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All Journal Global Medical and Health Communication SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmiah Mahasiswa Fakultas Ilmu Sosial & Ilmu Politik PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Abdi Insani Jurnal Integrasi Kesehatan dan Sains Cermin Dunia Kedokteran Jurnal Riset Kedokteran Bandung Conference Series : Medical Science Bangun Desa : Jurnal Pengabdian Masyarakat Cermin Dunia Kedokteran Global Medical and Health Communication

Yani Triyani

Departemen Patologi Klinik, Universitas Islam Bandung, Bandung, Indonesia

Author-ID : 499636

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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RANCANGAN PRIMER SPESIFIK GEN MACROPHAGE MANNOSE RECEPTOR (MMR) UNTUK POLYMERASE CHAIN REACTION (PCR) DAN SEKUENSING DEOXYRIBO NUCLEIC ACID (DNA) Yani Triyani; Nurizzatun Nafsi; Lelly Yuniarti; Nanan Sekarwana; Endang Sutedja; Dida Ahmad Gurnida; Ida Parwati; Bachti Alisjahbana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 2 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i2.1120

The order (sequencing) determinationof DeoxyribonucleicAcid (DNA) bases is the gene’s most basic information, using the methodof Polymerase Chain Reaction (PCR) as its stage. A key factor of successful detection by PCR is specific PCR primer design choice. Thedetection of diversity of Mycobacterium Mannose Receptor (MMR) gene, responsible for recognizing mannosylated antigen structureof Mycobacterium tuberculosis (M.tb) by DNA sequencing of exon 7 chromosome 10p12, related to susceptiblity for PulmonaryTuberculosis(TB), was first performed in China in 2012. The purpose of this study was to find specific primerfromboth design originatedfrom the research in China/primer I and my own design/primer IIby using Primer3 software. This study was based on 10 healthy subjectsand was a preliminary study of a research titled. The Relationship of Single Nucleotide Polymorphisms (SNPs) of Macrophage MannoseReceptor Gene to Pulmonary Tuberculosis Cases. The examination materials consist of 3 mL of EDTA blood and DNA extraction from itsbuffy coat. The resulting DNA was processed by PCR to amplify MMR gene with primer I and II. The primer I successfully amplified DNAfragments up to 780bp while primer II only 329 bp. The MMR gene DNA sequencing analysis was performed on the amplification resultof both kinds primers by using DNA Baser and Ensembl−BLAST software. The results were different, DNA sequencing result by using theprimer I was found in several chromosomes and also in several loci. Whereas, by using the primer II, it was only found in chromosome10 and in the same locus. Based on this study, it can be concluded that the specific primer design is one of the most important factorsin the success of DNA sequencing.

Pendidikan Seks dalam Keluarga (studi Komunikasi Interpersonal Orang Tua dan Remaja dalam Mencegah Perilaku Seks Pra Nikah di Kecamatan Darul Makmur Kabupaten Nagan Raya Triyani yani; Dr. Rasyidah, S.Ag.,M.ag
Jurnal Ilmiah Mahasiswa Fakultas Ilmu Sosial & Ilmu Politik Vol 3, No 1 (2018): Februari 2018
Publisher : Jurnal Ilmiah Mahasiswa Fakultas Ilmu Sosial & Ilmu Politik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (23.795 KB)

