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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN MEDIA MEDIKA INDONESIANA ODONTO Dental Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Universa Medicina Media Medika Muda Jurnal Ilmu Kedokteran dan Kesehatan Medica Hospitalia Medica Arteriana (Med-Art) Life Science Odonto dental journal

Udadi Sadhana, Udadi

Anatomical Pathology Department Of Medical Faculty Of Diponegoro University

Author-ID : 500148

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pain Stimulated by Electric Foot Shock to Liver and Spleen Microscopic Immunological Response Features (BALB/c Mice Experimental Study) Dwi Pudjonarko; M Naharuddin Jenie; Udadi Sadhana
MEDIA MEDIKA INDONESIANA 2010:MMI VOLUME 44 ISSUE 1 YEAR 2010
Publisher : MEDIA MEDIKA INDONESIANA

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Background: Pain affects immune system by decreasing type I-immune response that might be seen on microscopic features of liver and spleen. The objective of the study is to prove the effect of pain to immune response that confirmed by liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells of Balb/c mice suffered from pain.Method: This study adapts Laboratory Experimental and Post-Test Only Control Group Design. The samples were 12 female BALB/c mice (average weight 21.88 (SD=1.75) grams and divided into two groups. The control group (C) received no other additional treatment. The Pain (P) group received pain stimulated by Electric Foot Shock (EFS) 1-3 mA at day 12th to 21st. All groups were intravenously injected with 104 live L. monocytogenes at day 21st and sacrificed at day 26th by chloroform anaesthesia. Then, liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells were counted. Data were analyzed by independent t-test (significant if p<0.05).Result: There were significant differences in the liver microabscess formation, hepatocytes destruction and spleen multinucleated giant cells (p<0.05) between the groups. The number of liver microabscess formation and hepatocytes destruction in the P group were higher than C group. The number of spleen multinucleated giant cells in the P group were lower than C group. Conclusion: Pain has an immunosuppressive effect not only on high liver microabscess formation and hepatocytes destruction, but also low spleen multinucleated giant cells.ABSTRAKPengaruh nyeri yang distimulasi electric foot shock terhadap gambaran mikroskopis respon imunologis di hepar dan lien. (Studi eksperimental pada mencit Balb/c).Latar belakang: Nyeri dapat mempengaruhi imunitas tubuh dengan menurunkan produksi sitokin tipe 1 yang kemungkinan akan mempengaruhi gambaran mikroskopis respon imunologis baik di hepar maupun lien. Penelitian ini bertujuan untuk membuktikan penurunan imunitas seluler yang dilihat dari mikroabses dan kerusakan hepatosit pada hepar serta sel datia lien mencit BALB/c yang mendapatkan stimulasi nyeri dengan electric foot shock (EFS).Metode: Penelitian ini merupakan penelitian eksperimental laboratorik, dengan pendekatan the post test–only control group design yang menggunakan 12 ekor mencit betina strain BALB/c, umur 6-8 minggu dan rerata barat badan 21,88 (SD=1,75) gram. Sampel dibagi dalam 2 kelompok dan mendapatkan makanan standar. Pada kelompok Kontrol (K), mencit tidak mendapatkan perlakuan, sedangkan kelompok Nyeri (N), mencit mendapat sensasi nyeri menggunakan EFS mulai hari ke-12 sampai 21. Pada hari ke-21, semua mencit disuntik 104 listeria monocytogenes hidup iv. Dilakukan terminasi mencit pada hari ke-26 untuk dilakukan penghitungan mikroabses dan kerusakan hepatosit pada hepar serta sel datia lien. Dilakukan uji beda antar kelompok perlakuan dengan independent t-test. Perbedaan dinyatakan bermakna bila didapatkan nilai p<0,05.Hasil: Terdapat perbedaan yang bermakna pada jumlah mikroabses dan kerusakan hepatosit pada hepar serta sel datia lien pada mencit yang distimulasi nyeri dengan EFS dibandingkan kontrol (p<0,05). Stimulasi nyeri dengan EFS menyebabkan mikroabses dan kerusakan hepatosit pada hepar lebih tinggi terhadap kontrol, sedangkan sel datia pada lien jumlahnya lebih rendah bila dibandingkan kontrol

