Article Per Year (5 Year)
p-Index From 2021 - 2026
2.405
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Dedikasi Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Kedokteran Brawijaya Pharmaciana: Jurnal Kefarmasian Pharmacon MPI (Media Pharmaceutica Indonesiana) Martabe : Jurnal Pengabdian Kepada Masyarakat PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Studi Kasus Inovasi Ekonomi Journal of Fundamental and Applied Pharmaceutical Science Journal of Global Pharma Technology
Hidajah Rachmawati
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

Published : 24 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 24 Documents
Search

 1   2   3 
Network-Based and Experimental Evaluation of Vitamin D and Tinospora cordifolia in Immune Modulation Jamil, Ahmad Shobrun; Syifa, Nailis; Puspitasari, Alvina Arum; Rachmawati, Hidajah; Anggraeni, Amaliyah Dina; Farmasari, Novan Visia
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.31191

Abstract

Vitamin D (VD) and Tinospora cordifolia (TC) play important roles in maintaining immune homeostasis and combating infections by modulating the immune response. This study aimed to investigate the combined effects of VD and TC on immune modulation, particularly inflammatory cytokine expression and immune cell maturation. The in silico analysis identified TC compounds using the Knapsack and PubChem databases, followed by ADME profiling with SwissADME. Putative target proteins were predicted using SwissTargetPrediction and STRING-DB. In vivo experiments were conducted using female BALB/c mice assigned to five experimental groups to evaluate the effects of VD, TC, and their combination in an Escherichia coli infection model established by intraperitoneal injection. Hematological parameters were analyzed using a hematology analyzer, while inflammatory cytokine and granulocyte cell marker expression were assessed by flow cytometry. Statistical analysis employed one-way analysis of variance (ANOVA) followed by Tukey’s HSD post hoc test. In silico network analysis identified 183 overlapping proteins between hematopoiesis-related proteins and the target proteins of 15 bioactive TC compounds, suggesting potential interactions within hematopoiesis pathways. Network visualization further demonstrated complex interactions involving receptors, enzymes, and transcription factors, supporting the potential immunomodulatory roles of TC. Flow cytometry revealed that VD, TC, and their combination significantly reduced IL-1β expression, indicating anti-inflammatory activity. CD11b+ expression remained unchanged across treatment groups, whereas the combination of VD and TC enhanced the maturation of Gr1+-marked granulocytes. These findings suggest that combined VD and TC may have potential as an anti-inflammatory intervention and may support granulocyte maturation in the immune system.
Knowledge of the Madurese Community-Indonesia Regarding Bioprospection of the Traditional Herb Kamandin Saebo (Glossocardia leschenaultii [Cass.] Veldkamp) Purwanti, Elly; Nuryady, Moh. Mirza; Permana, Tutut Indria; Rachmawati, Hidajah; Anggraeni, Amaliyah Dina
Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Vol. 7 No. 3 (2023): November
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/esaintika.v7i3.1403

Abstract

The purpose of this study was to describe the knowledge of the Sumenep Madura community (village elders and gatherers) about the Kamandin Saebo (Glossocardia leschenaultii) plant and its utilization. This study uses observational research that aims to observe a fact at a certain time using a descriptional approach model. The research was conducted in the Sumenep-Madura area, East Java Province. The research was conducted in July 2023-August 2023 by observational method. We discussed the results of information regarding the knowledge of the Sumenep people about the existence and growing areas of Kamandin saebo, a literature search regarding the morphological characterization, benefits, or uses of Kamandin saebo in medicine as conveyed by the gatherers. We also found that Kamandin Saebo is of great value. There are 14 healing functions associated with Kamandin Saebo. The Madurese people believe this plant to have many benefits or even cure all diseases.
Antibiotic Use Evaluation in ICU/HCU of Muhammadiyah University General Hospital Malang using DDD and Gyssens Methods Rachmawati, Hidajah; Muktamiroh, Muktamiroh; Hasmono, Didik; Kusumaningtyas, Atika Putri; Yunita, Sendi Lia; Yusetyani, Lilik
Jurnal Kedokteran Brawijaya Vol. 32 No. 3 (2023)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.032.03.7