ABSTRAK Permasalahan yang menjadi kekhawatiran masyarakat terutama orang tua di Kecamatan Darul Makmur Kabupaten Nagan Raya adalah persoalan pernikahan dini dan perilaku seks pra-nikah, berakibat hamil diluar nikah.Penelitian ini bertujuan untuk mengetahui bagaimana situasi komunikasi interpersonal orang tua dan remaja dalam mencegah perilaku seks pra-nikah. Dengan menggunakan teori Definisi Situasi WilliamIThomas. Mengawali setiap tindakan perilaku yang ditentukan sendiri selalu ada satu tahap pengujian dan pertimbangan yang dapat disebut Definisi Situasi.Penelitian ini menggunakan pendekatan deskriptif kualitatif dan wawancara mendalam (in depth interview) sebagai pengumpulan data. Hasil penelitian ini menunjukkan bahwa masyarakat memberi tanggapan tabu terhadap pendidikan seks, sehingga orang tua sendiri memberikan tindakan enggan untuk memberikan pendidikan seks kepada remaja. Hal ini disebabkan kurangnya pengetahuan terhadap pendidikan seks, orang tua hanya memberikan sebatas arahan, orang tua juga tidak memberikan sikap terbuka dan perasaan positif terhadap remaja, selain itu orang tua juga tidak memiliki ketrampilan khusus dalam berkomunikasi, interaksi orang tua dan remaja terjadi ketika ada masalah yang muncul dilingkungannya, secara spontan orang tua memberikan arahan tanpa membuat perencanaan khusus untuk mendiskusikan pendidikan seks.Hubungan interpersonal orang tua dan remaja menunjukan bahwa definisi situasi pada komunikasi yang terjalin adalah kurang baik.Kata Kunci :Pendidikan Seks, Komunikasi Interpersonal, Orang TuaEducation Sex in Family (Interpersonal Comunication Studies Of Parents and Adolescents in Preventing Pre-Marriage Sex Behavior in Darul Makmur Sub-District, Nagan Raya District)ABSTRACT The problems that become the concern of the community, especially the parents in Darul Makmur Sub-district, Nagan Raya District, is the issue of early marriage and pre-marital sex behavior, resulting in pregnancy outside of marriage. This study aims to find out how the situation of interpersonal communication between parents and adolescents in preventing pre-marital sex behavior. By using William I Thomas Situation Definition theory. Initiating any self-defined behavioral action there is always a testing and consideration stage that can be called a Situation Definition. This research uses qualitative descriptive approach and in depth interview as data collection. The results of this study indicate that people give a taboo response to sex education, so parents themselves provide reluctant action to provide sex education to adolescents. This is due to the lack of knowledge of sex education, parents only provide limited direction, parents also do not give an open attitude and positive feelings towards adolescents, but parents also do not have special skills in communicating, parents and adolescent interactions occur when there is a problem which appears in the environment, spontaneously giving parents directions without making a special plan to discuss sex. The interpersonal relationship of parents and adolescents shows hat definition of situation in the comunication is not good. Keywords: Sex Education, Interpersonal Communication, Parents

Optimasi Formula Lipid Nanostruktur dengan Pentarget Manosa sebagai Sistem Penghantaran Rifampisin Tri Suciati; Nurani Istiqomah; Benny Permana; Elin Julianti; Marlia Singgih Wibowo; Titah Yudistira; Yani Triyani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Limited accumulation of anti-tuberculosis drugs in macrophages become a barrier to the success of latent tuberculosis therapy. The purpose of this study is to develop a D-mannose modified nanoparticle formula as a targeting agent to the mannose receptors to increase the internalization of rifampicin into macrophages. D-mannose was conjugated with chitosan using an amine reducing agent. Chitosan-D-mannose conjugate was characterized using FTIR. Subsequently, the conjugate was adsorbed onto the nanostructured lipid carrier (NLC) electrostatically. The NLC formula consisted of an ethyl acetate solution of solid-liquid lipid blend and rifampicin and an aqueous solution of chitosan-D-mannose conjugate, which were emulsified using polysorbate 80. Solidification of the NLC-chitosan-mannose nanoparticles was carried out by ionotropic gelation and solvent evaporation. The nanoparticle formula was optimized using Box-Behnken design. The formation of chitosan-D-mannose conjugate was shown by the change of the amide band wave number and the Schiff base formation of the FTIR spectra. The optimum formula of nanoparticles had a diameter of 766.1 ± 57.56 nm with a polydispersity index of 0.32 ± 0.02, encapsulation efficiency of 91.54 ± 0.18% and drug loading of 36.62 ± 0.07%. Rifampicin was released from the nanoparticles at pH 5.2 or 7.4 with a similar rate. This D-mannose modified NLC formula has the potential to be further developed as an intracellular antibiotic targeting to macrophages.