EKSPRESI LATENT MEMBRAN PROTEIN-1 (LMP-1) EPSTEIN BARR VIRUS (EBV) PADA LIMFOMA MALIGNA Hapsari Galih Setyowati; Udadi Sadhana; Meira Dewi Kusuma; Dik Puspasari
Media Medika Muda Vol 2, No 3 (2017)
Publisher : Faculty of Medicine Diponegoro University

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Latar Belakang: Limfoma maligna menempati 3,37% dari seluruh keganasan di seluruh dunia. Insiden Limfoma maligna di dunia mengalami peningkatan dengan rata-rata 3-4% dalam 4 dekade terakhir. Kenaikan insiden Limfoma Non Hodgkin pada pria 6% dan wanita 4,1%. Limfoma Hodgkin 1,1% pada pria dan 0,7% pada wanita. Data dari Kementrian Kesehatan Indonesia pada tahun 2013, angka kejadian Limfoma di Indonesia sebesar 0,06% dengan estimasi 14.905 pasien. VEB memiliki peran pada perkembangan Neoplasma Limforetikuler sel B. Beberapa penelitian telah menunjukkan bahwa ekspresi gen-gen laten VEB menyumbangkan perubahan fenotipe ganas, terutama LMP-1. Gen laten VEB ditemukan dapat merubah perkembangan sel, merubah fenotip dari sel, menginduksi proliferasi dan mencegah apoptosis. Tujuan: mengetahui adanya ekspresi gen laten LMP-1 dari VEB pada Limfoma Maligna.Metode: Populasi dan sampel penelitian diambil dari blok parafin Departemen Patologi Anatomi RSUP Dr. Kariadi, Semarang, Indonesia pada Januari 2015 sampai Mei 2017. Dua puluh (20) blok parafin yang telah didiagnosis dan dire-evaluasi sebagai Limfoma Non Hodgkin sel B dan Limfoma Hodgkin, dilakukan pemeriksaan imunohistokimia LMP-1. Data ekspresi LMP-1 dianalisis menggunakan uji Fisher’s Exact.Hasil: Terdapat ekspresi LMP-1 positif pada 5 sampel (25%) sediaan Limfoma Non Hodgkin sel B dan 3 sampel (15%) pada sediaan Limfoma Hodgkin, dengan Uji Fisher’s Exact memberikan hasil tidak terdapat perbedaan bermakna (p = 0,325) dari ekspresi LMP-1 pada Limfoma Non Hodgkin sel B dan Limfoma Hodgkin. Simpulan: Tidak didapatkan perbedaan bermakna dari ekspresi LMP-1 pada Limfoma Non Hodgkin sel B dan Limfoma Hodgkin. Kata kunci: VEB, LMP-1, Limfoma Maligna, Limfoma Non Hodgkin sel B, Limfoma Hodgkin

EKSPRESI WT1 DAN P16 PADA KARSINOMA SEROSUM DERAJAT TINGGI DAN KARSINOMA ENDOMETRIOID DERAJAT TINGGI PADA OVARIUM DI RS Dr. KARIADI SEMARANG, PERIODE 2015–2017 Djamila Zakaria; Udadi Sadhana; Devia Eka
Media Medika Muda Vol 3, No 3 (2018)
Publisher : Faculty of Medicine Diponegoro University

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Latar belakang: Karsinoma serosum derajat tinggi dan karsinoma endometrioid derajat tinggi pada ovarium adalah keganasan epithelial terbanyak dan yang kedua terbanyak pada ovarium, yang sering terdeteksi pada tahap lanjut dengan prognosis yang buruk. Secara histopatologi sulit untuk membedakan kedua keganasan ini. Ekspresi WT1 dan p16 dapat digunakan untuk membedakan kedua keganasan ini.Metode: Penelitian analitik deskriptif dengan desain belah lintang. Sampel sebanyak 30 sampel blok paraffin yang telah didiagnosis sebagai karsinoma ovarium tahun 2015–2017 di laboratorium Patologi Anatomi RSUP Dr. Kariadi, yang dibagi menjadi 2 kelompok yaitu karsinoma serosum derajat tinggi sebanyak 18 sampel dan karsinoma endometrioid derajat tinggi sebanyak 12 sampel, dan dilakukan pengecatan imunohistokimia antibodi monoklonal WT1 dan p16, kemudian dianalisis dengan uji Mann-Whitney.Hasil: Ekspresi WT1 pada karsinoma serosum derajat tinggi dan karsinoma endometrioid derajat tinggi pada ovarium tidak bermakna (p=0,513). Ekspresi p16 pada karsinoma serosum derajat tinggi dan karsinoma endometrioid derajat tinggi pada ovarium tidak bermakna (p=0,356).Simpulan: Terdapat perbedaan yang tidak bermakna antara Ekspresi WT1 dan p16 pada karsinoma serosum derajat tinggi dan karsinoma endometrioid derajat tinggi pada ovarium