Abstract

Infection is a condition caused by the propagation of harmful microorganisms with or without clinical symptoms. Improper use of antibiotics can lead to antibiotic resistance. The Ministry of Health of the Republic of Indonesia recommended a quantitative evaluation of the use of antibiotics using the Defined Daily Dose (DDD) method and a qualitative evaluation using the Gyssens method. This study evaluated antibiotics usage using DDD and Gyssens methods in ICU/HCU of the Muhammadiyah University General Hospital Malang. Employing retrospective observational method, data were collected from patient medical records hospitalized during January-December 2020. Results of the DDD quantitative analysis showed that the most widely used antibiotic was Ceftriaxone with a 35.79 DDD/100 patient-days. The Gyssenss qualitative analysis showed that the category VI (incomplete patient's medical record data) was 3%, category IVa (antibiotic use is more effective) (2%), category IIIb (duration of antibiotic use is too short) (3%), category IIb (antibiotic use is not at the right interval) (3%).
HUBUNGAN TINGKAT PENGETAHUAN DAN PERILAKU SWAMEDIKASI OBAT NATRIUM DIKLOFENAK DI APOTEK Dwi Ajeng Eli Ananda; Liza Pristianty; Hidajah Rachmawati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 10 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v10i2.795

Abstract

ABSTRAK Swamedikasi adalah perilaku manusia yang biasanya dilakukan masyrakat untuk mendapatkan solusi terkait masalah kesehatan, untuk alasan ini swamedikasi harus diawasi oleh apoteker. Masyarakat membutuhkan pengetahuan yang sesuai untuk mendapatkan perilaku yang tepat dalam swamedikasi. Sodium diklofenak adalam salah satu obat analgesik dari golongan NSAID yang termasuk dalam obat wajib apotik (OWA) No. 2 dan No. 3. Penelitian ini bertujuan untuk menentukan hubungan antara pengetahuan dan perilaku swamedikasi dari sodium diklofenak di apotik. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan metode cross sectional. Pengambilan sampel secara accidental. Sampel yang digunakan sebanyak 100 responden. Penelitian ini dilakukan pada bulan Juni 2013. Hasil penelitian ini menunjukkan dimana 36% responden mempunyai pengetahuan yang bagus, 52% responden memepunyai pengetahuan yang cukup dan 12% responden pengetahuannya kurang. Perilaku swamedikasi sodium diklofenak menunjukkan 52% responden mempunyai perilaku positif dan 48% reponden mempunyai perilaku negative. Terdapat korelasi yang signifikan antara pengetahuan dan perilaku swamedikasi, dengan nilai signifikansi 0,000 (
Co-Authors Agus Sunarko Ahmad Shobrun Jamil Amaliyah Dina Anggraeni Andi Suhendi Annisa, Yuslinda Asmiati, Elva Dian Ermawati Didik Hasmono Didik Setiawan Dwi Ajeng Eli Ananda Dwi Ajeng Eli Ananda, Dwi Ajeng Eli Dwi Lestari El Baroroh, Alif Rosyidah Elly Purwanti Elva Asmiati Engrid Juni Astuti Farmasari, Novan Visia Firasti Agung Nugrahening Sumadi Hadi, Ismanurrahman Hendra Susanto Heni Lutfiyati, Heni Hidayah Karuniawati Ika Ratna Hidayati Irsan Fahmi Almuhtarihan Joko Priyanto Wibowo Kusumaningtyas, Atika Putri Lilik Yusetyani Liza Pristianty Miasih, Dewi Sekar Moch Sasmito Djati Moh. Mirza Nuryady Muktamiroh, Muktamiroh Nailis Syifa Puspitasari, Alvina Arum Raditya Weka Nugraheni Ria Utami, Primanitha Rony Irawanto Sendi Lia Yunita Sri Rahayu Lestari Sunaryono Sunaryono, Sunaryono Tista Ayu Fortuna Tutut Indria Permana Yusuf, Helmy