Perbandingan Cure Rate Obat-obat Antiskabies di Formularium Nasional dengan Non Formularium Nasional Rizki Amalia Nashuha; Satryo Waspodo; Yani Triyani
Cermin Dunia Kedokteran Vol 48, No 12 (2021): General Medicine
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v48i12.1581

Skabies adalah penyakit kulit yang disebabkan oleh tungau Sarcoptes scabiei var hominis. Di Indonesia, skabies menduduki urutan ketiga dari 12 penyakit kulit tersering. Di antara sebelas faktor yang bisa memengaruhi prevalensi skabies di komunitas, salah satunya adalah kegagalan pengobatan. Penelitian ini bertujuan untuk mengetahui perbandingan cure rate obat-obat antiskabies di Formularium Nasional, yaitu Permethrin dan Salep 2–4 dengan Non Formularium Nasional seperti Benzyl Benzoate, Ivermectin, Gamma Benzene Hexachloride, Crotamiton, dan Tinospora cordifolia. Metode penelitian ini adalah scoping review dari September 2020–Desember 2020. Pencarian sistematis melalui database elektronik PubMed, Science Direct, Springer Link, Google Scholar, dan Cochrane sesuai kriteria inklusi dan eksklusi; skrining menggunakan kriteria PICOS (Pasien, Intervention, Comparison, Outcome, dan Study). Hasil pencarian adalah 15 artikel; 11 artikel menunjukkan bahwa Permethrin memiliki cure rate lebih tinggi daripada Benzyl Benzoate, Ivermectin, Gamma benzene hexachloride dan Crotamiton. Dua artikel menunjukkan Ivermectin memiliki cure rate lebih tinggi daripada Lindane dan Sulfur. Satu artikel menunjukkan terapi kombinasi sulfur lebih baik daripada terapi tunggal. Satu artikel menunjukkan bahwa Tinospora cordifolia memiliki cure rate yang tinggi. Disimpulkan bahwa Permethrin sebagai salah satu obat antiskabies yang terdapat di Formularium Nasional, memiliki cure rate lebih tinggi daripada obat-obat antiskabies Non Formularium NasionalScabies is the third most common skin disease in Indonesia; it is caused by Sarcoptes scabiei var hominis mite. This study aims to compare the cure rate of antiscabietic drugs in the National Formulary, namely Permethrin and 2–4 ointment with the Non-National Formularies such as Benzyl Benzoate, Ivermectin, Gamma Benzene Hexachloride, Crotamiton, and Tinospora cordifolia.. The systematic search was done in September 2020–December 2020 from electronic databases i.e. PubMed, Science Direct, Springerlink, Google Scholar, and Cochrane; using the inclusion and exclusion criteria and PICOS (Patient, Intervention, Comparison, Outcome, and Study) criteria, The search resulted in 15 articles; 11 articles show that Permethrin has better cure rate than Benzyl Benzoate, Ivermectin, Gamma benzene hexachloride and Crotamiton. Two articles show that Ivermectin has higher cure rate than Lindane and Sulfur. One article suggests sulfur combination therapy is preferable to single therapy. One article shows that Tinospora cordifolia has a high cure rate. The conclusion is that Permethrin as one of antiscabietic drug in National Formulary has higher cure rate than Non-National Formulary antiscabietic drugs.