PERBEDAAN EKSPRESI p53 DAN PR (PROGESTERONE RECEPTOR) PADA MENINGIOMA DERAJAT I, II, III DI RSUP DR. KARIADI Edy Prasetyo; Udadi Sadhana; Meira Dewi Kusuma Astuti
Media Medika Muda Vol 2, No 3 (2017)
Publisher : Faculty of Medicine Diponegoro University

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Latar belakang: Meningioma berasal dari sel-sel selaput arachnoid pada meninges, menyumbang sekitar 30% dari semua tumor primer di otak. WHO 2016 membagi menjadi 3 grade : Grade I (jinak), Grade II (atipik) dan Grade III (anaplastik). Sistem derajat histopatologi tersebut belum mampu memprediksi prognosis dan rekurensi meningioma, sehingga dibutuhkan penanda protein dan hormonal yang bertanggung jawab pada proses tumorigenesis. Tujuan penelitian ini mengetahui perbedaan ekspresi p53 dan PR pada meningioma grade I, II, III di RSUP dr. Kariadi periode antara tahun 2011 sampai 2014.Metode: Sebanyak 30 sampel meningioma yang telah diklasifikasikan diberi pewarnaan khusus imunohistokimia p53 dan PR. Ekspresinya dinilai dengan menggunakan Allred score.Hasil: Dari 30 sampel didapatkan 14 grade I, 10 grade II dan 6 grade III. Jumlah wanita 23(76,67%) dan laki-laki 7(23,33%), kejadian meningioma terbanyak pada usia 36-45 tahun yaitu sebanyak 19 kasus (63,33%) dan paling sedikit usia 5-11 tahun sebanyak 1 kasus (3,33%). Dari hasil uji Kruskal Wallis didapatkan nilai p hasil pemeriksaan ekspresi p53 pada tiap derajat meningioma adalah 0,163. Nilai p hasil pemeriksaan ekspresi PR pada tiap derajat meningioma adalah 0,045.Simpulan: Tidak terdapat perbedaan bermakna hasil pemeriksaan ekspresi p53 dan terdapat perbedaan ekspresi PR dengan ketiga grade meningioma. Kata kunci: Meningioma, p53, PR

PENGARUH EKSPRESI LMP-1 DAN P53 MUTAN DENGAN PROGNOSIS PASIEN KARSINOMA NASOFARING (UNDIFFERENTIATED TYPE) Atikah Atikah; Udadi Sadhana; Ika Pawitra Miranti; Dik Puspasari; Vega Karlowee
Jurnal Ilmu Kedokteran dan Kesehatan Vol 9, No 1 (2022): Volume 9 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i1.6284

Undifferentiated carcinoma merupakan subtipe KNF yang mempunyai titer antibodi EBV lebih tinggi daripada orang sehat. Efek karsinogenik EBV melibatkan LMP-1 yang berhubungan dengan buruknya prognosis sedangkan p53 mutan memprediksi kekambuhan tumor. Penelitian ini menilai pengaruh LMP-1 dan p53 mutan dengan prognosis pasien KNF (Undifferentiated carcinoma). Studi analitik observasional dengan cross-sectional di Laboratorium Patologi Anatomi RSUP Dr. Kariadi Semarang. Empat puluh buah blok parafin dari jaringan nasofaring menggunakan teknik consecutive sampling. Dilakukan pewarnaan LMP-1 dan p53 mutan. Uji statistik menggunakan uji korelasi Pearson. Nilai p < 0,05 dianggap bermakna secara statistik. Terbanyak pada kelompok usia > 40 tahun, jenis kelamin laki-laki, keterlibatan kelenjar getah bening (N) pada kelompok N2 dan tidak ada metastasis (M). Tingkat ekspresi LMP-1 dan p53 mutan terbanyak positif kuat. Korelasi antara ekspresi LMP-1 dengan usia (p=0,327), jenis kelamin (p=0,599), kategori N (p= 0,512), kategori M (p=0,019). Ekspresi p53 mutan dengan usia (p=0,329), jenis kelamin (p=0,981), kategori N (p=0,013), kategori M (p=0,705). Ekspresi LMP-1 dengan p53 mutan (p=0,760). Terdapat perbedaan antara ekspresi LMP-1 dengan p53 mutan (p=0,000). Dapat disimpulkan LMP-1 dan p53 mutan dapat digunakan sebagai faktor prognosis pada pasien KNF.

