakukan di mesjid kampung Pereng, bulan Agustus–Oktober 2022. Hasil penjaringan kepada 135 orang, ditemukan warga berusia >61 tahun sebanyak 106 warga (79%), dan penyakit terbanyak yang ditemukan adalah jaringan otot dan sendi 32 orang (24%), kedua kasus hipertensi 24 orang (18%), hal ini sangat berhubungan dengan gaya dan pola hidup yang masih belum baik. Sebagai kesimpulan pendampingan yang dilakukan dapat menambah pengetahuan tentang pencegahan penyakit degeneratif kepada para tokoh masyarakat, yang terlihat dari adanya peningkatan skor pengisian post test setelah pendampingan dibandingkan pre test. Kata kunci: pemberdayaan; pencegahan penyakit degenerative; tokoh masyarakat. ABSTRACTThe results of a community survey in Pereng, Pangauban Village, Pacet District, Bandung Regency, around 70% consisted of parents who often complained of degenerative diseases, especially rheumatism, but rarely went to the puskesmas. Community service aim to provide solutions to problems by assisting community leaders to know the healthy Islamic way of life as one of the preventions of diseases often complained. The method used in the early stages was a citizen health screening to find the diseases most commonly found. The next stage is to assist community leaders as public health mouthpieces, according by interactive dialogue and to fill in the pre and post-tests to assess knowledge about degenerative diseases. The activity was carried out at the Pereng village mosque, August–October 2022.The screening results found 135 residents, 106 residents aged >61 years (79%), and most of the diseases found were muscle and joint tissue (rheumatism) in 32 people (24%), this is very related to lifestyle and lifestyle which is still not good. In conclusion, the assistance provided can increase knowledge about preventing degenerative diseases to community leaders, which can be seen from the increase in post-test filling scores after mentoring compared to the pre-test. Keywords: community leaders; empowerment; prevention of degenerative diseases

Correlation between NLR and PLR with the Severity of COVID-19 Inpatients Fitriana Andiani; Rita Herawati; Yani Triyani
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 1 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i1.1924

When the COVID-19 outbreak is ongoing, the classification of COVID-19 patients based on the severity assessment is necessary to optimize the allocation of existing resources and early management interventions to improve prognosis. Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are two of the most common, simple, inexpensive, rapid, and widely available tests in all health facilities, which indirectly indicate the inflammatory status of COVID-19 patients. This study aimed to analyze the correlation between NLR and PLR with the severity of COVID-19 inpatients. This cross-sectional study was conducted retrospectively using medical record data of COVID-19 patients hospitalized at Al Islam Hospital, Bandung, from January to March 2021. COVID-19 patients involved in this study were classified into moderate, severe, and critical degrees. Statistical analysis was carried out using ANOVA or Kruskal-Wallis and Spearman with a significant value of p < 0.05. The median NLR and PLR results based on the severity were 3.49; 6.27; 8.4 (p<0.001) and 159.2; 202.6; 250.9 (p<0001), respectively. There was a correlation between NLR and PLR and the severity with r= 0.415 (p<0.001) and r=0.216 (p<0.001), respectively. The correlation between NLR and the severity was stronger than PLR. Therefore, it was concluded that there was a correlation between NLR and PLR with the severity of COVID-19 patients.

Evaluating Risk Factors for Early-onset Neonatal Sepsis Iskandar, Wedi; Juniartho, Rizky Dwi; Triyani, Yani; Permatagalih, Vidi
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13940

Neonatal sepsis is a systemic infection that occurs in infants at 28 days of life and is a significant cause of morbidity and death in newborns. Early-onset neonatal sepsis (EONS) occurs within 72 hours after birth and is often associated with infections contracted before or during childbirth. The study aims to evaluate the risk factors of EONS. The study design was a case-control retrospective observational study that evaluated the medical records of neonates who were admitted to the neonatal care unit of Al Islam Hospital Bandung from January 2020 to December 2022. This study assessed the impact of independent variables such as gestational age, birth weight, premature rupture of membrane (PROM), miconeal amniotic fluid, APGAR score of 5 minutes, and the mother's white blood cell count elevation (>15,000/µl). The logistic regression analyses were employed to analyze the data. The logistic regression analyses were employed to analyze the data. The study included 3,103 neonates, of whom 124 met the inclusion criteria. Thirty-nine patients (31.35%) were diagnosed with sepsis, while 85 patients (68.55%) did not have sepsis. Based on bivariate analysis, EONS was significantly linked to low birth weight (p=0.027, 95% CI=0.184 to 0.902, OR=2.455), PROM (p=0.000, 95% CI=4.359 to 26.582, OR=10.764), and the mother's white blood cell count elevation (p=0.002, 95% CI=1.560 to 7.622, OR=3.448). On multivariate analysis, the risk factors were significantly associated (p<0.05), which had an influence of 38.4% on EONS (Nagelkerke R square=0.384). In conclusion, the risk factors for EONS were low birth weight, PROM, and elevation of white blood cell count in the mother, which increased by 38.4% with EONS.

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