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All Journal PROSIDING SEMINAR NASIONAL MANDALA of Health Universa Medicina Jurnal Pengabdian Pada Masyarakat Journal Of Holistic Nursing Science Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Budimas : Jurnal Pengabdian Masyarakat Mandala of Health : A Scientific Journal Medical and Health Journal Journal of Public Health and Pharmacy Journal of Applied Science for Pharmaceuticals and Health
Fajar Wahyu Pribadi
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Religion Agriculture, Biological Sciences & Forestry Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : MANDALA of Health

 1 
PENGARUH PEMBERIAN SIMETIDIN TERHADAP KADAR SGOT DAN SGPT TIKUS PUTIH (Rattus norvegicus) YANG DIBERI ANTI TUBERKULOSIS RIFAMPISIN DAN ISONIAZID Siswandari, Wahyu; Pribadi, Fajar Wahyu; Perdini, Eska
MANDALA of Health Vol 4, No 2 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Tuberkulosis (TB) has long been known as an infection diseases, and has been reported to increased.The INH dan Rifampisin are two different drugs that are known tobe the most active drugs, therefore bothdrugs are being used as never ending drugs in curing the TB. Utilization of both INH and rifampisin in acombination to cure the TB patients, however could increase the possibility of hepar lession risk. Thisresearch was aimed to firstly, knowing whether cimetidine could prevent increase of SGOT and SGPT levelsof rats (Rattus norvegicus) given by both drugs INH and rifampisin, and secondly what was the minimumdose of cimetidine that able to prevent the increase of SGOT and SGPT levels. A Completely Random Design(CRD) was applied in this research, 24 male rats (Rattus norvegicus) of the wistar variety were divided into4 different groups. The first group, was only given the INH and rifampisin orally at the doses of 50 mg/Kgbody weight/day, the next groups groups II, III, and IV were also given those two drugs at the same dose, butthe cimetidine was also given at 112,5 , 225, and 450 mg/Kg body weight/day for the 28 days. Consequentlythe SGOT and SGPT levels were measured twice pre and post treatments. The data obtained were analysiedby the paired t test, a one way ANOVA, Post Hoc Tukey’s HSD, Kruskal-Wallis and Mann-Whitney test. Thisresearch result showed that the cimetidine that given following the INH and rifampisin could prevent theincrease of SGOT and SGPT levels. The highest dose of 450 mg/Kg body weight/day that given orally showedhighly significant different from other (p<0,00) in preventing the SGOT and SGPT of treated animals
PENGARUH PEMBERIAN SUSPENSI MENIRAN (Phyllanthus niruri L.) TERHADAP KERUSAKAN HEPAR TIKUS PUTIH YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID Sulistyoningrum, Evy; Pribadi, Fajar Wahyu
MANDALA of Health Vol 4, No 1 (2010): Mandala Of Health
Publisher : Jurusan Kedokteran FK Unsoed

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Abstract

Tuberculosis treatment required at least two antituberculosis drugs (ATDs) and long term course.Isoniazid (INH) and Rifampicin are the two most active ATDs and were used in whole course of treatment.INH and Rifampicin combination increased risk of hepatotoxixity. Meniran (Phyllanthus niruri L.) containsphyllanthin, active subtance that is believed to have hepatoprotective activity. The aim of this study was toknow the effect of meniran suspension on AST/ALT blood levels and histopathological findings afterinduction of Rifampicin and INH. Twenty five male albino rats (Rattus norvegicus) wistar strain aged twomonths and weighed 150-200 grams were divided into five groups of five each. Positive control (A) wastreated with aquadest, negative control (B) was treated with Rifampicin and INH; one dose meniran (I) waspre-treated with 16,2 mg meniran before ATDs; two dose meniran (II) was pre-treated with 32,4 mg meniranbefore ATDs, three dose meniran (III) was pre-treated with 48,6 mg meniran before ATDs. The drugs wereadministered orally for 28 days. Blood samples for ALT/AST levels and histopathology sample were taken atthe end of study. One way ANOVA, post hoc and linear regression were used for data analysis. There wassignificant mean difference for ALT levels (p=0,000) but not for AST level (p> 0,05). Increasing dose ofmeniran decreased serum level of ALT (r=-0,539). Vacuolar degeneration, necrosis and portal triadleucocytes infiltration were most common in negative control groups, while these changes were reduced inmeniran-treated groups. We can conclude that meniran pretreatment reduces INH-rifampicin-inducedhepatotoxicity.
Co-Authors Afifah Afifah Alice Yuniaty Aulia Salsabiela Dimo Hari Anggara Dody Novrial Dwi Utami Anjarwati Eliada Herwiyanti Eska Perdini, Eska Evy Sulistyoningrum Fareza, Muhamad Salman Gita Nawangtantrini Gita Nawangtantrini Hidayat Sulistyo Idsap Peramiarti Miko Ferine Muhammad Afif Nawangtantrini, Gita Panuntun, Hilmi Puguh Putri Nur'afni Sa'adah Riski Fatah, Muhammad Robby Al Fauzy Setiawati - Thianti Sylviningrum Viva Ratih Bening Ati Wahyu Dwi Kusdaryanto Wahyu Siswandari Wahyudin Wahyudin Widiartini, Catharina Zahra Muthmainnah Komara Zainuddin Zainuddin