RELATIONSHIP BETWEEN FAMILY HISTORY, BLOODY STOOL, PALPABLE MASS, ANEMIA, AND MSCT ABDOMEN AND KOLON CARSINOMA Cross-Sectional Study at Dr.Kariadi General Hospital in 2016 Malik, Ricat Hinaywan; Winarto, Winarto; Budijitno, Selamat; Sadhana, Udadi; Prajoko, Yan Wisnu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): June 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: Colon cancer, a colorectal cancer, is the third most common epithelial malignancy in the world. Family history, bloody stool, palpable mass, anemia, and abdominal MSCT are symptoms and signs of colon carcinoma.Objective: To determine the relationship between the 5 variables and the incidence of colon carcinoma at Dr. Kariadi Hospital, Semarang in 2016.Methods: a Cross-sectional observational analytical study using medical record (RM) and complementary primary data. The inclusion criteria werethe complete medical record, and clinical diagnosis of suspected colon carcinoma. Data obtained from the department of Anatomy Pathology/PA (11,794PA results) were traced to the medical record section (46 patients with suspected colon carcinoma). The incomplete data were confirmed by: contacting the patient/family, obtaining the archive in the laboratory and radiology resulting in 27 patients meeting the inclusion criteria. Analysis was done using chi-square test, Spearman-Kendall bivariate correlation, and logistic regression.Results: Abdominal MSCT was moderately associated with colon carcinoma (p = 0.003; r = 0.488), while family history, bloody stool, palpable mass, and anemia were not associated with colon cancer. Analysis between predictors of outcome: Bloody stool was moderately associated with anemia (p = 0.006; r = 0.411), and anemia was weakly associated MSCT (p = 0.035; r = 0.351). Abdominal MSCT was the predictive factor for colon carcinoma (p = 0.021).Conclusion: Abdominal MSCT was found to be associated with the incidence of colon carcinoma. Bloody stool was associated with anemia, and anemia was associated with abdominal MSCT. MSCT was the predictive factor for colon cancer.

THE EFFECT OF GREEN TEA AND STEVIA EXTRACT ON LIVER HISTOPATHOLOGY WISTAR RATs TYPE II DIABETES MELLITUS Novit, Elmawati; Sadhana, Udadi; Mahati, Endang
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): June 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Glucose metabolism abnormality on type 2 diabetes mellitus (T2DM) caused liver damage due to dyslipidemia and increasing oxidative stress. Antidiabetic and antioxidants within green tea leaf and stevia leaf extract prevent liver damage due to T2DM complications. Objective: To investigate green tea and stevia leaf extract effects on liver histopathology on T2DM rats.Methods: This study used Post Test Only Control Group Design. A total of 30 Wistar rats were divided into 5 groups: control group (C-G), normal rats; negative control group (NC-G), T2DM induction; positive control group (PC-G), treated by Metformin; the first treatment group (T1-G), was treated by green tea leaf extract and stevia leaf extract; and the second treatment group (T2-G) was treated by a Metformin also green tea and stevia leaf extract. The treatment was given to subjects for 21 days starting 3 days after the induction of Nicotinamide (NA) and Streptozotocine (STZ). Histopathological assessment of liver cells uses assessment parameters in the form of features of necrosis, vacuolization, sinusoidal dilation and number of inflammatory cells. Hypothesis will be tested by Kruskal-Wallis (p<0,05) dan Mann-Whitney test (P<0,05) Results: The difference of liver damage in all group shows a significant difference, p<0.05. Significant differences in liver damage scores between the 2 groups there are between the negative control group and the control group (0.031), positive control (0.042), and second treatment group (0.011), and between first treatment group and second treatment group (0.041).Conclusion: The administration of green tea extract, stevia leaf, and standard drug may reduce liver damage score of Wistar with T2DM