Peran Parameter Trombosit sebagai Biomarker Keparahan dan Prognosis Pasien Coronavirus Disease 2019 Nadya Aulia Rahmadhanty; Yani Triyani
Jurnal Riset Kedokteran Volume 2, No.1, Juli 2022, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. Increased risk of mortality of Coronavirus Disease 2019 (COVID-19) patients with severe symptoms, often associated with cytokine storms. Cytokine storms can cause damage to bone marrow progenitor cells so that reduced platelet production leads to thrombocytopenia. Monitoring platelet parameters as a laboratory test that is easily available, affordable, and widely used, can also be used to monitor cytokine storms of COVID-19 patients. The aim of this study was to determine the role of platelet parameters as potential indicators of assessing the clinical degree of COVID-19 patients. The method of this study was scoping review. The databases used were PubMed, SpringerLink, and ScienceDirect with a total of 788 search results. The screening result of articles that suit the inclusion criteria were 162 articles and those that suit the eligibility criteria are reviewed as many as 6 articles. The results of the analysis of 6 articles reviewed, 5 articles showed that platelet count can assess the severity and prognosis in COVID-19 patients and 1 article shows that the Mean Platelet Volume value does not act as a good predictor for the severity of COVID-19 disease. The conclusion of this study is that platelet parameters act as biomarkers of the severity and prognosis of COVID-19 patients. Platelet count is more effective as a biomarker of the severity and prognosis of COVID-19 patients compared to Mean Platelet Volume, Plateletcrit, Platelet Distribution Width, and Platelet Large Cell Ratio. Abstrak. Peningkatan risiko mortalitas pasien Coronavirus Disease 2019 (COVID-19) dengan gejala parah, sering dikaitkan dengan adanya badai sitokin. Badai sitokin dapat menyebabkan kerusakan sel progenitor bone marrow sehingga produksi trombosit berkurang menyebabkan trombositopenia. Pemantauan parameter trombosit sebagai tes laboratorium yang mudah tersedia, terjangkau, dan banyak digunakan, dapat juga dilakukan untuk memantau badai sitokin pasien COVID-19. Tujuan penelitian ini untuk mengetahui peran parameter trombosit sebagai indikator potensial menilai derajat klinis pasien COVID-19. Penelitian ini menggunakan metode scoping review. Database yang digunakan yaitu PubMed, SpringerLink, dan ScienceDirect dengan jumlah artikel hasil pencarian sebanyak 788. Jumlah artikel yang sesuai dengan kriteria inklusi sebanyak 162 dan yang memenuhi kriteria eligibility direview sebanyak 6 artikel. Hasil analisis 6 artikel yang di-review, 5 artikel menunjukkan bahwa hitung jumlah trombosit dapat menilai tingkat keparahan dan prognosis pada pasien COVID-19 serta 1 artikel menunjukkan bahwa nilai Mean Platelet Volume tidak berperan sebagai prediktor yang baik untuk tingkat keparahan penyakit COVID-19. Kesimpulan penelitian ini adalah parameter trombosit berperan sebagai biomarker keparahan dan prognosis pasien COVID-19. Hitung jumlah trombosit lebih efektif berperan sebagai biomarker keparahan dan prognosis pasien COVID-19 dibanding dengan Mean Platelet Volume, Plateletcrit, Platelet Distribution Width, dan Platelet Large Cell Ratio.

Hubungan Usia dan Lingkungan Pasien Tuberkulosis Paru Berdasarkan Hasil Positif dan Negatif Tes Cepat Molekular di RS Al-Islam Bandung Tahun 2018-2019 Nadya Safira; Yani Triyani; Dadang Rukanta
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.167

