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All Journal Althea Medical Journal Majalah Kulit, Karet, dan Plastik Global Medical and Health Communication Universa Medicina Jurnal Biomedika dan Kesehatan Jurnal Dharma Bhakti Ekuitas Bioscientist : Jurnal Ilmiah Biologi Narra J Jurnal Abdi Masyarakat Indonesia
Meiyanti Meiyanti, Meiyanti
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Penyuluhan Pencegahan Tuberkulosis Resistan Obat pada Masyarakat di Desa Nagrak dan Desa Ciangsana, Kabupaten Bogor, Provinsi Jawa Barat Khusfiani, Triasti; Kalumpiu, Joice Viladelvia; Meiyanti, Meiyanti; Kurniasari, Kurniasari
Jurnal Abdi Masyarakat Indonesia Vol 5 No 4 (2025): JAMSI - Juli 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.1720

Abstract

Tuberkulosis resistan obat (Tb-RO) dapat terjadi akibat pengobatan tuberkulosis yang tidak adekuat baik dari segi paduan, dosis, ataupun durasinya. Saat ini, Indonesia menempati peringkat 5 negara dengan beban tinggi Tb-RO. Peran aktif dari  masyarakat dibutuhkan pada umumnya, terutama keluarga untuk terus memberikan motivasi kepada pasien Tb agar bisa mengkonsumsi obat sampai dengan selesainya pengobatan sehingga tidak terjadi resistensi obat. Desa Nagrak dan Desa Ciangsana di kabupaten Bogor merupakan salah satu wilayah dengan tingkat kasus Tb tertinggi di Indonesia. Oleh sebab itu, penyuluhan ini bertujuan untuk meningkatkan pengetahuan masyarakat setempat tentang Tb-RO serta memotivasi mereka sehingga dapat melakukan upaya pencegahan Tb-RO sedini mungkin. Kegiatan ini melibatkan 30 peserta usia dewasa dengan menggunakan media poster dan powerpoint untuk menyampaikan materi yang meliputi definisi, gejala, faktor risiko, pengobatan dan efek sampingnya serta terutama pencegahannya.   Evaluasi dilakukan menggunakan kuesioner pretest dan post-test untuk menilai peningkatan pemahaman peserta. Hasil Wilcoxon signed rank test menunjukan bahwa hasil post-test lebih tinggi secara bermakna dibandingkan pretest (p <0,001). Dampak dari penyuluhan ini adalah peningkatan pengetahuan peserta terhadap penyakit Tb-RO diharapkan akan mempengaruhi sikap dan upaya mereka untuk memotivasi masyarakat yang lain untuk mencegah terjadinya Tb-RO.
Kadar Vitamin D dengan Sindrom Mata Kering pada Karyawan Margo, Eveline; Meiyanti, Meiyanti; Kartadinata, Erlani; Kartadinata, Noviani
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.264-274

Abstract

Background Dry eye syndrome (DES) is the most common eye disease with a prevalence of around 5 – 50% of the worldwide population. In Indonesia alone, the prevalence of DES is around 27.5%. DES is a multifactorial disorder indicating that inflammation plays an important role in the pathophysiology of DES. The inflammation causes increased oxidative stress which can cause decreased tear production and inflammation on the ocular surface can cause an increase in excessive tear evaporation, causing instability of the tear film. Vitamin D has an anti-inflammation effect. The role of vitamin D in the eye through receptor vitamin D (VDR), which is expressed in the retinal pigment epithelium, retinal photoreceptors, ganglion cells layer, ciliary body, lens, cornea epithelium, and endothelium, as well as in aqueous humor, vitreous humor, and tears film. Vitamin D deficiency is said to have a contribution to DES. For that reason, this study aims to examine the relationship between vitamin D levels with DES. Methods The research design in this study was an observational analytic with a cross-sectional approach, which was followed by FK USAKTI employees in February – March 2021. Fifty-seven employees aged 25 – 60 were according to criteria and willing to take part in this study. OSDI questionnaire, Schimer’s test and tear break-up time (TBUT) were used to examine DES. Examination of vitamin D by measuring 25(OH)D levels. The data were analyzed using a chi-square test with significance level p<0.05. Results The vitamin D levels examination with DES using Schimer’s test was found to be unrelated (p=0.948), comparing vitamin D levels with the TBUT test, it was found significantly related to DES (p=0.030), meanwhile using the OSDI questionnaire was found to be unrelated (p=0.285). Conclusions There is a significant relationship between vitamin D levels and DES through TBUT examination.
mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Abstract

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.
Co-Authors Adang Bachtiar Alfiyyah, Arifah Alvina Alvina Alvina Lesmana, Alvina Anastasya, Karina Shasri Eddy Purnomo Erlani Kartadinata, Erlani Esti Rahayu Eveline Margo, Eveline Faradilla, Meutia Atika Hairunisa, Nany Hasan Basalamah, Hasan Isahak, Marzuki bin Joice Viladelvia Kalumpiu, Joice Viladelvia Julius E. Surjawidjaja, Julius E. Julius I Mulia, Julius I Kartadinata, Noviani Kurniasari Kurniasari Kurniasari Kurniasari Kusuma, Muhammad Cariefzi Zahdffa Lie T Merijanti, Lie T Lie Tanu Merijanti, Lie Tanu Machrumnizar, Machrumnizar Mochtar Lutfie, Mochtar Monica Dwi Hartanti, Monica Dwi Muchtar Lutfie, Muchtar Murad Lesmana Novia I. Sudharma, Novia I. Nur Endah, Nur Oktavianus Ch. Salim, Oktavianus Ch. Pusparini Pusparini Ridwan, Alvin Muhamad Rina K. Kusumaratna, Rina K. Sugeng Supriadi, Sugeng Titik Purwati Widowati, Titik Purwati Tjahjadi, Muljadi Triasti Khusfiani Widari Widari, Widari Yohana Yohana Yohana