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All Journal Damianus Journal of Medicine The Indonesian Biomedical Journal Paediatrica Indonesiana Acta Biochimica Indonesiana Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Biomedika dan Kesehatan Majalah Kedokteran Neurosains Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal SOSIOEDUKASI : JURNAL ILMIAH ILMU PENDIDIKAN DAN SOSIAL Journal SAGO Gizi dan Kesehatan Muhammadiyah Journal of Geriatric Indonesian Journal of Medical Chemistry and Bioinformatics Eduvest - Journal of Universal Studies Neurona Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Ninik Mudjihartini
Departemen Biokimia Dan Biologi Molekuler, Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Hyperbaric Oxygen Therapy for Traumatic Brain Injury: A Review Of History, Development, Current Techniques, and Future Directions Wiwoho, Yudi Yuwono; Sadikin, Abdul Halim; Jusuf, Ahmad Aulia; Mulyawan, Wawan; Mudjihartini, Ninik; Ibrahim, Nurhadi; Jusman, Sri Widia A.; Sadikin, Mohamad
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.321

Abstract

Hyperbaric oxygen therapy (HBOT) has gained increasing attention as a potential adjunctive treatment for traumatic brain injury (TBI) patients. This narrative review discusses the historical background, current preclinical and clinical studies, and explores its underlying mechanisms from biomolecular, histological, and clinical perspectives. HBOT promotes neural recovery by improving oxygenation, preserving mitochondrial integrity, enhancing neurotrophic support and synaptic connectivity, mitigating secondary injury pathways (including oxidative stress, inflammation, and apoptosis), and promoting angiogenesis and vascular stability. These mechanisms have demonstrated improvements of motor, cognitive, and memory functions both in preclinical and clinical studies, although outcomes and treatment protocols vary. However, challenges remain regarding optimal protocols, patient selection, and adverse effects. Further high-quality clinical trials are required to define the optimal HBOT regimen are required.
Co-Authors Abd. Rasyid Syamsuri Achmad Mulawarman Jayusman Ahmad A. Jusuf Ahmad Aulia Almira Devina Gunawan Andriani Andriani Ani Retno Prijanti Astrid Mariam Khairani Siregar Atikah Chalida Barasila Chandra, Dian Novita claresta diella Defli Yuandika Ruso Dewi Sukmawati Diana Sunardi Diyah Eka Andayani Diyah Eka Andayani Ekawati, Maria Endrico Xavierees Erlina, Linda Erni Purwaningsih Estiana Filzadiyanti Fadilah Fadilah Febriana Catur Iswanti Frans Ferdinal Hadiyati Fudla Hajar, Siti Sarah Harmelia, Dwi Helena Fabiani Ika Superti Daruningrum Immanuelle Kezia Indah Bachti Setyarini Inge Permadhi Irawan Satriotomo Issabella Nisrina Pratiwi Karin Wiradarma Karlina Lestari Khusun, Helda Krisadelfa Sutanto Krisnamurti, Desak G.B. Livia Kurniati Saputra Marsella Dervina Amisi Mohamad Sadikin Mohamad Saekhu Muchtaruddin Mansyur Mulyana Mulyana Nani Dharmasetiawani Natasha Dianasari Devana Nieka Adhara Wahono Novi Dewi Tanjung Novi Dewi Tanjung Nurdina, Nazlah Nurhadi Ibrahim Nurhadi Ibrahim Nurul Ratna Nurul Ratna Mutu Manikam Pratiwi, Sandi Puspita Prawirohajo, Pukovisa Pungguri Ayu Nega Sarsanti Purwaningsih, Erni H. Rahmawaty Ridwan, Rahmawaty Raphael Kosasih Ray Sugianto, Ray Reni Paramita Ria Andreinie Rini Sekartini Rita Lahirin, Rita Sadikin, Abdul Halim Saptawati Bardosono Saptawati Bardosono Sheira Taflah Putri Handana Sheira Taflah Putri Handana Sianipar, Imelda M. Siska Amelia Siti Farida Sri W.A. Jusman Sri Widia A.Jusman Wahyu Ika Wardhani Wardaya Wardaya Wawan Mulyawan Widia AJ, Sri Wiji Lestari Wiji Lestari Wina Sinaga Wiwoho, Yudi Yuwono Yuditiya Purwosunu Yulhasri Yulhasri Yulhasri