Abstract. The infectious disease with the highest mortality caused by the bacterium Mycobacterium tuberculosis is Tuberculosis (TB). There are several risk factors that can cause a person to get TB including the environment in which they live, age, and gender. The purpose of this study was to corelation the age and address of TB patients with positive and negative results of the rapid molecular diagnostics (RMD) at AL-Islam Hospital, Bandung. This research was conducted by analytical observation with a cross-sectional approach. The sampling technique used was purposive sampling from medical record data for 2018-2019 with the number of samples that entered the inclusion criteria as many as 253 people. Data analysis using Chi-square test. The results showed that there were 122 positive pulmonary TB patients (48.2%) and 131 negative patients (51.8%). Based on the positive age, the productive age was 99 people (39.1%) and based on the positive environment was the dense environment as many as 117 people (46.2%). The results of the bivariate statistical test showed that there was a relationship between productive age and the incidence of TB because many of these ages did things outside, but with the environment there was no relationship because apart from density there was another risk factor, namely humidity. Abstrak. Penyakit infeksi yang menular dengan kematian paling tinggi yang disebabkan bakteri Mycobacterium tuberculosis adalah penyakit Tuberkulosis (TB). Terdapat beberapa faktor risiko yang bisa menyebabkan seseorang terkena TB diantaranya adalah lingkungan tempat tinggal, usia, dan jenis kelamin. Tujuan penelitian ini adalah menghubungkan bagaimana usia, dan alamat pasien TB dengan hasil positif dan negatif Tes Cepat Molekular (TCM) di RS AL-Islam Bandung. Penelitian ini dilakukan secara observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan Purposive Sampling dari data rekam medis tahun 2018-2019 dengan jumlah sampel yang masuk dalam kriteria inklusi sebanyak 253 orang. Analisis data menggunakan uji Chi-square. Hasil penelitian didapatkan bahwa pasien TB Paru yang positif 122 orang (48,2%) dan negatif 131 orang (51,8%). Berdasarkan usia yang lebih banyak yang positif adalah usia produktif sebanyak 99 orang (39,1%) dan berdasarkan lingkungan yang positif adalah lingkungan padat sebanyak 117 orang (46,2%). Hasil uji statistic bivariat menunjukkan terdapat hubungan antara usia produktif dengan kejadian TB dikarenakan banyak usia tersebut melakukan hal diluar, namun dengan lingkungan tidak terdapat hubungan dikarenakan selain kepadatan terdapat faktor risiko lain yaitu kelembapan.

Gambaran Usia dan Jenis Kelamin Pasien Tuberkulosis Rifampisin Sensitif Berdasar Atas Tes Cepat Molekuler di RS Al-Islam Kota Bandung Tahun 2018−2019 Elfira Azmi Nabilah; Yani Triyani; Siti Annisa Devi Trusda
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.429

Abstract. Tuberculosis (TB) is an infectious disease that is still a major cause of health problems and one of the top ten causes of global mortality. The World Health Organization (WHO) has recommended the diagnosis of tuberculosis patients using the Rapid Molecular Test (Xpert MTB/RIF test), which detect the rifampin resistance (rpoB) gene encoding M. tuberculosis in sputum in approximately two hours and can help diagnose new patients TB can be quickly detected. The objective of this study was to determine the characteristics of rifampin-sensitive. This is was a descriptive study with a cross sectional approach, describing the characteristics of rifampin-sensitive and resistant TB patients based on age and sex. Data in the form of medical records were taken from the clinical pathology lab section of the Al Islam Hospital, Bandung City in 2018–2019. Data collection was carried out in July-August 2021. Total research subjects were 265 people who met the inclusion criteria. The results showed that TB patients with positive rifampin-sensitive Xpert MTB/RIF test had the characteristics of the early adolescent to the ederly age group, the most frequent was adult age group as many as 92 people (34.7%), while female (51.7%) was higher than male. The conclusion of this study that the characteristics of sensitive rifampin TB patients based on Xpert MTB/RIF test at Al Islam Hospital in Bandung City in 2018–2019 were mostly found to be adults and female. Abstrak. Tuberkulosis (TB) merupakan salah satu penyakit menular yang dapat menjadi penyebab utama dalam gangguan kesehatan dan salah satu dari sepuluh penyebab kematian utama di seluruh dunia. World Health Organization (WHO) telah merekomendasikan diagnosis pasien tuberkulosis menggunakan Tes Cepat Molekuler (TCM) dengan Xpert MTB/RIF, alat ini dapat mendeteksi gen pengkode resisten rifampisin (rpoB) M.tuberculosis pada sputum kurang lebih dua jam serta dapat membantu penegakan diagnostik pasien TB yang baru bisa dengan cepat terdeteksi. Tujuan penelitian ini melihat karakteristik usia dan jenis kelamin pasien TB rifampisin sensitif. Rancangan penelitian ini adalah deskriptif dengan pendekatan cross sectional yang menggambarkan karakteristik pasien TB rifampisin sensitif berdasar atas usia dan jenis kelamin. Data berupa rekam medis diambil dari bagian Lab Patologi Klinik Rumah Sakit Al Islam Kota Bandung periode 2018–2019. Pengambilan data dilakukan pada Juli−Agustus 2021. Total subjek penelitian 265 orang yang memenuhi kriteria inklusi. Hasil penelitian menunjukan pasien TB dengan hasil TCM positif rifampisin sensitif memiliki karakteristik kelompok usia remaja awal hingga manula, kelompok usia terbanyak adalah dewasa (26−45 tahun) sebanyak 92 orang (34,7%). Jumlah pasien laki-laki dan perempuan hampir sama, tetapi lebih banyak pasien berjenis kelamin perempuan yaitu sebanyak (51,7%). Kesimpulan dari penelitian ini bahwa pasien TB rifampisin sensitif berdasar atas hasil TCM di RS-Al Islam Kota Bandung tahun 2018–2019 paling banyak ditemukan kelompok usia dewasa, berjenis kelamin perempuan.