Pattern and Frequency of Skin Malignancies at Laboratory of Pathology Anatomy Dr. Kariadi General Hospital in 2008-2009 Susilorini, Susilorini; Sadhana, Udadi; Widjaya, Indra
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: A periodical database is important including for skin cancer. Periodical registration is needed to acknowledge changes in pattern and frequencies of skin lesion. Objective: The purpose of this study was to describe the pattern and the frequency of skin lesion in RSUD Kariadi.Method: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed skin lesion in the pathology labolatory of RSUD Kariadi between 2008 and 2009. The variables were secondary data including age, gender, specimen area, dan histopathology diagnosis. Data was choosen by consecutive sampling from 381 medical records of skin tissues examined at laboratorium of pathology anatomy of Dr. Kariadi general hospital during 2008-2009.Result: 381 cases were recorded comprising of 246 (65%) neoplastic and 135 (35%) non neoplastic lesion. 120 patients presented with skin cancer, and 126 with benign skin lesion. Most malignancy was observed among female patients (62.5%) on age catagory of 15-39 (65%). The most common lesion was basal cell carcinoma (48.3%) followed by squamous cell carcinoma (33.3%), malignant melanoma (10%), skin appendix carcinoma (2.5%), other malignancies (4.9%).Conclusion: the most common malignancies in Dr. Kariadi general hospital before 2008 was similar to data from 13 laboratory of pathology anatomy in Indonesia, which is squamous cell carcinoma.

ROLE OF COMBINATION CASEIN AND LACTOFERRIN BOVINE’S COLLOSTRUM AS A PULP CAPPING ON MACROPHAGE EXPRESSION IN MALE WISTAR RATS Endah Ariyati Eko Ningtyas; Oedijani Santoso; Udadi Sadhana; Siti Sunarintyas
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

ABSTRACTBackground: Inflammatory and/or non-inflammatory processes play a role in stimulating pulp repair and the formation of hard tissue, namely reparative dentin. Macrophages play a role in the pathogenesis and chronic inflammatory disorders. The combination casein lactoferrin of bovine colostrum as an immunomodulator has therapeutic potential. This study aims to determine the therapeutic effect and duration of application of the combination of casein lactoferrin of bovine colostrum, on the expression of macrophages as pulp capping.Method: This study was a true experimental laboratories post test only control group design, consisting of three groups of 60 male wistar rats with 4 observation times, namely day to day 7, 14, 21 and 28 each of 5 mice. The maxillary 1st molars were prepared until the roof of the pulp was exposed. Three groups, namely the combination of casein and lactoferrin bovine colostrum (CKL) and calcium hydroxide (K1) and the untreated group (K0). Each group was filled with glassionomer as a permanent restoration. The tissue was made histological preparations with hematoxylin-eosin staining and the number of macrophages were counted, then analyzed by two way ANOVA and post hoc LSD tests.Result: The results showed that the therapeutic effect and duration of application of the combination of casein and lactoferrin bovine colostrum on the expression of macrophages as pulp cappingConclusion: The combination of casein and lactoferrin of bovine colostrum as capping material can increase the number of macrophages in the healing process of dental pulp.

