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All Journal HAYATI Journal of Biosciences Jurnal Kebijakan dan Pengembangan Pendidikan Jurnal Pendidikan Biologi Indonesia JIP: Jurnal Ilmiah PGMI Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini Jurnal Pendidikan Biologi Jurnal Penelitian Pendidikan IPA (JPPIPA) Biosfer: Jurnal Pendidikan Biologi Jurnal Pertanian Agros International Journal of Community Service Learning Jurnal Biosilampari: Jurnal Biologi Jurnal Ilmiah Profesi Pendidikan Journal of Community Service and Empowerment G-Couns: Jurnal Bimbingan dan Konseling Bioscientist : Jurnal Ilmiah Biologi Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Proceeding Biology Education Conference Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Journal Evaluation in Education (JEE) JEER (Journal of Elementary Educational Research) Pancaran Pendidikan Educational Technology Journal International Journal of Learning Reformation in Elementary Education Quagga: Jurnal Pendidikan dan Biologi Sasambo: Jurnal Abdimas (Journal of Community Service)
Lud Waluyo
Universitas Muhammadiyah Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : HAYATI Journal of Biosciences

 1 
In Silico Analysis of 14-Deoxy 11, 12-Didehydro Andrographolide (AGP 2) from Sambiloto (Andrographis paniculata) as Drug Candidate Against SARS-CoV-2 Muhammad Vicky Astria; Lud Waluyo; Roimil Latifa; Moh. Mirza Nuryadi; Rr. Eko Susetyarini; Mohd. Affendi Labo
HAYATI Journal of Biosciences Vol. 30 No. 3 (2023): May 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.3.480-490

Abstract

The outbreak of the COVID-19 pandemic in the world has urged researchers to develop a vaccine or therapeutic drugs to fight this virus. This study aimed to assay 14 deoxy-11,12-didehydroandrographolide (AGP 2) ability as an inhibitor of 3-chymotrypsin like-protease (3CLPro), Papain-like protease (PLPro), and RNA-dependent RNA-polymerase (RdRp), the viral proteins of SARS-CoV-2 and to evaluate it safeness as a drug candidate. In-silico technique was performed in this study to analyze the binding interaction, complex stability between protein and ligand, and drug-likeness properties. The proteins and ligands were obtained from Protein Data Bank (PDB) and PubChem web tools, then using PyRx to identify the binding affinity score, PyMoL to visualize the 3D binding interaction, and WebGro web tools to analyze the stability of each complex. A drug-likeness evaluation was done using SwissADME, pkCSM, and Way2drug web tools. The result of this study showed that the binding affinity score for each complex is; AGP 2-3CLPro (-6.7 kcal/mol), AGP 2- PLPro (-6.4 kcal/mol), and AGP 2-RdRp (-7.0 kcal/mol) where the AGP 2-RdRp and AGP 2-3CLPro showed a stable form indicating the inhibitor ability of AGP 2. This study also demonstrates that the drug-likeness properties of AGP 2 are safe to use. Additionally, it has been proved that AGP 2 can be developed into a therapeutic drug with further studies.
Synergism of Consortium of Heterotrophic Bacterial Strains with Pistia stratiotes L. and Salvinia molesta D. Mitch as Biophytoremediator for Heavy Metal Removal in Domestic Wastewater Lud Waluyo; Nyono; Sukarsono; Atok Miftachul Hudha; Abdulkadir Raharjanto
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.21-29

Abstract

High levels of organic matter and heavy metals in domestic wastewater can increase the pollution of water bodies. The water pollution results correspond to the degree of public health. Waste must be controlled and processed first using management methods such as biophytoremedyator to decrease the rate of pollution because its advantages do not negatively impact public health and the environment. Biophytoremediation offers a better alternative method to repair environmental conditions by combining microorganisms and plants. This study aimed to analyze the effect of heterotrophic bacterial strains with Pistia stratiotes L. and Salvinia molesta D. Mitch for heavy metal removal in domestic wastewater. It also investigated the influence of heterotrophic bacterial strains with Pistia stratiotes L. and Salvinia molesta D. Mitch which were also carried out to observe the BOD and COD levels. The results showed decreased heavy metal levels from the three treatment groups. The consortium treatment group of heterotrophs and Salvinia molesta D. Mitch bacteria strains reduced heavy metal levels faster than the other groups by 59%. In addition, it is also able to reduce BOD and COD levels. This study has shown the significant effect of combining heterotrophic bacterial (HB) strains with Pistia stratiotes L. or Salvinia molesta D. Mitch for heavy metal removal in domestic wastewater.
Co-Authors Abdulkadir Rahardjanto Abdulkadir Rahardjanto Abdulkadir Rahardjanto Abdulkadir Rahardjanto, Abdulkadir Abdulkadir Raharjanto Aci, Sahid Setiawan Agus Setiawan Ahmad Fauzi Ajizatunnisa Ajizatunnisa Ajizatunnisa, Ajizatunnisa Ali Mokhtar Alvin Dewa Yanuar Ardiansyah, Ivan Armi Larasati Arsya Lingga Datu Atok Miftachul Hudha Atok Miftachul Hudha Baiduri Diani Fatmawati Diani Fatmawati Didit Shela Nurfatul Daniar Dwi Puji Hastuti Eko Susetyorini Elly Purwanti Erni Yohani Mahtuti Fatah, M. Arya Fendy Hardian Permana Fitri, Nur Lailatul Fuad Jaya Miharja Haerana Harahap, Dakkal Hikmah, Lailatul Husamah Husamah Iis Siti Aisyah Ivan Ardiansyah Khoirin Maghfiroh Limsi Limsi Moch. Agus Krisno Budiyanto Moch. Agus Krisno Budiyanto Moch. Agus Krisno Budiyanto Moch. Agus Krisno Budiyanto, Moch. Agus Krisno Moh. Mirza Nuryadi Moh. Mirza Nuryady Moh. Rofiq Mohd. Affendi Labo Muhammad Vicky Astria Nafisa Nur Azizah Nikman Azmin Nur Lailatul Fitri Nurhayati Nurhayati Nurinayah Nurinayah Nurinayah, Nurinayah Nurrohman, Endrik Nurul Mahmudati Nurul Mahmudati Nyono Onky Paramanda Arma Purwati, Elly Rahadjanto, Abdulkadir Raharja, Diva Yunta Ratna Wulandari Ratna Wulandari Rima Kholifatul Janah Ririn Harini Roimil Latifa Roro Eko Susetyarini Rozikin Rr. Eko Susetyarini Rr. Eko Susetyarini Salsabila Mumtasah Samsun hadi Sari, Citra Dewi Indra Sitaresmi Weka Sukrisno Siti Zubaidah Sri Wahyuni Sri Wahyuni Sri Wahyuni Sri Wahyuni Sukarsono Suwandayani, Beti Istanti Syahrul Syahrul Tien Aminah Ulpa Riski Kumala Sari Warye, Aulia Yayuk Robidah Yeyen Fitri Yuni Pantiwati Yus Mochamad Cholily Zulyamin Kimo