Scoping Review: Efektivitas Chest X-Ray Brixia Score untuk Menilai Derajat Keparahan COVID-19 Natassja Salsabilla; Yani Triyani; Dyana Eka Hadiati
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.922

Abstract. The use of chest x-rays in Covid-19 pandemic has become an alternative radiological examination that is extensively carried out, although it is less sensitive, but is widely available and its use is mobile to detect lung abnormalities in Covid-19 patients using the brixia score assessment. The purpose of this study was to determine the effectiveness of chest x-rays using the brixia score to assess the severity of Covid-19. This research was taken by scoping review method with a sample of international scientific articles that meet the eligibility criteria. The databases used in this study are Spingerlink, Sciencedirect, Pubmed, Google scholar, and Proquest with the number of articles obtained as many as 833 articles. The results of the screening of articles that met the inclusion criteria were 275 articles and there were three articles that met the eligibility criteria. The results of the three reviewed articles, one article compared the use of chest x-ray and CT in detecting lesions of Covid-19 patients with the result that chest x-ray had low sensitivity. Two articles compared the brixia score in patients who died and discharged with higher outcomes in patients who died. The conclusion of this study shows that the use of chest x-rays is not effective for detecting early-stage abnormalities and the brixia score is effective for assessing the severity of Covid-19 patients. Abstrak. Penggunaan Chest x-ray di era pandemi Covid-19 menjadi pemeriksaan radiologis alternatif yang banyak dilakukan walaupun kurang sensitif, tetapi tersedia luas dan penggunaannya mobile untuk mendeteksi kelainan paru pada pasien Covid-19 menggunakan penilaian brixia score. Tujuan penelitian ini adalah untuk mengetahui efektivitas chest x-ray menggunakan penilaian brixia score untuk menilai keparahan Covid-19. Penelitian ini diambil dengan metode scoping review dengan sampel artikel ilmiah internasional yang memenuhi kriteria kelayakan (eligible). Database yang digunakan pada penelitian ini adalah Spingerlink, Sciencedirect, Pubmed, Google scholar, dan Proquest dengan jumlah artikel yang didapatkan sebanyak 833 artikel. Hasil skrining artikel yang sesuai dengan kriteria inklusi sebanyak 275 artikel dan artikel yang memenuhi kelayakan terdapat tiga artikel. Hasil dari tiga artikel yang telah di-review, satu artikel membandingkan penggunaan chest x-ray dan CT dalam mendeteksi lesi pasien Covid-19 dengan hasil adalah pemeriksaan chest x-ray mempunyai sensitivitas yang rendah. Dua artikel membandingkan nilai brixia score pada pasien meninggal dan dipulangkan dengan hasil lebih tinggi pada pasien meninggal yaitu 12 poin. Kesimpulan penelitian ini menunjukkan penggunan chest x-ray tidak efektif untuk mendeteksi kelainan tahap awal dan brixia score efektif untuk menilai derajat keparahan pasien Covid-19.