Ekspresi Reseptor Estrogen, Reseptor Progesteron Dan Digit Ratio Pada Pasien Meningioma Prakoso, Teguh Iman; Arifin, Mohammad Thohar; Sadhana, Udadi; Puspasari, Dik; Kusuma Astuti, Meira Dewi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar belakang Meningioma merupakan tumor jinak intrakranial primer yang dipengaruhi oleh keseimbangan hormon estrogen dan progesteron. Digit Ratio (2D : 4D) sangat dipengaruhi oleh paparan hormon androgen prenatal khususnya estrogen dan testosteron. Tujuan Mengetahui hubungan reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio (2D : 4D) pada pasien meningioma. Metode Penelitian observasional analitik dengan desain cross sectional study. Jumlah sampel sebesar 25 pasien meningioma yang dilakukan pemeriksaan ER dan PR. Pengukuran Digit Ratio dilakukan di poliklinik dan bangsal bedah syaraf RSUP Dr. Kariadi Semarang. Uji statistik menggunakan uji spearman. Hasil Digit Ratio kanan, kiri dan selisih kanan-kiri dengan nilai rerata 1,0046; 1,0021 dan 0,0492. Uji spearman, hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan PR didapatkan masin–masing nilai p = 0,5 (r = 0,1), p = 0,8 ( r = 0,1), dan p = 0,3 (r = 0,2). Hubungan Digit Ratio kanan, Digit Ratio kiri dan Selisih Digit Ratio kanan kiri dengan ER didapatkan masing–masing nilai p = 0,4 (r = 0,2), p = 0,5 ( r = -0,1), dan p = 0,9 (r = 0,1). Secara statistik terdapat hubungan yang sangat lemah antara Digit Ratio kanan, Digit Ratio kiri, selisih Digit Ratio kanan kiri dengan ER dan PR pada pasien meningioma Simpulan Terdapat hubungan yang sangat lemah antara reseptor estrogen (ER) dan reseptor progesteron (PR) dengan Digit Ratio pada pasien meningioma. Kata kunci : Reseptor Estrogen, Reseptor Progesteron, Digit Ratio, Meningioma. Background Meningiomas are primary intracranial benign tumors that are affected by the balance of estrogen and progesterone. Digit Ratio (2D: 4D) is strongly influenced by exposure to prenatal androgen hormones especially estrogen and testosterone. Objective To determine the relationship between estrogen receptor (ER) and progesterone receptor (PR) with Digit Ratio (2D: 4D) in meningioma patients. Method Analytical observational research with cross-sectional study design. The total sample of 25 meningioma patients who underwent ER and PR examinations. Digit Ratio measurements were performed at the clinic and neurosurgical ward of RSUP Dr. Kariadi Semarang. The Spearman test was used for the statistical test. Results Right, left and right-left difference digit ratio with mean value of 1.0046; 1,0021 and 0,0492. After Spearman test, the relationship between right Digit Ratio, left Digit Ratio and Difference between right and left Digit Ratio with PR was p = 0.5 (r = 0.1), p = 0.8 (r = 0.1), and p = 0.3 (r = 0.2). Correlation between right Digit Ratio, left Digit Ratio and Difference between left and right Digit Ratio with ER was p = 0.4 (r = 0.2), p = 0.5 (r = -0.1), and p = 0.9 (r = 0.1). Statistically there is a very weak relationship between right Digit Ratio, left Digit Ratio, difference between right and left Digit Ratio with ER and PR in patients with meningiomas. Conclusions There is a very weak relationship between estrogen receptors (ER) and progesterone receptors (PR) and Digit Ratio in meningioma patient. Keywords: Estrogen Receptor, Progesterone Receptor, Digit Ratio, Meningioma.

Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Aminuyati Antari, Arlita Leniseptaria Apriana, Ledisda Ariani, Resti Asri, Hairul Atikah Atikah Awal Prasetyo Bambang Hendro Putranto, Bambang Hendro Devia Eka Dik Puspasari Dik Puspasari Dik Puspasari, Dik Djamila Zakaria Dwi Pudjonarko Edy Prasetyo Endah Ariyati Eko Ningtyas Endang Mahati Eny Dyah Kurniawati, Eny Dyah Hamidiyah, Silpi Hapsari Galih Setyowati Hermawan Istiadi Ika Pawitra Miranti Indra Widjaya Karlowee, Vega Kusuma Astuti, Meira Dewi Lestari, Nadia Nur Lina Damayanti, Lina M Naharuddin Jenie Malik, Ricat Hinaywan Meira Dewi Kusuma Meira Dewi Kusuma Astuti Mohammad Thohar Arifin, Mohammad Thohar Nani Maharani Neni Susilaningsih Novit, Elmawati Nurkholis, Fathur Oedijani Oedijani, Oedijani Prakoso, Teguh Iman Prastyo K, Yuni Puspita`, Rina Rahajeng, Herera RR. Ella Evrita Hestiandari Selamat Budijitno Siti Sunarintyas Susilorini Susilorini, Susilorini Tri Nur Kristina Vega Karlowee Winarto Winarto Yan Wisnu Prajoko

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