Scoping Review: Hubungan Index Keparahan Gambaran Chest X-Ray dengan Usia pada Pasien Terkonfirmasi COVID-19 Naya Valenski; Yani Triyani; Dede Setiapriagung
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1351

Abstract. One of the impacts of COVID-19 infection is the manifestation in the lungs due to the COVID-19 virus attacks the respiratory tract. Therefore, radiographic examination is needed for monitoring the severity of the lungs of patients with confirmed COVID-19. The severity of the Chest X-Ray can be calculated using an assessment score such as Brixia Score. Factors that affect the severity of chest X-Ray include age in patients with confirmed COVID-19. Older age increases the severity of Chest X-Ray because the immune system declines with age. Thus, the aim of this study was to determine the relationship between the severity index of Chest X-Ray with age in patients with confirmed COVID-19. The study was taken using the scoping review method with a sample of international scientific articles that met the eligibility criteria (elegible). The results in this study were taken from three databases, namely Science Direct, Springer Link and Proquest as well as the Google Scholar scientific publication search feature with 795 initial search results and three eligible articles. The results of three articles, one article uses the RALE (Radiographic Assessment of Lung Edema) score with the results that there is a relationship between the severity of Chest X-Ray and the age of patients with confirmed COVID-19, namely the higher the age, the higher the severity of the Chest X-Ray. The other two articles used the Brixia score with similar results using the RALE score. The conclusion of this study shows that there is a relationship between the severity of Chest X-Ray and age in patients with confirmed COVID-19. Abstrak. Salah satu dampak infeksi COVID-19 adanya manifestasi pada organ paru dikarenakan virus COVID-19 menyerang saluran pernapasan. Oleh karena itu, diperlukan pemeriksaan radiografi untuk monitoring keparahan pada paru pasien terkonfirmasi COVID-19. Keparahan pada gambaran Chest X-Ray dapat dihitung dengan menggunakan skor penilaian seperti skor Brixia. Faktor yang mempengaruhi tingkat keparahan gambaran Chest X-Ray antara lain usia pada pasien terkonfirmasi COVID-19. Usia yang lebih tua meningkatkan tingkat keparahan gambaran Chest X-Ray disebabkan oleh sistem imun yang menurun seiring bertambah usia. Tujuan penelitian untuk mengetahui hubungan indeks keparahan gambaran Chest X-Ray dengan usia pada pasien terkonfirmasi COVID-19. Penelitian diambil dengan metode scoping review dengan sampel artikel ilmiah internasional yang memenuhi kriteria kelayakan (elegible). Hasil pada penelitian ini diambil dari tiga database yaitu Science Direct, Springer Link dan Proquest serta fitur pencarian publikasi ilmiah Google Scholar dengan hasil pencarian awal terdapat 795 dan artikel yang memenuhi kelayakan (eligible) ada tiga artikel. Hasil dari tiga artikel, satu artikel menggunakan skor RALE (Radiographic Assesment of Lung Edema) dengan hasil terdapat hubungan antara tingkat keparahan gambaran Chest X-Ray dengan usia pasien terkonfirmasi COVID-19 yaitu semakin tinggi usia maka semakin tinggi tingkat keparahan gambaran Chest X-Ray. Dua artikel lainnya menggunakan skor Brixia dengan hasil yang sama dengan menggunakan skor RALE. Kesimpulan penelitian ini menunjukan bahwa terdapat hubungan antara tingkat keparahan gambaran Chest X-Ray dengan usia pada pasien terkonfirmasi COVID-19.

Protective Effect of the T1212C Macrophage Mannose Receptor Gene Polymorphism on Pulmonary Tuberculosis Yani Triyani; Julia Hartati; Budiman Budiman; Ida Parwati; Bachti Alisjahbana
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.10706

The interaction between the mannose receptor, which is encoded by the macrophage mannose receptor (MMR) gene, and the most virulent antigen (the mannose-capped lipoarabinomannan) cell wall of virulent strains of Mycobacterium tuberculosis trigger an innate and adaptive immune response. It also produces pro and anti-inflammatory cytokines, which play a role in the pathogenesis of tuberculosis (TB) infection. Therefore, MMR gene polymorphism is a risk factor associated with the prognosis for active pulmonary TB. This study aimed to determine the correlation between MMR gene polymorphism and active or latent pulmonary tuberculosis. In this phase, MMR gene polymorphism was analyzed using a case-control design consisting of 74 control group subjects (patients with latent TB) and 74 case groups (patients with active pulmonary TB). The subject’s MMR gene DNA sequencing examination. The study was conducted at the Teaching Hospital, Faculty of Medicine, Universitas Padjadjaran Bandung, from February 2014 to January 2015. The statistical analysis used chi-square and odds ratio. The study’s result has shown the MMR gene polymorphism factor that correlated to the incidence of active pulmonary TB was T1212C (OR=0.253; 95% CI=0.111−0.575; p=0.001). There was an MMR gene in one SNP in the control group (C1323T) only and five single nucleotide polymorphisms (SNPs) in both groups (C1303T, C1221, T1212C, G1186A, and G1195A). Therefore, it can be concluded that MMR gene polymorphism on the T1212C site correlated with the incidence of active pulmonary tuberculosis and was protective.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad, Sadiah Alfiyya Nur Mahdiyyah Amalia Salima Apen Afgani Bachti Alisjahbana Budiman , Budiman Clara Juniasari Dadang Rukanta Dede Setiapriagung Dede Setiapriagung Dida Ahmad Gurnida Dr. Rasyidah, S.Ag.,M.ag Dyana Eka Hadiati Eka Hendryanny Eka Hendyanny Eka Hendyanny, Eka Ekowati, RA Retno Elfira Azmi Nabilah Elin Julianti Endang Sutedja Fauzan Rahman Latama Fitriana Andiani Heni Muflihah Herawati, Rita Hikmawati, Deis I. Sjahid Ida Parwati Ilhan Rakha Aryawardana Intan Purnamasari Irma Rahmawati Irma Rahmawati Irna Herliani Irna Herliani, Irna Iskandar, Wedi Ismet Muchtar Nur J. E. Gunawan Julia Hartati Juniartho, Rizky Dwi Lelly Yuniarti Lisa Adhia Garina Lukman Hakim Muttaqien Marlia Singgih Wibowo Maya Tejasari Meike Rachmawati Meta Maulida Damayanti Miranti Kania Dewi Muhammad Iqbal Nadya Aulia Rahmadhanty Nadya Safira Nanan Sekarwana Nashuha, Rizki Amalia Natassja Salsabilla Naufal Fadhillah Alam Naya Valenski Noormartany Nurani Istiqomah Nuri Amalia Nurizzatun Nafsi Nurul Patrisia Nurul Patrisia, Nurul Permana, Benny Permatasari, Ranti Purbaningsih, Purbaningsih Puspita, Sara Raden Anita Indriyanti Rahmawati, Rahmawati Rahmi, Fadhilat Sabila Retno Ekowati Rika Nilapsari Rio Dananjaya Rita Herawati Rizki Amalia Nashuha Rizki Amalia Nashuha Rizki Amalia Nashuha Rizky Dwi Juniartho Sadeli Masria Sadiah Achmad Samsudin Surialaga Sara Puspita Satryo Waspodo Satryo Waspodo Satryo Waspodo Siti Annisa Devi Trusda, Siti Annisa Devi Suryani, Yani Dewi Susan Fitriyana Tania Titah Yudistira Titik Respati Tri Suciati Vidi Permatagalih Vidi Permatagalih, Vidi Waspodo, Satryo Wedi Iskandar Wida Purbaningsih Winni Maharani zahra salsabila Zahra Salsabila Zaki Tashdiq Imani

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